MX368577B - Compuestos quimicos. - Google Patents

Compuestos quimicos.

Info

Publication number
MX368577B
MX368577B MX2016011681A MX2016011681A MX368577B MX 368577 B MX368577 B MX 368577B MX 2016011681 A MX2016011681 A MX 2016011681A MX 2016011681 A MX2016011681 A MX 2016011681A MX 368577 B MX368577 B MX 368577B
Authority
MX
Mexico
Prior art keywords
compound
chemical compounds
copd
asthma
preparing
Prior art date
Application number
MX2016011681A
Other languages
English (en)
Other versions
MX2016011681A (es
Inventor
Connolly Stephen
Elisabeth Berglund Susanne
Hemmerling Martin
Kristoffersson Anna
Rune Michael Lundkvist Johan
Hossain Nafizal
Nikitidis Grigorios
Elisabeth Ripa Lena
Shamovsky Igor
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of MX2016011681A publication Critical patent/MX2016011681A/es
Publication of MX368577B publication Critical patent/MX368577B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
    • C07D241/28—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms in which said hetero-bound carbon atoms have double bonds to oxygen, sulfur or nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención proporciona un compuesto de una fórmula (I) (ver Fórmula) o una sal farmacéuticamente aceptable de este; un proceso para preparar tal compuesto; y el uso de tal compuesto en el tratamiento de un estado de enfermedad mediado por ENaC (tal como asma, CF o COPD).
MX2016011681A 2014-03-18 2015-03-17 Compuestos quimicos. MX368577B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461954674P 2014-03-18 2014-03-18
PCT/GB2015/050765 WO2015140527A1 (en) 2014-03-18 2015-03-17 Chemical compounds

Publications (2)

Publication Number Publication Date
MX2016011681A MX2016011681A (es) 2016-10-28
MX368577B true MX368577B (es) 2019-10-08

Family

ID=52780553

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016011681A MX368577B (es) 2014-03-18 2015-03-17 Compuestos quimicos.

Country Status (38)

Country Link
US (3) US9873678B2 (es)
EP (1) EP3119752B1 (es)
JP (1) JP6502469B2 (es)
KR (1) KR102296041B1 (es)
CN (1) CN106103423B (es)
AP (1) AP2016009447A0 (es)
AR (1) AR099790A1 (es)
AU (1) AU2015233195B2 (es)
CA (1) CA2941807C (es)
CL (1) CL2016002303A1 (es)
CR (1) CR20160479A (es)
CY (1) CY1120509T1 (es)
DK (1) DK3119752T3 (es)
DO (1) DOP2016000232A (es)
EA (1) EA029952B1 (es)
ES (1) ES2679618T3 (es)
GT (1) GT201600190A (es)
HR (1) HRP20181123T1 (es)
HU (1) HUE039425T2 (es)
IL (1) IL247610B (es)
LT (1) LT3119752T (es)
ME (1) ME03056B (es)
MX (1) MX368577B (es)
NI (1) NI201600134A (es)
NZ (1) NZ724063A (es)
PE (1) PE20170205A1 (es)
PH (1) PH12016501808B1 (es)
PL (1) PL3119752T3 (es)
PT (1) PT3119752T (es)
RS (1) RS57487B1 (es)
SG (1) SG11201607751SA (es)
SI (1) SI3119752T1 (es)
SV (1) SV2016005278A (es)
TR (1) TR201810207T4 (es)
TW (1) TWI687410B (es)
UY (1) UY36034A (es)
WO (1) WO2015140527A1 (es)
ZA (1) ZA201607136B (es)

