MX2020012940A - Metodos de uso de moduladores de empalme. - Google Patents

Metodos de uso de moduladores de empalme.

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Publication number
MX2020012940A
MX2020012940A MX2020012940A MX2020012940A MX2020012940A MX 2020012940 A MX2020012940 A MX 2020012940A MX 2020012940 A MX2020012940 A MX 2020012940A MX 2020012940 A MX2020012940 A MX 2020012940A MX 2020012940 A MX2020012940 A MX 2020012940A
Authority
MX
Mexico
Prior art keywords
methods
splicing modulators
modulators
splicing
neoantigen
Prior art date
Application number
MX2020012940A
Other languages
English (en)
Inventor
Ermira Pazolli
Ping Zhu
Lihua Yu
Silvia Buonamici
James Palacino
Michael Seiler
Evan Barry
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of MX2020012940A publication Critical patent/MX2020012940A/es

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A—HUMAN NECESSITIES
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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  • General Health & Medical Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biotechnology (AREA)
  • Endocrinology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Flanged Joints, Insulating Joints, And Other Joints (AREA)

Abstract

La presente descripción se refiere a métodos para el tratamiento de trastornos neoplásicos mediante la administración del compuesto 1 o una sal farmacéuticamente aceptable del mismo en solitario y/o como parte de un conjugado o composición y la inducción de la producción de al menos un neoantígeno.
MX2020012940A 2018-06-01 2019-05-31 Metodos de uso de moduladores de empalme. MX2020012940A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862679696P 2018-06-01 2018-06-01
US201862679699P 2018-06-01 2018-06-01
PCT/US2019/034992 WO2019232433A2 (en) 2018-06-01 2019-05-31 Methods of using splicing modulators

Publications (1)

Publication Number Publication Date
MX2020012940A true MX2020012940A (es) 2021-03-25

Family

ID=67070907

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020012940A MX2020012940A (es) 2018-06-01 2019-05-31 Metodos de uso de moduladores de empalme.

Country Status (11)

Country Link
US (2) US11998544B2 (es)
EP (1) EP3801523B1 (es)
JP (1) JP7346466B2 (es)
KR (1) KR20210016406A (es)
CN (1) CN112367996B (es)
AU (1) AU2019279012A1 (es)
BR (1) BR112020024551A2 (es)
CA (1) CA3101205A1 (es)
IL (2) IL278740B2 (es)
MX (1) MX2020012940A (es)
WO (1) WO2019232433A2 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL312725A (en) 2018-04-09 2024-07-01 Eisai R&D Man Co Ltd Palladianolide compounds and their use
WO2019232433A2 (en) 2018-06-01 2019-12-05 Eisai R&D Management Co., Ltd. Methods of using splicing modulators
EP4149483A4 (en) * 2020-05-15 2024-09-11 Fred Hutchinson Cancer Center COMPOSITIONS AND METHODS FOR ENHANCING CANCER IMMUNOTHERAPY
AU2021284401A1 (en) 2020-06-05 2023-01-05 Eisai R&D Management Co., Ltd. Anti-BCMA antibody-drug conjugates and methods of use

