NO20051103L - Indol-3-karboksamider som Glukokinase-(GK)-Aktivatorer - Google Patents

Indol-3-karboksamider som Glukokinase-(GK)-Aktivatorer

Info

Publication number
NO20051103L
NO20051103L NO20051103A NO20051103A NO20051103L NO 20051103 L NO20051103 L NO 20051103L NO 20051103 A NO20051103 A NO 20051103A NO 20051103 A NO20051103 A NO 20051103A NO 20051103 L NO20051103 L NO 20051103L
Authority
NO
Norway
Prior art keywords
activators
glucokinase
carboxamides
indole
glucokinase activators
Prior art date
Application number
NO20051103A
Other languages
English (en)
Inventor
Wendy Lea Corbett
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO20051103L publication Critical patent/NO20051103L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Foreliggende oppfinnelse tilveiebringer glukokinase-aktivatorer med formel I: hvor R1, R2 og R3 er definert i beskrivelsen. Glukokinase-aktivatorer er anvendelige for å øke insulinsekresjonen ved behandling av type II diabetes.
NO20051103A 2002-10-03 2005-03-01 Indol-3-karboksamider som Glukokinase-(GK)-Aktivatorer NO20051103L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41573702P 2002-10-03 2002-10-03
PCT/EP2003/010776 WO2004031179A1 (en) 2002-10-03 2003-09-26 Indole-3-carboxamides as glucokinase (gk) activators

Publications (1)

Publication Number Publication Date
NO20051103L true NO20051103L (no) 2005-04-08

Family

ID=32069904

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20051103A NO20051103L (no) 2002-10-03 2005-03-01 Indol-3-karboksamider som Glukokinase-(GK)-Aktivatorer

Country Status (29)

Country Link
US (1) US6881844B2 (no)
EP (1) EP1549638B1 (no)
JP (1) JP4390704B2 (no)
KR (1) KR100646486B1 (no)
CN (1) CN100348596C (no)
AR (1) AR041467A1 (no)
AT (1) ATE374768T1 (no)
AU (1) AU2003270285B2 (no)
BR (1) BR0315047A (no)
CA (1) CA2499329C (no)
DE (1) DE60316709T2 (no)
DK (1) DK1549638T3 (no)
ES (1) ES2293005T3 (no)
HK (1) HK1083098A1 (no)
HR (1) HRP20050287A2 (no)
MX (1) MXPA05003391A (no)
MY (1) MY136764A (no)
NO (1) NO20051103L (no)
NZ (1) NZ538466A (no)
PA (1) PA8584001A1 (no)
PE (1) PE20050090A1 (no)
PL (1) PL375149A1 (no)
PT (1) PT1549638E (no)
RU (1) RU2309956C2 (no)
SI (1) SI1549638T1 (no)
TW (1) TW200413364A (no)
UY (1) UY28005A1 (no)
WO (1) WO2004031179A1 (no)
ZA (1) ZA200502619B (no)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0102299D0 (sv) 2001-06-26 2001-06-26 Astrazeneca Ab Compounds
SE0102764D0 (sv) 2001-08-17 2001-08-17 Astrazeneca Ab Compounds
CN1703408A (zh) * 2002-10-03 2005-11-30 诺瓦提斯公司 作为葡糖激酶激活剂、可用于治疗ⅱ型糖尿病的取代的(噻唑－2－基)酰胺或磺酰胺
GB0226931D0 (en) 2002-11-19 2002-12-24 Astrazeneca Ab Chemical compounds
GB0226930D0 (en) * 2002-11-19 2002-12-24 Astrazeneca Ab Chemical compounds
EP1532980A1 (en) * 2003-11-24 2005-05-25 Novo Nordisk A/S N-heteroaryl indole carboxamides and analogues thereof, for use as glucokinase activators in the treatment of diabetes
RU2006138426A (ru) 2004-04-02 2008-05-10 Новартис АГ (CH) Производные тиазолопиридина, содержащие их фармацевтические композиции и способы лечения состояний, опосредованных глюкокиназой
WO2005095418A1 (en) 2004-04-02 2005-10-13 Novartis Ag Sulfonamide-thiazolpyridine derivatives as glucokinase activators useful the treatment of type 2 diabetes
WO2006112549A1 (ja) 2005-04-20 2006-10-26 Takeda Pharmaceutical Company Limited 縮合複素環化合物
US7622492B2 (en) 2005-08-31 2009-11-24 Hoffmann-La Roche Inc. Pyrazolones as inhibitors of 11β-hydroxysteroid dehydrogenase
JP2007063225A (ja) 2005-09-01 2007-03-15 Takeda Chem Ind Ltd イミダゾピリジン化合物
CN101272784A (zh) 2005-09-29 2008-09-24 塞诺菲-安万特股份有限公司 苯基-和吡啶基-1,2,4-噁二唑酮衍生物、它们的制备方法和它们作为药物的用途
GT200600429A (es) * 2005-09-30 2007-04-30 Compuestos organicos
GT200600428A (es) * 2005-09-30 2007-05-21 Compuestos organicos
JP4990783B2 (ja) * 2005-09-30 2012-08-01 Ｍｓｄ株式会社 ２−ヘテロアリール置換インドール誘導体
JP2009013065A (ja) * 2005-10-14 2009-01-22 Astellas Pharma Inc 縮合へテロ環化合物
JP2009515997A (ja) * 2005-11-18 2009-04-16 タケダ サン ディエゴ インコーポレイテッド グルコキナーゼ活性剤
US7351706B2 (en) * 2006-01-05 2008-04-01 Hoffmann-La Roche Inc. Indol-3-yl-carbonyl-spiro-piperidine derivatives
WO2007104034A2 (en) 2006-03-08 2007-09-13 Takeda San Diego, Inc. Glucokinase activators
EP1849785A1 (en) * 2006-04-28 2007-10-31 Neuropharma, S.A. N-(2-Thiazolyl)-amide derivatives as GSK-3 inhibitors
PE20110235A1 (es) 2006-05-04 2011-04-14 Boehringer Ingelheim Int Combinaciones farmaceuticas que comprenden linagliptina y metmorfina
EP2049518B1 (en) 2006-05-31 2011-08-31 Takeda San Diego, Inc. Indazole and isoindole derivatives as glucokinase activating agents.
EP2074119A1 (en) 2006-10-19 2009-07-01 Takeda Pharmaceutical Company Limited Indole compound
WO2008074694A1 (en) * 2006-12-20 2008-06-26 F. Hoffmann-La Roche Ag Crystallization of glucokinase activators
US8163779B2 (en) 2006-12-20 2012-04-24 Takeda San Diego, Inc. Glucokinase activators
US8173645B2 (en) 2007-03-21 2012-05-08 Takeda San Diego, Inc. Glucokinase activators
EA020332B1 (ru) * 2007-08-10 2014-10-30 Х. Лундбекк А/С Аналоги гетероариламидов
MY152749A (en) * 2008-05-16 2014-11-28 Takeda California Inc Pyrazole and fused pyrazole glucokinase activators
US8835644B2 (en) 2009-03-20 2014-09-16 University Of Virginia Patent Foundation Broad spectrum benzothiophene-nitrothiazolide and other antimicrobials
JP2011006366A (ja) 2009-06-26 2011-01-13 Sanwa Kagaku Kenkyusho Co Ltd 新規チオフェンカルボキサミド誘導体及びその医薬用途
US9333193B2 (en) 2010-09-20 2016-05-10 University Of Virginia Patent Foundation Compositions and methods for treating tuberculosis
CN103044310B (zh) * 2013-01-18 2015-02-04 贵阳医学院 二氢吲哚-3-乙酸衍生物、其制备方法以及在药物中的应用
WO2023067628A1 (en) * 2021-10-20 2023-04-27 Council Of Scientific And Industrial Research An Indian Registered Body Incorporated Under The Regn. Of Soc. Act (Act Xxi Of 1860) A method for the preparation of indole-3-carboxylic acid derivatives

