PE20090477A1 - OXAZOLE DERIVATIVES AS INHIBITORS OF SODIUM CHANNELS - Google Patents

OXAZOLE DERIVATIVES AS INHIBITORS OF SODIUM CHANNELS

Info

Publication number
PE20090477A1
PE20090477A1 PE2008001166A PE2008001166A PE20090477A1 PE 20090477 A1 PE20090477 A1 PE 20090477A1 PE 2008001166 A PE2008001166 A PE 2008001166A PE 2008001166 A PE2008001166 A PE 2008001166A PE 20090477 A1 PE20090477 A1 PE 20090477A1
Authority
PE
Peru
Prior art keywords
alkyl
halo
inhibitors
methyl
dichlorophenyl
Prior art date
Application number
PE2008001166A
Other languages
Spanish (es)
Inventor
Yevgeni Besidski
Alf Claesson
Istvan Macsari
Lars Sandberg
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of PE20090477A1 publication Critical patent/PE20090477A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/14—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE OXAZOL DE FORMULA (I) DONDE R1 ES H, HALO, CN, ALQUILO(C1-C4), ENTRE OTROS; R2 Y R3 SON CADA UNO HALO, ALQUILO(C1-C4), ALQUENILO(C2-C4), CN, ENTRE OTROS; R4 ES H O ALQUILO(C1-C4) OPCIONALMENTE SUSTITUIDO CON ALCOXI(C1-C3), HALO O CN; R5 ES HALOGENO, ALQUILO(C1-C4), CICLOALQUILO(C3-C6), CN, ENTRE OTROS; m ES DE 0 A 3; A ES NH U O; L ES ALQUILENO(C1-C4) OPCIONALMENTE SUSTITUIDO CON R6, EN DONDE R6 ES ALQUILO(C1-C4), ALQUENILO(C2-C4), FLUOROALQUILO(C1-C6), ENTRE OTROS; M ES ARILO(C6-C10) O HETEROARILO(C5-C10) OPCIONALMENTE SUSTITUIDO CON R7, EN DONDE R7 ES OH, HALO, CN, NITRO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N-[3-(2,6-DICLOROFENIL)-5-ETIL-1,2-OXAZOL-4-IL]CARBAMATO DE (2-CLORO-6-FLUORO-FENIL)METILO, N-[3-(2,6-DICLOROFENIL)-5-METIL-1,2-OXAZOL-4-IL]CARBAMATO DE (2-CLOROFENIL)METILO, N-[3-(2,6-DICLOROFENIL)-5-METIL-1,2-OXAZOL-4-IL]CARBAMATO DE (2,5-DICLOROFENIL)METILO, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LOS CANALES DE SODIO SIENDO UTILES EN EL TRATAMIENTO DEL DOLORREFERS TO COMPOUNDS DERIVED FROM OXAZOLE OF FORMULA (I) WHERE R1 IS H, HALO, CN, ALKYL (C1-C4), AMONG OTHERS; R2 AND R3 ARE EACH HALO, ALKYL (C1-C4), ALKENYL (C2-C4), CN, AMONG OTHERS; R4 IS H OR ALKYL (C1-C4) OPTIONALLY SUBSTITUTED WITH ALCOXY (C1-C3), HALO OR CN; R5 IS HALOGEN, ALKYL (C1-C4), CYCLOALKYL (C3-C6), CN, AMONG OTHERS; m IS 0 TO 3; A IS NH U O; L IS ALKYLENE (C1-C4) OPTIONALLY SUBSTITUTE WITH R6, WHERE R6 IS ALKYL (C1-C4), ALKYLENE (C2-C4), FLUOROALKYL (C1-C6), AMONG OTHERS; M IS ARYL (C6-C10) OR HETEROARILO (C5-C10) OPTIONALLY SUBSTITUTED WITH R7, WHERE R7 IS OH, HALO, CN, NITRO, AMONG OTHERS. PREFERRED COMPOUNDS ARE: N- [3- (2,6-DICHLOROPHENYL) -5-ETHYL-1,2-OXAZOL-4-IL] (2-CHLORO-6-FLUORO-PHENYL) CARBAMATE, N- [3 - (2,6-DICHLOROPHENIL) -5-METHYL-1,2-OXAZOL-4-IL] (2-CHLOROPHENYL) METHYL CARBAMATE, N- [3- (2,6-DICHLOROPHENYL) -5-METHYL-1 , 2-OXAZOLE-4-IL] (2,5-DICHLOROPHENYL) METHYL CARBAMATE, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. SUCH COMPOUNDS ARE INHIBITORS OF SODIUM CHANNELS, BEING USEFUL IN THE TREATMENT OF PAIN

