OA04406A - Procédé de préparation de dérivés de 14-hydroxy-morphinane. - Google Patents

Procédé de préparation de dérivés de 14-hydroxy-morphinane.

Info

Publication number
OA04406A
OA04406A OA54906A OA54906A OA04406A OA 04406 A OA04406 A OA 04406A OA 54906 A OA54906 A OA 54906A OA 54906 A OA54906 A OA 54906A OA 04406 A OA04406 A OA 04406A
Authority
OA
OAPI
Prior art keywords
hydroxy
preparation
morphinan derivatives
morphinan
derivatives
Prior art date
Application number
OA54906A
Other languages
English (en)
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of OA04406A publication Critical patent/OA04406A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C07C49/755—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/28—Morphinans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/26—Phenanthrenes; Hydrogenated phenanthrenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
OA54906A 1972-05-10 1973-05-09 Procédé de préparation de dérivés de 14-hydroxy-morphinane. OA04406A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25187972A 1972-05-10 1972-05-10

Publications (1)

Publication Number Publication Date
OA04406A true OA04406A (fr) 1980-02-29

Family

ID=22953785

Family Applications (1)

Application Number Title Priority Date Filing Date
OA54906A OA04406A (fr) 1972-05-10 1973-05-09 Procédé de préparation de dérivés de 14-hydroxy-morphinane.

Country Status (13)

Country Link
US (1) US3775414A (fr)
JP (1) JPS535672B2 (fr)
CA (1) CA989827A (fr)
CH (1) CH590238A5 (fr)
CS (3) CS178446B2 (fr)
DD (1) DD106841A5 (fr)
DK (1) DK138492B (fr)
HU (2) HU169023B (fr)
IL (1) IL42219A (fr)
NL (1) NL155256B (fr)
OA (1) OA04406A (fr)
SE (2) SE403106B (fr)
YU (1) YU36505B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3910920A (en) * 1973-11-07 1975-10-07 Bristol Myers Co 3,14,17-Substituted-6,7-tetramethylenemorphinans
US3980641A (en) * 1975-07-31 1976-09-14 Bristol-Myers Company Process for the preparation of 14-hydroxymorphinans
US4017497A (en) * 1975-11-18 1977-04-12 Bristol-Myers Company Process for the preparation of 14-hydroxymorphinan derivatives
JPS52136176A (en) * 1976-03-23 1977-11-14 Bristol Myers Co Method of improving 144hydroxymorphinan derivatives
US4139534A (en) * 1977-02-17 1979-02-13 Bristol-Myers Company Process for the preparation of 14-hydroxymorphinan derivatives
US4052389A (en) * 1976-03-23 1977-10-04 Bristol-Myers Company Derivatives of 9,10-dihydroxy-1-(p-alkoxybenzyl)-perhydroisoquinoline oxazine-3-one
US4115389A (en) * 1977-05-02 1978-09-19 Bristol-Myers Company Process of N-demethylating (-)-1-(p-methoxybenzyl)-2-methyl-1,2,3,4,5,6,7,8-octahydroisoquinoline
NO793297L (no) * 1978-10-19 1980-04-22 Mallinckrodt Inc Fremgangsmaate til fremstilling av oksymorfon
US4272540A (en) * 1979-04-24 1981-06-09 Sisa, Incorporated 14-Methoxymorphinan-6-one compounds and therapeutic methods of treating pain and drug dependence with them
NO802139L (no) * 1979-08-09 1981-02-10 Mallinckrodt Inc Utgangsforbindelser for fremstilling av morfinderivater, samt fremgangsmaate til fremstilling av utgangsforbindelsene
US5109136A (en) * 1990-08-09 1992-04-28 Warner-Lambert Company Tetracyclic amines useful as cerebrovascular agents
US10307381B2 (en) 2014-10-14 2019-06-04 Hisamitsu Pharmaceutical Co., Inc. Patch
MX2018011877A (es) * 2016-03-29 2019-03-06 Hikal Ltd Proceso mejorado para la preparacion de tartrato de butorfanol.
KR102279552B1 (ko) 2016-12-28 2021-07-19 히사미쓰 세이야꾸 가부시키가이샤 부토르파놀 함유 첩부제
WO2018198925A1 (fr) 2017-04-25 2018-11-01 久光製薬株式会社 Patch adhésif
CN110545816B (zh) 2017-04-25 2023-04-11 久光制药株式会社 贴附剂
CN112592342B (zh) * 2021-01-15 2022-02-22 福安药业集团重庆礼邦药物开发有限公司 一种布托啡诺脱环丁基杂质化合物的制备方法

Also Published As

Publication number Publication date
NL155256B (nl) 1977-12-15
HU168597B (fr) 1976-06-28
CA989827A (en) 1976-05-25
DK138492C (fr) 1979-02-19
SE411042B (sv) 1979-11-26
IL42219A (en) 1977-06-30
YU119773A (en) 1982-02-25
CS178447B2 (fr) 1977-09-15
SE7604162L (sv) 1976-04-08
SE403106B (sv) 1978-07-31
NL7306344A (fr) 1973-11-13
DD106841A5 (fr) 1974-07-05
CH590238A5 (fr) 1977-07-29
HU169023B (fr) 1976-09-28
DK138492B (da) 1978-09-18
YU36505B (en) 1984-02-29
JPS535672B2 (fr) 1978-03-01
US3775414A (en) 1973-11-27
IL42219A0 (en) 1973-07-30
CS178425B2 (fr) 1977-09-15
CS178446B2 (fr) 1977-09-15
JPS4961169A (fr) 1974-06-13

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