RU2598740C1 - Therapeutic mouthwash for gums - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention relates to dentistry, specifically to devices for medical and preventive gingival mucosa and oral cavity care. Disclosed therapeutic mouthwash for gums contains hyaluronic acid and oil extract of camomile, maclei, clove tree, black chokeberry, mangosteen and sea-buckthorn in equal ratios in following proportions, wt%: hyaluronic acid 0.01-3; oil extract of camomile, maclei, clove tree, black chokeberry fruits, mangosteen and sea-buckthorn in equal proportions 0.01-10; distilled water - balance.

EFFECT: creation of effective oral care agent with additional effect of deep prolonged action on periodontal tissues.

1 cl, 2 tbl, 3 ex

Description

The invention relates to dentistry, and in particular to means for therapeutic and prophylactic care of the mucous membrane of the gums and oral cavity.

Hyaluronic acid-based preparations are actively used in medicine and cosmetology as an effective regenerating and hydrating agent. Recently, in medical bioengineering, plastic materials have been developed on its basis for regenerative surgery (Rakhmatulin PP Bioplastic material based on a hydrocolloid of hyaluronic acid and a peptide complex for reconstructive and reconstructive surgery: Abstract of the dissertation of a doctor of biological sciences. - M., 2014. - 26 p. )

For therapeutic purposes, the zinc salt of hyaluronic acid (the active substance of the curiosin preparation) is widely used for tissue regeneration (https://drugfinder.ru/drug/kuriozin/). Hyaluronic acid is a natural biopolymer of mucopolysaccharide nature, an important element of connective tissue. Due to its physicochemical properties, it is able to interact with other molecules (water, protein, etc.), which plays a central role in specific biological processes. In pathological conditions, the concentration of hyaluronic acid in the tissues decreases, and cell proliferation and overall regeneration slow down. Local application of hyaluronic acid allows you to make this process reversible and thereby achieve natural regeneration in the tissues. Hyaluronic acid provides the migration of fibroblasts to the lesion and stimulates the process of angiogenesis, thereby improving local microcirculation (https://drugfinder.ru/drug/kuriozin/).

However, the currently used hyaluronic acid solutions are not used as mouthwashes for the following reasons:

1. Aqueous solutions of hyaluronic acid are not able to form hydrating films on the mucous membrane of the oral cavity and, accordingly, have a short-term effect. To achieve the optimal therapeutic effect, frequent use of these drugs is required, which leads to inconvenience for patients.

2. Hyaluronic acid salts have low organoleptic qualities and cause adverse reactions (dyspeptic disorders).

Thus, modern technological solutions to overcome these causes will allow us to develop new effective therapeutic and prophylactic agents for use in dentistry.

The prototype of this invention is an agent for therapeutic and prophylactic oral care - a rinse for gums "Forest Balsam" on a decoction of herbs, OJSC Concern "Kalina" (https://www.kalina.org/brands/balm/section.ptp?SECTION_ID = 733).

The composition of the mouth rinse is based on extracts of oak bark, fir, and a decoction of herbs (chamomile, yarrow, St. John's wort, celandine, nettle). Composition: Aqua, Glycerin, Alcohol (rectified ethyl alcohol from food raw materials), PEG-40 Hydrogenated Castor Oil, PVM / MA Copolymer, Aloe Barbadensis Leaf Extract, Aroma, Disodium EDTA, Propylene Glycol, Sodium Fluoride, Sodium Hydroxide, Triclosan, 2 -Bromo-2-Nitropropane-1,3-Diol, Abies Alba Leaf Oil, Sodium Saccharin, Methylparaben, Sodium Benzoate, Potassium Sorbate, Achillea Millefolium Extract, Hypericum Perforatum Flower / Leaf / Stem Extract, Chelidonium Majus Extract, Chamomilla Recutita (Matricaria ) Flower, Pyrus Communis (Pear) Fruit Juice, Lonicera Japonica (Honeysuckle) Flower Extract, Sophora Japonica Flower Extract, Trideceth-9, Echinacea Purpurea Extract, Vanilla Planifola Fruit Extract, Camellia Sinensis Leaf Extract, Avena Sativa (Oat) Straw Extract, Cananga Odorata Rower Oil, Santalum Album (Sandalwood) Oil, Hydrolyzed Silk, Urtica Oioica (Nettle) Leaf Powder, Propylparaben, Diazolidinyl Urea, Methylisothiazolinone, Methyl chloroisothiazolinone, Eugenol, Limonene, CI 42090, CI 19140.

