NO890408L - 3-indolpyrodruesyre-derivater og deres farmasoeytiske anvendelse. - Google Patents

3-indolpyrodruesyre-derivater og deres farmasoeytiske anvendelse.

Info

Publication number: NO890408L
Authority: NO; Norway
Prior art keywords: pct; acid derivatives; indolpyrodruic; pharmaceutical use; sec
Prior art date: 1987-06-03

Application number

NO89890408A

Other languages

English (en)

Other versions

NO890408D0 (no

Inventor

Giovanna De Luca

Giovanni Di Stazio

Andrea Margonelli

Mario Materazzi

Vincenzo Politi

Original Assignee

Polifarma Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-06-03

Filing date

1989-02-01

Publication date

1989-03-30

1989-02-01 Application filed by Polifarma Spa filed Critical Polifarma Spa

1989-02-01 Publication of NO890408D0 publication Critical patent/NO890408D0/no

1989-03-30 Publication of NO890408L publication Critical patent/NO890408L/no

Links

239000002253 acid Substances 0.000 title 1
RSTKLPZEZYGQPY-UHFFFAOYSA-N 3-(indol-3-yl)pyruvic acid Chemical class C1=CC=C2C(CC(=O)C(=O)O)=CNC2=C1 RSTKLPZEZYGQPY-UHFFFAOYSA-N 0.000 abstract 1
210000003169 central nervous system Anatomy 0.000 abstract 1
239000003257 excitatory amino acid Substances 0.000 abstract 1
230000002461 excitatory amino acid Effects 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Neurology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Epidemiology (AREA)
Cardiology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Heart & Thoracic Surgery (AREA)
Indole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

NO89890408A 1987-06-03 1989-02-01 3-indolpyrodruesyre-derivater og deres farmasoeytiske anvendelse. NO890408L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT8748014A IT1206078B (it)	1987-06-03	1987-06-03	Procedimento per la produzione di acido 3-indolpiruvico e suoi derivati loro uso farmaceutico
PCT/IT1988/000041 WO1988009789A2 (en)	1987-06-03	1988-06-01	3-indolepyruvic acid derivatives and pharmaceutical use thereof

Publications (2)

Publication Number	Publication Date
NO890408D0 NO890408D0 (no)	1989-02-01
NO890408L true NO890408L (no)	1989-03-30

Family

ID=11263959

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO89890408A NO890408L (no)	1987-06-03	1989-02-01	3-indolpyrodruesyre-derivater og deres farmasoeytiske anvendelse.

Country Status (13)

Country	Link
US (1)	US5002963A (no)
EP (1)	EP0321516B1 (no)
JP (1)	JPH02500369A (no)
KR (1)	KR960016522B1 (no)
AT (1)	ATE86247T1 (no)
AU (1)	AU609500B2 (no)
CA (1)	CA1328658C (no)
DE (1)	DE3878866T2 (no)
DK (1)	DK170438B1 (no)
FI (1)	FI92055C (no)
IT (1)	IT1206078B (no)
NO (1)	NO890408L (no)
WO (1)	WO1988009789A2 (no)

