PT1261593E - Derivados de 8,8a-di-hidro-ideno¬1,2-d|tiazole que possuem na posicao 2 um substituinte com uma estrutura de sulfona; procedimentos para a sua sintese e a sua utilizacao como farmacos - Google Patents

Derivados de 8,8a-di-hidro-ideno¬1,2-d|tiazole que possuem na posicao 2 um substituinte com uma estrutura de sulfona; procedimentos para a sua sintese e a sua utilizacao como farmacos

Info

Publication number
PT1261593E
PT1261593E PT01916989T PT01916989T PT1261593E PT 1261593 E PT1261593 E PT 1261593E PT 01916989 T PT01916989 T PT 01916989T PT 01916989 T PT01916989 T PT 01916989T PT 1261593 E PT1261593 E PT 1261593E
Authority
PT
Portugal
Prior art keywords
substituent
derivatives
idenoid
tiazole
pharmacies
Prior art date
Application number
PT01916989T
Other languages
English (en)
Inventor
Martin Bickel
Lang Dr Hans-Jochen
Gerhard Jaehne
Matthias Gossel
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of PT1261593E publication Critical patent/PT1261593E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Indole Compounds (AREA)
PT01916989T 2000-02-26 2001-02-13 Derivados de 8,8a-di-hidro-ideno¬1,2-d|tiazole que possuem na posicao 2 um substituinte com uma estrutura de sulfona; procedimentos para a sua sintese e a sua utilizacao como farmacos PT1261593E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10009311 2000-02-26

Publications (1)

Publication Number Publication Date
PT1261593E true PT1261593E (pt) 2004-01-30

Family

ID=7632679

Family Applications (1)

Application Number Title Priority Date Filing Date
PT01916989T PT1261593E (pt) 2000-02-26 2001-02-13 Derivados de 8,8a-di-hidro-ideno¬1,2-d|tiazole que possuem na posicao 2 um substituinte com uma estrutura de sulfona; procedimentos para a sua sintese e a sua utilizacao como farmacos

Country Status (29)

