SA516380328B1 - مركبات مستبدلة-8،6-دايوكسابيسيكلو[3-2-1]أوكتان-3،2-دايول asgpr كعوامل استهداف - Google Patents

مركبات مستبدلة-8،6-دايوكسابيسيكلو[3-2-1]أوكتان-3،2-دايول asgpr كعوامل استهداف

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Publication number
SA516380328B1
SA516380328B1 SA516380328A SA516380328A SA516380328B1 SA 516380328 B1 SA516380328 B1 SA 516380328B1 SA 516380328 A SA516380328 A SA 516380328A SA 516380328 A SA516380328 A SA 516380328A SA 516380328 B1 SA516380328 B1 SA 516380328B1
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Saudi Arabia
Prior art keywords
asgpr
targeting agents
dioxabicyclo
octane
substituted
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SA516380328A
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English (en)
Inventor
ثوما بنجامين
ليراس سبايروس
ماسكيتي فينسن
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.فايزر انك
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Application filed by .فايزر انك filed Critical .فايزر انك
Publication of SA516380328B1 publication Critical patent/SA516380328B1/ar

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Abstract

يتعلق الاختراع الحالي بمركبات الصيغة (A) وباستخدامها في معالجة أمراض، حالات و/أو اضطرابات تتدخل فيها بصورة غير مباشرة تركيبات دوائية واستخداماتها كعوامل لاستهداف مستقبل الجليكوبروتين اللاسيالي asialoglycoprotein receptor (ASGPR). مركب تمثيلي من الصيغة (A) مبين في الشكل 1، وموصوف كذلك في المثال 23. الشكل 1.
SA516380328A 2014-05-19 2016-11-17 مركبات مستبدلة-8،6-دايوكسابيسيكلو[3-2-1]أوكتان-3،2-دايول asgpr كعوامل استهداف SA516380328B1 (ar)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462000211P 2014-05-19 2014-05-19
US201462001540P 2014-05-21 2014-05-21
US201562139254P 2015-03-27 2015-03-27

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SA516380328B1 true SA516380328B1 (ar) 2021-06-24

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EP (1) EP3145934B1 (ar)
JP (2) JP6193513B2 (ar)
KR (1) KR102149572B1 (ar)
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AU (1) AU2015262993B2 (ar)
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