PT105315B - A NEW CRYSTALIN HYDRATE FORM OF PERINDOPRIL ERBUMINE, METHODS FOR PREPARATION AND USE IN PHARMACEUTICAL PREPARATIONS - Google Patents

A NEW CRYSTALIN HYDRATE FORM OF PERINDOPRIL ERBUMINE, METHODS FOR PREPARATION AND USE IN PHARMACEUTICAL PREPARATIONS

Info

Publication number
PT105315B
PT105315B PT105315A PT10531510A PT105315B PT 105315 B PT105315 B PT 105315B PT 105315 A PT105315 A PT 105315A PT 10531510 A PT10531510 A PT 10531510A PT 105315 B PT105315 B PT 105315B
Authority
PT
Portugal
Prior art keywords
new
preparation
crystalin
methods
pharmaceutical preparations
Prior art date
Application number
PT105315A
Other languages
Portuguese (pt)
Other versions
PT105315A (en
Inventor
Pedro Paulo De Lacerda E Oliveira Santos
Maria Teresa Nogueira Leal Da Silva
Vania Mafalda De Oliveira Andre
Luis Manuel Cunha Silva
Jose Manuel Abecassis Empis
Original Assignee
Inst Superior Tecnico
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Superior Tecnico filed Critical Inst Superior Tecnico
Priority to PT105315A priority Critical patent/PT105315B/en
Priority to PCT/PT2011/000033 priority patent/WO2012044189A1/en
Publication of PT105315A publication Critical patent/PT105315A/en
Publication of PT105315B publication Critical patent/PT105315B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

O OBJECTO DO INVENTO É UMA NOVA FORMA HIDRATADA DE ERBUMINA DE PERINDOPRIL (I) CARACTERIZADA POR DIFERENTES TÉCNICAS, INCLUINDO DIFRACÇÃO DE RAIOS-X EM PÓS E CRISTAL ÚNICO, SENDO ÚTIL NA PREPARAÇÃO DE PRODUTOS FARMACÊUTICOS. ESTA NOVA FORMA CRISTALINA PODE SER OBTIDA POR CRISTALIZAÇÃO DE SOLUÇÃO ALCOÓLICA OU DIRECTAMENTE A PARTIR DE OUTRAS FORMAS CRISTALINAS POR MOAGEM. TODOS OS PROCESSOS DE PREPARAÇÃO DESCRITOS PERMITEM OBTER A NOVA FORMA A PARTIR DE QUALQUER UMA DAS FORMAS POLIMÓRFICAS DE ERBUMINA DE PERINDOPRIL.OBJECT OF THE INVENTION IS A NEW HYDRATED FORM OF PERINDOPRIL (I) ERBUMINE CHARACTERIZED BY DIFFERENT TECHNIQUES, INCLUDING DIFFRACTION OF X-RAYS IN POWDER AND SINGLE CRYSTAL, BEING USEFUL IN THE PREPARATION OF PHARMACEUTICAL PRODUCTS. THIS NEW CRYSTALLINE FORM CAN BE OBTAINED BY CRYSTALLIZATION OF ALCOHOLIC SOLUTION OR DIRECTLY FROM OTHER CRYSTALLINE FOR GRINDING. ALL OF THE PREPARATION PROCEDURES DESCRIBED ALLOW TO OBTAIN THE NEW FORM FROM ANY OF THE POLYMERIC FORMS OF PERINDOPRIL ERBUMINE.

PT105315A 2010-09-29 2010-09-29 A NEW CRYSTALIN HYDRATE FORM OF PERINDOPRIL ERBUMINE, METHODS FOR PREPARATION AND USE IN PHARMACEUTICAL PREPARATIONS PT105315B (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PT105315A PT105315B (en) 2010-09-29 2010-09-29 A NEW CRYSTALIN HYDRATE FORM OF PERINDOPRIL ERBUMINE, METHODS FOR PREPARATION AND USE IN PHARMACEUTICAL PREPARATIONS
PCT/PT2011/000033 WO2012044189A1 (en) 2010-09-29 2011-09-26 A new hydrated crystalline form of perindopril erbumine, methods for its preparation and its use in pharmaceutical preparations

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PT105315A PT105315B (en) 2010-09-29 2010-09-29 A NEW CRYSTALIN HYDRATE FORM OF PERINDOPRIL ERBUMINE, METHODS FOR PREPARATION AND USE IN PHARMACEUTICAL PREPARATIONS

