NO883587L - Fremgangsmaate for fremstilling av terapeutisk aktive indolderivater. - Google Patents

Fremgangsmaate for fremstilling av terapeutisk aktive indolderivater.

Info

Publication number
NO883587L
NO883587L NO88883587A NO883587A NO883587L NO 883587 L NO883587 L NO 883587L NO 88883587 A NO88883587 A NO 88883587A NO 883587 A NO883587 A NO 883587A NO 883587 L NO883587 L NO 883587L
Authority
NO
Norway
Prior art keywords
preparation
indold
derivatives
procedure
therapeutically active
Prior art date
Application number
NO88883587A
Other languages
English (en)
Other versions
NO174052C (no
NO883587D0 (no
NO174052B (no
Inventor
Alexander William Oxford
Darko Butina
Martin Richard Owen
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB878719167A external-priority patent/GB8719167D0/en
Priority claimed from GB888814002A external-priority patent/GB8814002D0/en
Priority claimed from GB888814481A external-priority patent/GB8814481D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of NO883587D0 publication Critical patent/NO883587D0/no
Publication of NO883587L publication Critical patent/NO883587L/no
Publication of NO174052B publication Critical patent/NO174052B/no
Publication of NO174052C publication Critical patent/NO174052C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
NO883587A 1987-08-13 1988-08-12 Analogifremgangsmåte for fremstilling av terapeutisk aktive indolderivater NO174052C (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB878719167A GB8719167D0 (en) 1987-08-13 1987-08-13 Chemical compounds
GB888814002A GB8814002D0 (en) 1988-06-14 1988-06-14 Chemical compounds
GB888814481A GB8814481D0 (en) 1988-06-17 1988-06-17 Chemical compounds

Publications (4)

Publication Number Publication Date
NO883587D0 NO883587D0 (no) 1988-08-12
NO883587L true NO883587L (no) 1989-02-14
NO174052B NO174052B (no) 1993-11-29
NO174052C NO174052C (no) 1994-03-09

Family

ID=27263551

Family Applications (2)

Application Number Title Priority Date Filing Date
NO883587A NO174052C (no) 1987-08-13 1988-08-12 Analogifremgangsmåte for fremstilling av terapeutisk aktive indolderivater
NO1998008C NO1998008I1 (no) 1987-08-13 1998-02-05 Naratriptan

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO1998008C NO1998008I1 (no) 1987-08-13 1998-02-05 Naratriptan

Country Status (28)

