PT628311E - Derivado de xantina com actividade antidepressiva - Google Patents

Derivado de xantina com actividade antidepressiva

Info

Publication number
PT628311E
PT628311E PT93914963T PT93914963T PT628311E PT 628311 E PT628311 E PT 628311E PT 93914963 T PT93914963 T PT 93914963T PT 93914963 T PT93914963 T PT 93914963T PT 628311 E PT628311 E PT 628311E
Authority
PT
Portugal
Prior art keywords
optionally substituted
different
same
group
xantine
Prior art date
Application number
PT93914963T
Other languages
English (en)
Inventor
Akio Ishii
Shunji Ichikawa
Junichi Shimada
Nobuaki Koike
Joji Nakamura
Fumio Suzuki
Shigeto Kitamura
Original Assignee
Kyowa Hakko Kogyo Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Kk filed Critical Kyowa Hakko Kogyo Kk
Publication of PT628311E publication Critical patent/PT628311E/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52Purines, e.g. adenine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/02Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/02Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16BDEVICES FOR FASTENING OR SECURING CONSTRUCTIONAL ELEMENTS OR MACHINE PARTS TOGETHER, e.g. NAILS, BOLTS, CIRCLIPS, CLAMPS, CLIPS OR WEDGES; JOINTS OR JOINTING
    • F16B37/00Nuts or like thread-engaging members
    • F16B37/04Devices for fastening nuts to surfaces, e.g. sheets, plates
    • F16B37/048Non-releasable devices

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mechanical Engineering (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
PT93914963T 1992-07-08 1993-07-07 Derivado de xantina com actividade antidepressiva PT628311E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP18102592 1992-07-08

Publications (1)

Publication Number Publication Date
PT628311E true PT628311E (pt) 2002-09-30

Family

ID=16093453

Family Applications (1)

Application Number Title Priority Date Filing Date
PT93914963T PT628311E (pt) 1992-07-08 1993-07-07 Derivado de xantina com actividade antidepressiva

Country Status (11)