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US3573306A (en) 1969-03-05 1971-03-30 Merck & Co Inc Process for preparation of n-substituted 3,5-diamino-6-halopyrazinamides
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EP0086564B1 (en) 1982-01-29 1985-11-21 Imperial Chemical Industries Plc Alkanolamine derivatives
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GB8810934D0 (en) 1987-05-26 1988-06-15 Ici America Inc Amides
US4803206A (en) 1988-03-07 1989-02-07 Schering Corporation Antihypertensive acylpyrazines
GB8812343D0 (en) 1988-05-25 1988-06-29 Ici America Inc Amino compounds
GB8812342D0 (en) 1988-05-25 1988-06-29 Ici America Inc Bicyclic compounds
JP3771591B2 (ja) 1997-02-26 2006-04-26 ファイザー・インク ヘテロアリールヘキサン酸アミド誘導体、それらの製造法およびそのＣＣＲ１レセプターと結合するＭＩＰ−１αの選択的な阻害剤としてのそれらの使用
GB9930557D0 (en) 1999-12-23 2000-02-16 Rolic Ag Optically active materials
KR100840816B1 (ko) 2000-05-12 2008-06-23 젠자임 코포레이션 ＴＮＦ-α시그널링의 조절물질
AP2004003049A0 (en) 2001-11-08 2004-06-30 Elan Pharm Inc N,N' -substituted-1,3-diamino -2-hydroxypropane derivatives.
US6858615B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
US7154002B1 (en) 2002-10-08 2006-12-26 Takeda San Diego, Inc. Histone deacetylase inhibitors
US20040087571A1 (en) 2002-10-30 2004-05-06 Pfizer Inc Methods of using CCR1 antagonists as immunomodulatory agents
WO2004056775A1 (en) 2002-12-20 2004-07-08 Pfizer Products Inc. Microsomal triglyceride transfer protein inhibitors
US6903105B2 (en) 2003-02-19 2005-06-07 Parion Sciences, Inc. Sodium channel blockers
MX2007004536A (es) 2004-10-13 2007-07-17 Univ Connecticut Ligandos de lipido canabinergico.
GB0511065D0 (en) 2005-05-31 2005-07-06 Novartis Ag Organic compounds
GB0526240D0 (en) 2005-12-22 2006-02-01 Novartis Ag Organic compounds
GB0526244D0 (en) 2005-12-22 2006-02-01 Novartis Ag Organic compounds
JP5330274B2 (ja) 2007-03-01 2013-10-30 ノバルティス アーゲー Ｐｉｍキナーゼ阻害剤およびその使用方法
DE602008005140D1 (de) 2007-05-07 2011-04-07 Novartis Ag Organische verbindungen
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JP2011520831A (ja) 2008-05-13 2011-07-21 ノバルティス アーゲー ３，５−ジアミノ−６−クロロ−ピラジン−２−カルボン酸誘導体および気道疾患処置用上皮性ナトリウムチャネルブロッカーとしてのその使用
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ES2535736T3 (es) * 2008-06-10 2015-05-14 Novartis Ag Derivados de pirazina como bloqueadores de los canales de sodio epitelial
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Also Published As

Publication number Publication date
JP6502469B2 (ja) 2019-04-17
SI3119752T1 (en) 2018-08-31
CN106103423B (zh) 2019-12-06
AP2016009447A0 (en) 2016-09-30
NZ724063A (en) 2018-02-23
LT3119752T (lt) 2018-08-10
US10336725B2 (en) 2019-07-02
TWI687410B (zh) 2020-03-11
EA201691641A1 (ru) 2017-02-28
ME03056B (me) 2018-10-20
RS57487B1 (sr) 2018-10-31
KR102296041B1 (ko) 2021-08-30
AU2015233195B2 (en) 2017-04-20
CR20160479A (es) 2017-02-24
TW201620880A (zh) 2016-06-16
CA2941807C (en) 2023-03-07
CN106103423A (zh) 2016-11-09
IL247610B (en) 2019-05-30
SG11201607751SA (en) 2016-10-28
TR201810207T4 (tr) 2018-08-27
US9873678B2 (en) 2018-01-23
KR20160127135A (ko) 2016-11-02
SV2016005278A (es) 2016-11-30
UY36034A (es) 2015-09-30
EP3119752A1 (en) 2017-01-25
HUE039425T2 (hu) 2018-12-28
PE20170205A1 (es) 2017-04-06
AR099790A1 (es) 2016-08-17
NI201600134A (es) 2017-03-13
WO2015140527A1 (en) 2015-09-24
PH12016501808A1 (en) 2017-01-09
AU2015233195A1 (en) 2016-09-22
MX2016011681A (es) 2016-10-28
PT3119752T (pt) 2018-07-24
DOP2016000232A (es) 2016-10-16
ZA201607136B (en) 2018-04-25
DK3119752T3 (en) 2018-07-30
CY1120509T1 (el) 2019-07-10
GT201600190A (es) 2019-07-29
IL247610A0 (en) 2016-11-30
HRP20181123T1 (hr) 2018-09-21
US10954211B2 (en) 2021-03-23
CL2016002303A1 (es) 2017-01-13
US20190330187A1 (en) 2019-10-31
ES2679618T3 (es) 2018-08-29
PL3119752T3 (pl) 2018-09-28
JP2017512830A (ja) 2017-05-25
EP3119752B1 (en) 2018-05-16
US20180162838A1 (en) 2018-06-14
CA2941807A1 (en) 2015-09-24
US20170107195A1 (en) 2017-04-20
PH12016501808B1 (en) 2017-01-09
EA029952B1 (ru) 2018-06-29

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