PT2768857T - Métodos para purificar anticorpos - Google Patents
Métodos para purificar anticorposInfo
- Publication number
- PT2768857T PT2768857T PT128426897T PT12842689T PT2768857T PT 2768857 T PT2768857 T PT 2768857T PT 128426897 T PT128426897 T PT 128426897T PT 12842689 T PT12842689 T PT 12842689T PT 2768857 T PT2768857 T PT 2768857T
- Authority
- PT
- Portugal
- Prior art keywords
- methods
- purifying antibodies
- antibodies
- purifying
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/248—IL-6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/249—Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161548958P | 2011-10-19 | 2011-10-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2768857T true PT2768857T (pt) | 2020-01-27 |
Family
ID=48142817
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT128426897T PT2768857T (pt) | 2011-10-19 | 2012-10-19 | Métodos para purificar anticorpos |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US10047144B2 (pt) |
| EP (1) | EP2768857B1 (pt) |
| JP (2) | JP6435193B2 (pt) |
| AU (2) | AU2012351751B2 (pt) |
| CA (1) | CA2853011C (pt) |
| DK (1) | DK2768857T3 (pt) |
| ES (1) | ES2767135T3 (pt) |
| PT (1) | PT2768857T (pt) |
| WO (1) | WO2013088259A2 (pt) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6435193B2 (ja) | 2011-10-19 | 2018-12-05 | ノビミューン エスアー | 抗体を精製する方法 |
| US10704021B2 (en) | 2012-03-15 | 2020-07-07 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
| WO2014087248A2 (en) | 2012-12-03 | 2014-06-12 | Novimmune S.A. | Anti-cd47 antibodies and methods of use thereof |
| BR112016003196A8 (pt) | 2013-08-19 | 2020-02-04 | Hoffmann La Roche | método para separar anticorpos biespecíficos |
| US9725710B2 (en) | 2014-01-08 | 2017-08-08 | Flodesign Sonics, Inc. | Acoustophoresis device with dual acoustophoretic chamber |
| GB201414823D0 (en) | 2014-08-20 | 2014-10-01 | Argen X Bv | Multispecific antibodies |
| CN107922476A (zh) * | 2015-03-13 | 2018-04-17 | 诺夫免疫股份有限公司 | 纯化双特异性抗体的方法 |
| US11708572B2 (en) | 2015-04-29 | 2023-07-25 | Flodesign Sonics, Inc. | Acoustic cell separation techniques and processes |
| US11377651B2 (en) | 2016-10-19 | 2022-07-05 | Flodesign Sonics, Inc. | Cell therapy processes utilizing acoustophoresis |
| US20180201693A1 (en) | 2015-07-09 | 2018-07-19 | Genmab A/S | Bispecific and multispecific antibodies and method for isolation of such |
| JP7082604B2 (ja) | 2016-03-21 | 2022-06-08 | マレンゴ・セラピューティクス，インコーポレーテッド | 多重特異性および多機能性分子ならびにその使用 |
| US11214789B2 (en) | 2016-05-03 | 2022-01-04 | Flodesign Sonics, Inc. | Concentration and washing of particles with acoustics |
| CN109641050A (zh) * | 2016-08-16 | 2019-04-16 | 里珍纳龙药品有限公司 | 用于对混合物中的个体抗体进行量化的方法 |
| WO2018038469A1 (ko) * | 2016-08-20 | 2018-03-01 | (주)아이벤트러스 | 목적하는 이중특이성 항체의 선택적 생산 확인 방법 |
| KR101933656B1 (ko) | 2016-08-20 | 2018-12-28 | (주) 아이벤트러스 | 목적하는 이중특이성 항체의 선택적 생산 확인 방법 |
| CN109906232B (zh) * | 2016-09-23 | 2023-11-07 | 马伦戈治疗公司 | 包含λ轻链和κ轻链的多特异性抗体分子 |
| WO2018083535A1 (en) | 2016-11-04 | 2018-05-11 | Novimmune Sa | Anti-cd19 antibodies and methods of use thereof |