Publications (2)

Publication Number Publication Date
PT105315A PT105315A (en) 2012-03-29
PT105315B true PT105315B (en) 2013-01-16

Family

ID=44908060

Family Applications (1)

Application Number Title Priority Date Filing Date
PT105315A PT105315B (en) 2010-09-29 2010-09-29 A NEW CRYSTALIN HYDRATE FORM OF PERINDOPRIL ERBUMINE, METHODS FOR PREPARATION AND USE IN PHARMACEUTICAL PREPARATIONS

Country Status (2)

Country Link
PT (1) PT105315B (en)
WO (1) WO2012044189A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016178591A2 (en) 2015-05-05 2016-11-10 Gene Predit, Sa Genetic markers and treatment of male obesity

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4508729A (en) 1979-12-07 1985-04-02 Adir Substituted iminodiacids, their preparation and pharmaceutical compositions containing them
FR2503155A2 (en) 1980-10-02 1982-10-08 Science Union & Cie NOVEL SUBSTITUTED IMINO DIACIDES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS AN ENZYME INHIBITOR
FR2620709B1 (en) 1987-09-17 1990-09-07 Adir PROCESS FOR THE INDUSTRIAL SYNTHESIS OF PERINDOPRIL AND ITS MAIN INTERMEDIATE SYNTHESIS
FR2811319B1 (en) 2000-07-06 2002-08-23 Adir NOVEL BETA CRYSTALLINE FORM OF TERT-BUTYLAMINE SALT OF PERINDOPRIL, ITS PREPARATION METHOD AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
FR2811320B1 (en) 2000-07-06 2002-08-23 Adir NOVEL ALPHA CRYSTALLINE FORM OF TERT-BUTYLAMINE SALT OF PERINDOPRIL, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
FR2811318B1 (en) 2000-07-06 2002-08-23 Adir NOVEL GAMMA CRYSTALLINE FORM OF TERT-BUTYLAMINE SALT OF PERINDOPRIL, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
US7705046B2 (en) 2003-06-24 2010-04-27 Les Laboratoires Servier Crystalline forms of perindopril erbumine
ATE452124T1 (en) 2003-10-21 2010-01-15 Servier Lab METHOD FOR PRODUCING CRYSTALLINE PERINDOPRIL ERBUMIN
JP2005181450A (en) 2003-12-16 2005-07-07 Nitto Denko Corp Method for manufacturing birefringent film and optical film and image forming apparatus using the same
SI21704A (en) 2004-01-14 2005-08-31 Lek Farmacevtska Druzba Dd New crystal form of perindopril, procedure of its preparation, pharmaceutical preparations containing this form and their application in treatment of hypertensia
WO2005108365A1 (en) 2004-05-07 2005-11-17 Glenmark Pharmaceuticals Limited Processes for the preparation of alpha polymorph of perindopril erbumine
SI21881A (en) 2004-10-15 2006-04-30 Diagen, Smartno Pri Ljubljani, D.O.O. New crystal forms of perindopril erbumine hydrates, procedure of their preparation and pharmaceutical forms containing these compounds
WO2007017894A2 (en) 2005-05-05 2007-02-15 Arch Pharmalabs Limited PREPARATION OF NOVEL CRYSTALLINE η(ETA) FORM OF PERINDOPRIL ERBUMINE
WO2007017893A2 (en) 2005-05-05 2007-02-15 Arch Pharmalabs Limited Preparation of novel crystalline form of perindopril erbumine monohydrate
MX2008002066A (en) 2005-08-12 2008-04-16 Sandoz Ag New crystalline form of perindopril erbumine.
WO2007092758A2 (en) 2006-02-03 2007-08-16 Dr. Reddy's Laboratories Ltd. Crystalline forms of perindopril erbumine
WO2008050185A2 (en) 2006-10-26 2008-05-02 Glenmark Pharmaceuticals Limited Novel polymorphs of perindopril erbumine
WO2008114270A1 (en) 2007-03-22 2008-09-25 Aarti Healthcare Limited Process for the preparation of perindopril erbumine salt and novel polymorph (s) thereof

Also Published As

Publication number Publication date
PT105315A (en) 2012-03-29
WO2012044189A1 (en) 2012-04-05
WO2012044189A8 (en) 2014-10-16

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Effective date: 20110712

FG3A Patent granted, date of granting

Effective date: 20130109