NO158681B - ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE N2-ARYLSULPHONYL-L-ARGINAMIDES AND PHARMASOEYTIC TARGET SALTS THEREOF. - Google Patents

ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE N2-ARYLSULPHONYL-L-ARGINAMIDES AND PHARMASOEYTIC TARGET SALTS THEREOF. Download PDF

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Publication number
NO158681B
NO158681B NO780191A NO780191A NO158681B NO 158681 B NO158681 B NO 158681B NO 780191 A NO780191 A NO 780191A NO 780191 A NO780191 A NO 780191A NO 158681 B NO158681 B NO 158681B
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Norway
Prior art keywords
flue
housing
oil
hearth
therapeutically active
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NO780191A
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Norwegian (no)
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NO780191L (en
NO158681C (en
Inventor
Shosuke Okamoto
Ryoji Kikumoto
Yoshikuni Tamao
Kazuo Ohkubo
Tohru Tezuka
Shinji Tonomura
Akiko Hitjikata
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Mitsubishi Chem Ind
Shosuke Okamoto
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Publication date
Priority claimed from US05/760,668 external-priority patent/US4073913A/en
Priority claimed from US05/760,676 external-priority patent/US4097472A/en
Priority claimed from US05/760,745 external-priority patent/US4066773A/en
Priority claimed from US05/760,929 external-priority patent/US4101653A/en
Priority claimed from US05/760,672 external-priority patent/US4093712A/en
Priority claimed from US05/776,195 external-priority patent/US4097591A/en
Priority claimed from JP6650877A external-priority patent/JPS6010028B2/en
Priority claimed from US05/804,331 external-priority patent/US4140681A/en
Priority claimed from US05/804,368 external-priority patent/US4131673A/en
Application filed by Mitsubishi Chem Ind, Shosuke Okamoto filed Critical Mitsubishi Chem Ind
Publication of NO780191L publication Critical patent/NO780191L/en
Publication of NO158681B publication Critical patent/NO158681B/en
Publication of NO158681C publication Critical patent/NO158681C/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/16—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with acylated ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/14—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/14—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 6 and unsubstituted in position 7
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    • C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
    • C07D327/06—Six-membered rings
    • C07D327/08—[b,e]-condensed with two six-membered carbocyclic rings
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    • C07—ORGANIC CHEMISTRY
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    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
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    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C07K5/06095—Arg-amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

ANALOGI FREMGANGSMÅTE VED FREMSTILLING. AV TERAPEUTISK AKTIVE NARYLSULFONYL-L-ARGINAMIDER OG FARMASØYTISK FORDRAGELIGE SALTER DERAV.ANALOGY METHOD OF MANUFACTURE. OF THERAPEUTICALLY ACTIVE NARYLSULPHONYL-L-ARGINAMIDS AND PHARMACEUTICAL TOLERATE SALTS THEREOF.

Description

Frittstående romoppvarmingsanordning. Freestanding space heating device.

Oppfinnelsen vedrorer en frittstående romoppvarmingsanordning omfattende en gass- eller oljekamin med et hus for et gass-eller oljebrennkammer med et rokavlop ved husets bakside og omgitt av et luftrom med luftinntak nedentil og luftutlop oventil i huset, som er losbart forbundet med en foran åpen, separat prefabrikert ildsteds- eller peisenhet for fast brensel og med et bakoverrettet rokavlop. The invention relates to a free-standing space heating device comprising a gas or oil stove with a housing for a gas or oil combustion chamber with a flue outlet at the back of the housing and surrounded by an air space with an air intake at the bottom and an air outlet at the top of the housing, which is releasably connected to a front open, separate prefabricated hearth or fireplace unit for solid fuel and with a rearward-directed smoke outlet.