Mass fraction of fluorides in the composition of the rinse "Forest Balsam" 0.02%. The volume fraction of ethyl alcohol 1.32% vol.

With regular use, according to the manufacturer, after 14 days, bleeding of the gums decreases, inflammation decreases, the rate of plaque formation decreases, pain in the gums is eliminated. Apply it twice a day, after eating and brushing your teeth: fill the cap with rinse aid "Forest Balsam" and then carefully rinse your mouth for 1 minute.

However, along with the positive properties of the conditioner "Forest Balsam" has the following disadvantages:

- the action of the rinse aid is limited in time only for the period of its direct presence in the oral cavity (1-2 minutes);

- it contains rectified ethyl alcohol (volume fraction of ethyl alcohol 1.32% vol.), which is problematic for the use of this product in school children and adolescents, as well as patients treated for alcoholism. For drivers of vehicles, the use of a rinse agent containing alcohol is also not recommended;

- the mouth rinse contains triclosan (antimicrobial effect), therefore, the course of use of such a tool can not exceed 2-3 weeks, otherwise it is possible to develop dysbiosis in the oral cavity, dryness and irritation of the mucous membrane, persistent bad breath after canceling the mouth rinse;

- the “Forest Balsam” conditioner, in addition to the plant components, includes organic solvents and perfumes, which can cause allergic reactions.

The technical result of the invention is the creation of an effective means for caring for the oral cavity with the additional effect of a deep prolonged effect on periodontal tissues.

The problem is solved by a therapeutic and preventive rinse for gums, characterized in that it contains hyaluronic acid and oil extracts of chamomile, maklea, clove, fruits of aronia, mangosteen and sea buckthorn in equal proportions in the following ratio of components, wt. %:

Hyaluronic acid 0.01-3 Chamomile oil extract, Maclea, clove tree, fruits of aronia, mangosteen and sea buckthorn in equal proportions 0.01-10 Distilled water rest

Hyaluronic acid is introduced into the formulation in an amount of 0.01-3%, because below the lower limit, the concentration of hyaluronic acid does not provide a physiological effect, and above 3% a viscous solution forms, which is not able to form a balsamic complex (oil emulsion) due to the high specific gravity of the hydrocolloid.

The introduction into the rinse of oil extracts of chamomile, macklea, clove, chokeberry, mangosteen and sea buckthorn in excess of the claimed amount can lead to irritation and allergic reactions, and the introduction of a quantity less than the claimed amount will not lead to significant result.

The positive properties of such a therapeutic and preventive rinse for gums are:

- the ability to hydrate (moisturize) the oral mucosa (including the gingival mucosa), because a hydrophilic film forms on the mucous membrane;

- any hydrophilic or hydrophobic drug can be introduced into the composition;

- the gradual withdrawal of beneficial substances from the composition of the hydrophilic film provides a prolonged therapeutic effect for more effective treatment of diseases of the oral mucosa and periodontium;

- hyaluronic acid directly improves microcirculation and tissue repair of the oral cavity;

- the rinse agent does not contain alcohol, it contains plant components (oil extracts of herbs), so it can be used to prevent exacerbations of chronic inflammation in the oral cavity and is used constantly and regularly;

- It has pleasant organoleptic properties and does not cause discomfort when rinsing.

Table 1 shows the comparison of the prototype and the developed therapeutic and preventive rinse for gums.

The inventive treatment and prophylactic rinse for gums (100 ml) is obtained as follows.

The technology for producing a therapeutic and preventive rinse for gums is based on the principle of dispersing hydrophilic (hyaluronic acid) and hydrophobic (oil extracts) components in a temperature range of 40-50 ° C.

A prescription amount of dry matter of hyaluronic acid is used, which, when stirred, is added to 100 ml of distilled water at a temperature of 40-50 ° C. A viscous hydrogel is formed, in which the calculated amount of oil extract of chamomile, maclea, clove, chokeberry, mangosteen and sea buckthorn is added, the resulting mixture is heated to 40-50 ° C and homogenized in the dispersion mode on an UPS unit (Prombiofit, Russia) over 10-15 minutes. The resulting mass is cooled to the temperature of the working room, poured into bottles of glass and sealed with plastic caps.

Examples of component composition are given below.

