PT71436B - Process for preparing pharmaceutical compositions - Google Patents
Process for preparing pharmaceutical compositionsInfo
- Publication number
- PT71436B PT71436B PT71436A PT7143680A PT71436B PT 71436 B PT71436 B PT 71436B PT 71436 A PT71436 A PT 71436A PT 7143680 A PT7143680 A PT 7143680A PT 71436 B PT71436 B PT 71436B
- Authority
- PT
- Portugal
- Prior art keywords
- pharmaceutical compositions
- preparing pharmaceutical
- preparing
- compositions
- pharmaceutical
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1277—Processes for preparing; Proliposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH586379 | 1979-06-22 |
Publications (2)
Publication Number | Publication Date |
---|---|
PT71436A PT71436A (en) | 1980-07-01 |
PT71436B true PT71436B (en) | 1981-10-23 |
Family
ID=4300559
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT71436A PT71436B (en) | 1979-06-22 | 1980-06-20 | Process for preparing pharmaceutical compositions |
Country Status (21)
Country | Link |
---|---|
US (1) | US4411894A (en) |
EP (1) | EP0021337B1 (en) |
JP (1) | JPS567714A (en) |
KR (1) | KR850001301B1 (en) |
AR (1) | AR230178A1 (en) |
AT (1) | ATE5508T1 (en) |
AU (1) | AU534959B2 (en) |
CA (1) | CA1173360A (en) |
DE (1) | DE3065818D1 (en) |
DK (1) | DK155172C (en) |
ES (1) | ES492676A0 (en) |
FI (1) | FI72875C (en) |
HU (1) | HU186296B (en) |
IE (1) | IE49615B1 (en) |
IL (1) | IL60326A (en) |
MC (1) | MC1336A1 (en) |
NO (1) | NO155226C (en) |
NZ (1) | NZ194047A (en) |
PH (1) | PH16795A (en) |
PT (1) | PT71436B (en) |
ZA (1) | ZA803567B (en) |
Families Citing this family (74)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59152348A (en) * | 1983-02-19 | 1984-08-31 | Kaken Pharmaceut Co Ltd | Biphenylylpropionic acid ester derivative and its preparation |
US5186941A (en) * | 1983-05-06 | 1993-02-16 | Vestar, Inc. | Vesicle formulation for the controlled release of therapeutic agents |
JPH0768117B2 (en) * | 1983-05-06 | 1995-07-26 | ベスター・インコーポレイテツド | Vesicle formulation for controlled drug release |
US5059591B1 (en) * | 1983-05-26 | 2000-04-25 | Liposome Co Inc | Drug preparations of reduced toxicity |
CA1237670A (en) * | 1983-05-26 | 1988-06-07 | Andrew S. Janoff | Drug preparations of reduced toxicity |
JPS601122A (en) * | 1983-06-20 | 1985-01-07 | Green Cross Corp:The | Fat emulsion of biphenylylpropionic acid derivative |
CA1264162A (en) * | 1984-03-15 | 1990-01-02 | Manfred Breuninger | Glycerol ether phosphatides |
JPS60208910A (en) * | 1984-03-31 | 1985-10-21 | Green Cross Corp:The | Preparation of composite of hardly water-soluble drug and phospholipid |
US4891208A (en) * | 1985-04-10 | 1990-01-02 | The Liposome Company, Inc. | Steroidal liposomes |
US5231112A (en) | 1984-04-12 | 1993-07-27 | The Liposome Company, Inc. | Compositions containing tris salt of cholesterol hemisuccinate and antifungal |
PT78628B (en) * | 1984-05-02 | 1986-06-18 | Liposome Co Inc | Pharmaceutical composition with reduced toxicity |
CA1264668C (en) * | 1984-06-20 | 1990-01-23 | Extrusion techniques for producing liposomes | |
US5736155A (en) * | 1984-08-08 | 1998-04-07 | The Liposome Company, Inc. | Encapsulation of antineoplastic agents in liposomes |
CA1270198A (en) * | 1984-08-08 | 1990-06-12 | Marcel B. Bally | Encapsulation of antineoplastic agents in liposomes |
US4880635B1 (en) * | 1984-08-08 | 1996-07-02 | Liposome Company | Dehydrated liposomes |