PE2008001166A 2007-07-13 2008-07-11 OXAZOLE DERIVATIVES AS INHIBITORS OF SODIUM CHANNELS PE20090477A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US94966507P 2007-07-13 2007-07-13

Publications (1)

Publication Number Publication Date
PE20090477A1 true PE20090477A1 (en) 2009-05-24

Family

ID=39709355

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008001166A PE20090477A1 (en) 2007-07-13 2008-07-11 OXAZOLE DERIVATIVES AS INHIBITORS OF SODIUM CHANNELS

Country Status (6)

Country Link
AR (1) AR067513A1 (en)
CL (1) CL2008002038A1 (en)
PE (1) PE20090477A1 (en)
TW (1) TW200911766A (en)
UY (1) UY31219A1 (en)
WO (1) WO2009010784A1 (en)

Families Citing this family (19)

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Publication number Priority date Publication date Assignee Title
ES2559449T3 (en) 2010-09-13 2016-02-12 Novartis Ag Triazin-oxadiazoles
CN104024251B (en) 2011-10-31 2017-08-11 克赛农制药股份有限公司 Benzenesulfonamide compounds and its purposes as therapeutic agent
CA2855019A1 (en) 2011-10-31 2013-05-10 Xenon Pharmaceuticals Inc. Biaryl ether sulfonamides and their use as therapeutic agents
TW201400446A (en) 2012-05-22 2014-01-01 Genentech Inc N-substituted benzamides and methods of use thereof
RU2015103913A (en) 2012-07-06 2016-08-27 Дженентек, Инк. N-SUBSTITUTED BENZAMIDES AND WAYS OF THEIR APPLICATION
CN105263490B (en) 2013-03-14 2018-05-22 基因泰克公司 Substituted Triazolopyridine and its application method
EP2970156B1 (en) 2013-03-15 2018-07-25 Genentech, Inc. Substituted benzoxazoles and methods of use thereof
MX2016006936A (en) 2013-11-27 2016-10-05 Genentech Inc Substituted benzamides and methods of use thereof.
WO2015102929A1 (en) 2013-12-30 2015-07-09 Novartis Ag Tricyclic sulfonamide derivatives
JP2017525677A (en) 2014-07-07 2017-09-07 ジェネンテック， インコーポレイテッド Therapeutic compounds and methods of use thereof
MA42118A (en) 2015-05-22 2018-03-28 Genentech Inc BENZAMIDES SUBSTITUTED AND THEIR METHODS OF USE
CN108137477A (en) 2015-08-27 2018-06-08 基因泰克公司 Therapeutic compounds and its application method
WO2017058821A1 (en) 2015-09-28 2017-04-06 Genentech, Inc. Therapeutic compounds and methods of use thereof
US10899732B2 (en) 2015-11-25 2021-01-26 Genentech, Inc. Substituted benzamides useful as sodium channel blockers
EP3436432B1 (en) 2016-03-30 2021-01-27 Genentech, Inc. Substituted benzamides and methods of use thereof
WO2018072602A1 (en) 2016-10-17 2018-04-26 Genentech, Inc. Therapeutic compounds and methods of use thereof
CN110546148A (en) 2017-03-24 2019-12-06 基因泰克公司 4-piperidine-N- (pyrimidin-4-yl) chroman-7-sulfonamide derivatives as sodium channel inhibitors
AR114263A1 (en) 2018-02-26 2020-08-12 Genentech Inc THERAPEUTIC COMPOUNDS AND METHODS TO USE THEM
WO2019191702A1 (en) 2018-03-30 2019-10-03 F. Hoffmann-La Roche Ag Substituted hydro-pyrido-azines as sodium channel inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007075896A2 (en) * 2005-12-22 2007-07-05 Kemia, Inc. Heterocyclic cytokine inhibitors

Also Published As

Publication number Publication date
TW200911766A (en) 2009-03-16
CL2008002038A1 (en) 2009-07-17
WO2009010784A1 (en) 2009-01-22
UY31219A1 (en) 2009-03-02
AR067513A1 (en) 2009-10-14

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