Country Link
US (2) US6352987B2 (pt)
EP (1) EP1261593B1 (pt)
JP (1) JP4950405B2 (pt)
KR (1) KR100763214B1 (pt)
CN (1) CN1173959C (pt)
AT (1) ATE248155T1 (pt)
AU (2) AU2001244136B2 (pt)
BR (1) BR0108631A (pt)
CA (1) CA2400704C (pt)
CZ (1) CZ301253B6 (pt)
DE (1) DE50100558D1 (pt)
DK (1) DK1261593T3 (pt)
EE (1) EE04963B1 (pt)
ES (1) ES2206412T3 (pt)
HK (1) HK1052515B (pt)
HR (1) HRP20020687B1 (pt)
HU (1) HU229137B1 (pt)
IL (1) IL151460A (pt)
MX (1) MXPA02007025A (pt)
NO (1) NO323400B1 (pt)
NZ (1) NZ520981A (pt)
PL (1) PL202763B1 (pt)
PT (1) PT1261593E (pt)
RS (1) RS49933B (pt)
RU (1) RU2263113C2 (pt)
SI (1) SI1261593T1 (pt)
SK (1) SK285571B6 (pt)
WO (1) WO2001062747A1 (pt)
ZA (1) ZA200206580B (pt)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
US7261482B2 (en) * 2004-01-21 2007-08-28 Silverbrook Research Pty Ltd Photofinishing system with slitting mechanism
EP1734963A4 (en) 2004-04-02 2008-06-18 Merck & Co Inc METHOD FOR TREATING PEOPLE WITH METABOLIC AND ANTHROPOMETRIC DISORDER
ES2559319T3 (es) 2007-06-04 2016-02-11 Synergy Pharmaceuticals Inc. Agonistas de guanilato cliclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
JP2011522828A (ja) 2008-06-04 2011-08-04 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
WO2010009319A2 (en) 2008-07-16 2010-01-21 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
CA2741125A1 (en) 2008-10-22 2010-04-29 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
JP5557845B2 (ja) 2008-10-31 2014-07-23 メルク・シャープ・アンド・ドーム・コーポレーション 糖尿病用剤として有用な新規環状ベンゾイミダゾール誘導体
AU2011218830B2 (en) 2010-02-25 2014-07-24 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
EA201690035A1 (ru) 2011-02-25 2016-05-31 Мерк Шарп Энд Домэ Корп. Новые циклические производные азабензимидазола, используемые в качестве антидиабетических агентов
WO2012118972A2 (en) 2011-03-01 2012-09-07 Synegy Pharmaceuticals Inc. Process of preparing guanylate cyclase c agonists
AU2013296470B2 (en) 2012-08-02 2016-03-17 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
CN104994848A (zh) 2013-02-22 2015-10-21 默沙东公司 抗糖尿病二环化合物
EP2970119B1 (en) 2013-03-14 2021-11-03 Merck Sharp & Dohme Corp. Novel indole derivatives useful as anti-diabetic agents
EP2968439A2 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
US9708367B2 (en) 2013-03-15 2017-07-18 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
PT3004138T (pt) 2013-06-05 2024-06-18 Bausch Health Ireland Ltd Agonistas ultrapuros de guanilato ciclase c, método de produção e utilização dos mesmos
WO2015051496A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
US11072602B2 (en) 2016-12-06 2021-07-27 Merck Sharp & Dohme Corp. Antidiabetic heterocyclic compounds
US10968232B2 (en) 2016-12-20 2021-04-06 Merck Sharp & Dohme Corp. Antidiabetic spirochroman compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2640358A1 (de) 1976-09-08 1978-03-16 Hoechst Ag Thiazolidinderivate und verfahren zu ihrer herstellung
DE19831878C2 (de) * 1998-07-17 2001-05-17 Aventis Pharma Gmbh Polycyclische Thiazolidin-2-yliden Amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE19844547C2 (de) * 1998-09-29 2002-11-07 Aventis Pharma Gmbh Polycyclische Dihydrothiazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE19908533A1 (de) * 1999-02-26 2000-08-31 Aventis Pharma Gmbh Polycyclische Thiazol-Systeme, Verfahren zu ihrer Herstellung und Arzneimittel enthaltend diese Verbindungen
CZ2001170A3 (cs) * 1999-07-03 2001-06-13 Aventis Pharma Gmbh Polycyklické thiazolidin-2-ylidenaminy, způsob jejich přípravy a léčivo, které je obsahuje
CZ20011111A3 (cs) * 1999-09-16 2001-07-11 Aventis Pharma Deutschland Gmbh Deriváty indeno-, nafto- a benzocyklohepťadihydrothiazolu, jejich příprava a použití jako anorektická léčiva

Also Published As

Publication number Publication date
SK285571B6 (sk) 2007-04-05
ES2206412T3 (es) 2004-05-16
NO20023977D0 (no) 2002-08-21
NO20023977L (no) 2002-10-18
EE04963B1 (et) 2008-02-15
KR20020079897A (ko) 2002-10-19
US20010039278A1 (en) 2001-11-08
RS49933B (sr) 2008-09-29
EP1261593B1 (de) 2003-08-27
CN1173959C (zh) 2004-11-03
US6352987B2 (en) 2002-03-05
WO2001062747A1 (de) 2001-08-30
JP2003531117A (ja) 2003-10-21
PL357195A1 (en) 2004-07-26
NZ520981A (en) 2004-08-27
JP4950405B2 (ja) 2012-06-13
HUP0300304A3 (en) 2004-10-28
HUP0300304A2 (hu) 2003-06-28
HU229137B1 (en) 2013-08-28
NO323400B1 (no) 2007-04-23
US6444669B1 (en) 2002-09-03
CA2400704C (en) 2008-11-04
EE200200467A (et) 2003-12-15
CN1406234A (zh) 2003-03-26
MXPA02007025A (es) 2003-03-27
HK1052515A1 (en) 2003-09-19
HRP20020687B1 (en) 2011-01-31
PL202763B1 (pl) 2009-07-31
DE50100558D1 (de) 2003-10-02
US20020103231A1 (en) 2002-08-01
RU2002125673A (ru) 2004-01-10
YU56402A (sh) 2005-11-28
AU4413601A (en) 2001-09-03
ZA200206580B (en) 2003-05-15
CA2400704A1 (en) 2001-08-30
AU2001244136B2 (en) 2005-04-14
RU2263113C2 (ru) 2005-10-27
HRP20020687A2 (en) 2004-12-31
CZ20022861A3 (cs) 2002-11-13
SI1261593T1 (en) 2004-02-29
IL151460A (en) 2008-08-07
BR0108631A (pt) 2002-12-03
KR100763214B1 (ko) 2007-10-08
ATE248155T1 (de) 2003-09-15
HK1052515B (zh) 2005-04-22
CZ301253B6 (cs) 2009-12-23
SK12252002A3 (sk) 2003-03-04
EP1261593A1 (de) 2002-12-04
DK1261593T3 (da) 2003-12-01