US5077056A (en) * | 1984-08-08 | 1991-12-31 | The Liposome Company, Inc. | Encapsulation of antineoplastic agents in liposomes |
JPS61100518A (en) * | 1984-10-22 | 1986-05-19 | Ono Pharmaceut Co Ltd | Lyophilized ribosome pharmaceutical preparation comprising dimyristoylphosphatidylcholine as main component |
US4857319A (en) * | 1985-01-11 | 1989-08-15 | The Regents Of The University Of California | Method for preserving liposomes |
AU587600B2 (en) * | 1985-01-11 | 1989-08-24 | Regents Of The University Of California, The | Method for preserving liposomes |
US4753788A (en) * | 1985-01-31 | 1988-06-28 | Vestar Research Inc. | Method for preparing small vesicles using microemulsification |
CA1256372A (en) * | 1985-04-11 | 1989-06-27 | Koichiro Miyazima | Process for producing liposome composition |
US5409704A (en) * | 1985-06-26 | 1995-04-25 | The Liposome Company, Inc. | Liposomes comprising aminoglycoside phosphates and methods of production and use |
IL79114A (en) * | 1985-08-07 | 1990-09-17 | Allergan Pharma | Method and composition for making liposomes |
US5622713A (en) * | 1985-09-17 | 1997-04-22 | The Regents Of The University Of California | Method of detoxifying animal suffering from overdose |
US4766046A (en) * | 1985-09-27 | 1988-08-23 | Liposome Technology, Inc. | Stabilized liposome/amphotericin composition and method |
US5041278A (en) * | 1985-10-15 | 1991-08-20 | The Liposome Company, Inc. | Alpha tocopherol-based vesicles |
IE58981B1 (en) * | 1985-10-15 | 1993-12-15 | Vestar Inc | Anthracycline antineoplastic agents encapsulated in phospholipid micellular particles |
US4861580A (en) * | 1985-10-15 | 1989-08-29 | The Liposome Company, Inc. | Composition using salt form of organic acid derivative of alpha-tocopheral |
SE8505047L (en) * | 1985-10-25 | 1987-04-26 | Nutritional Int Res Inst | fat emulsion |
US4806343A (en) * | 1986-03-13 | 1989-02-21 | University Of Southwestern Louisiana | Cryogenic protectant for proteins |
US5252263A (en) * | 1986-06-16 | 1993-10-12 | The Liposome Company, Inc. | Induction of asymmetry in vesicles |
MX9203808A (en) * | 1987-03-05 | 1992-07-01 | Liposome Co Inc | HIGH DRUG CONTENT FORMULATIONS: LIPID, FROM LIPOSOMIC-ANTINEOPLASTIC AGENTS. |
US4950432A (en) * | 1987-10-16 | 1990-08-21 | Board Of Regents, The University Of Texas System | Polyene microlide pre-liposomal powders |
US4946683A (en) * | 1987-11-18 | 1990-08-07 | Vestar, Inc. | Multiple step entrapment/loading procedure for preparing lipophilic drug-containing liposomes |
JP2792702B2 (en) * | 1988-10-05 | 1998-09-03 | ネクスター・フアーマシユーテイカルズ・インコーポレイテツド | Method for preparing liposomes with improved stability when dried |
US5091187A (en) * | 1990-04-26 | 1992-02-25 | Haynes Duncan H | Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs |
US5246707A (en) * | 1990-04-26 | 1993-09-21 | Haynes Duncan H | Sustained release delivery of water-soluble bio-molecules and drugs using phospholipid-coated microcrystals, microdroplets and high-concentration liposomes |
US5091188A (en) * | 1990-04-26 | 1992-02-25 | Haynes Duncan H | Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs |
DK0555229T3 (en) * | 1990-07-31 | 1996-08-19 | Liposome Co Inc | Accumulation of amino acids and peptides in liposomes |
US5462740A (en) * | 1993-09-17 | 1995-10-31 | Athena Neurosciences, Inc. | Rectally-administered, epileptic-seizure-inhibiting composition |
US5840328A (en) * | 1994-01-11 | 1998-11-24 | The Liposome Company, Inc. | Treatment using arachidonic acid metabolite and particulate formulations |
