PL3700913T3 - Proleki podstawionych pochodnych triazolu i ich zastosowania - Google Patents

Proleki podstawionych pochodnych triazolu i ich zastosowania

Info

Publication number
PL3700913T3
PL3700913T3 PL18785394T PL18785394T PL3700913T3 PL 3700913 T3 PL3700913 T3 PL 3700913T3 PL 18785394 T PL18785394 T PL 18785394T PL 18785394 T PL18785394 T PL 18785394T PL 3700913 T3 PL3700913 T3 PL 3700913T3
Authority
PL
Poland
Prior art keywords
prodrugs
triazole derivatives
substituted triazole
substituted
derivatives
Prior art date
Application number
PL18785394T
Other languages
English (en)
Inventor
Marie-Pierre COLLIN-KROEPELIN
Peter Kolkhof
Thomas Neubauer
Chantal Fuerstner
Elisabeth Pook
Matthias Beat WITTWER
Carsten Schmeck
Pierre Wasnaire
Heiko Schirmer
Hana CERNECKA
Karoline Droebner
Hanna Tinel
Anja Buchmueller
Thomas MONDRITZKI
Axel Kretschmer
Klemens Lustig
Robert Fricke
Guillaume Levilain
Ursula Krenz
Norbert Witowski
Original Assignee
Bayer Aktiengesellschaft
Bayer Pharma Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Aktiengesellschaft, Bayer Pharma Aktiengesellschaft filed Critical Bayer Aktiengesellschaft
Publication of PL3700913T3 publication Critical patent/PL3700913T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL18785394T 2017-10-24 2018-10-17 Proleki podstawionych pochodnych triazolu i ich zastosowania PL3700913T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17197935 2017-10-24
EP18785394.0A EP3700913B1 (en) 2017-10-24 2018-10-17 Prodrugs of substituted triazole derivatives and uses thereof
PCT/EP2018/078364 WO2019081292A1 (en) 2017-10-24 2018-10-17 PRODRUGS OF SUBSTITUTED TRIAZOLE DERIVATIVES AND USES THEREOF

Publications (1)

Publication Number Publication Date
PL3700913T3 true PL3700913T3 (pl) 2022-02-21

Family

ID=60162099

Family Applications (1)

Application Number Title Priority Date Filing Date
PL18785394T PL3700913T3 (pl) 2017-10-24 2018-10-17 Proleki podstawionych pochodnych triazolu i ich zastosowania

Country Status (38)

Country Link
US (1) US11298367B2 (pl)
EP (1) EP3700913B1 (pl)
JP (1) JP2021500365A (pl)
KR (1) KR20200069361A (pl)
CN (1) CN111225921A (pl)
AR (1) AR113791A1 (pl)
AU (1) AU2018356352A1 (pl)
BR (1) BR112020007983A2 (pl)
CA (1) CA3079767A1 (pl)
CL (1) CL2020001076A1 (pl)
CO (1) CO2020004945A2 (pl)
CR (1) CR20200176A (pl)
CU (1) CU24604B1 (pl)
CY (1) CY1124938T1 (pl)
DK (1) DK3700913T3 (pl)
DO (1) DOP2020000076A (pl)
EA (1) EA202091025A1 (pl)
EC (1) ECSP20023056A (pl)
ES (1) ES2906305T3 (pl)
HR (1) HRP20220060T1 (pl)
HU (1) HUE057278T2 (pl)
IL (1) IL273949A (pl)
JO (1) JOP20200099A1 (pl)
LT (1) LT3700913T (pl)
MA (1) MA50438B1 (pl)
MX (1) MX2020004191A (pl)
NI (1) NI202000030A (pl)
PE (1) PE20210394A1 (pl)
PH (1) PH12020550473A1 (pl)
PL (1) PL3700913T3 (pl)
PT (1) PT3700913T (pl)
RS (1) RS62984B1 (pl)
SG (1) SG11202003049WA (pl)
SI (1) SI3700913T1 (pl)
TW (1) TW201932117A (pl)
UA (1) UA126456C2 (pl)
UY (1) UY37948A (pl)
WO (1) WO2019081292A1 (pl)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021259852A1 (en) 2020-06-25 2021-12-30 Bayer Aktiengesellschaft Process for preparing 5-(alkoxycarbonyl)-and 5-(carboxamide)-1-aryl-1,2,4-triazole derivatives
WO2022112213A1 (en) 2020-11-30 2022-06-02 Bayer Aktiengesellschaft Crystalline forms of 3-[[3-(4-chlorophenyl)-5-oxo-4-((2s)-3,3,3-trifluoro- 2-hydroxypropyl)-4,5-dihydro-1h-1,2,4-triazol-1-yl]methyl]-1-[3- (trifluoromethyl)pyridin-2-yl]-1h-1,2,4-triazole-5-carboxamide