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2740686B1 (fr) 1995-11-03 1998-01-16 Sanofi Sa Formulation pharmaceutique lyophilisee stable
US6262096B1 (en) 1997-11-12 2001-07-17 Bristol-Myers Squibb Company Aminothiazole inhibitors of cyclin dependent kinases
US6040321A (en) 1997-11-12 2000-03-21 Bristol-Myers Squibb Company Aminothiazole inhibitors of cyclin dependent kinases
JP5278983B2 (ja) 1999-11-17 2013-09-04 塩野義製薬株式会社 アミド化合物の新規用途
EP1341774B1 (en) 2000-12-06 2006-02-01 F. Hoffmann-La Roche Ag Fused heteroaromatic glucokinase activators
US6433188B1 (en) 2000-12-06 2002-08-13 Wendy Lea Corbett Fused heteroaromatic glucokinase activators
US6482951B2 (en) 2000-12-13 2002-11-19 Hoffmann-La Roche Inc. Isoindolin-1-one glucokinase activators
KR100884877B1 (ko) * 2000-12-28 2009-02-23 다이이찌 세이야꾸 가부시기가이샤 Ｖｌａ-４ 저해제
UA77303C2 (en) * 2002-06-14 2006-11-15 Pfizer Derivatives of thienopyridines substituted by benzocondensed heteroarylamide useful as therapeutic agents, pharmaceutical compositions and methods for their use

Also Published As

Publication number Publication date
RU2309956C2 (ru) 2007-11-10
DK1549638T3 (da) 2008-01-21
PL375149A1 (en) 2005-11-28
NZ538466A (en) 2007-05-31
ZA200502619B (en) 2006-03-29
EP1549638B1 (en) 2007-10-03
PT1549638E (pt) 2007-12-11
CN100348596C (zh) 2007-11-14
TW200413364A (en) 2004-08-01
ES2293005T3 (es) 2008-03-16
DE60316709T2 (de) 2008-07-17
AU2003270285B2 (en) 2007-04-26
KR20050046817A (ko) 2005-05-18
JP4390704B2 (ja) 2009-12-24
WO2004031179A1 (en) 2004-04-15
RU2005113719A (ru) 2006-02-27
AR041467A1 (es) 2005-05-18
PE20050090A1 (es) 2005-02-28
US20040067939A1 (en) 2004-04-08
BR0315047A (pt) 2005-08-23
PA8584001A1 (es) 2004-11-02
US6881844B2 (en) 2005-04-19
ATE374768T1 (de) 2007-10-15
HRP20050287A2 (en) 2006-12-31
DE60316709D1 (de) 2007-11-15
CN1688574A (zh) 2005-10-26
AU2003270285A1 (en) 2004-04-23
SI1549638T1 (sl) 2008-02-29
UY28005A1 (es) 2004-04-30
HK1083098A1 (en) 2006-06-23
JP2006504707A (ja) 2006-02-09
CA2499329C (en) 2009-04-21
KR100646486B1 (ko) 2006-11-15
CA2499329A1 (en) 2004-04-15
EP1549638A1 (en) 2005-07-06
MXPA05003391A (es) 2005-06-22
MY136764A (en) 2008-11-28

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Legal Events

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