NO942765D0 - Anvendelse av substituerte adenin derivater for behandling av multiple sclerose - Google Patents

Anvendelse av substituerte adenin derivater for behandling av multiple sclerose

Info

Publication number
NO942765D0
NO942765D0 NO942765A NO942765A NO942765D0 NO 942765 D0 NO942765 D0 NO 942765D0 NO 942765 A NO942765 A NO 942765A NO 942765 A NO942765 A NO 942765A NO 942765 D0 NO942765 D0 NO 942765D0
Authority
NO
Norway
Prior art keywords
multiple sclerosis
treatment
adenine derivatives
substituted adenine
formula
Prior art date
Application number
NO942765A
Other languages
English (en)
Other versions
NO942765L (no
NO309025B1 (no
Inventor
Ernest Beutler
Original Assignee
Scripps Research Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Inst filed Critical Scripps Research Inst
Publication of NO942765D0 publication Critical patent/NO942765D0/no
Publication of NO942765L publication Critical patent/NO942765L/no
Publication of NO309025B1 publication Critical patent/NO309025B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
NO942765A 1992-02-19 1994-07-25 Anvendelse av substituerte adeninderivater for fremstilling av preparater til behandling av multippel sklerose NO309025B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/838,546 US5310732A (en) 1986-02-03 1992-02-19 2-halo-2'-deoxyadenosines in the treatment of rheumatoid arthritis
PCT/US1993/001467 WO1993016706A1 (en) 1992-02-19 1993-02-18 Use of substituted adenine derivatives for treating multiple sclerosis

Publications (3)

Publication Number Publication Date
NO942765D0 true NO942765D0 (no) 1994-07-25
NO942765L NO942765L (no) 1994-09-13
NO309025B1 NO309025B1 (no) 2000-12-04

Family

ID=25277387

Family Applications (2)

Application Number Title Priority Date Filing Date
NO942765A NO309025B1 (no) 1992-02-19 1994-07-25 Anvendelse av substituerte adeninderivater for fremstilling av preparater til behandling av multippel sklerose
NO20000762A NO322328B1 (no) 1992-02-19 2000-02-16 Anvendelse av substituerte adeninderivater til behandling av multippel sklerose

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO20000762A NO322328B1 (no) 1992-02-19 2000-02-16 Anvendelse av substituerte adeninderivater til behandling av multippel sklerose

Country Status (15)

Country Link
US (4) US5310732A (no)
EP (1) EP0626853B1 (no)
JP (1) JP2688113B2 (no)
AT (1) ATE192045T1 (no)
AU (1) AU682818B2 (no)
BR (1) BR9305907A (no)
CA (1) CA2130275C (no)
CH (1) CH684310A5 (no)
DE (1) DE69328474T2 (no)
DK (1) DK0626853T3 (no)
FI (1) FI943805A (no)
HU (1) HU218656B (no)
NO (2) NO309025B1 (no)
RU (1) RU2130308C1 (no)
WO (1) WO1993016706A1 (no)

