PL2440562T3 - Otrzymywanie 6-alfa-amino-N-podstawionych morfinanów w wyniku katalitycznego przeniesienia wodoru - Google Patents

Otrzymywanie 6-alfa-amino-N-podstawionych morfinanów w wyniku katalitycznego przeniesienia wodoru

Info

Publication number
PL2440562T3
PL2440562T3 PL10724967T PL10724967T PL2440562T3 PL 2440562 T3 PL2440562 T3 PL 2440562T3 PL 10724967 T PL10724967 T PL 10724967T PL 10724967 T PL10724967 T PL 10724967T PL 2440562 T3 PL2440562 T3 PL 2440562T3
Authority
PL
Poland
Prior art keywords
alpha
amino
preparation
hydrogen transfer
catalytic hydrogen
Prior art date
Application number
PL10724967T
Other languages
English (en)
Inventor
Christopher W. Grote
Gary L. Cantrell
Joseph P. Mcclurg
Catherine E. Thomasson
Frank W. Moser
Original Assignee
Mallinckrodt Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Llc filed Critical Mallinckrodt Llc
Publication of PL2440562T3 publication Critical patent/PL2440562T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D489/00Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
PL10724967T 2009-06-11 2010-06-10 Otrzymywanie 6-alfa-amino-N-podstawionych morfinanów w wyniku katalitycznego przeniesienia wodoru PL2440562T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18609109P 2009-06-11 2009-06-11
EP10724967.4A EP2440562B1 (en) 2009-06-11 2010-06-10 Preparation of 6-alpha-amino n-substituted morphinans by catalytic hydrogen transfer

Publications (1)

Publication Number Publication Date
PL2440562T3 true PL2440562T3 (pl) 2017-07-31

Family

ID=42357348

Family Applications (1)

Application Number Title Priority Date Filing Date
PL10724967T PL2440562T3 (pl) 2009-06-11 2010-06-10 Otrzymywanie 6-alfa-amino-N-podstawionych morfinanów w wyniku katalitycznego przeniesienia wodoru

Country Status (8)

Country Link
US (1) US8519133B2 (pl)
EP (1) EP2440562B1 (pl)
JP (2) JP5697215B2 (pl)
CN (1) CN102803267A (pl)
CA (1) CA2764915C (pl)
ES (1) ES2598496T3 (pl)
PL (1) PL2440562T3 (pl)
WO (1) WO2010144641A1 (pl)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8946419B2 (en) 2009-02-23 2015-02-03 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
PL2440562T3 (pl) * 2009-06-11 2017-07-31 Mallinckrodt Llc Otrzymywanie 6-alfa-amino-N-podstawionych morfinanów w wyniku katalitycznego przeniesienia wodoru
PL2440561T3 (pl) 2009-06-11 2014-09-30 SpecGx LLC Redukcyjne aminowanie 6-keto-normorfinanow przez katalityczne przeniesienie wodoru
PL2453895T3 (pl) * 2009-07-16 2018-10-31 Mallinckrodt Llc (+)-morfinany jako antagonisty receptora toll-like 9 i ich zastosowania terapeutyczne
WO2011009020A2 (en) 2009-07-16 2011-01-20 Mallinckrodt Inc. Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
US10363251B2 (en) * 2009-07-16 2019-07-30 Mallinckrodt Llc (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
TWI590835B (zh) 2010-05-10 2017-07-11 歐 賽提克股份有限公司 含有氫嗎啡酮(hydromorphone)和納洛酮(naloxone)之藥學組成物
EP2568968B1 (en) 2010-05-10 2017-07-12 Euro-Celtique S.A. Manufacturing of active-free granules and tablets comprising the same
CA2798885C (en) 2010-05-10 2014-11-18 Euro-Celtique S.A. Combination of active loaded granules with additional actives
AU2010357625B2 (en) 2010-07-16 2015-04-23 Mallinckrodt Llc (+)-morphinans as antagonists of Toll-like receptor 9 and therapeutic uses thereof
PL2718294T3 (pl) * 2011-06-09 2019-04-30 SpecGx LLC Redukcyjne aminowanie 6-keto morfinanów przez katalityczne przeniesienie wodoru
EA030310B1 (ru) 2013-11-13 2018-07-31 Эро-Селтик С.А. Гидроморфон и налоксон для лечения боли и индуцированного опиоидами синдрома дисфункции кишечника
AU2015287663B2 (en) * 2014-07-10 2019-02-28 SpecGx LLC Process for preparing substituted phenylalkanes
CN113614089B (zh) * 2019-03-29 2024-08-20 人福医药美国公司 可用于治疗医学病症的新型吗啡喃

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Also Published As

Publication number Publication date
ES2598496T3 (es) 2017-01-27
JP2015057448A (ja) 2015-03-26
EP2440562B1 (en) 2016-08-10
JP2012529533A (ja) 2012-11-22
JP5697215B2 (ja) 2015-04-08
WO2010144641A1 (en) 2010-12-16
CA2764915A1 (en) 2010-12-16
CN102803267A (zh) 2012-11-28
US20100317683A1 (en) 2010-12-16
EP2440562A1 (en) 2012-04-18
CA2764915C (en) 2017-07-11
US8519133B2 (en) 2013-08-27

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