NO953620L - Use of substituted alkyl nitrates in the treatment of morbidly increased pressure in the inner eye - Google Patents

Use of substituted alkyl nitrates in the treatment of morbidly increased pressure in the inner eye

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Publication number
NO953620L
NO953620L NO953620A NO953620A NO953620L NO 953620 L NO953620 L NO 953620L NO 953620 A NO953620 A NO 953620A NO 953620 A NO953620 A NO 953620A NO 953620 L NO953620 L NO 953620L
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Norway
Prior art keywords
substituted
alkyl
residue
halo
group
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Application number
NO953620A
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Norwegian (no)
Other versions
NO953620D0 (en
Inventor
Jan Bron
Geert Jan Sterk
Jan Fetze Van Der Werf
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Byk Nederland Bv
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Publication date
Application filed by Byk Nederland Bv filed Critical Byk Nederland Bv
Publication of NO953620D0 publication Critical patent/NO953620D0/en
Publication of NO953620L publication Critical patent/NO953620L/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/59—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
    • C07C205/35—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/36—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
    • C07C205/37—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/39—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups
    • C07C205/41—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups having nitro groups or esterified hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/39—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups
    • C07C205/42—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups having nitro groups or esterified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/59—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C07C205/60—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms in ortho-position to the carboxyl group, e.g. nitro-salicylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C219/04—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C219/16—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the hydroxy groups esterified by an inorganic acid or a derivative thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/67—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/68—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/69—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of an acyclic saturated carbon skeleton

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Ophthalmology & Optometry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Anvendelse av forbindelser med formel (R1R2)CHON02/ hvor RI er H, l-4C-alkyl, -CH2-R8 eller -CH2OCH2R8, eller sammen med R2 samt CH-gruppen, som er bundet til RI og R2, en med en OH-gruppe eller en nitryloksygruppe substituert cykloheksyl- eller bicyklo[4.4.0]decylrest eller en i 8-stilling med resten R3-0- substituert 2,6- dioksabicyklo-[3.3.0]okt-4-yl-rest; R2 er rettkjedet eller forgrenet l-12C-alkyl substituert NH2/ R3, R3-0, R4, R4-0, R4-S, R4-NH, R4-CO-0, R4-CO-NH, R5 eller R6, eller er substituert med R3 og R5, eller med R4-0 og R5, eller R4.og R5, eller R2 er 2-7C-alkyl som ev. er substituert med R3, eller betyr R3 eller 3-7C-cykloalk- yl som ev. er substituert med R4 og R5, eller betyr en dibenzo-5-7C-cykloalkanylrest, eller sammen med RI samt CH-gruppen, er bundet til RI og R2, en med en nitryl- oksygruppe substituert cykloheksyl- eller bicyklo[4.4.- 0]decylrest eller en i B-stilling med resten R3-0- substituert 2,6-dioksabicyklo[3.3.0]okt-4-yl-rest; R3 er en med R7 og R8 substituert metylrest [CH(R7)R8]; R4 er fenyl, l-4C-alkyl, 3-7C-cykloalkyl, fenyl substi- tuert med en, to eller tre like eller forskjellige substituenter fra gruppen l-4C-alkyl, l-4C-alkoksy, nitro, halo, nitryloksy-l-4C-alkyl, hydroksy og karb- oksy, naftyl eller tienyl som ev. er substituert med halo; R5 betyr nitryloksy-l-4C-alkyl, hydroksy-l-4C- alkyl eller nitryloksy; R6 betyr nitryloksy-l-4C-alkyl- tetrametylfenyl, dibenzo-5-7C-cykloalkanyl, dibenzo- cykloheptenyl, ev. med halo substituert tioxantenyl ev. i benzodelen med nitro substituert benzo-5-7C-cyklo- alkanyl eller benzyloksy; R7 betyr fenyl, fenyl substi- tuert med en eller to l-4C-alkyl, l-4C-alkoksy, nitro og halo, pyridyl eller tienyl ev. substituert med halo; og R8 er fenyl ev. substituert med l-4C-alkyl, 1-4C- alkoksy, nitro eller halo, og deres farmakologisk akseptable salter for fremstilling av legemidler for behandling av sykelig øket trykk i det indre øye.Use of compounds of formula (R1R2) CHONO2 / wherein R1 is H, 1-4C-alkyl, -CH2 -R8 or -CH2OCH2R8, or together with R2 and the CH group bonded to R1 and R2, one having an OH -group or a nitryloxy group substituted cyclohexyl or bicyclo [4.4.0] decyl residue or an 8-position with the residue R3-0- substituted 2,6-dioxabicyclo- [3.3.0] oct-4-yl residue; R 2 is straight-chain or branched 1- 12C-alkyl substituted NH 2 / R 3, R 3 -O, R 4, R 4 -O, R 4 -S, R 4 -NH, R 4 -CO-0, R 4 -CO-NH, R 5 or R 6, or is substituted with R3 and R5, or with R4-0 and R5, or R4 and R5, or R2 is 2-7C-alkyl as optionally is substituted with R 3, or means R 3 or 3-7C-cycloalkyl as optionally is substituted with R4 and R5, or represents a dibenzo-5-7C-cycloalkanyl residue, or together with RI and the CH group, is bonded to RI and R2, a cyclohexyl or bicyclo substituted with a nitryl oxy group [4.4.-O ] decyl residue or a B-position with the residue R 3 -O-substituted 2,6-dioxabicyclo [3.3.0] oct-4-yl residue; R3 is a methyl radical substituted with R7 and R8 [CH (R7) R8]; R 4 is phenyl, 1-4C-alkyl, 3-7C-cycloalkyl, phenyl substituted with one, two or three equal or different substituents from the group 1-4C-alkyl, 1-4C-alkoxy, nitro, halo, nitryloxy 1-4C-alkyl, hydroxy and carboxy, naphthyl or thienyl, as the case may be. is substituted with halo; R5 is nitryloxy-1-4C-alkyl, hydroxy-1-4C-alkyl or nitryloxy; R6 means nitryloxy-1-4C-alkyl-tetramethylphenyl, dibenzo-5-7C-cycloalkanyl, dibenzo-cycloheptenyl, and the like. with halo substituted thioxanthenyl ev. in the benzo moiety with nitro-substituted benzo-5-7C-cycloalkanyl or benzyloxy; R7 means phenyl, phenyl substituted with one or two 1-4C-alkyl, 1-4C-alkoxy, nitro and halo, pyridyl or thienyl or the like. substituted with halo; and R8 is phenyl, ev. substituted with 1-4C-alkyl, 1-4C-alkoxy, nitro or halo, and their pharmacologically acceptable salts for the manufacture of drugs for the treatment of morbidly increased pressure in the inner eye.