Similar Documents

Publication Publication Date Title
PT1261593E (pt) Derivados de 8,8a-di-hidro-ideno¬1,2-d|tiazole que possuem na posicao 2 um substituinte com uma estrutura de sulfona; procedimentos para a sua sintese e a sua utilizacao como farmacos
BRPI0407387A (pt) Derivados de hexahidro-pirazino[1,2-a]pirimidin-4,7-diona substituìdos por nitrogênio, processos para a sua preparação e sua aplicação com medicamento
ECSP055531A (es) "nuevos derivados de glicósido de tiofeno, metodos para la preparacion de los mismos, medicamentos que comprenden dichos compuestos, y su uso"
BR0108605A (pt) Derivados de 8,8a-dihidro-indeno[1,2-d]tiazol, que na posição 8a são substituìdos; processos para a sua preparação e seu emprego como medicamentos, por exemplo, como anoréxicos
BRPI0407507A (pt) derivados de hexahidro-pirazino[1,2-a]pirimidin-4,7-diona, processos para sua preparação de sua aplicação como medicamento
BRPI0407734A (pt) derivados de adamantano, processo para sua preparação e composições farmacêuticas os contendo
BR0317283A (pt) Derivados heterocìclicos de flúor-glicosìdeo, medicamentos contendo estes compostos e seu uso
BRPI0408347A (pt) derivados de pirimidina
BR0307575A (pt) Derivados de sulfonila como inibidores de histona desacetilase
AR055076A1 (es) Derivados de1,1-dioxido de 1,4-benzotiazepina,procedimiento para prepararlos,composiciones farmaceuticas que los contienen y usos en terapeutica.
BR0312549A (pt) Derivados de indolin-fenilsulfonamida
BR0312695A (pt) Derivados de 1h-pirrolidina-2,4-diona espirocìclicos substituìdos por cis-alcóxi
ECSP066542A (es) Derivados de disulfuro, sulfuro, sulfóxido, y sulfota de azúcares cíclicos y sus usos
BRPI0113146B8 (pt) "derivados de prolina e composição farmacêutica que os compreende".
BRPI0510770A (pt) derivados de fluorglicosìdeos de pirazóis, medicamentos contendo esses compostos e seu uso
BR0214666A (pt) Derivados de acetileno tendo atividade antagonìstica de mglur5
BRPI0414948A (pt) derivados de pirazolo-e-imidazo pirimidina
BR0015322A (pt) Derivados de indeno-, nafto- e benzociclohepta-dihidrotiazol, sua preparação e seu emprego como medicamentos anoréticos
BR0012478A (pt) Derivados de aminotiazóis, sua preparação e composição farmacêuticas contendo os mesmos
BR0309668A (pt) Imidazolinilmetil aralquilsulfonamidas
BR0317693A (pt) Derivados de epotilona
PT1183247E (pt) Sistemas tiazole policiclicos e sua utilizacao como anorecticos
PA8509601A1 (es) "PIRAZOLO [4,3,e] DIAZEPINAS SUSTITUIDAS NOVEDOSAS, COMPOSICIONES FARMACEUTICAS QUE LAS CONTIENEN, SU USO COMO PRODUCTOS MEDICINALES Y PROCESOS PARA PREPARARLAS
BR0318295A (pt) derivados de sulfamato de benzotiofeno utilizados como inibidores da esteróide sulfatase
BR0012329A (pt) Derivados de benzofurano