PE20001083A1 - Derivados de mononitrato de isosorbide - Google Patents

Derivados de mononitrato de isosorbide

Info

Publication number
PE20001083A1
PE20001083A1 PE1999001005A PE00100599A PE20001083A1 PE 20001083 A1 PE20001083 A1 PE 20001083A1 PE 1999001005 A PE1999001005 A PE 1999001005A PE 00100599 A PE00100599 A PE 00100599A PE 20001083 A1 PE20001083 A1 PE 20001083A1
Authority
PE
Peru
Prior art keywords
mononitrate
isosorbide
nicotinate
alkyl
aryl
Prior art date
Application number
PE1999001005A
Other languages
English (en)
Inventor
Moliner Jose Repolles
Coy Francisco Pubill
Banus Marcel Li Carbo
Riudavets Juan Antonio Cerda
Marek W Radomski
Bonnin Juan Martinez
Perez-Rasilla Eduardo Salas
Siso Alicia Ferrer
Rofes Cristina Negrie
Llorente Lydia Cabeza
Original Assignee
Lacer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lacer Sa filed Critical Lacer Sa
Publication of PE20001083A1 publication Critical patent/PE20001083A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)

Abstract

SE REFIERE A DERIVADOS DE MONONITRATO DE ISOSORBIDE DE FORMULA (I), DONDE A Y B SON -ONO2, ZC(=O)R; Z ES O, S; R ES ALQUILO C1-C4, ARILO O ARALQUILO SUSTITUIDO CON UN GRUPO a; DONDE R1 ES H, ALQUILO C1-C4, ARILO O ARALQUILO SUSTITUIDO; DE MANERA QUE SIEMPRE UNO DE A o B ES -ONO2 PERO NUNCA LOS DOS A LA VEZ; CUANDO Z ES S, R ES UN ALQUILO C1-C4, ARILO o ARALQUILO Y CUANDO Z ES O, R ES UN GRUPO a, DONDE R1 ES H, ALQUILO C1-C4. SON COMPUESTOS PREFERIDOS 5-MONONITRATO DE 2-(2`-ETILTIO)NICOTINATO DE ISOSORBIDE; 2-MONONITRATO DE 5-(2'-ETILTIO)NICOTINATO DE ISOSORBIDE; 5-MONONITRATO DE 2-(2'MERCAPTO)NICOTINATO DE ISOSORBIDE; 2-MONONITRATO DE 5-(2'-MERCAPTO)NICOTINATO DE ISOSORBIDE; 5-MONONITRATO DE 2-ACETILMERCAPTOISOSORBIDE Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. EL COMPUESTO DE FORMULA I TIENE EFECTO VASODILATADOR POR LO QUE PUEDE SER UTIL PARA EL TRATAMIENTO DE DISFUNCIONES DEL SISTEMA CIRCULATORIO, CARDIOVASCULAR Y CORONARIO
PE1999001005A 1998-10-07 1999-10-04 Derivados de mononitrato de isosorbide PE20001083A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009802076A ES2142773B1 (es) 1998-10-07 1998-10-07 Derivados de mononitrato de isosorbida y su empleo como agentes vasodilatadores con tolerancia desminuida.

Publications (1)

Publication Number Publication Date
PE20001083A1 true PE20001083A1 (es) 2000-11-28

Family

ID=8305360

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1999001005A PE20001083A1 (es) 1998-10-07 1999-10-04 Derivados de mononitrato de isosorbide

Country Status (40)