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IT1224546B (it) *	1988-09-29	1990-10-04	Polifarma Spa	Utilizzatore farmaceutica di acido 3 -indolpiruvico come agente inibitore di patologie degenerative
US4960786A (en) *	1989-04-24	1990-10-02	Merrell Dow Pharmaceuticals Inc.	Excitatory amino acid antagonists
PT93943A (pt) *	1989-05-05	1991-02-08	Searle & Co	Processo para a preparacao de composicoes contendo compostos indole-2-carboxilato para tratamento de perturbacoes do snc
DE3917880A1 (de) *	1989-06-01	1990-12-06	Kali Chemie Ag	Neue acylaminosaeurederivate enthaltende arzneimittel und diaetetika
IT218019Z2 (it) *	1989-09-08	1992-03-05	Enea	Dispositivo protettivo individuale, portatile ad isolamento totale conatmosfera controllata
IT1237472B (it) *	1989-10-04	1993-06-07	Polifarma Spa	Derivati di acido 3-indolpiruvico, loro procedimento di produzione ed impiego terapeutico.
US5037846A (en) *	1990-01-02	1991-08-06	Pfizer Inc.	Indolyl-3 polyamines and their use as antagonists of excitatory amino acid neurotransmitters
US5360814A (en) *	1991-02-28	1994-11-01	Merrell Dow Pharmaceuticals Inc.	NMDA antagonists
US5484814A (en) *	1991-02-28	1996-01-16	Merrell Dow Pharmaceuticals Inc.	NMDA antagonists
DK0501378T3 (da) *	1991-02-28	1995-03-20	Merrell Dow Pharma	NMDA-antagonister
IT1261165B (it) *	1993-01-25	1996-05-09	Polifarma Spa	Agente attivo per ridurre il livello ematico di glucocorticoidi e prevenire disturbi cerebrali da stress e senilita'.
FR2701948B1 (fr) *	1993-02-22	1996-07-26	Exsymol Sa	Produit de couplage de l'histamine ou l'histamine méthyl-substituée et d'un acide aminé, procédé de préparation et applications thérapeutiques, cosmétologiques et agroalimentaires.
US7056935B2 (en) *	1995-06-07	2006-06-06	Gpi Nil Holdings, Inc.	Rotamase enzyme activity inhibitors
US5859031A (en) *	1995-06-07	1999-01-12	Gpi Nil Holdings, Inc.	Small molecule inhibitors of rotamase enzyme activity
US5801197A (en) *	1995-10-31	1998-09-01	Gpi Nil Holdings, Inc.	Rotamase enzyme activity inhibitors
US6218424B1 (en)	1996-09-25	2001-04-17	Gpi Nil Holdings, Inc.	Heterocyclic ketone and thioester compounds and uses
US5786378A (en) *	1996-09-25	1998-07-28	Gpi Nil Holdings, Inc.	Heterocyclic thioesters
US5801187A (en)	1996-09-25	1998-09-01	Gpi-Nil Holdings, Inc.	Heterocyclic esters and amides
US6242468B1 (en)	1997-02-27	2001-06-05	Jia-He Li	Carbamate and urea compositions and neurotrophic uses
US5846979A (en)	1997-02-28	1998-12-08	Gpi Nil Holdings, Inc.	N-oxides of heterocyclic esters, amides, thioesters, and ketones
US5945441A (en) *	1997-06-04	1999-08-31	Gpi Nil Holdings, Inc.	Pyrrolidine carboxylate hair revitalizing agents
US6187796B1 (en)	1998-06-03	2001-02-13	Gpi Nil Holdings, Inc.	Sulfone hair growth compositions and uses
US6271244B1 (en)	1998-06-03	2001-08-07	Gpi Nil Holdings, Inc.	N-linked urea or carbamate of heterocyclic thioester hair growth compositions and uses
US6274602B1 (en)	1998-06-03	2001-08-14	Gpi Nil Holdings, Inc.	Heterocyclic thioester and ketone hair growth compositions and uses
US6187784B1 (en)	1998-06-03	2001-02-13	Gpi Nil Holdings, Inc.	Pipecolic acid derivative hair growth compositions and uses
US6075150A (en) *	1998-01-26	2000-06-13	Cv Therapeutics, Inc.	α-ketoamide inhibitors of 20S proteasome
US6429215B1 (en)	1998-06-03	2002-08-06	Gpi Nil Holdings, Inc.	N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
SK18302000A3 (sk)	1998-06-03	2001-06-11	Gpi Nil Holdings, Inc.	N-viazané sulfónamidy n-heterocyklických karboxylových kyselín a izosterov karboxylových kyselín, farmaceutický prostriedok s ich obsahom a ich použitie
US6331537B1 (en)	1998-06-03	2001-12-18	Gpi Nil Holdings, Inc.	Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds
US6172087B1 (en)	1998-06-03	2001-01-09	Gpi Nil Holding, Inc.	N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
WO1999062487A1 (en)	1998-06-03	1999-12-09	Gpi Nil Holdings, Inc.	Heterocyclic ester and amide hair growth compositions and uses
US6384056B1 (en)	1998-08-14	2002-05-07	Gpi Nil Holdings, Inc.	Heterocyclic thioesters or ketones for vision and memory disorders
US7338976B1 (en)	1998-08-14	2008-03-04	Gpi Nil Holdings, Inc.	Heterocyclic esters or amides for vision and memory disorders
US6395758B1 (en)	1998-08-14	2002-05-28	Gpi Nil Holdings, Inc.	Small molecule carbamates or ureas for vision and memory disorders
US6218423B1 (en)	1998-08-14	2001-04-17	Gpi Nil Holdings, Inc.	Pyrrolidine derivatives for vision and memory disorders
US6335348B1 (en)	1998-08-14	2002-01-01	Gpi Nil Holdings, Inc.	Nitrogen-containing linear and azepinyl/ compositions and uses for vision and memory disorders
US6337340B1 (en)	1998-08-14	2002-01-08	Gpi Nil Holdings, Inc.	Carboxylic acids and isosteres of heterocyclic ring compounds having multiple heteroatoms for vision and memory disorders
US6399648B1 (en)	1998-08-14	2002-06-04	Gpi Nil Holdings, Inc.	N-oxides of heterocyclic ester, amide, thioester, or ketone for vision and memory disorders
US6506788B1 (en)	1998-08-14	2003-01-14	Gpi Nil Holdings, Inc.	N-linked urea or carbamate of heterocyclic thioesters for vision and memory disorders
US6333340B1 (en)	1998-08-14	2001-12-25	Gpi Nil Holdings, Inc.	Small molecule sulfonamides for vision and memory disorders
US6376517B1 (en)	1998-08-14	2002-04-23	Gpi Nil Holdings, Inc.	Pipecolic acid derivatives for vision and memory disorders
US6339101B1 (en)	1998-08-14	2002-01-15	Gpi Nil Holdings, Inc.	N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders
US6462072B1 (en)	1998-09-21	2002-10-08	Gpi Nil Holdings, Inc.	Cyclic ester or amide derivatives
US7253169B2 (en)	1999-11-12	2007-08-07	Gliamed, Inc.	Aza compounds, pharmaceutical compositions and methods of use
US6417189B1 (en)	1999-11-12	2002-07-09	Gpi Nil Holdings, Inc.	AZA compounds, pharmaceutical compositions and methods of use
MXPA02006134A (es)	1999-12-21	2002-12-13	Guilford Pharm Inc	Compuestos derivados de hidantoina, composiciones farmaceuticas y metodos de uso de los mismos.
ES2314100T3 (es) *	2001-05-03	2009-03-16	Monsanto Technology Llc	Derivados de piruvato.
US6608196B2 (en)	2001-05-03	2003-08-19	Galileo Pharmaceuticals, Inc.	Process for solid supported synthesis of pyruvate-derived compounds
WO2003056026A1 (fr)	2001-12-27	2003-07-10	Ajinomoto Co., Inc.	Procede de production de derives d'acide glutamique
CN102027117B (zh)	2007-08-24	2012-11-07	味之素株式会社	新的氧化酶基因及使用该基因生产3-吲哚-丙酮酸的方法
JPWO2012050125A1 (ja)	2010-10-14	2014-02-24	味の素株式会社	モナティンの製造方法
WO2020012373A1 (en) *	2018-07-10	2020-01-16	Polindols S.R.L.S.	New drugs chronic invalidating pathologies and to slow aging, based on a new metabolic tryptophan route and production process thereof

