RS58594B1 - Jedinjenja dimetilbenzoeve kiseline - Google Patents

Jedinjenja dimetilbenzoeve kiseline

Info

Publication number
RS58594B1
RS58594B1 RS20190469A RSP20190469A RS58594B1 RS 58594 B1 RS58594 B1 RS 58594B1 RS 20190469 A RS20190469 A RS 20190469A RS P20190469 A RSP20190469 A RS P20190469A RS 58594 B1 RS58594 B1 RS 58594B1
Authority
RS
Serbia
Prior art keywords
acid compounds
dimethylbenzoic acid
dimethylbenzoic
compounds
acid
Prior art date
Application number
RS20190469A
Other languages
English (en)
Inventor
Maria-Jesus Blanco-Pillado
Peter Rudolph Manninen
Matthew Allen Schiffler
Tatiana Natali Vetman
Alan M Warshawsky
Jeremy Schulenburg York
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of RS58594B1 publication Critical patent/RS58594B1/sr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00Carboxylic acid amides
    • C07C233/64Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/84Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81Amides; Imides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
    • C07D215/52Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
RS20190469A 2013-12-17 2014-12-11 Jedinjenja dimetilbenzoeve kiseline RS58594B1 (sr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361916824P 2013-12-17 2013-12-17
PCT/US2014/069783 WO2015094912A1 (en) 2013-12-17 2014-12-11 Dimethylbenzoic acid compounds
EP14827908.6A EP3083554B1 (en) 2013-12-17 2014-12-11 Dimethylbenzoic acid compounds

Publications (1)

Publication Number Publication Date
RS58594B1 true RS58594B1 (sr) 2019-05-31

Family

ID=52355186

Family Applications (1)

Application Number Title Priority Date Filing Date
RS20190469A RS58594B1 (sr) 2013-12-17 2014-12-11 Jedinjenja dimetilbenzoeve kiseline

Country Status (23)

Country Link
US (1) US10005721B2 (sr)
EP (1) EP3083554B1 (sr)
JP (1) JP6200596B2 (sr)
KR (1) KR101937186B1 (sr)
CN (1) CN105793236B (sr)
AU (1) AU2014366371B2 (sr)
CA (1) CA2929562A1 (sr)
CY (1) CY1121677T1 (sr)
DK (1) DK3083554T3 (sr)
EA (1) EA028675B1 (sr)
ES (1) ES2727329T3 (sr)
HR (1) HRP20190793T1 (sr)
HU (1) HUE043614T2 (sr)
LT (1) LT3083554T (sr)
ME (1) ME03398B (sr)
MX (1) MX368178B (sr)
PL (1) PL3083554T3 (sr)
PT (1) PT3083554T (sr)
RS (1) RS58594B1 (sr)
SA (1) SA516371324B1 (sr)
SI (1) SI3083554T1 (sr)
TR (1) TR201904327T4 (sr)
WO (1) WO2015094912A1 (sr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016037954A1 (de) 2014-09-09 2016-03-17 Bayer Pharma Aktiengesellschaft Substituierte n,2-diarylchinolin-4-carboxamide und ihre anti-inflammatorische verwendung
US10745382B2 (en) * 2015-10-15 2020-08-18 Bristol-Myers Squibb Company Compounds useful as immunomodulators
CR20180323A (es) 2015-11-20 2018-08-06 Idorsia Pharmaceuticals Ltd Derivados de indol n-sustituídos como moduladores de los receptores de pge2
WO2017153235A1 (de) * 2016-03-09 2017-09-14 Bayer Pharma Aktiengesellschaft Substituierte n-cyclo-3-aryl-1-naphthamide und ihre verwendung
MX2019012153A (es) 2017-04-10 2019-11-21 Bayer Ag N-ariletil-2-arilquinolina -4-carboxamidas sustituidas y su uso.
TWI770157B (zh) 2017-04-10 2022-07-11 德商拜耳廠股份有限公司 經取代之n-芳基乙基-2-胺基喹啉-4-甲醯胺及其用途
KR102612649B1 (ko) 2017-05-18 2023-12-11 이도르시아 파마슈티컬스 리미티드 Pge2 수용체 조절제로서의 벤조푸란 및 벤조티오페논 유도체
JP7159215B2 (ja) 2017-05-18 2022-10-24 イドーシア ファーマシューティカルズ リミテッド Pge2レセプター調節剤としてのピリミジン誘導体
HRP20211532T1 (hr) 2017-05-18 2022-01-07 Idorsia Pharmaceuticals Ltd N-supstituirani derivati indola
PE20191814A1 (es) 2017-05-18 2019-12-27 Idorsia Pharmaceuticals Ltd Derivados de pirimidina como moduladores del receptor de pge2
TW201900180A (zh) 2017-05-18 2019-01-01 瑞士商愛杜西亞製藥有限公司 嘧啶衍生物
AU2020212111A1 (en) * 2019-01-22 2021-08-05 Keythera (Suzhou) Pharmaceuticals Co. Ltd. Compound for inhibiting PGE2/EP4 signaling transduction inhibiting, preparation method therefor, and medical uses thereof
JPWO2022102731A1 (sr) 2020-11-13 2022-05-19