Country Link
US (2) US20010051735A1 (es)
EP (1) EP1120419B1 (es)
JP (1) JP4659214B2 (es)
KR (1) KR100641801B1 (es)
CN (1) CN1096465C (es)
AP (1) AP1555A (es)
AR (1) AR020538A1 (es)
AT (1) ATE323707T1 (es)
AU (1) AU762724B2 (es)
BG (1) BG65135B1 (es)
BR (1) BR9914355B1 (es)
CA (1) CA2346010C (es)
CO (1) CO5180544A1 (es)
CU (1) CU23162A3 (es)
CZ (1) CZ294551B6 (es)
DE (2) DE19983612T1 (es)
DK (1) DK1120419T3 (es)
EA (1) EA003360B1 (es)
EE (1) EE04374B1 (es)
ES (2) ES2142773B1 (es)
GB (1) GB2359810B (es)
GE (1) GEP20043162B (es)
GT (1) GT199900173A (es)
HR (1) HRP20010256B1 (es)
HU (1) HUP0103937A3 (es)
ID (1) ID29946A (es)
IL (2) IL142391A0 (es)
IS (1) IS2312B (es)
NO (1) NO328584B1 (es)
NZ (1) NZ510855A (es)
OA (1) OA11661A (es)
PA (1) PA8483901A1 (es)
PE (1) PE20001083A1 (es)
PL (1) PL200028B1 (es)
PT (1) PT1120419E (es)
RS (1) RS50112B (es)
TR (1) TR200100961T2 (es)
WO (1) WO2000020420A1 (es)
YU (1) YU25201A (es)
ZA (1) ZA200102836B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2258365B1 (es) * 2003-10-03 2007-12-01 Lacer, S.A. Derivados de disulfuro, sulfuro, sulfoxido y sulfona de azucares ciclicos y sus usos.
EP1941876A1 (en) * 2006-12-28 2008-07-09 Lacer, S.A. Isosorbide mononitrate derivatives for the treatment of Inflammation and ocular hypertension
ES2332565B1 (es) * 2007-01-23 2010-10-21 Lacer, S.A. Uso de derivados de mononitrato de dianhidrohexita como agentes antiinflamatorios.
IE20070934A1 (en) 2007-12-21 2009-06-24 Trinity College Dublin Efficient aspirin prodrugs
EP2719700A1 (en) 2008-01-09 2014-04-16 Amura Therapeutics Limited Tetrahydrofuro(3,2-b)pyrrol-3-one derivatives as inhibitors of cysteine proteinases
EP2238143B1 (en) * 2008-02-07 2012-08-15 Nicox S.A. Nitric oxide donor compounds
EP2149576A1 (en) * 2008-07-22 2010-02-03 Lacer, S.A. Isosorbide Nitrates having vasodilating activity
EP2149577B1 (en) * 2008-07-22 2011-04-27 Lacer, S.A. New stereospecific method for the preparation of dioxa-bicyclooctane compounds
EP2177216A1 (en) * 2008-10-13 2010-04-21 Lacer, S.A. Use of dianhydrohexite mononitrate derivatives as healing agents
WO2010055138A1 (en) * 2008-11-14 2010-05-20 Lacer, S.A. New stereospecific method for the preparation of dioxa-bicyclooctane compounds
EP2199294A1 (en) * 2008-12-19 2010-06-23 Lacer, S.A. New stereospecific method for the preparation of dioxa bicyclooctane nitrate compounds
EP2301941B1 (en) * 2009-09-10 2013-06-19 Cognis IP Management GmbH Isosorbide glyceryl ether derivatives and their use in household applications
US20130131161A1 (en) * 2009-12-23 2013-05-23 Michael R. Bristow Methods and compositions for cardiovascular diseases and conditions
CN102241687A (zh) * 2011-05-23 2011-11-16 中国人民解放军第四军医大学 抗缺血/再灌注损伤的药物
CN103687843B (zh) 2011-10-24 2016-11-16 尼科斯科学爱尔兰公司 醌基一氧化氮供体化合物
RU2015139514A (ru) * 2013-03-05 2017-04-07 Арчер Дэниелс Мидлэнд Компани Монотрифлаты изогексида и способ их синтеза
WO2014169976A1 (en) 2013-04-18 2014-10-23 Nicox Science Ireland Quinone based nitric oxide donating compounds
CN104650108B (zh) * 2013-11-18 2017-05-24 富力 连翘脂素硫酸酯及其衍生物、制备方法及其应用
CN105461731B (zh) * 2014-08-07 2017-05-24 富力 连翘脂素布洛芬酯、其制备及其应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1356374A (fr) 1963-02-12 1964-03-27 Machine à fonctions multiples pour le travail du bois
AU465217B2 (en) 1971-04-29 1975-09-18 American Home Products Corporation Mononitrte esters of 1,4:3, 6-dianhydro-d-glucitol
US3886196A (en) 1973-02-07 1975-05-27 Phillips Petroleum Co Magnesium-aluminum-silicate-phosphate catalysts for ammonialytic cleavage of lactams to form omega-aminonitriles
DE3028289C2 (de) 1980-07-25 1986-11-27 Dr. Willmar Schwabe GmbH & Co, 7500 Karlsruhe 2-O- und 5-O-substituierte 1.4;3.6-Dianhydro-hexit-mononitrate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zubereitungen
