NL178074C - Geneeskrachtige preparaten met een remmende werking op de aggregatie van bloedplaatjes en op de fosfodiesterase, alsmede in deze preparaten te gebruiken carbostyrilderivaten. - Google Patents

Geneeskrachtige preparaten met een remmende werking op de aggregatie van bloedplaatjes en op de fosfodiesterase, alsmede in deze preparaten te gebruiken carbostyrilderivaten.

Info

Publication number
NL178074C
NL178074C NLAANVRAGE7806245,A NL7806245A NL178074C NL 178074 C NL178074 C NL 178074C NL 7806245 A NL7806245 A NL 7806245A NL 178074 C NL178074 C NL 178074C
Authority
NL
Netherlands
Prior art keywords
preparations
phosphodis
sterase
inhibitory effect
blade plate
Prior art date
Application number
NLAANVRAGE7806245,A
Other languages
English (en)
Dutch (nl)
Other versions
NL7806245A (nl
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP6931977A external-priority patent/JPS545981A/ja
Priority claimed from JP7586377A external-priority patent/JPS5412385A/ja
Priority claimed from JP53023012A external-priority patent/JPS6059912B2/ja
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of NL7806245A publication Critical patent/NL7806245A/xx
Application granted granted Critical
Publication of NL178074C publication Critical patent/NL178074C/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
NLAANVRAGE7806245,A 1977-06-10 1978-06-08 Geneeskrachtige preparaten met een remmende werking op de aggregatie van bloedplaatjes en op de fosfodiesterase, alsmede in deze preparaten te gebruiken carbostyrilderivaten. NL178074C (nl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP6931977A JPS545981A (en) 1977-06-10 1977-06-10 Carbostyryl derivatives
JP7586377A JPS5412385A (en) 1977-06-24 1977-06-24 Carbostyril derivative
JP53023012A JPS6059912B2 (ja) 1978-02-28 1978-02-28 カルボスチリル誘導体

Publications (2)

Publication Number Publication Date
NL7806245A NL7806245A (nl) 1978-12-12
NL178074C true NL178074C (nl) 1986-01-16

Family

ID=27284068

Family Applications (1)

Application Number Title Priority Date Filing Date
NLAANVRAGE7806245,A NL178074C (nl) 1977-06-10 1978-06-08 Geneeskrachtige preparaten met een remmende werking op de aggregatie van bloedplaatjes en op de fosfodiesterase, alsmede in deze preparaten te gebruiken carbostyrilderivaten.

Country Status (21)

Country Link
US (1) US4298739A (da)
AR (2) AR224345A1 (da)
AT (1) AT367038B (da)
AU (1) AU510138B2 (da)
CA (1) CA1098907A (da)
CH (1) CH636087A5 (da)
DE (1) DE2825048A1 (da)
DK (1) DK149449C (da)
ES (2) ES470690A1 (da)
FI (1) FI69300C (da)
FR (1) FR2393795B1 (da)
GB (1) GB2002745B (da)
IE (1) IE46852B1 (da)
IT (1) IT1108326B (da)
MX (1) MX5527E (da)
NL (1) NL178074C (da)
NO (1) NO148813C (da)
NZ (1) NZ187452A (da)
PH (1) PH14670A (da)
PT (1) PT68157A (da)
SE (1) SE444562B (da)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU843739A3 (ru) * 1978-02-17 1981-06-30 Карл Томэ Гмбх (Фирма) Способ получени карбостириловыхили ОКСиНдОлОВыХ пРОизВОдНыХ
AT383594B (de) * 1980-02-29 1987-07-27 Otsuka Pharma Co Ltd Verfahren zum herstellen von neuen carbostyrilderivaten und ihren salzen
JPS56122356A (en) * 1980-02-29 1981-09-25 Otsuka Pharmaceut Co Ltd Carbostyril derivative
FI77852C (fi) * 1981-02-17 1989-05-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av nya, saosom hjaertmediciner anvaendbara substituerade amid- och (maettad heterocykel)karbonylkarbostyrilderivat.
US4442111A (en) * 1981-07-25 1984-04-10 Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung Antithrombotic sulfimino and sulfoximino indolinones-2
US4578381A (en) * 1982-07-05 1986-03-25 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
CH655110A5 (de) * 1982-09-03 1986-03-27 Otsuka Pharma Co Ltd Carbostyrilderivate, verfahren zu deren herstellung und arzneimittel, welche diese enthalten.
US4490371A (en) * 1983-02-16 1984-12-25 Syntex (U.S.A.) Inc. N,N-Disubstituted-(2-oxo-1,2,3,5-tetrahydroimidazo-[2,1-B]quinazolinyl)oxyalkylamides
US4663320A (en) * 1983-02-16 1987-05-05 Syntex (U.S.A.) Inc. (2-oxo-1,2,3,5-tetrahydroimidazo[2,1-b]quinoazolinyl)oxyalkylamides, compositions and the use thereof
DK69285A (da) * 1984-02-15 1985-08-16 Syntex Inc Tetrahydroimidazolderivater
US4670434A (en) * 1985-11-14 1987-06-02 Syntex (U.S.A.) Inc. (2-oxo-3-methylene-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolinyl)oxyalkylamides useful as cyclic AMP phosphodiesterase inhibitors
US5227381A (en) * 1988-05-02 1993-07-13 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivative
JP2753622B2 (ja) 1988-05-02 1998-05-20 大塚製薬株式会社 カルボスチリル誘導体
TW201305B (da) * 1991-04-03 1993-03-01 Otsuka Pharma Co Ltd
US5506239A (en) * 1991-08-23 1996-04-09 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivative and platelets aggregation inhibitory agent
US5958926A (en) * 1996-11-01 1999-09-28 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
US8067433B2 (en) 2005-11-09 2011-11-29 Zalicus Inc. Methods, compositions, and kits for the treatment of ophthalmic disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EP2527360B1 (en) 2007-06-04 2015-10-28 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
DE102008022221A1 (de) 2008-05-06 2009-11-12 Universität des Saarlandes Inhibitoren der humanen Aldosteronsynthase CYP11B2
AU2009256157B2 (en) 2008-06-04 2014-12-18 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
JP2011528375A (ja) 2008-07-16 2011-11-17 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
EP2196453A1 (en) * 2008-12-10 2010-06-16 Cellvir Novel substituted aryl derivatives, their process of preparation and their therapeutical uses as anti-HIV agents
WO2011021676A1 (ja) 2009-08-21 2011-02-24 大塚製薬株式会社 ベンゾ［ｂ］［１，４］ジアゼピン－２，４－ジオン化合物の製造方法
TWI481601B (zh) 2009-08-21 2015-04-21 Otsuka Pharma Co Ltd 含氮化合物及藥學組成物
US8541404B2 (en) 2009-11-09 2013-09-24 Elexopharm Gmbh Inhibitors of the human aldosterone synthase CYP11B2
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CN108676076A (zh) 2011-03-01 2018-10-19 辛纳吉制药公司 制备鸟苷酸环化酶c激动剂的方法
EP2804603A1 (en) 2012-01-10 2014-11-26 President and Fellows of Harvard College Beta-cell replication promoting compounds and methods of their use
JP6499591B2 (ja) 2013-02-25 2019-04-10 シナジー ファーマシューティカルズ インコーポレイテッド 結腸洗浄において用いるためのグアニル酸シクラーゼ受容体アゴニスト
US9708367B2 (en) 2013-03-15 2017-07-18 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
JP2016514670A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド 他の薬物と組み合わせたグアニル酸シクラーゼ受容体アゴニスト
EP4424697A2 (en) 2013-06-05 2024-09-04 Bausch Health Ireland Limited Ultra-pure agonists of guanylate cyclase c, method of making and using same
IL280864B2 (en) 2013-08-09 2024-03-01 Ardelyx Inc Compounds and methods for inhibiting phosphate transport
EP3972599A1 (en) 2019-05-21 2022-03-30 Ardelyx, Inc. Combination for lowering serum phosphate in a patient