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Publication number	Priority date	Publication date	Assignee	Title
CA1096881A (en) *	1976-10-07	1981-03-03	Roger R. Gaudette	Preparation of aliphatic and heterocyclic alpha-keto carboxylic acids
GR74635B (no) *	1980-08-18	1984-06-29	Merck & Co Inc
EP0278530A3 (de) *	1980-08-30	1989-08-02	Hoechst Aktiengesellschaft	Aminosäurederivate, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und deren Verwendung
GR75019B (no) *	1980-09-17	1984-07-12	Univ Miami
IT1148618B (it) *	1982-10-11	1986-12-03	Polifarma Spa	Procedimento enzimatico per la produzione di acido 3-indolpiruvico e utilizzazione farmaceutica di questo
IT1184282B (it) *	1985-06-28	1987-10-22	Polifarma Spa	Procedimento per la produzione di alfa-chetoacidi indolici a partire da un rispettivo alfa-ammino-acido,particolarmente per produrre acido indolpiruvico

1987
- 1987-06-03 IT IT8748014A patent/IT1206078B/it active
1988
- 1988-05-25 CA CA000567675A patent/CA1328658C/en not_active Expired - Fee Related
- 1988-06-01 JP JP63504630A patent/JPH02500369A/ja active Pending
- 1988-06-01 KR KR1019890700193A patent/KR960016522B1/ko not_active IP Right Cessation
- 1988-06-01 EP EP88904984A patent/EP0321516B1/en not_active Expired - Lifetime
- 1988-06-01 AT AT88904984T patent/ATE86247T1/de not_active IP Right Cessation
- 1988-06-01 DE DE8888904984T patent/DE3878866T2/de not_active Expired - Lifetime
- 1988-06-01 WO PCT/IT1988/000041 patent/WO1988009789A2/en active IP Right Grant
- 1988-06-01 AU AU19433/88A patent/AU609500B2/en not_active Expired
- 1988-06-01 US US07/327,804 patent/US5002963A/en not_active Expired - Lifetime
1989
- 1989-02-01 NO NO89890408A patent/NO890408L/no unknown
- 1989-02-02 FI FI890508A patent/FI92055C/fi active IP Right Grant
- 1989-02-02 DK DK046789A patent/DK170438B1/da not_active IP Right Cessation