NO953620A 1993-03-15 1995-09-14 Use of substituted alkyl nitrates in the treatment of morbidly increased pressure in the inner eye NO953620L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH76693 1993-03-15
PCT/EP1994/000773 WO1994021248A1 (en) 1993-03-15 1994-03-12 Use of substituted alkyl nitrates for the treatment of pathologically increased intra-ocular pressure

Publications (2)

Publication Number Publication Date
NO953620D0 NO953620D0 (en) 1995-09-14
NO953620L true NO953620L (en) 1995-09-14

Family

ID=4194683

Family Applications (1)

Application Number Title Priority Date Filing Date
NO953620A NO953620L (en) 1993-03-15 1995-09-14 Use of substituted alkyl nitrates in the treatment of morbidly increased pressure in the inner eye

Country Status (9)

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EP (1) EP0689435A1 (en)
JP (1) JPH08507773A (en)
KR (1) KR960700702A (en)
AU (1) AU6376894A (en)
CA (1) CA2158368A1 (en)
FI (1) FI954367A (en)
HU (1) HUT72416A (en)
NO (1) NO953620L (en)
WO (1) WO1994021248A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5807847A (en) * 1996-06-04 1998-09-15 Queen's University At Kingston Nitrate esters
US6310052B1 (en) 1996-06-04 2001-10-30 Queen's University At Kingston Nitrate esters and their use for neurological conditions
IL120531A (en) * 1997-03-26 2006-12-31 Yissum Res Dev Co Nitric oxide donors and pharmaceutical compositions containing them
US6056966A (en) * 1998-05-18 2000-05-02 Baker Norton Pharmaceuticals, Inc. Method and compositions for treating impotence
WO2006130982A1 (en) * 2005-06-09 2006-12-14 University Of Manitoba Compositions and methods for enhancing nitric oxide delivery
EP2167070A1 (en) 2007-07-09 2010-03-31 Nicox S.A. Use of nitric oxide releasing compounds in the treatment of chronic pain
EP2048129A1 (en) * 2007-10-12 2009-04-15 Lonza Ag Method for the preparation of organic nitrates
WO2014063923A1 (en) * 2012-10-23 2014-05-01 Nicox S.A. Quinone based nitric oxide donating compounds for ophthalmic use

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5481222A (en) * 1977-12-09 1979-06-28 Chugai Pharmaceut Co Ltd Aminoethanol nitrate ester derivative
JPS60149521A (en) * 1984-01-18 1985-08-07 Eisai Co Ltd Eye drop for remedy and prevention of hypertonia bulbi and glaucoma
JPS6115847A (en) * 1984-07-03 1986-01-23 Kowa Co Nitration process
AU3693789A (en) * 1988-05-10 1989-11-29 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) New ophthalmic preparation for treating glaucoma
NL8802276A (en) * 1988-09-15 1990-04-02 Cedona Pharm Bv MEDICINAL PRODUCT WITH RELAXING EFFECT, CONTAINING A NITRATE ESTER AS ACTIVE SUBSTANCE.
JPH02167279A (en) * 1988-09-30 1990-06-27 Taisho Pharmaceut Co Ltd Apovincaminic acid derivative
NL9001955A (en) * 1990-09-05 1992-04-01 Cedona Pharm Bv NEW THIAZOLIDINE DERIVATIVES.
US5298516A (en) * 1991-03-27 1994-03-29 Sankyo Company, Limited Thiazolidone compounds and method of using the same as a vasodilator

Also Published As

Publication number Publication date
AU6376894A (en) 1994-10-11
CA2158368A1 (en) 1994-09-29
EP0689435A1 (en) 1996-01-03
HU9502623D0 (en) 1995-11-28
JPH08507773A (en) 1996-08-20
FI954367A (en) 1995-11-03
WO1994021248A1 (en) 1994-09-29
FI954367A0 (en) 1995-09-15
HUT72416A (en) 1996-04-29
NO953620D0 (en) 1995-09-14
KR960700702A (en) 1996-02-24

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