PE20201444A1 - Polimorfos cristalinos de la base libre de 2-hidroxi-6-((2-(1-isopropil-1h-pirazol-5-il)piridin-3-il)metoxi)benzaldehido - Google Patents

Polimorfos cristalinos de la base libre de 2-hidroxi-6-((2-(1-isopropil-1h-pirazol-5-il)piridin-3-il)metoxi)benzaldehido

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Publication number
PE20201444A1
PE20201444A1 PE2020000511A PE2020000511A PE20201444A1 PE 20201444 A1 PE20201444 A1 PE 20201444A1 PE 2020000511 A PE2020000511 A PE 2020000511A PE 2020000511 A PE2020000511 A PE 2020000511A PE 20201444 A1 PE20201444 A1 PE 20201444A1
Authority
PE
Peru
Prior art keywords
metoxy
pyrazol
benzaldehyde
pyridin
isopropyl
Prior art date
Application number
PE2020000511A
Other languages
English (en)
Inventor
Zhe Li
Travis Houston
Stephan D Parent
Original Assignee
Global Blood Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53774359&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20201444(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Global Blood Therapeutics Inc filed Critical Global Blood Therapeutics Inc
Publication of PE20201444A1 publication Critical patent/PE20201444A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A UNA FORMA CRISTALINA DE LA BASE LIBRE DE 2-HIDROXI-6-((2-(1-ISOPROPIL-1H-PIRAZOL-5-IL)PIRIDIN-3-IL)METOXI)BENZALDEHIDO (COMPUESTO 1) CARACTERIZADO POR UN PATRON DE DIFRACCION DE RAYOS X EN POLVO (RADIACION Cu Kalfa) QUE TIENE PICOS DE DIFRACCION DE RAYOS X EN POLVO CON RADIACION Cu Kalfa A 13.37°, 14.37°, 19.95° Y 23.92° 2THETA (CADA UNO ±0.2 °2THETA). REFERIDA ADEMAS A UNA COMPOSICION FARMACEUTICA. DICHA FORMA CRISTALINA ES UTIL PARA EL TRATAMIENTO DE LA ANEMIA DREPANOCITICA
PE2020000511A 2014-02-07 2015-02-05 Polimorfos cristalinos de la base libre de 2-hidroxi-6-((2-(1-isopropil-1h-pirazol-5-il)piridin-3-il)metoxi)benzaldehido PE20201444A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461937393P 2014-02-07 2014-02-07
US201461937404P 2014-02-07 2014-02-07
PCT/US2015/014589 WO2015120133A1 (en) 2014-02-07 2015-02-05 Crystalline polymorphs of the free base of 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde

Publications (1)

Publication Number Publication Date
PE20201444A1 true PE20201444A1 (es) 2020-12-10

Family

ID=53774359

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2016000022A PE20160179A1 (es) 2014-02-07 2015-02-05 Polimorfos cristalinos de la base libre de 2-hidroxi-6-((2-(1-isopropil-1h-pirazol-5-il)piridin-3-il)metoxi)benzaldehido
PE2020000511A PE20201444A1 (es) 2014-02-07 2015-02-05 Polimorfos cristalinos de la base libre de 2-hidroxi-6-((2-(1-isopropil-1h-pirazol-5-il)piridin-3-il)metoxi)benzaldehido

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PE2016000022A PE20160179A1 (es) 2014-02-07 2015-02-05 Polimorfos cristalinos de la base libre de 2-hidroxi-6-((2-(1-isopropil-1h-pirazol-5-il)piridin-3-il)metoxi)benzaldehido

Country Status (30)

Country Link
US (6) US9447071B2 (es)
EP (2) EP3102208B2 (es)
JP (4) JP6809681B2 (es)
KR (2) KR102588476B1 (es)
CN (4) CN105431147A (es)
AP (1) AP2016009261A0 (es)
AU (3) AU2015214182B2 (es)
BR (1) BR112015032160B1 (es)
CA (1) CA2916564C (es)
CY (1) CY1124097T1 (es)
DK (1) DK3102208T4 (es)
EA (1) EA028529B1 (es)
ES (1) ES2860648T3 (es)
FI (1) FI3102208T4 (es)
HR (1) HRP20210388T4 (es)
HU (1) HUE053706T2 (es)
IL (2) IL243214B (es)
LT (1) LT3102208T (es)
MX (2) MX361810B (es)
MY (1) MY189995A (es)
NZ (1) NZ715029A (es)
PE (2) PE20160179A1 (es)
PL (1) PL3102208T5 (es)
PT (1) PT3102208T (es)
RS (1) RS61653B2 (es)
SA (1) SA516370358B1 (es)
SG (4) SG10201911668VA (es)
SI (1) SI3102208T2 (es)
TW (4) TWI755952B (es)
WO (1) WO2015120133A1 (es)

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US9422279B2 (en) 2013-03-15 2016-08-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
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CA2903220C (en) 2013-03-15 2023-01-24 Qing Xu Aldehyde compounds and uses thereof for the modulation of hemoglobin
US10266551B2 (en) 2013-03-15 2019-04-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
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