| MX2019006266A (es) * | 2016-12-21 | 2019-08-21 | Hoffmann La Roche | Glucomanipulacion in vitro de anticuerpos. |
| CA3045970A1 (en) | 2016-12-21 | 2018-06-28 | F. Hoffmann-La Roche Ag | Method for in vitro glycoengineering of antibodies |
| US20200291089A1 (en) | 2017-02-16 | 2020-09-17 | Elstar Therapeutics, Inc. | Multifunctional molecules comprising a trimeric ligand and uses thereof |
| WO2018159615A1 (en) * | 2017-02-28 | 2018-09-07 | Chugai Seiyaku Kabushiki Kaisha | Protein purification with protein l |
| EP3630167A1 (en) | 2017-05-26 | 2020-04-08 | NovImmune SA | Anti-cd47 x anti-mesothelin antibodies and methods of use thereof |
| EP3630836A1 (en) | 2017-05-31 | 2020-04-08 | Elstar Therapeutics, Inc. | Multispecific molecules that bind to myeloproliferative leukemia (mpl) protein and uses thereof |
| WO2019016411A1 (en) * | 2017-07-21 | 2019-01-24 | Novimmune Sa | GENERATION OF MULTISPECIFIC ANTIBODY MIXTURES AND METHODS OF USE |
| CN114900773A (zh) | 2017-12-14 | 2022-08-12 | 弗洛设计声能学公司 | 声泳系统及其操作方法、控制声换能器及声学系统的方法 |
| US20210238280A1 (en) | 2018-03-14 | 2021-08-05 | Elstar Therapeutics, Inc. | Multifunctional molecules that bind to calreticulin and uses thereof |
| WO2019175658A1 (en) | 2018-03-14 | 2019-09-19 | Novimmune Sa | Anti-cd3 epsilon antibodies and methods of use thereof |
| US20210009711A1 (en) | 2018-03-14 | 2021-01-14 | Elstar Therapeutics, Inc. | Multifunctional molecules and uses thereof |
| KR20210029158A (ko) | 2018-06-03 | 2021-03-15 | 람카프 바이오 베타 엘티디. | Ceacam5 및 cd47에 대한 이중특이성 항체 |
| CA3104390A1 (en) | 2018-06-22 | 2019-12-26 | Genmab A/S | Method for producing a controlled mixture of two or more different antibodies |
| CA3105448A1 (en) | 2018-07-03 | 2020-01-09 | Elstar Therapeutics, Inc. | Anti-tcr antibody molecules and uses thereof |
| WO2020115283A1 (en) * | 2018-12-07 | 2020-06-11 | Baxalta GmbH | Bispecific antibodies binding factor ixa and factor x |
| TW202041534A (zh) | 2018-12-24 | 2020-11-16 | 法商賽諾菲公司 | 基於假Fab的多特異性結合蛋白 |
| CA3130754A1 (en) | 2019-02-21 | 2020-08-27 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to t cell related cancer cells and uses thereof |
| CA3130628A1 (en) | 2019-02-21 | 2020-08-27 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to t cells and uses thereof to treat autoimmune disorders |
| GB2597851B (en) | 2019-02-21 | 2024-05-29 | Marengo Therapeutics Inc | Antibody molecules that bind to NKP30 and uses thereof |
| EP3927431A1 (en) | 2019-02-21 | 2021-12-29 | Marengo Therapeutics, Inc. | Anti-tcr antibody molecules and uses thereof |
| GB2599229B (en) | 2019-02-21 | 2024-04-24 | Marengo Therapeutics Inc | Multifunctional molecules that bind to calreticulin and uses thereof |
| EP4013512B1 (en) | 2019-09-18 | 2024-02-14 | LamKap Bio alpha AG | Bispecific antibodies against ceacam5 and cd3 |
| EP3831849A1 (en) | 2019-12-02 | 2021-06-09 | LamKap Bio beta AG | Bispecific antibodies against ceacam5 and cd47 |
| CN111018969A (zh) * | 2019-12-27 | 2020-04-17 | 上海药明生物技术有限公司 | 采用轻链select联合层析色谱纯化双特异性抗体的方法 |
