MY105822A - Combined use of n-imidazolyl derivatives of bicyclic compounds and cyclosporine in therapy. - Google Patents
Combined use of n-imidazolyl derivatives of bicyclic compounds and cyclosporine in therapy.Info
- Publication number
- MY105822A MY105822A MYPI90001063A MYPI19901063A MY105822A MY 105822 A MY105822 A MY 105822A MY PI90001063 A MYPI90001063 A MY PI90001063A MY PI19901063 A MYPI19901063 A MY PI19901063A MY 105822 A MY105822 A MY 105822A
- Authority
- MY
- Malaysia
- Prior art keywords
- hydrogen
- cyclosporine
- alkyl
- therapy
- bicyclic compounds
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Transplantation (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
THE INVENTION RELATES TO THE USE OF N-IMIDAZOLYL DERIVATIVES OF BICYCLIC COMPOUNDS OF GENERAL FORMULA WHEREIN Y COMPLETES A SINGLE BOND OR IS OXYGEN OR A -CH2-GROUP AND THE SYMBOL REPRESENTS A SINGLE OR A DOUBLE BOND OR (B) AND THE SYMBOL - - - - REPRESENTS A DOUBLE BOND; ONE OF R1,R2,R3 AND R4 IS -CH2OH2 C2-C4 ACYL,IN WHICH EACH OF R7, R8 AND R9 IS INDEPENDENTLY HYDROGEN OR C1-C4 ALKYL, AND THE OTHERS ARE INDEPENDENTLY CHOSEN FROM HYDROGEN, HYDROXY, HALOGEN, C1-C4 ALKYL, C1-C4 ALKOXY AND COOR7 WHEREIN R7 IS AS DEFINED ABOVE; AND ONE OF R5 AND R6 IS HYDROGEN AND THE OTHER IS HYDROGEN, C1-C6 ALKYL OR PHENYL; OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, IN PARTICULAR IN COMBINATION WITH CYCLOSPORIN A. THE COMPOUNDS OBTAINED ARE USEFUL IN PREVENTING AND/OR TREATING CYCLOSPORINE A-INDUCED NEPHROSIS IN MAMMALS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB898914525A GB8914525D0 (en) | 1989-06-23 | 1989-06-23 | Combined use of n-imidazolyl derivatives of bicyclic compounds and cyclosporine in therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MY105822A true MY105822A (en) | 1995-01-30 |
Family
ID=10658992
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MYPI90001063A MY105822A (en) | 1989-06-23 | 1990-06-22 | Combined use of n-imidazolyl derivatives of bicyclic compounds and cyclosporine in therapy. |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0433427A1 (en) |
| JP (1) | JPH04500375A (en) |
| KR (1) | KR920700669A (en) |
| AU (1) | AU636898B2 (en) |
| CA (1) | CA2035032A1 (en) |
| GB (1) | GB8914525D0 (en) |
| HU (1) | HUT55989A (en) |
| IE (1) | IE902266A1 (en) |
| IL (1) | IL94765A0 (en) |
| MY (1) | MY105822A (en) |
| PT (1) | PT94464A (en) |
| WO (1) | WO1991000102A1 (en) |
| ZA (1) | ZA904882B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL91542A0 (en) * | 1988-10-06 | 1990-04-29 | Erba Carlo Spa | N-imidazolyl-and n-imidazolyl-methyl derivatives of substituted bicyclic compounds,their preparation and pharmaceutical compositions containing them |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2141705B (en) * | 1983-06-20 | 1986-09-24 | Erba Farmitalia | Imidazoles |
| EP0300675A3 (en) * | 1987-07-21 | 1990-04-11 | Merck Frosst Canada Inc. | Method for the improvement of cyclosporine therapy |
-
1989
- 1989-06-23 GB GB898914525A patent/GB8914525D0/en active Pending
-
1990
- 1990-06-18 IL IL94765A patent/IL94765A0/en unknown
- 1990-06-22 PT PT94464A patent/PT94464A/en not_active Application Discontinuation
- 1990-06-22 ZA ZA904882A patent/ZA904882B/en unknown
- 1990-06-22 IE IE226690A patent/IE902266A1/en unknown
- 1990-06-22 MY MYPI90001063A patent/MY105822A/en unknown
- 1990-06-25 WO PCT/EP1990/001010 patent/WO1991000102A1/en not_active Application Discontinuation
- 1990-06-25 KR KR1019910700200A patent/KR920700669A/en not_active Application Discontinuation
- 1990-06-25 CA CA002035032A patent/CA2035032A1/en not_active Abandoned
- 1990-06-25 AU AU59584/90A patent/AU636898B2/en not_active Ceased
- 1990-06-25 EP EP90910697A patent/EP0433427A1/en not_active Withdrawn
- 1990-06-25 HU HU905625A patent/HUT55989A/en unknown
- 1990-06-25 JP JP2509951A patent/JPH04500375A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| IE902266A1 (en) | 1991-01-16 |
| JPH04500375A (en) | 1992-01-23 |
| IL94765A0 (en) | 1991-04-15 |
| KR920700669A (en) | 1992-08-10 |
| ZA904882B (en) | 1992-02-26 |
| PT94464A (en) | 1991-02-08 |
| WO1991000102A1 (en) | 1991-01-10 |
| EP0433427A1 (en) | 1991-06-26 |
| GB8914525D0 (en) | 1989-08-09 |
| CA2035032A1 (en) | 1990-12-24 |
| HUT55989A (en) | 1991-07-29 |
| AU636898B2 (en) | 1993-05-13 |
| HU905625D0 (en) | 1991-06-28 |
| AU5958490A (en) | 1991-01-17 |
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