PL410665A1 - Inhibitory arginazy oraz ich zastosowania terapeutyczne - Google Patents

Inhibitory arginazy oraz ich zastosowania terapeutyczne

Info

Publication number
PL410665A1
PL410665A1 PL410665A PL41066514A PL410665A1 PL 410665 A1 PL410665 A1 PL 410665A1 PL 410665 A PL410665 A PL 410665A PL 41066514 A PL41066514 A PL 41066514A PL 410665 A1 PL410665 A1 PL 410665A1
Authority
PL
Poland
Prior art keywords
arginase
arginase inhibitors
therapeutical applications
compounds
activity
Prior art date
Application number
PL410665A
Other languages
English (en)
Inventor
Roman Błaszczyk
Jacek Olczak
Adam Gołębiowski
Original Assignee
Oncoarendi Therapeutics Spółka Z Ograniczoną Odpowiedzialnością
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncoarendi Therapeutics Spółka Z Ograniczoną Odpowiedzialnością filed Critical Oncoarendi Therapeutics Spółka Z Ograniczoną Odpowiedzialnością
Priority to PL410665A priority Critical patent/PL410665A1/pl
Priority to CN201580077041.3A priority patent/CN107406464B/zh
Priority to PCT/PL2015/050073 priority patent/WO2016108707A1/en
Priority to US15/540,888 priority patent/US10329310B2/en
Priority to PL15823405T priority patent/PL3240777T3/pl
Priority to CA2973474A priority patent/CA2973474A1/en
Priority to AU2015372690A priority patent/AU2015372690A1/en
Priority to EP15823405.4A priority patent/EP3240777B1/en
Publication of PL410665A1 publication Critical patent/PL410665A1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Dentistry (AREA)
  • Physiology (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Związki stanowią małocząsteczkowe środki terapeutyczne, które są mocnymi inhibitorami aktywności arginazy 1 i arginazy 2. Ujawniono też kompozycje farmaceutyczne i sposoby stosowania tych związków do leczenia lub zapobiegania chorobom lub stanom związanym z aktywnością arginazy.
PL410665A 2014-12-29 2014-12-29 Inhibitory arginazy oraz ich zastosowania terapeutyczne PL410665A1 (pl)

Priority Applications (8)

Application Number Priority Date Filing Date Title
PL410665A PL410665A1 (pl) 2014-12-29 2014-12-29 Inhibitory arginazy oraz ich zastosowania terapeutyczne
CN201580077041.3A CN107406464B (zh) 2014-12-29 2015-12-22 精氨酸酶抑制剂及其治疗用途
PCT/PL2015/050073 WO2016108707A1 (en) 2014-12-29 2015-12-22 Arginase inhibitors and their therapeutic applications
US15/540,888 US10329310B2 (en) 2014-12-29 2015-12-22 Arginase inhibitors and their therapeutic applications
PL15823405T PL3240777T3 (pl) 2014-12-29 2015-12-22 Inhibitory arginazy oraz ich zastosowania terapeutyczne
CA2973474A CA2973474A1 (en) 2014-12-29 2015-12-22 Arginase inhibitors and their therapeutic applications
AU2015372690A AU2015372690A1 (en) 2014-12-29 2015-12-22 Arginase inhibitors and their therapeutic applications
EP15823405.4A EP3240777B1 (en) 2014-12-29 2015-12-22 Arginase inhibitors and their therapeutic applications

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL410665A PL410665A1 (pl) 2014-12-29 2014-12-29 Inhibitory arginazy oraz ich zastosowania terapeutyczne

Publications (1)

Publication Number Publication Date
PL410665A1 true PL410665A1 (pl) 2016-07-04

Family

ID=56234474

Family Applications (2)

Application Number Title Priority Date Filing Date
PL410665A PL410665A1 (pl) 2014-12-29 2014-12-29 Inhibitory arginazy oraz ich zastosowania terapeutyczne
PL15823405T PL3240777T3 (pl) 2014-12-29 2015-12-22 Inhibitory arginazy oraz ich zastosowania terapeutyczne

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL15823405T PL3240777T3 (pl) 2014-12-29 2015-12-22 Inhibitory arginazy oraz ich zastosowania terapeutyczne

Country Status (7)