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU634186B2 (en) 1988-11-11 1993-02-18 Medical Research Council Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors
CA2017507C (en) 1989-05-25 1996-11-12 Gary Van Nest Adjuvant formulation comprising a submicron oil droplet emulsion
US5595756A (en) * 1993-12-22 1997-01-21 Inex Pharmaceuticals Corporation Liposomal compositions for enhanced retention of bioactive agents
DE69629385T2 (de) 1995-11-10 2004-06-09 Elan Corp. Plc Peptide, die den transport über gewebe erhöhen und verfahren zu ihrer identifizierung und verwendung
EP3214175A1 (en) 1999-08-24 2017-09-06 E. R. Squibb & Sons, L.L.C. Human ctla-4 antibodies and their uses
TWI311558B (en) 2001-02-01 2009-07-01 Mercian Corporatio Novel physiologically active substance
TWI334866B (en) 2002-05-29 2010-12-21 Mercian Corp Novel physiologically active substances
EP1541570A4 (en) 2002-07-31 2008-05-21 Mercian Corp NEW PHYSIOLOGICALLY ACTIVE SUBSTANCE
KR101285695B1 (ko) 2002-07-31 2013-07-12 에자이 알앤드디 매니지먼트 가부시키가이샤 신규한 생리 활성 물질
WO2004050890A1 (ja) 2002-11-29 2004-06-17 Mercian Corporation マクロライド系化合物の製造方法
KR20060110865A (ko) * 2003-11-27 2006-10-25 에자이 가부시키가이샤 매크로라이드계 화합물의 수산화에 관여하는 ｄｎａ
KR100834488B1 (ko) 2004-07-20 2008-06-09 에자이 알앤드디 매니지먼트 가부시키가이샤 플라디에놀라이드의 생합성에 관여하는 폴리펩티드를코딩하는 ｄｎａ
NZ563193A (en) 2005-05-09 2010-05-28 Ono Pharmaceutical Co Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics
WO2007043621A1 (ja) 2005-10-13 2007-04-19 Eisai R & D Management Co., Ltd. プラジエノライド ｂ及びプラジエノライド ｄの全合成方法
US20090227795A1 (en) * 2006-08-02 2009-09-10 Eisai R & D Management Co., Ltd. Target molecules of pladienolides, compounds binding to such target molecules, and screening method thereof
US20080312317A1 (en) 2007-04-12 2008-12-18 Eisai R&D Management Co., Ltd. 12 membered-ring macrolactam derivatives
CA3213528A1 (en) 2012-05-15 2013-11-21 Bristol-Myers Squibb Company Cancer immunotherapy by disrupting pd-1/pd-l1 signaling
US9801951B2 (en) 2012-05-15 2017-10-31 Concortis Biosystems, Corp. Drug-conjugates, conjugation methods, and uses thereof
JP2016540042A (ja) * 2013-11-05 2016-12-22 コグネート バイオサービシズ， インコーポレイテッド がんを処置するためのチェックポイント阻害剤および治療薬の組合せ
KR102146726B1 (ko) * 2014-05-15 2020-08-21 에자이 알앤드디 매니지먼트 가부시키가이샤 플라디에놀리드 피리딘 화합물 및 사용 방법
JP7032929B2 (ja) 2014-07-11 2022-03-09 ヴェンタナ メディカル システムズ， インク． 抗ｐｄ－ｌ１抗体及びその診断上の使用
US10889866B2 (en) 2015-09-01 2021-01-12 Eisai R&D Management Co., Ltd. Splice variants associated with neomorphic SF3B1 mutants
RU2619208C2 (ru) 2015-10-08 2017-05-12 ДИАМОНДЗЛИТЕ ЛИМИТЕД Тридент Чамберс Способ профилактического лечения при развитии неопластических процессов кожной ткани, таких как меланома, базально-клеточный рак, плоскоклеточный рак
BR112018009995B1 (pt) * 2015-11-18 2024-04-30 Eisai R&D Management Co., Ltd Forma cristalina, composição farmacêutica, e, uso da forma cristalina
TW202408592A (zh) 2016-03-02 2024-03-01 日商衛材R&D企管股份有限公司 基於艾日布林之抗體-藥物結合物及使用方法
WO2017214182A1 (en) * 2016-06-07 2017-12-14 The United States Of America. As Represented By The Secretary, Department Of Health & Human Services Fully human antibody targeting pdi for cancer immunotherapy
US10669338B2 (en) * 2016-06-17 2020-06-02 Immunomedics, Inc. Anti-PD-1 checkpoint inhibitor antibodies that block binding of PD-L1 to PD-1
US10825015B2 (en) 2018-03-07 2020-11-03 Capital One Services, Llc Secure payment using a network of wearable devices
WO2019232433A2 (en) 2018-06-01 2019-12-05 Eisai R&D Management Co., Ltd. Methods of using splicing modulators
JOP20200268A1 (ar) 2018-06-01 2020-10-26 Eisai R&D Man Co Ltd تضفير مترافقات عقار جسم مضاد معدل وطرق استخدامها
US20220031859A1 (en) 2018-12-13 2022-02-03 Eisai R&D Management Co., Ltd. Herboxidiene antibody-drug conjugates and methods of use
BR112022008756A2 (pt) 2019-11-07 2022-07-26 Eisai R&D Man Co Ltd Conjugados anticorpo-fármaco anti-mesotelina eribulina e métodos de uso
JP2023511163A (ja) 2020-01-22 2023-03-16 上海森輝医薬有限公司 エリブリン誘導体の薬物複合体、その調製方法及びその医薬的応用
AU2021284401A1 (en) 2020-06-05 2023-01-05 Eisai R&D Management Co., Ltd. Anti-BCMA antibody-drug conjugates and methods of use

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