JPH10508578A (en) * | 1994-09-23 | 1998-08-25 | ザ リポソーム カンパニー、インコーポレーテッド | Method for producing a lyophilized liposome product |
US6689370B1 (en) | 1995-04-20 | 2004-02-10 | Societe D'exploitation De Produits Pour Les Industries Chimiques (S.E.P.P.I.C.) | Therapeutic composition comprising an antigen or an in vivo generator of a compound comprising an amino acid sequence |
FR2733151B1 (en) * | 1995-04-20 | 1997-05-23 | Seppic Sa | THERAPEUTIC COMPOSITION COMPRISING AN ANTIGEN OR AN IN VIVO GENERATOR OF A COMPOUND COMPRISING AN AMINO ACID SEQUENCE |
US6117432A (en) * | 1995-04-20 | 2000-09-12 | Societe D'exploitation De Produits Pour Les Industries Chimiques (S.E.P.P.I.C.) | Therapeutic composition comprising an antigen or an in vivo generator of a compound comprising an amino acid sequence |
US20040208922A1 (en) * | 1995-06-07 | 2004-10-21 | The Regents Of The University Of California | Method for loading lipid like vesicles with drugs or other chemicals |
EP0855906B1 (en) * | 1995-10-17 | 2008-02-20 | Jagotec AG | Insoluble drug delivery |
GB9609779D0 (en) | 1996-05-10 | 1996-07-17 | Univ Bruxelles | Freeze dried liposome encapsulated amphiphilic drug compositions and a process for the preparation thereof |
US6465016B2 (en) | 1996-08-22 | 2002-10-15 | Research Triangle Pharmaceuticals | Cyclosporiine particles |
US7255877B2 (en) | 1996-08-22 | 2007-08-14 | Jagotec Ag | Fenofibrate microparticles |
US5827532A (en) * | 1997-01-31 | 1998-10-27 | The Reagents Of The University Of California | Method for loading lipsomes with ionizable phosphorylated hydrophobic compounds, pharmaceutical preparations and a method for administering the preparations |
IT1289938B1 (en) * | 1997-02-20 | 1998-10-19 | Angelini Ricerche Spa | PHARMACEUTICAL PREPARATION INCLUDING LYOPHYLIZED LIPOSOMES IN WHICH A HIGHLY WATER-INSOLUBLE ACTIVE SUBSTANCE IS ENCAPSULATED AND |
US6037323A (en) * | 1997-09-29 | 2000-03-14 | Jean-Louis Dasseux | Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders |
US6518412B1 (en) | 1997-09-29 | 2003-02-11 | Jean-Louis Dasseux | Gene therapy approaches to supply apolipoprotein A-I agonists and their use to treat dyslipidemic disorders |
US6046166A (en) * | 1997-09-29 | 2000-04-04 | Jean-Louis Dasseux | Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders |
US6004925A (en) * | 1997-09-29 | 1999-12-21 | J. L. Dasseux | Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders |
US6287590B1 (en) | 1997-10-02 | 2001-09-11 | Esperion Therapeutics, Inc. | Peptide/lipid complex formation by co-lyophilization |
ATE241363T1 (en) * | 1998-02-11 | 2003-06-15 | Rtp Pharma Corp | COMBINATION PREPARATIONS CONTAINING UNSATURATED FATTY ACID AND STEROIDS FOR THE TREATMENT OF INFLAMMATION |
US6979456B1 (en) | 1998-04-01 | 2005-12-27 | Jagotec Ag | Anticancer compositions |
CA2333648C (en) | 1998-05-29 | 2008-10-21 | Rtp Pharma Inc. | Thermoprotected microparticle compositions and process for terminal steam sterilization thereof |
CN1221249C (en) | 1998-08-19 | 2005-10-05 | 斯凯伊药品加拿大公司 | Injectable aqueous dispersions of propofol |
CA2349203C (en) | 1998-11-20 | 2013-05-21 | Rtp Pharma Inc. | Dispersible phospholipid stabilized microparticles |
EP1276465B1 (en) | 2000-04-20 | 2014-03-12 | Jagotec AG | Improved water-insoluble drug particle process |