DE3248548A1 (de) 1982-12-29 1984-07-05 Heinrich Mack Nachf., 7918 Illertissen Acylderivate von 1,4:3,6-dianhydro-hexiten, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3421072A1 (de) 1984-06-06 1985-12-12 Heinrich Mack Nachf., 7918 Illertissen 1,4:3,6-dianhydro-hexit-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3602067A1 (de) 1986-01-24 1987-07-30 Mack Chem Pharm 2,6-dioxabicyclo(3.3.0)octan-derivate, ihre herstellung und verwendung als arzneimittel
DE3606634A1 (de) 1986-02-28 1987-09-03 Mack Chem Pharm Isohexid-nucleoside, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
IT1204571B (it) * 1987-05-08 1989-03-10 Chiesi Farma Spa Esteri di 1,4:3,6-dianidrosorbitolo-2-mononitrato e 5-mononitrato,loro procedimento di preparazione e loro composizioni farmaceutiche
DE3741005A1 (de) 1987-12-03 1989-06-15 Mack Chem Pharm Aminopropanol-derivate von 1,4:3,6-dianhydro-hexit-nitraten, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
JP2628756B2 (ja) * 1988-09-15 1997-07-09 シュバルツファルマ アクチェンゲゼルシャフト 新規有機ニトレート及びそれらの製造方法
US5428061A (en) 1988-09-15 1995-06-27 Schwarz Pharma Ag Organic nitrates and method for their preparation
US4891373A (en) * 1988-11-23 1990-01-02 Pfizer Inc. Aminopropanol derivatives of 1,4:3,6-dianhydrohexitol nitrates, processes for their preparation and their use as medicaments
CA2014520C (en) 1989-04-17 1996-07-16 Fumio Suzuki Hexitol derivatives
NL9001955A (nl) * 1990-09-05 1992-04-01 Cedona Pharm Bv Nieuwe thiazolidinederivaten.
FR2680173A1 (fr) 1991-08-07 1993-02-12 Hoechst Lab Nitrates organiques, leurs procedes de preparation et leur utilisation dans le traitement de maladies cardiovasculaires .
ATE172183T1 (de) * 1992-07-30 1998-10-15 Cal Int Ltd Ester und kombinationen von einem organischen nitrat und einem salicyclat
IL120531A (en) 1997-03-26 2006-12-31 Yissum Res Dev Co Nitric oxide donors and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
ID29946A (id) 2001-10-25
HUP0103937A2 (hu) 2002-02-28
ES2257871T3 (es) 2006-08-01
CN1096465C (zh) 2002-12-18
GB0111172D0 (en) 2001-06-27
IS5910A (is) 2001-03-29
PA8483901A1 (es) 2000-09-29
NO20011778L (no) 2001-04-06
US20030225134A1 (en) 2003-12-04
HUP0103937A3 (en) 2003-11-28
JP4659214B2 (ja) 2011-03-30
ATE323707T1 (de) 2006-05-15
YU25201A (sh) 2003-04-30
TR200100961T2 (tr) 2003-02-21
CU23162A3 (es) 2006-07-18
WO2000020420A1 (es) 2000-04-13
CZ294551B6 (cs) 2005-01-12
BG65135B1 (bg) 2007-03-30
RS50112B (sr) 2009-03-25
KR100641801B1 (ko) 2006-11-02
PL200028B1 (pl) 2008-11-28
BR9914355A (pt) 2001-06-26
BR9914355B1 (pt) 2014-10-21
HRP20010256A2 (en) 2002-04-30
AP2001002128A0 (en) 2001-06-30
AU762724B2 (en) 2003-07-03
ES2142773A1 (es) 2000-04-16
EP1120419B1 (en) 2006-04-19
GT199900173A (es) 2001-03-30
JP2002526544A (ja) 2002-08-20
BG105417A (en) 2001-12-29
AP1555A (en) 2006-01-18
EA003360B1 (ru) 2003-04-24
US6858632B2 (en) 2005-02-22
GB2359810A (en) 2001-09-05
CZ20011257A3 (cs) 2001-08-15
US20010051735A1 (en) 2001-12-13
ES2142773B1 (es) 2001-01-01
DE69930949D1 (de) 2006-05-24
CA2346010A1 (en) 2000-04-13
AR020538A1 (es) 2002-05-15
EE04374B1 (et) 2004-10-15
EP1120419A1 (en) 2001-08-01
HRP20010256B1 (en) 2009-08-31
CA2346010C (en) 2010-01-12
DE69930949T2 (de) 2006-12-28
KR20010088848A (ko) 2001-09-28
GEP20043162B (en) 2004-01-26
AU6204199A (en) 2000-04-26
OA11661A (en) 2004-12-08
ZA200102836B (en) 2002-09-25
CN1322205A (zh) 2001-11-14
DE19983612T1 (de) 2001-09-27
PL347030A1 (en) 2002-03-11
NO20011778D0 (no) 2001-04-06
PT1120419E (pt) 2006-07-31
IS2312B (is) 2007-11-15
IL142391A0 (en) 2002-03-10
DK1120419T3 (da) 2006-07-03
NO328584B1 (no) 2010-03-22
EE200100207A (et) 2002-06-17
IL142391A (en) 2007-07-24
GB2359810B (en) 2003-12-03
EA200100422A1 (ru) 2001-10-22
CO5180544A1 (es) 2002-07-30
NZ510855A (en) 2004-02-27

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Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed