PE20011258A1 - Derivados de benzocicloalquilenilamina como antagonistas de receptores muscarinicos - Google Patents

Derivados de benzocicloalquilenilamina como antagonistas de receptores muscarinicos

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Publication number
PE20011258A1
PE20011258A1 PE2001000464A PE2001000464A PE20011258A1 PE 20011258 A1 PE20011258 A1 PE 20011258A1 PE 2001000464 A PE2001000464 A PE 2001000464A PE 2001000464 A PE2001000464 A PE 2001000464A PE 20011258 A1 PE20011258 A1 PE 20011258A1
Authority
PE
Peru
Prior art keywords
alkyl
derivatives
benzocycloalkylenylamine
antagonists
butil
Prior art date
Application number
PE2001000464A
Other languages
English (en)
Inventor
Ann Marie Madera
Robert James Weikert
Russell Stephen Stabler
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20011258A1 publication Critical patent/PE20011258A1/es

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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
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    • A—HUMAN NECESSITIES
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  • Chemical & Material Sciences (AREA)
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Abstract

SE REFIERE A DERIVADOS DE BENZOCICLOALQUILENILAMINA DE FORMULA I DONDE R1 Y R2 SON H, HALOGENO, ALQUILO C1-C6, OR', SR', NR'R'', SOR' ENTRE OTROS; R' Y R'' SON H, ALQUILO C1-C6, ALQUILO C1-C6, ARILO, HETEROCICLICLO, HETEROARILO, ARIL-(ALQUILO C1-C3), HETEROARILALQUIL-ALQUILO, ENTRE OTROS; R3 ES ALQUILO C1-C6, ALQUENILO C1-C6, ALQUINILO C1-C6, CICLOALQUILO, ENTRE OTROS; X, Y o Z SON S, O, >N-R4; R4 ES H, ALQUILO C1-C6, HALOGENOALQUILO, ARIL-(ALQUILO C1-C6), ENTRE OTROS; p ES 1-3; m ES 0-3; n ES 1-6. SON COMPUESTOS PREFERIDOS 4-{4-[(7-METOXI-1,2,3,4-TETRAHIDRONAFTALEN-2-IL)-PROPIL-AMINO]-BUTIL}-[1,4]DIAZEPAN-5-ONA, 1-{4-[(7-METOXI-1,2,3,4-TETRAHIDRONAFTALEN-2-IL)-PROPIL-AMINO]-BUTIL}-[1,4]DIAZEPAN-2-ONA, 4-(2-DIMETILAMINOETANOSULFONIL)-1-{4-[(7-METOXI-1,2,3,4-TETRAHIDRONAFTALEN-2-IL)-PROPIL-AMINO]-BUTIL}-[1,4]DIAZEPAN-5-ONA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO PARA LA PREPARACION. LOS DERIVADOS DE BENZOCICLOALQUENILAMINA DE FORMULA I SON ANTAGONISTAS DE RECEPTOR MUSCARINICO M2/M3 Y SON UTILES PARA EL TRATAMIENTO DE ENFERMEDADES ASOCIADAS CON TRASTORNOS DEL MUSCULO LISO, TRACTO GENITOUNITARIO, GASTROINTESTINAL
PE2001000464A 2000-05-25 2001-05-22 Derivados de benzocicloalquilenilamina como antagonistas de receptores muscarinicos PE20011258A1 (es)

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Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6640155B2 (en) 2000-08-22 2003-10-28 Lam Research Corporation Chemical mechanical polishing apparatus and methods with central control of polishing pressure applied by polishing head
MXPA04005076A (es) * 2001-12-03 2004-08-19 Hoffmann La Roche Derivados de 4-piperidinil alquilamina como antagonistas del receptor muscarinico.
CN100358870C (zh) 2001-12-03 2008-01-02 弗·哈夫曼-拉罗切有限公司 作为毒蕈碱受体拮抗剂的氨基四氢萘衍生物
CA2472580A1 (en) * 2002-01-07 2003-07-17 Sequoia Pharmaceuticals Broad spectrum inhibitors
DE60230683D1 (de) 2002-07-08 2009-02-12 Ranbaxy Lab Ltd 3,6-disubstituierte azabicyclo-3.1.0 hexan-derivat
AU2003293834A1 (en) * 2002-12-23 2004-07-14 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with muscarinic acetylcholine receptor m2 (m2)
PT1599468E (pt) 2003-01-14 2008-01-14 Arena Pharm Inc Derivados de arilo e heteroarilo 1,2,3.-trissubstituídos comomoduladores do metabolismo, e profilaxia e tratamento dedesordens relacionadas tais como diabetes e hiperglicemia
AU2003214520A1 (en) 2003-04-09 2004-11-01 Ranbaxy Laboratories Limited Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
AU2004228452A1 (en) 2003-04-11 2004-10-21 Ranbaxy Laboratories Limited Azabicyclo derivatives as muscarinic receptor antagonists
EP1849465A4 (en) * 2005-02-18 2008-12-24 Takeda Pharmaceutical AGENT FOR CONTROLLING THE FUNCTION OF THE GPR34 RECEPTOR
US7736310B2 (en) * 2006-01-30 2010-06-15 Abbott Diabetes Care Inc. On-body medical device securement
MX2011000404A (es) * 2008-07-16 2011-03-04 Hoffmann La Roche Nuevos compuestos heterociclilo para el tratamiento de enfermedades cardiovasculares.
BRPI0916574A2 (pt) * 2008-07-28 2015-11-10 Hoffmann La Roche derivados de diazepano e piperazina moduladores de receptores de quiomiocinas
US8214928B1 (en) 2008-10-29 2012-07-10 Full90 Sports, Inc. Headguard with an eccentric dimple for accommodating the occipital bone
US8042198B1 (en) 2008-10-29 2011-10-25 Full90 Sports, Inc. Headguard with independently adjustable upper and lower bands
US20100101006A1 (en) * 2008-10-29 2010-04-29 Cleveland William K Headguard with temple protecting scallop that does not cover the ears
AU2010245932B2 (en) 2009-05-05 2015-08-06 Board Of Regents, The University Of Texas System Novel formulations of volatile anesthetics and methods of use for reducing inflammation
BR112013008100A2 (pt) 2010-09-22 2016-08-09 Arena Pharm Inc "moduladores do receptor de gpr19 e o tratamento de distúrbios relacionados a eles."
WO2012092990A2 (de) 2011-01-05 2012-07-12 Udo Wenske Medizinprodukt zur verbesserung der konzeptionsfähigkeit eines säugetiers
US8476221B2 (en) 2011-03-18 2013-07-02 Halimed Pharmaceuticals, Inc. Methods and compositions for the treatment of metabolic disorders
AU2016205361C1 (en) 2015-01-06 2021-04-08 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the S1P1 receptor
MA41629A (fr) 2015-03-04 2018-01-09 Center For Human Reproduction Compositions et méthodes d'utilisation de l'hormone anti-müllérienne pour le traitement de l'infertilité
WO2016149628A1 (en) * 2015-03-19 2016-09-22 Chembridge Corporation Tgr5 agonists
CN108349891B (zh) 2015-06-22 2022-04-05 艾尼纳制药公司 用于s1p1受体相关病症的化合物的结晶l-精氨酸盐
US20210330599A1 (en) 2016-08-01 2021-10-28 University Of Rochester Nanoparticles for Controlled Release of Anti-Biofilm Agents and Methods of Use
AU2018220521A1 (en) 2017-02-16 2019-09-05 Arena Pharmaceuticals, Inc. Compounds and methods for treatment of primary biliary cholangitis
WO2020076578A1 (en) 2018-10-09 2020-04-16 University Of Rochester Treatment of vulvovaginal disorders

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3418270A1 (de) 1984-05-17 1985-11-21 Dr. Karl Thomae Gmbh, 7950 Biberach Neue aminotetralinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US4748182A (en) 1986-03-05 1988-05-31 Merrell Dow Pharmaceuticals Inc. Aromatic 2-aminoalkyl-1,2-benzoisothiazol-3(2H)one-1,1-dioxide derivatives and their use as anti-hypertensive and anxiolytic agents
DE3718317A1 (de) 1986-12-10 1988-06-16 Bayer Ag Substituierte basische 2-aminotetraline
US5177089A (en) 1988-06-01 1993-01-05 Eisai Co., Ltd. Butenoic or propenoic acid derivative
FI892362A (fi) 1988-06-01 1989-12-02 Eisai Co Ltd Buten- eller propensyraderivat.
US5545755A (en) 1989-05-31 1996-08-13 The Upjohn Company Therapeutically useful 2-aminotetralin derivatives
US5118704A (en) 1989-08-30 1992-06-02 Whitby Research, Inc. Substituted 2-aminotetralins useful as dopaminergics
US6319920B1 (en) * 1998-02-27 2001-11-20 Syntex (U.S.A.) Llc 2-arylethyl-(piperidin-4-ylmethyl)amine derivatives

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US6645958B2 (en) 2003-11-11
HUP0302015A2 (hu) 2003-10-28
EP1289964B1 (en) 2004-10-20
US20030109524A1 (en) 2003-06-12
AU6031001A (en) 2001-12-03
EP1289964A1 (en) 2003-03-12
NO20025641D0 (no) 2002-11-22
NZ522410A (en) 2004-09-24
IL152700A0 (en) 2003-06-24
ATE280162T1 (de) 2004-11-15
KR20030003758A (ko) 2003-01-10
AR033377A1 (es) 2003-12-17
AU2001260310B2 (en) 2007-04-05
UY26728A1 (es) 2001-12-28
RU2243222C2 (ru) 2004-12-27
DE60106607T2 (de) 2006-02-09
DE60106607D1 (de) 2004-11-25
CA2408934C (en) 2009-04-14
US6818645B2 (en) 2004-11-16
CZ20024199A3 (cs) 2004-01-14
US20020004494A1 (en) 2002-01-10
NO20025641L (no) 2002-12-17
MA26904A1 (fr) 2004-12-20
US6500822B2 (en) 2002-12-31
CA2408934A1 (en) 2001-11-29
CN1430609A (zh) 2003-07-16
WO2001090082A1 (en) 2001-11-29
BR0111019A (pt) 2003-06-17
MXPA02011417A (es) 2003-04-25
PL361361A1 (en) 2004-10-04
JP3955211B2 (ja) 2007-08-08
YU89002A (sh) 2006-01-16
KR100599125B1 (ko) 2006-07-12
ES2230310T3 (es) 2005-05-01
JP2003534331A (ja) 2003-11-18
US20040034018A1 (en) 2004-02-19
CN1187342C (zh) 2005-02-02

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