SA516380600B1 - أجسام مضادة ثنائية التكافؤ مرتبطة تساهميا لها نشاط تفاعلي مناعي مع وطرق استخدامها lag-3 و pd-1 - Google Patents

أجسام مضادة ثنائية التكافؤ مرتبطة تساهميا لها نشاط تفاعلي مناعي مع وطرق استخدامها lag-3 و pd-1

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SA516380600B1
SA516380600B1 SA516380600A SA516380600A SA516380600B1 SA 516380600 B1 SA516380600 B1 SA 516380600B1 SA 516380600 A SA516380600 A SA 516380600A SA 516380600 A SA516380600 A SA 516380600A SA 516380600 B1 SA516380600 B1 SA 516380600B1
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lag
diabodies
epitope
specific
immunoreactivity
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SA516380600A
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بونفيني إزيو
ايه موري بول
لا موتي - موهس روس
كوينيج سكوت
شاه كالبانا
اس جونسون ليزلي
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ماكرو جينيكز، انك
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/626—Diabody or triabody
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74—Inducing cell proliferation

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  • Organic Chemistry (AREA)
  • Immunology (AREA)
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Abstract

يتعلق الاختراع الحالي بأجسام مضادة ثنائية التكافؤ مزدوجة النوعية bi-specific Fc diabody تشتمل على اثنين أو أكثر من سلاسل بولي ببتيد polypeptide chains وتتمتع بموقع ربط قمة لاصقة epitope واحد على الأقل يكون نوعي مناعي لقمة لاصقة من PD-1 وبموقع ربط قمة لاصقة واحد على الأقل يكون نوعي مناعي لقمة لاصقة من LAG-3 (أي، "PD-1 x LAG-3 جسم مضاد ثنائي التكافؤ مزدوج النوعية"). بصورة مفضلة، يتم توجيه الاختراع الحالي إلى أجسام مضادة ثنائية التكافؤ مزدوجة النوعية تشتمل على أربع سلاسل بولي ببتيد وتتمتع بموقعي ربط قمة لاصقة يكونان نوعيين مناعيين لقمة لاصقة واحدة (أو اثنتين) من PD-1 و موقعي ربط قمة لاصقة يكونان نوعيين مناعيين لقمة لاصقة واحدة (أو اثنتين) من LAG-3 (أي، "PD-1 x LAG-3 جسم مضاد ثنائي التكافؤ مزدوج النوعية، رباعي التكافؤ"). كما تم توجيه الاختراع الحالي إلى الأجسام الثنائية المذكورة التي تشتمل بالإضافة إلى ذلك على نطاق Fc لجلوبيولين مناعي immunoglobulin (أجسام ثنائية Fc مزدوجة النوعية وأجسام Fc مزدوجة النوعية رباعية التكافؤ"). الأجسام الثنائية للاختراع الحالي تكون قادرة على الارتباط المتزامن
SA516380600A 2014-06-26 2016-12-25 أجسام مضادة ثنائية التكافؤ مرتبطة تساهميا لها نشاط تفاعلي مناعي مع وطرق استخدامها lag-3 و pd-1 SA516380600B1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462017467P 2014-06-26 2014-06-26
PCT/US2015/036634 WO2015200119A1 (en) 2014-06-26 2015-06-19 Covalently bonded diabodies having immunoreactivity with pd-1 and lag-3, and methods of use thereof

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SA516380600B1 true SA516380600B1 (ar) 2022-02-08

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