| WO2021138407A2 (en) | 2020-01-03 | 2021-07-08 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to cd33 and uses thereof |
| WO2021170060A1 (en) * | 2020-02-28 | 2021-09-02 | Wuxi Biologics (Shanghai) Co., Ltd. | Purification of bispeciifc antibodies |
| IL296428A (en) | 2020-03-25 | 2022-11-01 | Lilly Co Eli | Multispecific binding proteins and methods for their development |
| WO2021217085A1 (en) | 2020-04-24 | 2021-10-28 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to t cell related cancer cells and uses thereof |
| AU2021331075A1 (en) | 2020-08-26 | 2023-04-06 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to calreticulin and uses thereof |
| GB2616354A (en) | 2020-08-26 | 2023-09-06 | Marengo Therapeutics Inc | Methods of detecting TRBC1 or TRBC2 |
| EP4204096A4 (en) | 2020-08-26 | 2024-10-02 | Marengo Therapeutics Inc | ANTIBODY MOLECULES BINDING TO NKP30 AND RELATED USES |
| PE20231386A1 (es) | 2020-12-18 | 2023-09-12 | Lamkap Bio Beta Ltd | Anticuerpos biespecificos contra ceacam5 y cd47 |
| US20220315655A1 (en) | 2021-03-22 | 2022-10-06 | Novimmune Sa | Bispecific antibodies targeting cd47 and pd-l1 and methods of use thereof |
| AU2022241935A1 (en) | 2021-03-22 | 2023-09-28 | Novimmune S.A. | Bispecific antibodies targeting cd47 and pd-l1 and methods of use thereof |
| AU2022255506A1 (en) | 2021-04-08 | 2023-11-09 | Marengo Therapeutics, Inc. | Multifunctional molecules binding to tcr and uses thereof |
| WO2023174925A1 (en) | 2022-03-14 | 2023-09-21 | Novimmune Sa | Bispecific gpc3xcd28 and gpc3xcd3 antibodies and their combination for targeted killing of gpc3 positive malignant cells |
| AU2023236932A1 (en) * | 2022-03-17 | 2024-10-24 | Astrazeneca Ab | Methods for purifying bispecific antibodies |
| WO2023178357A1 (en) | 2022-03-18 | 2023-09-21 | Evolveimmune Therapeutics, Inc. | Bispecific antibody fusion molecules and methods of use thereof |
| WO2023242351A1 (en) | 2022-06-16 | 2023-12-21 | Lamkap Bio Beta Ag | Combination therapy of bispecific antibodies against ceacam5 and cd47 and bispecific antibodies against ceacam5 and cd3 |
| US20240254234A1 (en) | 2022-10-21 | 2024-08-01 | Novimmune Sa | PD-L1xCD28 BISPECIFIC ANTIBODIES FOR IMMUNE CHECKPOINT-DEPENDENT T CELL ACTIVATION |
| WO2024173607A2 (en) | 2023-02-14 | 2024-08-22 | Evolveimmune Therapeutics, Inc. | Combination of bispecific antibodies and chimeric antigen receptor t cells for treatment |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US4745183A (en) * | 1984-02-21 | 1988-05-17 | Bio-Rad Laboratories, Inc. | Use of hydroxylapatite for the analysis and preparation of purified monoclonal antibodies |
| US5859205A (en) * | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US6075181A (en) | 1990-01-12 | 2000-06-13 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US6528624B1 (en) | 1998-04-02 | 2003-03-04 | Genentech, Inc. | Polypeptide variants |
| US6946292B2 (en) | 2000-10-06 | 2005-09-20 | Kyowa Hakko Kogyo Co., Ltd. | Cells producing antibody compositions with increased antibody dependent cytotoxic activity |