Country Link
US (1) US10329310B2 (pl)
EP (1) EP3240777B1 (pl)
CN (1) CN107406464B (pl)
AU (1) AU2015372690A1 (pl)
CA (1) CA2973474A1 (pl)
PL (2) PL410665A1 (pl)
WO (1) WO2016108707A1 (pl)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL417066A1 (pl) 2016-05-04 2017-11-06 Oncoarendi Therapeutics Spółka Z Ograniczoną Odpowiedzialnością Inhibitory arginazy oraz ich zastosowania terapeutyczne
JP7402167B2 (ja) 2018-03-05 2023-12-20 アーカス バイオサイエンシズ インコーポレイティド アルギナーゼ阻害剤
EP3774843B1 (en) 2018-03-29 2022-05-25 Molecure SA Dipeptide piperidine derivatives
US11274111B2 (en) 2018-06-20 2022-03-15 Merck Sharp & Dohme Corp. Arginase inhibitors and methods of use
EP3873608A1 (en) 2018-10-31 2021-09-08 Gilead Sciences, Inc. Substituted 6-azabenzimidazole compounds having hpk1 inhibitory activity
TW202136260A (zh) 2018-10-31 2021-10-01 美商基利科學股份有限公司 經取代之6-氮雜苯并咪唑化合物
CN113382998A (zh) * 2018-11-16 2021-09-10 艾库斯生物科学有限公司 Arg1和/或arg2的抑制剂
CN113395996B (zh) * 2019-02-08 2024-05-28 阿斯利康(瑞典)有限公司 精氨酸酶抑制剂及其使用方法
WO2020237025A1 (en) 2019-05-23 2020-11-26 Gilead Sciences, Inc. Substituted exo-methylene-oxindoles which are hpk1/map4k1 inhibitors
AU2020293645A1 (en) 2019-06-14 2021-12-23 Rijksuniversiteit Groningen Novel arginase inhibitors
EP4004004A1 (en) * 2019-07-23 2022-06-01 AstraZeneca AB Arginase inhibitors and methods of use thereof
TW202228720A (zh) 2020-12-22 2022-08-01 波蘭商昂科艾倫迪治療法股份公司 精胺酸酶抑制劑及其使用方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU643141B2 (en) 1991-03-15 1993-11-04 Amgen, Inc. Pulmonary administration of granulocyte colony stimulating factor
US5451569A (en) 1994-04-19 1995-09-19 Hong Kong University Of Science And Technology R & D Corporation Limited Pulmonary drug delivery system
WO1999019295A1 (en) 1997-10-10 1999-04-22 Trustees Of The University Of Pennsylvania Compositions and methods for inhibiting arginase activity
US20100056480A1 (en) 2006-11-21 2010-03-04 Rijks Univesiteit Groningen Use of arginase inhibitors in the treatment of asthma and allergic rhinitis
RS58965B1 (sr) 2009-01-26 2019-08-30 Univ Pennsylvania Inhibitori arginaze i postupci upotrebe
JP5898177B2 (ja) * 2010-04-22 2016-04-06 マーズ インコーポレイテッド アルギナーゼ阻害剤およびそれらの治療用途
JP5909239B2 (ja) 2010-10-26 2016-04-26 マーズ インコーポレイテッド アルギナーゼ阻害剤としてのボロネート
JP2014506253A (ja) 2010-12-31 2014-03-13 コリドー ファーマシューティカルズ インコーポレイテッド アルギナーゼ阻害剤およびその使用法
WO2013059437A1 (en) 2011-10-19 2013-04-25 Mars, Incorporated Inhibitors of arginase and their therapeutic applications
CN104540836B (zh) 2012-04-18 2016-11-09 马尔斯公司 作为精氨酸酶抑制剂的环约束类似物

Also Published As

Publication number Publication date
AU2015372690A1 (en) 2017-07-27
US10329310B2 (en) 2019-06-25
CN107406464A (zh) 2017-11-28
EP3240777B1 (en) 2019-07-24
US20180009830A1 (en) 2018-01-11
CN107406464A8 (zh) 2018-01-12
CA2973474A1 (en) 2016-07-07
EP3240777A1 (en) 2017-11-08
CN107406464B (zh) 2019-03-19
WO2016108707A1 (en) 2016-07-07
PL3240777T3 (pl) 2019-10-31

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