Example 1. The preparation of a therapeutic and preventive rinse for gums is carried out in the same way as described for the general case (per 100 ml), loading in the same sequence the following amounts of components: hyaluronic acid 0.01% and 10% oil extracts of chamomile, maklei, clove tree, fruits of aronia, mangosteen and sea buckthorn in equal proportions, the rest is up to 100%.

Example 2. The preparation of a therapeutic and preventive rinse for gums is carried out in the same way as described for the general case (per 100 ml), loading in the same sequence the following quantities of components: hyaluronic acid 1.5% and 5% oil extracts of chamomile, maklea, clove tree, fruits of aronia, mangosteen and sea buckthorn in equal proportions, the rest is up to 100%.

Example 3. The preparation of a therapeutic and preventive rinse for gums is carried out in the same way as described for the general case (per 100 ml), loading in the same sequence the following amounts of components: hyaluronic acid 3% and 0.01% oil extracts of chamomile, maklea, clove tree, fruits of aronia, mangosteen and sea buckthorn in equal proportions, the rest is up to 100%.

It is recommended to use a therapeutic and prophylactic rinse for gums in the form of rinses for 1 minute, 5 ml each morning and evening for therapeutic and preventive purposes.

Thus obtained treatment and preventive rinse has been clinically tested in volunteer patients suffering from dental diseases according to the following indications:

1) bleeding and soreness of the gums in chronic periodontitis of mild to moderate severity in the acute stage (20 people, not smokers);

2) hyperesthesia and increased tooth sensitivity (20 people);

3) chronic periodontitis of mild to moderate severity in smokers (20 people).

Before the start of the study, all patients got acquainted and signed an informed consent to participate in it.

After learning the rules of oral hygiene, volunteers were asked to use a therapeutic and preventive rinse for gums in the morning and evening after eating and brushing your teeth. The cap of the bottle of the therapeutic gum rinse aid was filled, which was carefully rinsed in the mouth for 1 minute, then spit out.

Assessment of organoleptic properties was carried out according to a survey of study participants. The possible local irritating and allergenic effects of the therapeutic and prophylactic rinse for the gums were determined by visual inspection of the patients' oral mucosa using a dental mirror.

Examination of the oral cavity was carried out by the dentist on the 3rd, 7th and 14th day of using the balsamic complex.

During the control dental examinations, the state of oral hygiene, periodontal tissues and the oral mucosa was determined with the use of therapeutic and preventive rinse for gums.

The results of the clinical study are presented in table 2.

As can be seen from the table, the best and accelerated result was obtained in the group of volunteers according to the indication “Hypesthesia and increased sensitivity of the teeth”, also on day 14 for all examined in the group according to the parameter “Bleeding and soreness of the gums in chronic periodontitis of mild to moderate severity stages of exacerbation ”a pronounced clinical effect was noted. In the group “chronic periodontitis of mild and moderate severity in smokers”, a positive result was noted in half the cases, which is associated with the continued smoking of volunteers.

During the study period of a therapeutic and preventive rinse for gums, an improvement in the hygienic condition of the oral cavity and a decrease in inflammatory phenomena in periodontal tissues are determined.

Convenience of use, a feeling of comfort and freshness in the oral cavity were noted by all volunteers. During the study period, adverse reactions in the form of a local irritant or allergenic effect were not detected.

Thus, the studies show that the therapeutic and prophylactic rinse for the gums has optimal physicochemical properties, has a pronounced clinical effect, is convenient to use and well tolerated.

A distinctive feature of the therapeutic gum rinse is its composition and the ability to form a hydrated film on the oral mucosa with the gradual release of oil extracts of organic substances.

Thus, compared with the prototype, the claimed therapeutic and preventive rinse for gums provides the effect of a deep prolonged effect on periodontal tissues, a regenerating effect, as well as a bactericidal and anti-inflammatory effect. In addition, it is convenient to use, and its good tolerance is also noted.

Claims (1)

Treatment and prophylactic rinse for gums, characterized in that it contains hyaluronic acid and oil extracts of chamomile, mackle, clove, fruits of chokeberry, mangosteen and sea buckthorn in equal proportions in the following ratio of components, wt.%:
Hyaluronic acid 0.01-3 Chamomile oil extract, Maclea, clove tree, fruits of aronia, mangosteen and sea buckthorn in equal proportions 0.01-10 Distilled water rest