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3966781A (en) 1970-12-17 1976-06-29 Merck Sharp & Dohme (I.A.) Corporation Deuteration of functional group-containing hydrocarbons
DE19834047A1 (de) 1998-07-29 2000-02-03 Bayer Ag Substituierte Pyrazolderivate
DE19834044A1 (de) 1998-07-29 2000-02-03 Bayer Ag Neue substituierte Pyrazolderivate
DE19943639A1 (de) 1999-09-13 2001-03-15 Bayer Ag Dicarbonsäurederivate mit neuartigen pharmazeutischen Eigenschaften
DE19943636A1 (de) 1999-09-13 2001-03-15 Bayer Ag Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE19943634A1 (de) 1999-09-13 2001-04-12 Bayer Ag Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE19943635A1 (de) 1999-09-13 2001-03-15 Bayer Ag Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften
AR031176A1 (es) 2000-11-22 2003-09-10 Bayer Ag Nuevos derivados de pirazolpiridina sustituidos con piridina
DE10110750A1 (de) 2001-03-07 2002-09-12 Bayer Ag Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE10110749A1 (de) 2001-03-07 2002-09-12 Bayer Ag Substituierte Aminodicarbonsäurederivate
DE10220570A1 (de) 2002-05-08 2003-11-20 Bayer Ag Carbamat-substituierte Pyrazolopyridine
EP1701959A1 (en) 2003-12-22 2006-09-20 Pfizer Limited Triazole derivatives as vasopressin antagonists
EP1742932A1 (en) 2004-04-28 2007-01-17 Pfizer Limited 3-heterocyclyl-4-phenyl-triazole derivatives as inhibitors of the vasopressin v1a receptor
AR069206A1 (es) * 2007-11-06 2010-01-06 Astrazeneca Ab Derivados de 2-pirazinona, proceso para preparalos, composiciones farmaceuticas que los comprenden, proceso de preparacion de las mismas y usos en el tratamiento de trastornos osteoarticularesy del aparato respiratorio, entre otros.
DE102010001064A1 (de) 2009-03-18 2010-09-23 Bayer Schering Pharma Aktiengesellschaft Substituierte 2-Acetamido-5-Aryl-1,2,4-triazolone und deren Verwendung
AR076542A1 (es) * 2009-05-22 2011-06-22 Merck Sharp & Dohme Antagonistas del receptor de orexina de isonicotinamida
NZ602018A (en) 2010-02-27 2014-10-31 Bayer Ip Gmbh Bisaryl-bonded aryltriazolones and use thereof
DE102010021637A1 (de) 2010-05-26 2011-12-01 Bayer Schering Pharma Aktiengesellschaft Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung
EP2708539A1 (de) 2010-07-09 2014-03-19 Bayer Intellectual Property GmbH Annellierte pyrimidine und triazine und ihre verwendung zur behandlung bzw. prophylaxe von herz-kreislauf-erkrankungen
DE102010040233A1 (de) 2010-09-03 2012-03-08 Bayer Schering Pharma Aktiengesellschaft Bicyclische Aza-Heterocyclen und ihre Verwendung
DE102010043379A1 (de) 2010-11-04 2012-05-10 Bayer Schering Pharma Aktiengesellschaft Substituierte 6-Fluor-1H-Pyrazolo[4,3-b]pyridine und ihre Verwendung
WO2012112363A1 (en) 2011-02-14 2012-08-23 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
NZ719975A (en) * 2013-10-16 2019-07-26 Bayer Cropscience Ag Active compound combinations comprising a (thio)carboxamide derivative and a fungicidal compound
MX2017005479A (es) * 2014-11-03 2017-07-04 Bayer Pharma AG Derivados de feniltriazol sustituido con hidroxialquilo y sus usos.
UY36571A (es) * 2015-03-05 2016-09-30 Bayer Cropscience Ag Combinaciones de compuestos activos
US9988367B2 (en) 2016-05-03 2018-06-05 Bayer Pharma Aktiengesellschaft Amide-substituted pyridinyltriazole derivatives and uses thereof
US10815205B2 (en) 2016-05-03 2020-10-27 Bayer Pharma Aktiengesellschaft Amide-substituted phenyltriazole derivatives and uses thereof
US20190119251A1 (en) 2016-05-03 2019-04-25 Bayer Pharma Aktiengesellschaft Amide-substituted aryltriazole derivatives and uses thereof
CA3022755A1 (en) 2016-05-03 2017-11-09 Carsten Schmeck Oxoalkyl-substituted phenyltriazole derivatives and uses thereof
WO2017191112A1 (en) 2016-05-03 2017-11-09 Bayer Pharma Aktiengesellschaft Fluoroalkyl-substituted aryltriazole derivatives and uses thereof
US10526314B2 (en) 2016-05-03 2020-01-07 Bayer Aktiengesellschaft Hydroxyalkyl-substituted heteroaryltriazole derivatives and uses thereof
US10927098B2 (en) 2016-10-20 2021-02-23 Bayer Pharma Aktiengesellschaft Hydroxyalkyl-substituted triazole derivatives and uses thereof