US6653062B1 (en) * | 2000-07-26 | 2003-11-25 | Wisconsin Alumni Research Foundation | Preservation and storage medium for biological materials |
CN100457090C (en) | 2000-08-31 | 2009-02-04 | 斯凯伊药品加拿大公司 | Milled particles |
US8586094B2 (en) | 2000-09-20 | 2013-11-19 | Jagotec Ag | Coated tablets |
EP1355634B8 (en) * | 2000-11-09 | 2009-03-04 | Neopharm, Inc. | Sn-38 lipid complexes and methods of use |
TWI288000B (en) * | 2001-02-22 | 2007-10-11 | Rtp Pharma Inc | Fibrate-statin combinations with reduced fed-fasted effects |
WO2003030864A1 (en) | 2001-05-29 | 2003-04-17 | Neopharm, Inc. | Liposomal formulation of irinotecan |
AU2003296897A1 (en) * | 2002-08-20 | 2004-05-04 | Neopharm, Inc. | Pharmaceutical formulations of camptothecine derivatives |
KR100651728B1 (en) * | 2004-11-10 | 2006-12-06 | 한국전자통신연구원 | Compounds having anchoring group and electronic device including the same and methods for producing the same |
CA2503087A1 (en) * | 2005-03-30 | 2006-09-30 | Medicure International Inc. | Intravenous formulations of pyridoxal 5'-phosphate and method of preparation |
ES2402823T3 (en) * | 2006-06-01 | 2013-05-09 | Institut De Cardiologie De Montreal | Compound for use in the treatment of valve stenosis |
ES2620478T3 (en) | 2009-02-16 | 2017-06-28 | Cerenis Therapeutics Holding Sa | Mimetics of apolipoprotein A-I |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2081586A2 (en) * | 1970-01-24 | 1971-12-10 | Orsymonde | Dehydrated pharmaceutical comps by - lyophilisation |
JPS5186117A (en) * | 1975-01-27 | 1976-07-28 | Tanabe Seiyaku Co | Johoseibiryushiseizainoseiho |
IT1202370B (en) * | 1976-07-12 | 1989-02-09 | Hoffmann La Roche | INJECTABLE SOLUTIONS IN WHICH THE EMOLITHIC LIFE OF NATURAL MICELLES TRAINING AGENTS IS AVOIDED BY THE ADDITION OF LIPOIDS AND RELATED PRODUCTS |
DE2656333C2 (en) * | 1976-12-13 | 1985-08-08 | Karl Prof. Dr.med. 7302 Ostfildern Theurer | Process for the production of liposomes which contain medicinal substances |
GB1575343A (en) * | 1977-05-10 | 1980-09-17 | Ici Ltd | Method for preparing liposome compositions containing biologically active compounds |
CH621479A5 (en) * | 1977-08-05 | 1981-02-13 | Battelle Memorial Institute |
-
1980
- 1980-06-09 CA CA000353627A patent/CA1173360A/en not_active Expired
- 1980-06-11 FI FI801876A patent/FI72875C/en not_active IP Right Cessation
- 1980-06-13 AU AU59289/80A patent/AU534959B2/en not_active Ceased
- 1980-06-13 NZ NZ194047A patent/NZ194047A/en unknown
- 1980-06-16 IL IL60326A patent/IL60326A/en unknown
- 1980-06-16 ZA ZA00803567A patent/ZA803567B/en unknown
- 1980-06-18 EP EP80103395A patent/EP0021337B1/en not_active Expired
- 1980-06-18 AT AT80103395T patent/ATE5508T1/en not_active IP Right Cessation
- 1980-06-18 DE DE8080103395T patent/DE3065818D1/en not_active Expired
- 1980-06-18 HU HU801512A patent/HU186296B/en not_active IP Right Cessation
- 1980-06-19 AR AR281473A patent/AR230178A1/en active
- 1980-06-19 JP JP8221780A patent/JPS567714A/en active Pending
- 1980-06-20 DK DK266680A patent/DK155172C/en not_active IP Right Cessation
- 1980-06-20 PT PT71436A patent/PT71436B/en unknown
- 1980-06-20 IE IE1281/80A patent/IE49615B1/en unknown
- 1980-06-20 NO NO801863A patent/NO155226C/en unknown
- 1980-06-20 MC MC801456A patent/MC1336A1/en unknown
- 1980-06-20 PH PH24172A patent/PH16795A/en unknown
- 1980-06-21 ES ES492676A patent/ES492676A0/en active Granted
- 1980-06-21 KR KR1019800002458A patent/KR850001301B1/en active
-
1981