Country Link
US (1) US4997841A (no)
EP (1) EP0303507B1 (no)
JP (1) JPH0633252B2 (no)
KR (1) KR0131327B1 (no)
AT (1) ATE92057T1 (no)
AU (1) AU611469B2 (no)
CA (1) CA1310968C (no)
CY (1) CY1728A (no)
CZ (1) CZ404291A3 (no)
DE (2) DE3882614T2 (no)
DK (1) DK172696B1 (no)
ES (1) ES2058292T3 (no)
FI (1) FI92397C (no)
GB (1) GB2208646B (no)
HK (1) HK86793A (no)
HU (1) HU211576A9 (no)
IE (1) IE61488B1 (no)
IL (1) IL87437A0 (no)
LU (1) LU90160I2 (no)
LV (1) LV5736B4 (no)
NL (1) NL970035I2 (no)
NO (2) NO174052C (no)
NZ (1) NZ225820A (no)
PH (1) PH24976A (no)
PT (1) PT88255B (no)
SG (1) SG65393G (no)
SK (1) SK281495B6 (no)
UY (1) UY23657A1 (no)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8819024D0 (en) * 1988-08-10 1988-09-14 Glaxo Group Ltd Chemical compounds
GB8903036D0 (en) * 1989-02-10 1989-03-30 Glaxo Group Ltd Chemical compounds
ATE204275T1 (de) * 1990-06-07 2001-09-15 Astrazeneca Ab Indolderivate als 5-ht1-like agonisten
DK152090D0 (da) * 1990-06-22 1990-06-22 Lundbaek A S H Piperidylsubstituerede indolderivater
US5643784A (en) * 1990-12-04 1997-07-01 H, Lundbeck A/S Indan derivatives
NZ243065A (en) * 1991-06-13 1995-07-26 Lundbeck & Co As H Piperidine derivatives and pharmaceutical compositions
TW222631B (no) * 1991-07-15 1994-04-21 Duphar Int Res
GB9209882D0 (en) * 1992-05-07 1992-06-24 Glaxo Lab Sa Compositions
GB9211277D0 (en) 1992-05-28 1992-07-15 Glaxo Group Inc Pharmaceutical compositions
AU675964B2 (en) * 1992-08-05 1997-02-27 John Wyeth & Brother Limited Amide derivatives
GB9320115D0 (en) * 1993-09-29 1993-11-17 Glaxo Group Ltd Process
US5521196A (en) * 1994-10-05 1996-05-28 Eli Lilly And Company 5-HT1F agonists for the treatment of migraine
US5521197A (en) * 1994-12-01 1996-05-28 Eli Lilly And Company 3-<1-alkylenearyl>-4-<1,2,3,6-tetrahydropyridinyl>-and 3-<1-alkylenearyl>-4-piperidinyl-1h-indoles: new 5-HT1F agonists
FR2731224B1 (fr) * 1995-03-02 1997-05-30 Pf Medicament Nouveaux derives bi-tryptaminiques sulfonamides, leur procede de preparation et leur utilisation a titre de medicaments
FR2731222A1 (fr) * 1995-03-02 1996-09-06 Pf Medicament Nouveaux derives de piperazine aminoindoles cycliques, leur procede de preparation et leur utilisation a titre de medicaments
KR19980703048A (ko) * 1995-03-20 1998-09-05 피터쥐.스트링거 5-치환-3-(1,2,3,6-테트라히드로피리딘-4-일)- 및 3-(피페리딘-4-일)-1ｈ-인돌: 신규한 5-ｈｔ1ｆ 아고니스트
WO1997033579A1 (en) * 1996-03-13 1997-09-18 Glaxo Group Limited Medicaments comprising 5ht1-like receptor agonists with an increased absorption
AR013669A1 (es) * 1997-10-07 2001-01-10 Smithkline Beecham Corp Compuestos y metodos
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
US6066092A (en) * 1997-11-06 2000-05-23 Cady; Roger K. Preemptive prophylaxis of migraine device and method
EP1305307B1 (en) * 2000-07-21 2004-05-06 H. Lundbeck A/S Indole derivatives useful for the treatment of cns disorders
WO2003079972A2 (en) 2002-02-22 2003-10-02 New River Parmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
US6864262B2 (en) * 2000-11-29 2005-03-08 Eli Lilly And Company 1-(2-m-methanesulfonamidophenylethyl)-4-(m-trifluoromethylphenyl) piperazine and pharmaceutically acceptable salts and solvents thereof
US8329734B2 (en) 2009-07-27 2012-12-11 Afgin Pharma Llc Topical therapy for migraine
US20070065463A1 (en) 2003-06-20 2007-03-22 Ronald Aung-Din Topical therapy for the treatment of migranes, muscle sprains, muscle spasms, spasticity and related conditions
CA2586553C (en) * 2004-11-24 2015-02-10 Alcon, Inc. Nasal sprayer containing a formulation with olopatadine
BRPI0715579A2 (pt) * 2006-10-19 2015-05-26 Auspex Pharmaceuticals Inc "composto, composição farmacêutica e uso de um composto"
WO2008056378A2 (en) * 2006-11-09 2008-05-15 Natco Pharma Limited Novel process for the preparation of naratriptan hydrochloride
WO2008072257A2 (en) * 2006-12-12 2008-06-19 Ind-Swift Laboratories Limited Process for the preparation of indole derivatives
WO2009016466A2 (en) * 2007-07-30 2009-02-05 Orchid Chemicals & Pharmaceuticals Limited A process for the preparation of naratriptan hydrochloride
WO2009118753A2 (en) * 2008-03-07 2009-10-01 Usv Limited Process for preparation of naratriptan hydrochloride
EP2296652B1 (en) 2008-06-30 2017-11-08 Afgin Pharma, Llc Topical regional neuro-affective therapy
WO2010004580A2 (en) * 2008-07-11 2010-01-14 Ind-Swift Laboratories Limited Process for preparing indole derivatives
WO2010084507A2 (en) * 2008-07-15 2010-07-29 Sun Pharmaceutical Industries Ltd. Process for the preparation of n-methyl-2-[3-(1-methyl-4-piperidyl)-1h-indol-5-yl]-ethanesulfonamide and its acid addition salts
KR20120084286A (ko) * 2009-08-20 2012-07-27 시플라 리미티드 나라트립탄의 합성방법
CN102276581B (zh) * 2011-08-05 2013-06-12 上海师范大学 N-取代四氢吡啶连吲哚类化合物及其制备方法及应用
AU2016226267A1 (en) 2015-03-02 2017-09-28 Afgin Pharma, Llc Topical regional neuro-affective therapy with cannabinoids
US10383816B2 (en) 2015-03-02 2019-08-20 Afgin Pharma, Llc Topical regional neuro-affective therapy with cannabinoid combination products
US20180049994A1 (en) 2016-08-16 2018-02-22 Afgin Pharma, Llc Topical regional neuro-affective therapy with caryophyllene
EP3766483A1 (en) 2019-07-19 2021-01-20 BioPharma Synergies, S. L. Orodispersible powder composition comprising a triptan