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR207554A1 (es) * 1972-12-02 1976-10-15 Otsuka Pharma Co Ltd Procedimiento para producir derivados de 3-alquil-5-((3,4-dihidro-5-carbostiril)oximetil)-oxazolidinona-(2)
JPS5239035B2 (da) * 1972-12-14 1977-10-03
JPS5234629B2 (da) * 1973-02-03 1977-09-05
SE431451B (sv) * 1973-10-24 1984-02-06 Otsuka Pharma Co Ltd Forfarande for framstellning av 2,3-dihydroxipropoxikinoliner eller -isokinoliner
US4022784A (en) * 1974-01-31 1977-05-10 Otsuka Pharmaceutical Company Limited 5-[1-Hydroxy-2-(substituted-amino)]alkyl-8-substituted-carbostyril and -3,4-dihydrocarbostyril derivatives
US4070470A (en) * 1974-06-24 1978-01-24 Otsuka Pharmaceutical Co., Ltd. Platelet aggregation inhibiting carbostyrils, their compositions and method of use
JPS54119478A (en) * 1978-03-06 1979-09-17 Otsuka Pharmaceut Co Ltd Carbostyril derivative

Also Published As

Publication number Publication date
DE2825048C2 (da) 1991-05-08
GB2002745A (en) 1979-02-28
IT1108326B (it) 1985-12-09
FI69300B (fi) 1985-09-30
DK149449C (da) 1986-11-24
NO782022L (no) 1978-12-12
CA1098907A (en) 1981-04-07
CH636087A5 (de) 1983-05-13
NO148813C (no) 1983-12-21
AU3686678A (en) 1979-12-13
PH14670A (en) 1981-10-30
MX5527E (es) 1983-09-23
IE781104L (en) 1978-12-10
US4298739A (en) 1981-11-03
AR225755A1 (es) 1982-04-30
GB2002745B (en) 1982-02-17
AU510138B2 (en) 1980-06-12
ES470690A1 (es) 1979-10-16
IE46852B1 (en) 1983-10-05
PT68157A (en) 1978-07-01
AT367038B (de) 1982-05-25
FI69300C (fi) 1986-01-10
FI781811A (fi) 1978-12-11
SE7806710L (sv) 1978-12-11
SE444562B (sv) 1986-04-21
ES479138A1 (es) 1979-07-01
FR2393795A1 (fr) 1979-01-05
DK149449B (da) 1986-06-16
NZ187452A (en) 1980-05-27
ATA421378A (de) 1981-10-15
NO148813B (no) 1983-09-12
DK254878A (da) 1979-02-09
IT7868355A0 (it) 1978-06-09
FR2393795B1 (fr) 1986-07-25
AR224345A1 (es) 1981-11-30
NL7806245A (nl) 1978-12-12
DE2825048A1 (de) 1978-12-14

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Legal Events

Date Code Title Description
BB A search report has been drawn up
BC A request for examination has been filed
A85 Still pending on 85-01-01
BK Erratum

Free format text: CORRECTION TO PAMPHLET

V1 Lapsed because of non-payment of the annual fee