Hensikten med oppfinnelsen er å oppnå at anordningen alt etter det aktuelle behov av romvarme og/eller behageligheten av en åpen ild skal kunne anvendes som kamin og/eller åpen peis, og like-vel tiltross for sin tyngde og omfang lett skal kunne transporteres i flere enheter og lett skal kunne settes opp på monteringsstedet. Kfr. kl. 36a-10 The purpose of the invention is to achieve that the device, depending on the current need for room heating and/or the comfort of an open fire, should be able to be used as a stove and/or open fireplace, and despite its weight and size should be easily transportable in several units and must be easy to set up at the installation site. Cf. at 36a-10

Dette oppnås ved at rokavlopene er tilsluttet hver sin del av et skorstensror, som er todelt av en langsgående mellomvegg, hvilken mellomvegg utgjor et i skorstensroret anordnet rokror. Fig. 1-3 viser en utforelsesform av anordningen delvis i snitt sett henholdsvis forfra, ovenfra og fra siden. Fig. 4 viser en annen utforelsesform sett fra siden, og fig. 5 viser sett forfra midtpartiet av en tredje utforelsesform. This is achieved by the flue pipes being connected to each part of a chimney pipe, which is divided into two parts by a longitudinal intermediate wall, which intermediate wall forms a flue pipe arranged in the chimney flue. Fig. 1-3 shows an embodiment of the device, partially in section, respectively from the front, from above and from the side. Fig. 4 shows another embodiment seen from the side, and Fig. 5 shows a front view of the middle part of a third embodiment.

Anordningen i henhold til fig. 1-3 nar e^ platehylster The device according to fig. 1-3 nar e^ plate sleeve

med skålformig sokkel 1, en forvegg 2 med en stor rektangulær åpning 3, en oventil med gitter forsynt sidevegg 4 i et stykke med en oventil og nedentil med gitter forsynt bakvegg 5» en nedentil med gitter forsynt bakut svingbar sidedor 6, en oventil med gitter forsynt mellomvegg 7 mellom to rom 8 og 9 og i et stykke med en indre forvegg 10 til rommet 8, et bakut oppsvingbart gjennombrutt lokk 11 over rommet 8 og et hensiktsmessig avloftbart tak 12 over rommet 9« Forveggen 2 er lett fastskrubar på delene 4> 10» som er mer permanent with a bowl-shaped base 1, a front wall 2 with a large rectangular opening 3, an upper vent with grid provided side wall 4 in one piece with an upper vent and below provided with grid rear wall 5" a below provided with grid provided with a rearward-swinging side door 6, an upper vent with grid provided with intermediate wall 7 between two rooms 8 and 9 and in one piece with an inner front wall 10 for room 8, a rearward-swinging perforated lid 11 above room 8 and an appropriate ventable roof 12 above room 9" The front wall 2 can easily be screwed onto the parts 4> 10” which is more permanent

forbundet med hverandre på sokkelen, r rommet 8 er det fast anbragt et oljebrennkammer 13 med oppsvingbart lokk 14, bakutrettet rokavlop 15 med trekkregulator 16 og såkalt pottebrenner 17 med oljeregulator l8, avskjermet fra brennkammeret ved en plate 19 og tilsluttbar til en oljetank i avstand fra den av delene 13 - l8 og deres hylster dannede oljekamin.. connected to each other on the plinth, in the room 8 there is a fixed oil combustion chamber 13 with a hinged lid 14, a rear-facing steam outlet 15 with a draft regulator 16 and a so-called pot burner 17 with an oil regulator l8, shielded from the combustion chamber by a plate 19 and connectable to an oil tank at a distance from that of the parts 13 - l8 and their casing formed oil stove..

