PT73711B - Process for preparing 3-aryl-5-isothiazolecarboxilic acids and related compounds used to lower uric levels - Google Patents

Process for preparing 3-aryl-5-isothiazolecarboxilic acids and related compounds used to lower uric levels

Info

Publication number
PT73711B
PT73711B PT73711A PT7371181A PT73711B PT 73711 B PT73711 B PT 73711B PT 73711 A PT73711 A PT 73711A PT 7371181 A PT7371181 A PT 7371181A PT 73711 B PT73711 B PT 73711B
Authority
PT
Portugal
Prior art keywords
isothiazolecarboxilic
aryl
acids
preparing
compounds used
Prior art date
Application number
PT73711A
Other languages
English (en)
Other versions
PT73711A (en
Inventor
James Richard Beck
Robert Peter Gajewski
Ronald Ervin Hackler
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PT73711A publication Critical patent/PT73711A/pt
Publication of PT73711B publication Critical patent/PT73711B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
    • C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57—Nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PT73711A 1980-09-22 1981-09-21 Process for preparing 3-aryl-5-isothiazolecarboxilic acids and related compounds used to lower uric levels PT73711B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/189,435 US4346094A (en) 1980-09-22 1980-09-22 3-Aryl-5-isothiazolecarboxylic acids and related compounds used to lower uric acid levels

Publications (2)

Publication Number Publication Date
PT73711A PT73711A (en) 1981-10-01
PT73711B true PT73711B (en) 1982-12-20

Family

ID=22697314

Family Applications (1)

Application Number Title Priority Date Filing Date
PT73711A PT73711B (en) 1980-09-22 1981-09-21 Process for preparing 3-aryl-5-isothiazolecarboxilic acids and related compounds used to lower uric levels

Country Status (22)

Country Link
US (1) US4346094A (pt)
EP (1) EP0048615B1 (pt)
JP (1) JPS5785379A (pt)
KR (1) KR830007597A (pt)
AR (1) AR229103A1 (pt)
AT (1) ATE7657T1 (pt)
AU (1) AU7551681A (pt)
CS (1) CS228536B2 (pt)
DD (1) DD201790A5 (pt)
DE (1) DE3163900D1 (pt)
DK (1) DK417981A (pt)
ES (1) ES505678A0 (pt)
FI (1) FI812940L (pt)
GB (1) GB2084573B (pt)
GR (1) GR75046B (pt)
IL (1) IL63890A0 (pt)
NO (1) NO813208L (pt)
PL (1) PL130497B1 (pt)
PT (1) PT73711B (pt)
RO (1) RO82216A (pt)
YU (1) YU227181A (pt)
ZA (1) ZA816549B (pt)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4428956A (en) 1980-12-29 1984-01-31 Merck & Co., Inc. 4-Hydroxy-5-substituted-3-(2H)-isothiazolone-1,1-dioxide derivatives useful in treating urinary tract calcium oxalate lithiasis
US4431652A (en) * 1980-12-29 1984-02-14 Merck & Co., Inc. 4-Hydroxy-5-substituted-3(2H)-isothiazolone-1,1-dioxide derivatives useful in treating urinary tract calcium oxalate lithiasis
US4539328A (en) * 1983-03-25 1985-09-03 Fmc Corporation Nematicidal isothiazole derivatives
US4620865A (en) * 1983-11-07 1986-11-04 Eli Lilly And Company Herbicidal and algicidal 1,5-disubstituted-1H-pyrazole-4-carboxamides
IE59813B1 (en) * 1986-05-09 1994-04-06 Warner Lambert Co Styryl pyrazoles, isoxazoles and analogs thereof having activity as 5-lipoxy-genase inhibitors and pharmaceutical compositions containing them
ZW21687A1 (en) * 1986-12-12 1988-07-20 Hoffmann La Roche Triazine derivatives
SG86971A1 (en) * 1990-11-30 2002-03-19 Teijin Ltd 2-arylthiazole derivatives and pharmaceutical composition thereof
US5294630A (en) * 1992-07-07 1994-03-15 Eli Lilly And Company Treatment of inflammatory bowel disease
US5436258A (en) * 1992-09-09 1995-07-25 Eli Lilly And Company Prevention of bone resorption
MY117352A (en) * 1995-10-31 2004-06-30 Ciba Sc Holding Ag Oximesulfonic acid esters and the use thereof as latent sulfonic acids.
ID21775A (id) * 1996-10-25 1999-07-22 Yoshitomi Pharmaceutical Senyawa-senyawa 1-fenilpirazol dan penggunaan farmasinya
WO1999024038A1 (en) 1997-11-07 1999-05-20 Johns Hopkins University Methods for treatment of disorders of cardiac contractility
TW575792B (en) * 1998-08-19 2004-02-11 Ciba Sc Holding Ag New unsaturated oxime derivatives and the use thereof as latent acids
SG78412A1 (en) 1999-03-31 2001-02-20 Ciba Sc Holding Ag Oxime derivatives and the use thereof as latent acids
BR0307501A (pt) 2002-02-06 2004-12-07 Ciba Sc Holding Ag Derivados de sulfonato e o uso destes como ácidos latentes
ES2331579T3 (es) * 2004-08-27 2010-01-08 Astellas Pharma Inc. Derivado de 2-fenilpiridina.
US7612108B2 (en) * 2004-08-27 2009-11-03 Astellas Pharma Inc. 2-phenylthiophene derivative
BRPI0616939A2 (pt) 2005-10-07 2011-07-05 Astellas Pharma Inc derivado de ácido triarilacarboxìlico
EP1992361B1 (en) 2006-02-24 2012-05-02 Astellas Pharma Inc. Remedy or preventive for digestive ulcer
GB2450975B (en) 2007-07-12 2010-02-24 Ciba Holding Inc Yellow radiation curing inks
CA2725047A1 (en) * 2008-05-22 2009-11-26 Bristol-Myers Squibb Company Method for treating hyperuricemia employing an sglt2 inhibitor and composition containing same
JP5312570B2 (ja) 2009-02-27 2013-10-09 帝人ファーマ株式会社 遷移金属触媒を用いたカップリング法によるフェニル置換複素環誘導体の製造法
EP2414894B1 (en) 2009-03-30 2014-02-12 Basf Se Uv-dose indicator films
HUE030166T2 (en) 2010-08-27 2017-05-29 Teijin Pharma Ltd Process for the preparation of a phenyl-substituted heterocyclic derivative by coupling using a palladium compound
WO2012101245A1 (en) 2011-01-28 2012-08-02 Basf Se Polymerizable composition comprising an oxime sulfonate as thermal curing agent
DK2980085T3 (en) * 2013-03-29 2018-05-22 Teijin Pharma Ltd pyrazole
CN106604912A (zh) 2014-08-29 2017-04-26 巴斯夫欧洲公司 肟磺酸酯衍生物
AU2016256186B2 (en) 2015-04-29 2020-01-16 Bsn Medical Gmbh Multi-step process for no production
WO2016174192A1 (de) 2015-04-29 2016-11-03 Bsn Medical Gmbh Medizinische badevorrichtung