| IL157309A0 (en) * | 2003-08-07 | 2004-02-19 | Applied Research Systems | Method for the purification of a non-immunoglobulin protein |
| WO2006043896A1 (en) * | 2004-10-21 | 2006-04-27 | Ge Healthcare Bio-Sciences Ab | Chromatography ligand |
| US7691980B2 (en) | 2007-01-09 | 2010-04-06 | Bio-Rad Laboratories, Inc. | Enhanced capacity and purification of antibodies by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers |
| EP2275431A3 (en) * | 2008-01-18 | 2011-05-25 | Bio-Rad Laboratories, Inc. | Enhanced fractionation of phosphorylated and nonphosphorylated biomolecules by apatite chromotography |
| CA2720615C (en) * | 2008-04-08 | 2016-06-07 | Bio-Rad Laboratories, Inc. | Chromatography purification of antibodies |
| CA2762837C (en) | 2009-05-20 | 2021-08-03 | Novimmune S.A. | Synthetic polypeptide libraries and methods for generating naturally diversified polypeptide variants |
| ES2542744T3 (es) | 2009-12-17 | 2015-08-11 | Novimmune Sa | Bibliotecas de polipéptidos sintéticos y métodos para generar variantes polipeptídicas diversificadas de forma natural |
| MY161534A (en) * | 2010-05-25 | 2017-04-28 | Genentech Inc | Methods of purifying polypeptides |
| DK2606064T3 (en) | 2010-08-16 | 2015-04-20 | Novimmune Sa | Methods for generating multispecific and multivalent antibodies |
| EP2635602B1 (en) * | 2010-11-03 | 2016-09-07 | Argen-X Nv | Anti c-met antibodies |
| JP6435193B2 (ja) | 2011-10-19 | 2018-12-05 | ノビミューン エスアー | 抗体を精製する方法 |
-
2012
- 2012-10-19 JP JP2014536354A patent/JP6435193B2/ja active Active
- 2012-10-19 CA CA2853011A patent/CA2853011C/en active Active
- 2012-10-19 WO PCT/IB2012/003028 patent/WO2013088259A2/en active Application Filing
- 2012-10-19 PT PT128426897T patent/PT2768857T/pt unknown
- 2012-10-19 AU AU2012351751A patent/AU2012351751B2/en active Active
- 2012-10-19 US US13/655,955 patent/US10047144B2/en active Active
- 2012-10-19 DK DK12842689.7T patent/DK2768857T3/da active
- 2012-10-19 EP EP12842689.7A patent/EP2768857B1/en active Active
- 2012-10-19 ES ES12842689T patent/ES2767135T3/es active Active
-
2017
- 2017-08-30 AU AU2017221794A patent/AU2017221794B2/en not_active Ceased
-
2018
- 2018-07-11 US US16/032,873 patent/US20190040117A1/en not_active Abandoned
- 2018-09-03 JP JP2018164683A patent/JP2018184487A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2013088259A2 (en) | 2013-06-20 |
| EP2768857A2 (en) | 2014-08-27 |
| DK2768857T3 (da) | 2020-02-03 |
| JP6435193B2 (ja) | 2018-12-05 |
| AU2012351751A1 (en) | 2014-06-05 |
| US20190040117A1 (en) | 2019-02-07 |
| AU2012351751B2 (en) | 2017-09-07 |
| ES2767135T3 (es) | 2020-06-16 |
| JP2014530848A (ja) | 2014-11-20 |
| US10047144B2 (en) | 2018-08-14 |
| CA2853011C (en) | 2022-09-06 |
| EP2768857B1 (en) | 2020-01-01 |
| AU2017221794A1 (en) | 2017-09-21 |
| JP2018184487A (ja) | 2018-11-22 |
| WO2013088259A3 (en) | 2013-11-14 |
| US20130317200A1 (en) | 2013-11-28 |
| AU2017221794B2 (en) | 2019-04-18 |
| CA2853011A1 (en) | 2013-06-20 |
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