Also Published As

Publication number	Publication date
WO1988009789A3 (en)	1989-02-09
DE3878866D1 (de)	1993-04-08
NO890408D0 (no)	1989-02-01
US5002963A (en)	1991-03-26
KR960016522B1 (ko)	1996-12-14
DK46789D0 (da)	1989-02-02
FI92055B (fi)	1994-06-15
FI890508A0 (fi)	1989-02-02
AU609500B2 (en)	1991-05-02
WO1988009789A2 (en)	1988-12-15
DK46789A (da)	1989-03-31
DK170438B1 (da)	1995-09-04
FI890508A (fi)	1989-02-02
DE3878866T2 (de)	1993-09-02
FI92055C (fi)	1994-09-26
AU1943388A (en)	1989-01-04
CA1328658C (en)	1994-04-19
IT8748014A0 (it)	1987-06-03
KR890701559A (ko)	1989-12-20
EP0321516A1 (en)	1989-06-28
JPH02500369A (ja)	1990-02-08
IT1206078B (it)	1989-04-14
ATE86247T1 (de)	1993-03-15
EP0321516B1 (en)	1993-03-03

Publication	Publication Date	Title
NO890408L (no)	1989-03-30	3-indolpyrodruesyre-derivater og deres farmasoeytiske anvendelse.
IL81887A0 (en)	1987-10-20	Dihydroisoxazole derivatives,their preparation and pharmaceutical compositions containing them
DE3684190D1 (de)	1992-04-16	Verwendung von tetrahydrobiopterinen zur herstellung eines medikaments zur behandlung von kinderautismus.
DE69634900D1 (de)	2005-08-04	Proteintyrosine-kinaseinhibitoren zur behandlung der osteoarthritis
ATE126232T1 (de)	1995-08-15	Neue derivate von a-nor-3-carboxysteroiden.
DE3856594D1 (de)	2008-11-27	Mittel zur behandlung der alzheimer-krankheit
DK0603301T3 (da)	1998-09-14	Farmaceutisk præparat indeholdende et urikosurikon og en excitatorisk-aminosyre-antagonist
IL94278A0 (en)	1991-03-10	2-saccharine derivatives,their preparation and pharmaceutical compositions containing them
DE3852935D1 (de)	1995-03-16	Substituierte Alpha-Aminosäuren mit pharmazeutischer Aktivität.
MX14957A (es)	1993-11-01	Nuevos derivados de tetrazol y procedimiento para su preparacion.
DK528086D0 (da)	1986-11-05	N-substituerede 3-piperidincarboxylsyrer eller n-substituerede 3-pyridincarboxylsyrer og derivater deraf
ATE124681T1 (de)	1995-07-15	Arzneimittelzusammensetzungen zur behandlung von psoriasis.
DE69010294D1 (de)	1994-08-04	Verwendung von Antiprogestomimetika zur Stimulierung des Eisprungs.
DE69431199D1 (de)	2002-09-26	Melatonin-Derivate zur Verwendung in der Behandlung von Schlafstörungen
DE59902666D1 (de)	2002-10-17	Edelfosin zur behandlung von hirntumoren
ATE239470T1 (de)	2003-05-15	Melatonin-derivate zur verwendung in der behandlung von desynchronisierungs-erkankungen
BG90414A (bg)	1993-12-24	2-азабицикло (2,2,1)-хепт-5- ен-2-оцетна киселина и нейни производни, метод за получаване и приложението им
ATE82850T1 (de)	1992-12-15	Verwendung von 2-pyrimidinyl-1-piperazinderivaten.
DE3855159D1 (de)	1996-05-02	Thienotricyclen zur Behandlung von Erkrankungen der Bronchien
DK4389A (da)	1989-01-06	Isoxazoler med nootrop virkning
DE3684825D1 (de)	1992-05-21	Verwendung von n-(1-allyl-2-pyrrolidinylmethyl)-2-methoxy-4-amino-5-methylsulfamoylbenzamid zur behandlung der parkinson-krankheit.
SE8700136D0 (sv)	1987-01-15	Forfarande for behandling av amfotera aminosyror