I rommet 9 er to vinkeljern 20 festet på bakveggen 5 og en fortil på veggene 4» 7 festet bjelke 21. De bærer et fortil åpent hensiktsmessig med teglsten 22 innforet ildsted 23 av jern med frem-stikkende bunndel 24 og bakutrettet rokavlop 25 som overlapper en stuss 26 på et med varmeisolasjon 27 forsynt skorstensror 28 som opptar et rokror 29 med en stuss 30 som overlapper kaminens rokavlop 15. Hver del 25, 26, 28 inneholder et ikke vist spjeld. Det for-holdsvis tunge ildsted 23 transporteres separat til oppstillingsste-det hvor det for forveggens 2 endelige anbringelse lett forfra kan innskyves på de vinkeljern 20 som styrer og bærer ildstedet, til en bestemt stilling hvori det fastholdes av sin egen tyngde eller av ikke viste skrue- eller nagleforbindelser f. eks. mellom bjelken 21 og nedadrettede anslag 31 Pa ildstedet. Deretter monteres forveggen 2 hvis åpning 3 er n°e videre enn ildstedets fremre del og gjennom hvilken ildstedets bunndel går. I ildstedets åpning innskyves og.. fastskrues en festeflens 32 på en stopejernramme med overstykke. 33 pg sidestykke 34 som i noen avstand foran veggen 2 dekker åpningens 3 motsvarende hensiktsmessige innbukkede kanter som således utvendig begrenser en luftspalte gjennom hvilken luft kan stromme inn i hyl-sterrommet 9 i henhold til pilen i fig. 3 °§ varmeoverforing fra ildstedet til forveggen 2 reduseres. In the room 9, two angle irons 20 are attached to the back wall 5 and a beam 21 is attached to the front of the walls 4, 7. They carry an open front fireplace 23 lined with bricks 22 made of iron with a protruding bottom part 24 and a rear-facing chimney 25 that overlaps a spigot 26 on a chimney pipe 28 provided with heat insulation 27 which accommodates a flue pipe 29 with a spigot 30 which overlaps the stove's flue outlet 15. Each part 25, 26, 28 contains a damper not shown. The relatively heavy hearth 23 is transported separately to the installation site where, for the final placement of the front wall 2, it can easily be pushed from the front onto the angle irons 20 that control and support the hearth, to a specific position in which it is held by its own weight or by a screw not shown - or riveted connections, e.g. between the beam 21 and the downward-facing projection 31 on the hearth. Next, the front wall 2 is mounted, the opening 3 of which is further than the front part of the fireplace and through which the bottom part of the fireplace passes. A fastening flange 32 is pushed into the opening of the hearth and screwed onto a stop-iron frame with a top piece. 33 pg side piece 34 which, at some distance in front of the wall 2, covers the opening 3's correspondingly appropriate indented edges which thus externally limit an air gap through which air can flow into the casing space 9 according to the arrow in fig. 3 °§ heat transfer from the hearth to the front wall 2 is reduced.

Forovrig kan luft komme inn nedentil i hylsteret mellom sokkelen 1 og forveggens 2 underkant, samt gjennom gitteret nedentil i bakveggen 5 °6 doren. 6, stromme oppover rundt ildstedet 23, respektivt brennkammeret 13» og oventil forlate hylsteret gjennom lokket 11 og gitteret oventil i veggene 2,5 (i visse fyringstil-feller via gitteret i veggen 7) hvilket bidrar til at hylsterets yttertemperatur blir onskelig lav også ved fyring i begge ildstedene 13, 23. Ved at rorene 28, 29 er anordnet i hverandre forstyrres ikke oljebrenneren 17 av ved- eller kullfyring i ildstedet 23, og det indre ror kan gjores mere tynnvegget enn ellers mulig, og trek-ken i det ene ildsted kan forbedres ved fyring i det annet ildsted ved varmeoverforing mellom rokgassene i rorene. Ved at oljetankene utelukkes fra hylsteret, får dette moderate dimensjoner på tross av at det også opptas en åpen peis 23. For å lette borttaging av spill-olje fra sokkelen 1, bor denne ha en terskel eller mellomvegg 35> som hindrer slik olje i å spre seg i sokkelen under ildstedet 23. Otherwise, air can enter at the bottom of the casing between the plinth 1 and the lower edge of the front wall 2, as well as through the grille at the bottom of the back wall 5 °6 the mandrel. 6, flow upwards around the hearth 23, respectively the combustion chamber 13" and at the top leave the casing through the lid 11 and the grid at the top in the walls 2.5 (in certain firing cases via the grid in the wall 7) which contributes to the casing's outer temperature becoming undesirably low even at firing in both hearths 13, 23. As the rudders 28, 29 are arranged in each other, the oil burner 17 is not disturbed by wood or coal burning in the hearth 23, and the inner rudder can be made more thin-walled than otherwise possible, and the draft in one fireplace can be improved by firing in the second fireplace by heat transfer between the flue gases in the rudders. By excluding the oil tanks from the casing, this takes on moderate dimensions despite the fact that an open fireplace 23 is also occupied. To facilitate the removal of waste oil from the base 1, this should have a threshold or partition 35> which prevents such oil from spread in the plinth under the hearth 23.