- 1981-08-17 US US06/293,587 patent/US4411894A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DK155172C (en) | 1989-09-18 |
PH16795A (en) | 1984-02-28 |
ZA803567B (en) | 1981-06-24 |
ES8104720A1 (en) | 1981-05-16 |
KR830002327A (en) | 1983-05-28 |
NZ194047A (en) | 1982-09-14 |
NO155226C (en) | 1987-03-04 |
CA1173360A (en) | 1984-08-28 |
EP0021337A2 (en) | 1981-01-07 |
DK155172B (en) | 1989-02-27 |
KR850001301B1 (en) | 1985-09-12 |
EP0021337B1 (en) | 1983-12-07 |
IL60326A (en) | 1983-09-30 |
ATE5508T1 (en) | 1983-12-15 |
JPS567714A (en) | 1981-01-27 |
MC1336A1 (en) | 1981-04-21 |
US4411894A (en) | 1983-10-25 |
EP0021337A3 (en) | 1981-04-22 |
DE3065818D1 (en) | 1984-01-12 |
IE49615B1 (en) | 1985-10-30 |
FI801876A (en) | 1980-12-23 |
AR230178A1 (en) | 1984-03-01 |
PT71436A (en) | 1980-07-01 |
DK266680A (en) | 1980-12-23 |
FI72875B (en) | 1987-04-30 |
NO155226B (en) | 1986-11-24 |
FI72875C (en) | 1987-08-10 |
ES492676A0 (en) | 1981-05-16 |
HU186296B (en) | 1985-07-29 |
AU5928980A (en) | 1981-01-08 |
IL60326A0 (en) | 1980-09-16 |
IE801281L (en) | 1980-12-22 |
AU534959B2 (en) | 1984-02-23 |
NO801863L (en) | 1980-12-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PT71436A (en) | Process for preparing pharmaceutical compositions | |
DE3060129D1 (en) | Tetrahydroisoquinoline compounds, process for preparing them and pharmaceutical compositions containing them | |
DE3064173D1 (en) | Novel 20-0-acylmaytansinoids, process for their preparation and pharmaceutical compositions containing them | |
GB2122085B (en) | A process for the preparation of activated pharmaceutical compositions | |
MY8500062A (en) | 1,2,4-troazome deriovatives, process for preparing such compounds and pharmaceutical compositions containing them | |
PT68980A (en) | Process for preparing surfactive compositions | |
DE3060861D1 (en) | Monophosphonate compounds, process for their preparation and pharmaceutical compositions containing them | |
PT70927A (en) | Process for preparing 9-aminoalkylfluorenes | |
PT71093A (en) | Process for preparing oxytetracycline compositions | |
PT69207A (en) | Process for preparing pharmaceutical formulations | |
PT72216A (en) | Process for preparing toothpaste compositions | |
DE3061152D1 (en) | Pyrazoloindazole derivatives and process for preparing the same and pharmaceutical compositions | |
GB2050833B (en) | Pharmaceutical compositions and process for the preparation thereof | |
DE3061037D1 (en) | Process for preparing dimethylaminosilanes | |
HUT36099A (en) | Pharmaceutical compositions containing process for preparing 4-aroyl-imidazol-2-one derivatives | |
DE3060079D1 (en) | Spiro-quinolylhydantoins, process for their preparation and pharmaceutical compositions thereof | |
DE3060089D1 (en) | Process for preparing 1-amino-2-phenoxy-4-hydroxy-anthraquinone | |
IL60907A0 (en) | Substituted quinoline-alkanecarboxylic acids,process for their preparation and pharmaceutical compositions containing them | |
PT72727A (en) | Process for preparing pharmaceutical compositions | |
PT71126A (en) | Process for preparing alkoxyalkylidenhydrazinopyridazines | |
PT75504A (en) | Process for preparing pharmaceutical compositions | |
GB2058068B (en) | Process for preparing 5-chloro-2-nitrophenol | |
DE3060850D1 (en) | Process for preparing naphthalenesulphochloride | |
ZA80521B (en) | Process for preparation of -lactam compounds | |
PT71697A (en) | Process for preparing substituted trichloropropylureas andfungicidal compositions thereof |