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1178604A (en) * 1966-03-21 1970-01-21 American Cyanamid Co Novel Pyridinium Salts and Methods for Preparing Same
US3464999A (en) * 1967-07-27 1969-09-02 R & L Molecular Research Ltd Thiadiazolylisothiazoles
GB1180268A (en) * 1967-09-26 1970-02-04 Ici Ltd Pharmaceutically Active Phenyl-Heterocyclic-Alkanol Derivatives
GB1192701A (en) * 1968-03-22 1970-05-20 Ici Ltd Novel Thiazole Derivatives, the preparation thereof and Compositions containing the same
US3681498A (en) * 1970-10-19 1972-08-01 American Cyanamid Co Isothiazolyl pyridinium salts as hypoglycemic agents

Also Published As

Publication number Publication date
KR830007597A (ko) 1983-11-04
EP0048615B1 (en) 1984-05-30
US4346094A (en) 1982-08-24
ES8301225A1 (es) 1982-12-01
GB2084573A (en) 1982-04-15
ES505678A0 (es) 1982-12-01
PL130497B1 (en) 1984-08-31
ZA816549B (en) 1983-04-27
PT73711A (en) 1981-10-01
CS228536B2 (en) 1984-05-14
GB2084573B (en) 1984-09-12
JPS5785379A (en) 1982-05-28
DD201790A5 (de) 1983-08-10
DK417981A (da) 1982-03-23
NO813208L (no) 1982-03-23
IL63890A0 (en) 1981-12-31
DE3163900D1 (en) 1984-07-05
PL233103A1 (pt) 1982-12-20
RO82216B (ro) 1983-06-30
FI812940L (fi) 1982-03-23
YU227181A (en) 1983-10-31
ATE7657T1 (de) 1984-06-15
AR229103A1 (es) 1983-06-15
GR75046B (pt) 1984-07-12
AU7551681A (en) 1982-04-01
EP0048615A1 (en) 1982-03-31
RO82216A (ro) 1983-07-07

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