Also Published As

Publication number Publication date
HUE057278T2 (hu) 2022-04-28
RS62984B1 (sr) 2022-03-31
AR113791A1 (es) 2020-06-10
EP3700913B1 (en) 2021-11-10
ECSP20023056A (es) 2020-12-31
CA3079767A1 (en) 2019-05-02
BR112020007983A2 (pt) 2020-10-27
ES2906305T3 (es) 2022-04-18
PT3700913T (pt) 2022-01-31
KR20200069361A (ko) 2020-06-16
UY37948A (es) 2019-05-31
US20200338096A1 (en) 2020-10-29
AU2018356352A1 (en) 2020-04-16
PH12020550473A1 (en) 2021-03-08
EP3700913A1 (en) 2020-09-02
NI202000030A (es) 2020-10-09
UA126456C2 (uk) 2022-10-05
CY1124938T1 (el) 2023-01-05
CR20200176A (es) 2020-07-24
PE20210394A1 (es) 2021-03-02
CU24604B1 (es) 2022-06-06
SI3700913T1 (sl) 2022-02-28
CN111225921A (zh) 2020-06-02
DOP2020000076A (es) 2020-08-31
TW201932117A (zh) 2019-08-16
MX2020004191A (es) 2020-08-03
MA50438A (fr) 2020-09-02
CU20200040A7 (es) 2021-03-11
US11298367B2 (en) 2022-04-12
CO2020004945A2 (es) 2020-05-05
IL273949A (en) 2020-05-31
LT3700913T (lt) 2022-01-25
JP2021500365A (ja) 2021-01-07
HRP20220060T1 (hr) 2022-04-15
DK3700913T3 (da) 2022-02-07
SG11202003049WA (en) 2020-04-29
JOP20200099A1 (ar) 2020-05-06
WO2019081292A1 (en) 2019-05-02
CL2020001076A1 (es) 2021-02-19
MA50438B1 (fr) 2022-03-31
EA202091025A1 (ru) 2020-07-30

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