PH12014501704A1 - Method for preparing compound by novel michael addition reaction using water or various acids as additive - Google Patents

Method for preparing compound by novel michael addition reaction using water or various acids as additive

Info

Publication number
PH12014501704A1
PH12014501704A1 PH12014501704A PH12014501704A PH12014501704A1 PH 12014501704 A1 PH12014501704 A1 PH 12014501704A1 PH 12014501704 A PH12014501704 A PH 12014501704A PH 12014501704 A PH12014501704 A PH 12014501704A PH 12014501704 A1 PH12014501704 A1 PH 12014501704A1
Authority
PH
Philippines
Prior art keywords
additive
water
addition reaction
michael addition
various acids
Prior art date
Application number
PH12014501704A
Other versions
PH12014501704B1 (en
Inventor
Park Ae Ri
Kim Bong Chan
An Ji Eun
Lee Hee Bong
Original Assignee
Lg Life Sciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lg Life Sciences Ltd filed Critical Lg Life Sciences Ltd
Publication of PH12014501704B1 publication Critical patent/PH12014501704B1/en
Publication of PH12014501704A1 publication Critical patent/PH12014501704A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/34—Esters of acyclic saturated polycarboxylic acids having an esterified carboxyl group bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/58—Preparation of carboxylic acid halides
    • C07C51/64—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B37/00—Reactions without formation or introduction of functional groups containing hetero atoms, involving either the formation of a carbon-to-carbon bond between two carbon atoms not directly linked already or the disconnection of two directly linked carbon atoms
    • C07B37/02—Addition
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C67/347—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by addition to unsaturated carbon-to-carbon bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/62—Use of additives, e.g. for stabilisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

The present invention relates to a novel method for preparing a compound represented by chemical formula 1 using water or various acids as an additive in a Michael addition reaction of a Michael receptor represented by chemical formula 2 and a compound represented by chemical formula 3.
PH12014501704A 2012-02-03 2014-07-28 Method for preparing compound by novel michael addition reaction using water or various acids as additive PH12014501704A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20120011317 2012-02-03
PCT/KR2013/000829 WO2013115595A1 (en) 2012-02-03 2013-02-01 Method for preparing compound by novel michael addition reaction using water or various acids as additive

Publications (2)

Publication Number Publication Date
PH12014501704B1 PH12014501704B1 (en) 2014-10-13
PH12014501704A1 true PH12014501704A1 (en) 2014-10-13

Family

ID=48905559

Family Applications (1)

Application Number Title Priority Date Filing Date
PH12014501704A PH12014501704A1 (en) 2012-02-03 2014-07-28 Method for preparing compound by novel michael addition reaction using water or various acids as additive

Country Status (16)

Country Link
KR (1) KR101539761B1 (en)
CN (1) CN104159884B (en)
AU (1) AU2013215796B2 (en)
BR (1) BR112014018985B1 (en)
CL (1) CL2014002029A1 (en)
CO (1) CO7030967A2 (en)
EA (1) EA026411B1 (en)
MA (1) MA35906B1 (en)
MX (1) MX355336B (en)
MY (1) MY168411A (en)
PE (1) PE20142331A1 (en)
PH (1) PH12014501704A1 (en)
SG (1) SG11201404396TA (en)
TN (1) TN2014000329A1 (en)
WO (1) WO2013115595A1 (en)
ZA (1) ZA201405598B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9774740B2 (en) 2008-01-28 2017-09-26 Afiniti Europe Technologies Limited Techniques for benchmarking pairing strategies in a contact center system

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108191647B (en) * 2018-02-22 2020-09-29 江苏尚莱特医药化工材料有限公司 Synthesis method of 2, 2-difluoro dicarboxylic acid dialkyl ester
CN113149823B (en) * 2021-03-29 2023-12-08 上海青平药业有限公司 2-R 1 Process for preparing valeric acid
CN113354495A (en) * 2021-05-20 2021-09-07 上海应用技术大学 Difluorone carbonyl substituted asymmetric nitrile compound and preparation and application thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS573159B2 (en) * 1973-12-05 1982-01-20
CA1336076C (en) * 1985-01-14 1995-06-27 Alan R. Fritzberg Metal radionuclide labeled proteins for diagnosis and therapy
EP1238962B1 (en) * 2001-03-07 2008-02-27 Firmenich Sa A process for the preparation of michael-adducts
BRPI0819719B8 (en) * 2007-12-21 2021-05-25 Lg Chemical Ltd dipeptidyl peptidase-iv inhibiting compounds, methods of preparation thereof, and pharmaceutical preparations containing them as active agent

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9774740B2 (en) 2008-01-28 2017-09-26 Afiniti Europe Technologies Limited Techniques for benchmarking pairing strategies in a contact center system

Also Published As

Publication number Publication date
PH12014501704B1 (en) 2014-10-13
EA026411B1 (en) 2017-04-28
BR112014018985A2 (en) 2017-06-20
CN104159884B (en) 2016-01-13
BR112014018985B1 (en) 2021-01-19
MA35906B1 (en) 2014-12-01
KR20130090360A (en) 2013-08-13
AU2013215796A1 (en) 2014-08-21
MX2014009309A (en) 2014-11-10
CL2014002029A1 (en) 2014-12-26
MY168411A (en) 2018-11-09
BR112014018985A8 (en) 2017-07-11
CO7030967A2 (en) 2014-08-21
MX355336B (en) 2018-04-16
CN104159884A (en) 2014-11-19
PE20142331A1 (en) 2015-01-17
WO2013115595A1 (en) 2013-08-08
AU2013215796B2 (en) 2016-09-15
TN2014000329A1 (en) 2015-12-21
EA201491463A1 (en) 2014-11-28
ZA201405598B (en) 2015-09-30
SG11201404396TA (en) 2015-06-29
KR101539761B1 (en) 2015-07-28

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