Country Link
US (1) US5543415A (pt)
EP (1) EP0628311B1 (pt)
JP (1) JP2928386B2 (pt)
AT (1) ATE216584T1 (pt)
CA (1) CA2116967C (pt)
DE (1) DE69331843T2 (pt)
DK (1) DK0628311T3 (pt)
ES (1) ES2176204T3 (pt)
NO (1) NO306237B1 (pt)
PT (1) PT628311E (pt)
WO (1) WO1994001114A1 (pt)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6781194A (en) * 1993-05-03 1994-11-21 United States Of America, Represented By The Secretary, Department Of Health And Human Services, The 8-substituted 1,3,7-trialkyl-xanthine derivatives as a2-selective adenosine receptor antagonists
DE69526822T2 (de) * 1994-02-23 2003-01-23 Kyowa Hakko Kogyo K.K., Tokio/Tokyo Xanthin-derivate
US5620676A (en) * 1994-03-08 1997-04-15 The United States Of America As Represented By The Department Of Health And Human Services Biologically active ATP analogs
US5786360A (en) * 1996-11-19 1998-07-28 Link Technology Incorporated A1 adenosine receptor antagonists
US6727259B2 (en) 1997-09-05 2004-04-27 Kyowa Hakko Kogyo Co., Ltd. Remedial agent for neural degeneration
CA2388176C (en) * 1999-10-29 2007-09-25 Kyowa Hakko Kogyo Co., Ltd. Therapeutic agent for eating disorders
DE60213372T2 (de) * 2001-02-15 2007-09-27 Great Lakes Chemical Corp., West Lafayette Neue hydroxyphenylphosphinoxid zusammensetzung, glycidylether und epoxidharzmischungen und davon abgeleitete verbundwerkstoffe und laminate
US20020172732A1 (en) * 2001-03-21 2002-11-21 Wies Ter Laak Composition comprising cocoa
CN1646132A (zh) 2002-01-28 2005-07-27 协和发酵工业株式会社 治疗运动疾病患者的方法
US20060106040A1 (en) * 2002-12-19 2006-05-18 Michael Grzelak Adenosine A2a receptor antagonists for the treatment of extra-pyramidal syndrome and other movement disorders
US20060128694A1 (en) * 2002-12-19 2006-06-15 Michael Grzelak Adenosine A2a receptor antagonists for the treatment of extra-pyramidal syndrome and other movement disorders
CA2516250A1 (en) * 2003-02-19 2004-09-02 Endacea, Inc. A1 adenosine receptor antagonists
ATE546450T1 (de) * 2003-05-09 2012-03-15 Kyowa Hakko Kirin Co Ltd Microkristall of (e)-8-(3,4-dimethoxystyryl)-1,3- diethyl-7-methyl-3,7-dihydro-1h-purine-2,6-dion
US7247639B2 (en) * 2003-06-06 2007-07-24 Endacea, Inc. A1 adenosine receptor antagonists
CA2528367A1 (en) * 2003-06-09 2004-12-23 Endacea, Inc. A1 adenosine receptor antagonists
CA2528710C (en) 2003-06-10 2012-04-17 Kyowa Hakko Kogyo Co., Ltd. A method of treating an anxiety disorder
TW200507850A (en) * 2003-07-25 2005-03-01 Kyowa Hakko Kogyo Kk Pharmaceutical composition
EP1709967A4 (en) 2004-01-28 2010-09-15 Kyowa Hakko Kirin Co Ltd MEDICINE AGAINST MIGRAINE
ES2273599B1 (es) 2005-10-14 2008-06-01 Universidad De Barcelona Compuestos para el tratamiento de la fibrilacion auricular.
GB0719544D0 (en) * 2007-10-08 2007-11-14 Barry Callebaut Ag Cocoa extract and use thereof
GB0719545D0 (en) * 2007-10-08 2007-11-14 Barry Callebaut Ag Novel use of cocoa extract
GB0719542D0 (en) * 2007-10-08 2007-11-14 Barry Callebaut Ag Use of cocoa extract
TWI473614B (zh) 2008-05-29 2015-02-21 Kyowa Hakko Kirin Co Ltd Anti-analgesic inhibitors
UA110097C2 (uk) 2009-09-02 2015-11-25 Терапевтичний агент для лікування розладів настрою
UA113383C2 (xx) 2009-09-02 2017-01-25 Терапевтичний агент для лікування тривожних розладів
RU2477726C1 (ru) * 2011-10-18 2013-03-20 Общество С Ограниченной Ответственностью "Ньювак" (Ооо "Ньювак") Замещенные феноксиуксусные кислоты, их эфиры и амиды, включающие 2,6-диоксо-2,3,6,7-тетрагидро-1н-пурин-8-иловый фрагмент, - антагонисты аденозинового a2a рецептора и их применение
CN103554109A (zh) * 2013-11-15 2014-02-05 南京华威医药科技开发有限公司 伊曲茶碱多晶型
CN104262342B (zh) * 2014-08-26 2019-01-29 南京恒道医药科技有限公司 一种伊曲茶碱中间体的制备方法
CN105884776A (zh) * 2014-11-05 2016-08-24 南京瑞天医药科技有限公司 一种伊曲茶碱的新晶型及其制备方法
CN110981876B (zh) * 2018-12-21 2021-10-01 广东东阳光药业有限公司 8-取代的苯乙烯基黄嘌呤衍生物及其用途
US20220202822A1 (en) * 2019-04-24 2022-06-30 Sunshine Lake Pharma Co., Ltd. 8-substituted aryl vinyl xanthine derivatives and uses thereof
CN110041331B (zh) * 2019-05-17 2020-08-07 广东东阳光药业有限公司 苯乙烯基黄嘌呤衍生物及其用途
CN111018856B (zh) * 2019-12-12 2021-10-01 广东东阳光药业有限公司 8-取代的苯乙烯基黄嘌呤衍生物及其用途
CN111072663B (zh) * 2019-12-12 2021-10-01 广东东阳光药业有限公司 8-取代的苯乙烯基黄嘌呤衍生物及其用途
CN113248505B (zh) * 2021-06-09 2021-09-21 南京安杰新生物医药有限公司 伊曲茶碱去甲基杂质的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3641010A (en) * 1970-06-11 1972-02-08 Parke Davis & Co Novel xanthine compounds and means for obtaining the same
FR2531713A2 (fr) * 1981-09-16 1984-02-17 Panmedica Sa Nouvelles compositions a base de 5-hydroxytryptophane, leur procede de preparation et medicaments les contenant
FR2512672A1 (fr) * 1981-09-16 1983-03-18 Panmedica Nouvelles compositions a base de 5-hydroxytryptophane, leur procede de preparation et medicaments les contenant
DE3224100A1 (de) * 1982-06-29 1983-12-29 Michael 6950 Schriesheim Long Depotmedikament zur behandlung von psychologischen aberrationen, erkrankungen und dergleichen
US4769377A (en) * 1983-02-18 1988-09-06 The Johns Hopkins University Adenosine receptor antagonists
JPH0256428A (ja) * 1988-08-19 1990-02-26 Rohto Pharmaceut Co Ltd 肥満症治療剤
US5047534A (en) * 1990-03-26 1991-09-10 Merrell Dow Pharmaceuticals Inc. Selective adenosine receptor agents
EP0559893B1 (en) * 1990-10-18 1999-02-03 Kyowa Hakko Kogyo Co., Ltd. Xanthine derivative
IT1260444B (it) * 1992-01-24 1996-04-09 Mario Brufani Derivati della 8-(1-amminocicloalchil)1,3-dialchilxantina, procedimenbto di preparazione e loro composizioni farmaceutiche antidepressive, nootropiche e psicostimolanti
CA2093403C (en) * 1992-04-08 1999-08-10 Fumio Suzuki Therapeutic agent for parkinson's disease

Also Published As

Publication number Publication date
NO306237B1 (no) 1999-10-11
ATE216584T1 (de) 2002-05-15
ES2176204T3 (es) 2002-12-01
EP0628311A1 (en) 1994-12-14
EP0628311A4 (en) 1999-03-10
EP0628311B1 (en) 2002-04-24
CA2116967A1 (en) 1994-01-20
DE69331843D1 (de) 2002-05-29
JPH09502006A (ja) 1997-02-25
NO940737L (pt) 1994-05-03
CA2116967C (en) 2003-08-19
US5543415A (en) 1996-08-06
DE69331843T2 (de) 2002-09-26
JP2928386B2 (ja) 1999-08-03
WO1994001114A1 (en) 1994-01-20
DK0628311T3 (da) 2002-07-22
NO940737D0 (no) 1994-03-03

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