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US5624913A (en) * 1991-04-05 1997-04-29 Wisconsin Alumni Research Foundation Method reducing TNF-alpha in mammals with cerebral malaria
CA2136226C (en) * 1992-05-19 2000-05-16 Ernest Beutler Use of 2-halo adenine derivatives as therapeutic agents against chronic myelogenous leukemia
US5424296A (en) * 1993-04-15 1995-06-13 The Scripps Research Institute 2-Halo-2'-deoxyadenosines as therapeutic agents against malignant astrocytoma
US5672622A (en) * 1994-04-21 1997-09-30 Berlex Laboratories, Inc. Treatment of multiple sclerosis
US5773570A (en) * 1994-05-20 1998-06-30 The Regents Of The University Of California Vaccine compositions and methods useful in inducing immune protection against arthritogenic peptides involved in the pathogenesis of rheumatoid arthritis
US7094597B1 (en) 1994-05-20 2006-08-22 The Regents Of The University Of California Vaccine compositions and methods useful in inducing immune protection against arthritogenic peptides involved in the pathogenesis of rheumatoid arthritis
JPH10505323A (ja) * 1994-05-26 1998-05-26 ザ スクリップス リサーチ インスティテュート ２−ハロ−２’−デオキシアデノシンによる炎症性腸疾患の治療
US6060501A (en) * 1994-06-02 2000-05-09 Schering Aktiengesellschaft Combined treatment of multiple sclerosis
WO1996003134A1 (en) * 1994-07-21 1996-02-08 Thomas Jefferson University Treatment of diarrhea with 2-substituted adenosine derivatives
US5510336A (en) * 1994-09-06 1996-04-23 Saven; Alan 2-halo-2'-deoxyadenosine treatment for histiocytosis
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US6989377B2 (en) 1999-12-21 2006-01-24 Wisconsin Alumni Research Foundation Treating vitamin D responsive diseases
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US7608683B2 (en) * 2000-08-09 2009-10-27 The Regents Of The University Of California Stress proteins and peptides and methods of use thereof
US6989146B2 (en) * 2000-08-09 2006-01-24 The Regents Of The University Of California Stress proteins and peptides and methods of use thereof
EP1355923B1 (en) 2000-11-01 2012-03-07 The Regents of The University of California Immunomodulatory peptides derived from heat shock proteins and uses thereof
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US7368423B1 (en) * 2001-12-05 2008-05-06 The Scripps Research Institute Composition and method for treating chronic allograft rejection
WO2004028463A2 (en) * 2002-09-27 2004-04-08 Bioenvision, Inc. Methods and compositions for the treatment of lupus using clofarabine
AU2003276988B2 (en) * 2002-09-27 2009-11-05 Bioenvision, Inc. Methods and compositions for the treatment of autoimmune disorders using clofarabine
US20080221029A1 (en) * 2002-10-31 2008-09-11 Regents Of The University Of Colorado Methods for treatment of thiol-containing compound deficient conditions
US20040087527A1 (en) * 2002-10-31 2004-05-06 Day Brian J. Methods for treatment of thiol-containing compound deficient conditions
US7790762B2 (en) * 2002-10-31 2010-09-07 National Jewish Health Compounds and methods for thiol-containing compound efflux and cancer treatment
GB0228723D0 (en) * 2002-12-09 2003-01-15 Cambridge Biotechnology Ltd Treatment of pain
GB0305153D0 (en) * 2003-03-07 2003-04-09 Cambridge Biotechnology Ltd Identification of therapeutic compounds
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ME00249B (me) * 2003-03-28 2011-05-10 Ivax Corp Oralne formulacije kladribina
UA81305C2 (en) 2003-07-02 2007-12-25 Ares Trading Sa Formulation of cladribine (variants), cladribine-cyclodextrin complex, use of cladribine-cyclodextrin complex, mixture
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JP2007517019A (ja) * 2003-12-29 2007-06-28 カン−フィテ・バイオファーマ・リミテッド 多発性硬化症の治療方法
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CN105264127B (zh) 2013-03-15 2019-04-09 Gpb科学有限责任公司 颗粒的片上微流体处理
CN113512522A (zh) 2013-03-15 2021-10-19 普林斯顿大学理事会 用于高通量纯化的方法和设备
US20150064153A1 (en) 2013-03-15 2015-03-05 The Trustees Of Princeton University High efficiency microfluidic purification of stem cells to improve transplants
GB201401465D0 (en) * 2014-01-29 2014-03-12 Roach Arthur H Use of cladribine for treating autoimmune inflammatory disease
US9839625B2 (en) 2014-11-06 2017-12-12 Northwestern University Inhibition of cancer cell motility
CA2996529A1 (en) * 2015-08-24 2017-03-02 Gpb Scientific, Llc Methods and devices for multi-step cell purification and concentration
US10976232B2 (en) 2015-08-24 2021-04-13 Gpb Scientific, Inc. Methods and devices for multi-step cell purification and concentration
GB2564717A (en) 2017-07-21 2019-01-23 Chord Therapeutics S A R L Use of cladribine for treating autoimmune neuromuscular disease
CN111356460A (zh) 2017-11-24 2020-06-30 默克专利股份公司 用于治疗进展型形式的多发性硬化症的克拉屈滨疗法
EP4210710A1 (en) 2020-09-10 2023-07-19 Merck Patent GmbH Novel treatment regimen for the treatment of autoimmune disorders
GB2601786A (en) 2020-12-10 2022-06-15 Chord Therapeutics S A R L Use of cladribine for treating immune brain disease
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US3472838A (en) * 1967-12-01 1969-10-14 Parke Davis & Co 9 - (beta - d - arabinofuranosyl) - 6 - (amidino) purine compounds and methods for their production
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Also Published As

Publication number Publication date
NO20000762L (no) 1994-09-13
ATE192045T1 (de) 2000-05-15
RU2130308C1 (ru) 1999-05-20
US5506214A (en) 1996-04-09
US5506213A (en) 1996-04-09
NO322328B1 (no) 2006-09-18
FI943805A (fi) 1994-10-19
DE69328474D1 (de) 2000-05-31
NO942765L (no) 1994-09-13
HUT68030A (en) 1995-05-29
JP2688113B2 (ja) 1997-12-08
CA2130275C (en) 1999-06-29
AU3724993A (en) 1993-09-13
RU94038043A (ru) 1996-11-20
US5310732A (en) 1994-05-10
EP0626853A1 (en) 1994-12-07
AU682818B2 (en) 1997-10-23
WO1993016706A1 (en) 1993-09-02
DE69328474T2 (de) 2000-09-28
JPH07507540A (ja) 1995-08-24
FI943805A0 (fi) 1994-08-18
CA2130275A1 (en) 1993-09-02
US5541164A (en) 1996-07-30
EP0626853B1 (en) 2000-04-26
BR9305907A (pt) 1997-10-21
HU218656B (hu) 2000-10-28
NO309025B1 (no) 2000-12-04
HU9402392D0 (en) 1994-10-28
DK0626853T3 (da) 2000-08-07
CH684310A5 (de) 1994-08-31
NO20000762D0 (no) 2000-02-16

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