NO20083909L - Bisykliske benzimidazolforbindelser, og deres anvendelse som metabotropiske glutamatreseptorforsterkere - Google Patents

Bisykliske benzimidazolforbindelser, og deres anvendelse som metabotropiske glutamatreseptorforsterkere

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Publication number
NO20083909L
NO20083909L NO20083909A NO20083909A NO20083909L NO 20083909 L NO20083909 L NO 20083909L NO 20083909 A NO20083909 A NO 20083909A NO 20083909 A NO20083909 A NO 20083909A NO 20083909 L NO20083909 L NO 20083909L
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NO
Norway
Prior art keywords
glutamate receptor
metabotropic glutamate
benzimidazole compounds
receptor enhancers
bicyclic
Prior art date
Application number
NO20083909A
Other languages
English (en)
Inventor
Abdelmalik Slassi
Methvin Isaac
Ian Egle
Rebecca Urbanek
Frances M Mclaren
Sally B Walsh
Gary B Steelman
Dean G Brown
David Nugiel
Deborah Chen
Fupeng Ma
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of NO20083909L publication Critical patent/NO20083909L/no

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P25/08—Antiepileptics; Anticonvulsants
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
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    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Addiction (AREA)
  • Ophthalmology & Optometry (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

hvori A, B, D, L, R1, R2, R3, R4, m og n er som definert for Formel I i beskrivelsen. Foreliggende oppfinnelse angår også fremgangsmåter for fremstilling av forbindelsene og nye intermediater anvendt ved fremstillingen, farmasøytiske sammensetninger som inneholder forbindelsene og anvendelsen av forbindelsene ved behandling.
NO20083909A 2006-03-31 2008-09-12 Bisykliske benzimidazolforbindelser, og deres anvendelse som metabotropiske glutamatreseptorforsterkere NO20083909L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78763406P 2006-03-31 2006-03-31
PCT/US2007/065469 WO2007115077A2 (en) 2006-03-31 2007-03-29 Bicyclic benzimidazole compounds and their use as metabotropic glutamate receptor potentiators

Publications (1)

Publication Number Publication Date
NO20083909L true NO20083909L (no) 2008-12-15

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NO20083909A NO20083909L (no) 2006-03-31 2008-09-12 Bisykliske benzimidazolforbindelser, og deres anvendelse som metabotropiske glutamatreseptorforsterkere

Country Status (12)

Country Link
US (1) US20090192169A1 (no)
EP (1) EP2004613A2 (no)
JP (1) JP2009532381A (no)
KR (1) KR20080111015A (no)
CN (1) CN101454292A (no)
AU (1) AU2007233179A1 (no)
BR (1) BRPI0711040A2 (no)
CA (1) CA2646755A1 (no)
IL (1) IL194082A0 (no)
MX (1) MX2008011968A (no)
NO (1) NO20083909L (no)
WO (1) WO2007115077A2 (no)

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US8940730B2 (en) 2007-09-18 2015-01-27 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions of treating a Flaviviridae family viral infection
US9101628B2 (en) 2007-09-18 2015-08-11 The Board Of Trustees Of The Leland Stanford Junior University Methods and composition of treating a flaviviridae family viral infection
WO2010107739A2 (en) 2009-03-18 2010-09-23 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions of treating a flaviviridae family viral infection
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MX2022004874A (es) 2019-10-25 2022-05-13 Gilead Sciences Inc Compuestos de modulacion de glp-1r.
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MX2008011968A (es) 2008-10-01
BRPI0711040A2 (pt) 2011-08-23
CN101454292A (zh) 2009-06-10
WO2007115077A3 (en) 2007-12-27
JP2009532381A (ja) 2009-09-10
EP2004613A2 (en) 2008-12-24
IL194082A0 (en) 2009-08-03
WO2007115077A2 (en) 2007-10-11
CA2646755A1 (en) 2007-10-11
US20090192169A1 (en) 2009-07-30
KR20080111015A (ko) 2008-12-22
AU2007233179A1 (en) 2007-10-11

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