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1270615B (it) * 1994-07-14 1997-05-07 Smithkline Beecham Farma Uso di derivati di chinolina
TW502026B (en) * 1995-06-20 2002-09-11 Zeneca Ltd Aromatic compounds useful as antagonists of e-type prostaglandins, processes for the preparation thereof, pharmaceutical compositions comprising the compounds, and intermediates
US6548514B1 (en) * 1999-03-17 2003-04-15 Astrazeneca Ab Amide derivatives
WO2005021508A1 (en) * 2003-09-03 2005-03-10 Pfizer Inc. Phenyl or pyridyl amide compounds as prostaglandin e2 antagonists
MXPA06003123A (es) 2003-09-22 2006-05-31 Euro Celtique Sa Agentes terapeuticos utiles para el tratamiento del dolor.
GB0324269D0 (en) * 2003-10-16 2003-11-19 Pharmagene Lab Ltd EP4 receptor antagonists
WO2005080367A1 (en) * 2004-02-12 2005-09-01 Pharmagene Laboratories Limited Ep2 receptor agonists
AU2005238292A1 (en) * 2004-05-04 2005-11-10 Pfizer Inc. Ortho substituted aryl or heteroaryl amide compounds
US20070054916A1 (en) * 2004-10-01 2007-03-08 Amgen Inc. Aryl nitrogen-containing bicyclic compounds and methods of use
JP5183628B2 (ja) * 2006-06-12 2013-04-17 メルク カナダ インコーポレイテッド Ep4受容体リガンドとしてのインドリンアミド誘導体
WO2009005076A1 (ja) * 2007-07-03 2009-01-08 Astellas Pharma Inc. アミド化合物
WO2010043592A1 (en) 2008-10-15 2010-04-22 Revotar Biopharmaceuticals Ag Lipase inhibitors for use for the treatment of obesity
RU2529860C2 (ru) * 2009-01-30 2014-10-10 Тояма Кемикал Ко., Лтд. Производное n-ацилантраниловой кислоты или его соль
CA2757615C (en) * 2009-03-31 2018-07-17 Renascience Co., Ltd. Plasminogen activator inhibitor-1 inhibitor
WO2012004293A2 (de) 2010-07-08 2012-01-12 Bayer Cropscience Ag Insektizide und fungizide wirkstoffkombinationen
JP2014514257A (ja) 2011-03-03 2014-06-19 ユニバーシテーテ デス ザールランデス 選択的17ベータ−ヒドロキシステロイドデヒドロゲナーゼ2型阻害剤としてのビアリール誘導体
AU2012300834A1 (en) * 2011-08-31 2014-04-17 Amakem Nv Biphenylcarboxamides as ROCK kinase inhibitors
CN103930396B (zh) * 2011-09-16 2016-11-16 赛诺菲 苯胺衍生物,其制备及其治疗应用
TWI572597B (zh) * 2012-06-29 2017-03-01 美國禮來大藥廠 二甲基-苯甲酸化合物
EP2765128A1 (en) * 2013-02-07 2014-08-13 Almirall, S.A. Substituted benzamides with activity towards EP4 receptors

Also Published As

Publication number Publication date
CY1121677T1 (el) 2020-07-31
SI3083554T1 (sl) 2019-04-30
EA201690911A1 (ru) 2016-09-30
US20160251306A1 (en) 2016-09-01
KR101937186B1 (ko) 2019-01-10
AU2014366371A1 (en) 2016-05-19
DK3083554T3 (da) 2019-05-13
CN105793236A (zh) 2016-07-20
MX368178B (es) 2019-09-23
PT3083554T (pt) 2019-06-11
HUE043614T2 (hu) 2019-08-28
TR201904327T4 (tr) 2019-04-22
WO2015094912A1 (en) 2015-06-25
AU2014366371B2 (en) 2017-02-16
JP2017500309A (ja) 2017-01-05
SA516371324B1 (ar) 2018-03-22
JP6200596B2 (ja) 2017-09-20
CN105793236B (zh) 2017-10-10
PL3083554T3 (pl) 2019-08-30
CA2929562A1 (en) 2015-06-25
US10005721B2 (en) 2018-06-26
KR20160086905A (ko) 2016-07-20
ES2727329T3 (es) 2019-10-15
MX2016007861A (es) 2017-01-11
LT3083554T (lt) 2019-05-10
EA028675B1 (ru) 2017-12-29
EP3083554A1 (en) 2016-10-26
EP3083554B1 (en) 2019-03-13
ME03398B (me) 2020-01-20
HRP20190793T1 (hr) 2019-06-28

Similar Documents

Publication Publication Date Title
IL249518A0 (en) A compound that inhibits trk
GB201309085D0 (en) Compounds
AP2015008713A0 (en) Tetrahydropyrrolothiazine compounds
GB201302927D0 (en) Compounds
LT3083554T (lt) Dimetilbenzoinės rūgšties junginiai
GB201302368D0 (en) Compound
HK1219100A1 (zh) 吡啶基吡唑並喹啉化合物
AP3850A (en) Azetidinyloxyphenylpyrrolidine compounds
EP2947066A4 (en) PHENOXYALKYLAMINVERBINDUNG
EP3010923A4 (en) PYRROLOCHINAZOLINVERBINDUNGEN
EP2948457A4 (en) COMPOUNDS
GB201306794D0 (en) Compounds
GB201307331D0 (en) Compound
GB201408643D0 (en) Compound
GB201322438D0 (en) Compound
GB201315772D0 (en) Compound
GB201305634D0 (en) Compound
GB201304250D0 (en) Compound
GB201301585D0 (en) Compound
GB201309015D0 (en) Compounds
GB201308975D0 (en) Compounds
GB201308409D0 (en) Compounds
GB201307938D0 (en) Compounds
GB201307093D0 (en) Compounds
GB201304694D0 (en) Compounds