Hylsteret ved den i fig. 4 viste anordning omfatter en un-derdel 40 med lett fastskrubar forvegg 41 °o en smalere sentralt over delen 40 anordnet overdel 42 som opptar et til brennkammerne 13 motsvarende oljebrennerkammer 43 °S hertil sluttede organer, så-som et bakutrettet rokavlop 24 og oljeregulator 45* Underdelen 40 opptar et fremad åpent ildsted 46 med bakutrettet rokavlop 47 som er lett losbart sluttet til et varmeisolert skorstensror 48 som opptar et til rokavlopet lett losbart sluttet rokror 49« Under delene 43, 45 finnes en ikke vist spillskål som eventuelt danner en ugjen-nombrutt skillevegg mellom hylsterdelene 40, 42, som da bor ha et luftinntak nedentil og utlop oventil. Ildstedet 46 kan være utfort og losbart anbragt på vesentlig samme måte som ildstedet 23 i fig. 1. Anordningen i henhold til fig. 4 er egnet for oppstilling i et hjorne av et rom. ;Anordningen i henhold til fig. 5 omfatter en gass- eller oljekamin 50 med sokkel 51 °§ hylster 52 samt en åpen peis 53 med like hoy sokkel 54 og et like hoyt hylster 55 for et-deri permanent eller losbart anbragt fremad åpent ildsted 56 for fast brensel. Hylsterne har sine forsider i samme plan og ligger an mot hverandre med sidevegger samt er innbyrdes lett losbart forbundet på en måte som ikke forstyrrer peisens og kaminens utside og er oppstilt hver for seg f. eks. oventil ved hjelp av et borttagbart klammer 57 som er fort gjennom motstående gittere i nevnte.sidevegger, og nedentil ved hjelp av en til soklene fastskrudd og ellers losbart festet boyle 38* Peisen og kaminen har bakutrettede ikke viste rokavlop som kan sluttes til en felles skorsten på vesentlig samme måte som vist i fig. 1. Anordningen i henhold til fig. 4 kan også i andre henseender,' f. eks. ved anordningen av inn- og utlop for luft, lig-ne anordningen i henhold til fig. 1-3» Den har den fordel at peisen og kaminen også kan oppstilles og anvendes hver for seg, hvilket gjor kjoperen mer uavhengig av forandrede lokale forhold, og for fabrikanten medforer salg av disse enheter både hver for seg og sammen og således fremstilling av enhetene i storre serier. The casing at the one in fig. The device shown in 4 comprises a lower part 40 with an easily screwed-on front wall 41 °o a narrower upper part 42 arranged centrally above the part 40 which accommodates an oil burner chamber 43 °S corresponding to the combustion chambers 13 and connected to it, such as a rear-facing rock drain 24 and oil regulator 45 * The lower part 40 occupies a forward-open hearth 46 with a rear-facing flue 47 which is easily releasably connected to a heat-insulated chimney flue 48 which occupies a flue pipe 49 easily releasably connected to the flue broken partition between the casing parts 40, 42, which should then have an air intake at the bottom and outlet at the top. The hearth 46 can be extended and releasably arranged in substantially the same way as the hearth 23 in fig. 1. The device according to fig. 4 is suitable for installation in a corner of a room. The device according to fig. 5 comprises a gas or oil stove 50 with plinth 51 °§ casing 52 as well as an open fireplace 53 with equally high plinth 54 and an equally high casing 55 for a permanently or releasably placed forward open hearth 56 for solid fuel. The casings have their fronts in the same plane and abut each other with side walls and are easily releasably connected to each other in a way that does not disturb the outside of the fireplace and stove and are arranged separately, e.g. above with the help of a removable clip 57 which is fast through opposite grids in the aforementioned side walls, and below with the help of a bolt 38 screwed to the plinths and otherwise releasably attached. in substantially the same way as shown in fig. 1. The device according to fig. 4 can also in other respects,' e.g. in the arrangement of inlet and outlet for air, similar to the arrangement according to fig. 1-3" It has the advantage that the fireplace and the stove can also be set up and used separately, which makes the buyer more independent of changed local conditions, and for the manufacturer it entails selling these units both separately and together and thus manufacturing the units in large series.