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2362628A1 (fr) * 1976-08-26 1978-03-24 Roussel Uclaf Nouveaux derives du piperidyl-indole et leurs sels, procede de preparation et application a titre de medicaments
FR2421899A1 (fr) * 1978-01-16 1979-11-02 Roussel Uclaf Nouveaux derives du tetrahydropyridinyl-indole et leurs sels, le procede de preparation et l'application a titre de medicaments de ces nouveaux produits
IT1170387B (it) * 1982-06-07 1987-06-03 Glaxo Group Ltd Composti eterociclici, procedimento per prepararli e composizioni farmaceutiche che li contengono
FR2533924A1 (fr) * 1982-10-05 1984-04-06 Roussel Uclaf Nouveaux derives du 4-(1h-indol-3-yl)a-methyl piperidine-1-ethanol, leurs sels, le procede de preparation, l'application a titre de medicaments et les compositions les renfermant
GB8332437D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Chemical compounds
GB8332435D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Chemical compounds
DE3419935A1 (de) * 1984-05-28 1985-11-28 Merck Patent Gmbh, 6100 Darmstadt Verwendung von hydroxyindolderivaten bei der senkung des blutdrucks
GB2162522B (en) * 1984-08-01 1988-02-24 Glaxo Group Ltd An indole derivative
US4548939A (en) * 1984-10-01 1985-10-22 Janssen Pharmaceutica N. V. 1H-Indol-3-yl containing 1,3-dimethyl-1H-purine-2,6-diones
FR2574077A1 (fr) * 1984-12-04 1986-06-06 Glaxo Group Ltd Derives d'indoles, leur preparation et les compositions pharmaceutiques les contenant
IE58370B1 (en) * 1985-04-10 1993-09-08 Lundbeck & Co As H Indole derivatives
GB8819024D0 (en) * 1988-08-10 1988-09-14 Glaxo Group Ltd Chemical compounds
GB8903036D0 (en) * 1989-02-10 1989-03-30 Glaxo Group Ltd Chemical compounds

Also Published As

Publication number Publication date
DE3882614T2 (de) 1993-11-18
PT88255A (pt) 1989-06-30
EP0303507B1 (en) 1993-07-28
NZ225820A (en) 1990-09-26
NL970035I2 (nl) 1998-01-05
IL87437A0 (en) 1989-01-31
FI883744A (fi) 1989-02-14
IE61488B1 (en) 1994-11-02
GB2208646B (en) 1991-06-26
PH24976A (en) 1990-12-26
NO174052C (no) 1994-03-09
AU611469B2 (en) 1991-06-13
LU90160I2 (fr) 1998-01-14
JPH01207288A (ja) 1989-08-21
JPH0633252B2 (ja) 1994-05-02
SK404291A3 (en) 2000-09-12
CZ404291A3 (en) 1993-04-14
GB8819200D0 (en) 1988-09-14
SG65393G (en) 1993-08-06
EP0303507A3 (en) 1990-09-19
LV5736A4 (lv) 1996-06-20
LV5736B4 (lv) 1997-06-20
DE19775082I2 (de) 2006-04-27
IE882477L (en) 1989-02-13
DK172696B1 (da) 1999-05-31
CA1310968C (en) 1992-12-01
PT88255B (pt) 1995-03-01
GB2208646A (en) 1989-04-12
FI883744A0 (fi) 1988-08-12
NL970035I1 (nl) 1997-11-03
DE3882614D1 (de) 1993-09-02
NO883587D0 (no) 1988-08-12
HU211576A9 (en) 1995-12-28
FI92397B (fi) 1994-07-29
DK455488D0 (da) 1988-08-12
AU2069288A (en) 1989-02-16
ES2058292T3 (es) 1994-11-01
EP0303507A2 (en) 1989-02-15
NO174052B (no) 1993-11-29
ATE92057T1 (de) 1993-08-15
UY23657A1 (es) 1994-02-25
US4997841A (en) 1991-03-05
HK86793A (en) 1993-08-27
SK281495B6 (sk) 2001-04-09
NO1998008I1 (no) 1998-02-05
KR890003731A (ko) 1989-04-17
DK455488A (da) 1989-02-14
CY1728A (en) 1994-05-06
FI92397C (fi) 1994-11-10
KR0131327B1 (en) 1998-04-17

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Legal Events

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