Også andre utforelsesformer er mulige innen patentkrave-nes ramme. Således kan ovennevnte rokavlSp være sluttet til hver sin del av et ved en langsgående mellomvegg todelt skorstensror, hvor mellomveggen ikke som ved de ovenfor beskrevne utforelsesformer utgjor et inne i skorstensroret anordnet rokror. Ved anordnin-ger med såkalt skallbrenner istedenfor pottebrenner kan rokavlopene ved en grenledning være tilsluttet et felles skorstensror. Other embodiments are also possible within the scope of the patent claims. Thus, the above-mentioned rokavlSp can be connected to each part of a two-part chimney flue at a longitudinal intermediate wall, where the intermediate wall does not, as in the above-described embodiments, form a flue arranged inside the chimney flue. In the case of devices with so-called shell burners instead of pot burners, the flue pipes can be connected to a common chimney flue via a branch line.

Claims (1)

Frittstående romoppvarmingsanordning omfattende en gass-eller oljekamin med et hus for et gass- eller oljebrennkammer (13) med et rokavlop (15) ved husets bakside og omgitt av et luftrom (8) med luftinntak nedentil og luftutlop oventil i huset, som er losbart forbundet med. en foran åpen, separat prefabrikert ildsteds-eller peisenhet (23) for fast brensel og med et bakoverrettet rokavlop, karakterisert ved at rokavlopene er tilsluttet hver sin del av et skorstensror (28), som er todelt av en langsgående mellomvegg (29), hvilken mellomvegg utgjor et i skorstensroret (26) anordnet rokror.Free-standing space heating device comprising a gas or oil stove with a housing for a gas or oil combustion chamber (13) with a flue outlet (15) at the rear of the housing and surrounded by an air space (8) with air intake below and air outlet at the top of the housing, which are releasably connected with. a front-open, separately prefabricated hearth or fireplace unit (23) for solid fuel and with a rearward-directed smoke flue, characterized in that the smoke flues are each connected to a separate part of a chimney flue (28), which is divided into two parts by a longitudinal intermediate wall (29), which intermediate wall constitutes a flue pipe arranged in the chimney flue (26).
NO780191A 1977-01-19 1978-01-18 ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE N2-ARYLSULPHONYL-L-ARGINAMIDES AND PHARMASOEYTIC TARGET SALTS THEREOF. NO158681C (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US05/760,672 US4093712A (en) 1974-11-08 1977-01-19 N2 -arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof
US05/760,668 US4073913A (en) 1974-11-08 1977-01-19 N2 -arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof
US05/760,929 US4101653A (en) 1974-11-08 1977-01-19 N2 -arylsulfonyl-argininamides and the pharmaceutically acceptable salts thereof
US05/760,745 US4066773A (en) 1974-11-08 1977-01-19 N2 -arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof
US05/760,676 US4097472A (en) 1974-11-08 1977-01-19 N2 -arylsulfonyl-l-argininamides and the pharmaceutically acceptable salts thereof
US05/776,195 US4097591A (en) 1974-11-08 1977-03-10 N2 -arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof
JP6650877A JPS6010028B2 (en) 1977-06-06 1977-06-06 N↑2-arylsulfonyl-L-argininamides and pharmaceutically acceptable salts thereof
US05/804,331 US4140681A (en) 1974-11-08 1977-06-07 N2 -Arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof
US05/804,368 US4131673A (en) 1974-11-08 1977-06-07 N2 -arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof

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Publication Number Publication Date
NO780191L NO780191L (en) 1978-07-20
NO158681B true NO158681B (en) 1988-07-11
NO158681C NO158681C (en) 1988-10-19

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CH (2) CH648293A5 (en)
DD (1) DD137352A5 (en)
DE (1) DE2801478A1 (en)
DK (1) DK150521C (en)
FI (1) FI72316C (en)
GB (1) GB1596971A (en)
GR (1) GR60787B (en)
IL (1) IL53685A (en)
IT (1) IT1126229B (en)
NL (1) NL187746C (en)
NO (1) NO158681C (en)
NZ (1) NZ186198A (en)
PH (1) PH15913A (en)
SE (1) SE452624B (en)
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UA (1) UA8370A1 (en)

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Publication number Priority date Publication date Assignee Title
IE48623B1 (en) * 1978-08-31 1985-03-20 Mitsubishi Chem Ind Alpha-(n-arylsulfonyl-l-argininamides,processes for their preparation and pharmaceutical compositions containing these substances
SU1042615A3 (en) * 1978-08-31 1983-09-15 Мицубиси Кемикал Индастриз Лимитед (Фирма) Process for preparing n2-arylsulfonyl-alpha-arginine amides
GB9209032D0 (en) * 1992-04-25 1992-06-10 Ciba Geigy Ag New peptide derivatives
GB9426038D0 (en) 1994-12-22 1995-02-22 Iaf Biochem Int Low molecular weight bicyclic thrombin inhibitors
US6057314A (en) * 1995-12-21 2000-05-02 Biochem Pharma Inc. Low molecular weight bicyclic thrombin inhibitors
FR2761065B1 (en) * 1997-03-20 2000-03-03 Synthelabo N- (ARGINYL) BENZENESULFONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
CN111961114A (en) * 2020-08-03 2020-11-20 扬州中宝药业股份有限公司 Argatroban intermediate and preparation method and application thereof

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US3978045A (en) * 1973-08-13 1976-08-31 Mitsubishi Chemical Industries Ltd. N2 -dansyl-L-arginine derivatives, and the pharmaceutically acceptable acid addition salts thereof

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UA8370A1 (en) 1996-03-29
DK150521B (en) 1987-03-16
NO780191L (en) 1978-07-20
NL7800448A (en) 1978-07-21
CA1131621A (en) 1982-09-14
DK150521C (en) 1987-10-19
NO158681C (en) 1988-10-19
IL53685A0 (en) 1978-03-10
IL53685A (en) 1985-12-31
DE2801478A1 (en) 1978-07-20
CH648293A5 (en) 1985-03-15
DD137352A5 (en) 1979-08-29
GB1596971A (en) 1981-09-03
FI780073A (en) 1978-07-20
DK26378A (en) 1978-07-20
IT1126229B (en) 1986-05-14
NZ186198A (en) 1980-12-19
PH15913A (en) 1983-04-22
GR60787B (en) 1978-08-28
NL187746B (en) 1991-08-01
FI72316C (en) 1987-05-11
FI72316B (en) 1987-01-30
SE7800512L (en) 1978-07-20
SU1181539A3 (en) 1985-09-23
NL187746C (en) 1992-01-02
SE452624B (en) 1987-12-07
DE2801478C2 (en) 1991-01-31
CH633773A5 (en) 1982-12-31

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