MX2018006781A - Inhibidores de mat2a para el tratamiento del cancer que no expresen mtap. - Google Patents

Inhibidores de mat2a para el tratamiento del cancer que no expresen mtap.

Info

Publication number
MX2018006781A
MX2018006781A MX2018006781A MX2018006781A MX2018006781A MX 2018006781 A MX2018006781 A MX 2018006781A MX 2018006781 A MX2018006781 A MX 2018006781A MX 2018006781 A MX2018006781 A MX 2018006781A MX 2018006781 A MX2018006781 A MX 2018006781A
Authority
MX
Mexico
Prior art keywords
mat2a
mtap null
inhibitors
null cancer
mat2a inhibitors
Prior art date
Application number
MX2018006781A
Other languages
English (en)
Inventor
Eun Choe Sung
Marjon Katya
Original Assignee
Agios Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agios Pharmaceuticals Inc filed Critical Agios Pharmaceuticals Inc
Publication of MX2018006781A publication Critical patent/MX2018006781A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A61K31/015—Hydrocarbons carbocyclic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/02—Halogenated hydrocarbons
    • A61K31/025—Halogenated hydrocarbons carbocyclic
    • A61K31/03—Halogenated hydrocarbons carbocyclic aromatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Physics & Mathematics (AREA)
  • Hospice & Palliative Care (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente invención proporciona métodos diagnósticos y pronósticos para predecir la efectividad de tratamiento de un paciente con cáncer con un inhibidor de MAT2A. Se proporcionan métodos para predecir la sensibilidad de crecimiento de células de tumor a inhibición por un inhibidor de MA2A, que comprende valorar si la célula de tumor está ausente de un gen de MTAP, por lo cual las células son MTAP nulas son sensibles a inhibición por inhibidores de MAT2A.
MX2018006781A 2015-12-03 2016-12-02 Inhibidores de mat2a para el tratamiento del cancer que no expresen mtap. MX2018006781A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562262750P 2015-12-03 2015-12-03
US201662297572P 2016-02-19 2016-02-19
PCT/US2016/064619 WO2017096165A1 (en) 2015-12-03 2016-12-02 Mat2a inhibitors for treating mtap null cancer

Publications (1)

Publication Number Publication Date
MX2018006781A true MX2018006781A (es) 2018-11-09

Family

ID=57614465

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018006781A MX2018006781A (es) 2015-12-03 2016-12-02 Inhibidores de mat2a para el tratamiento del cancer que no expresen mtap.

Country Status (12)

Country Link
US (1) US20180371551A1 (es)
EP (1) EP3383375A1 (es)
JP (2) JP6877429B2 (es)
KR (1) KR20180100125A (es)
CN (1) CN108601752A (es)
AU (1) AU2016364855B2 (es)
CA (1) CA3006743A1 (es)
EA (1) EA201891304A1 (es)
IL (1) IL259773A (es)
MX (1) MX2018006781A (es)
SG (1) SG11201804360XA (es)
WO (1) WO2017096165A1 (es)

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EA201691154A1 (ru) 2013-12-04 2016-10-31 Чугаи Сейяку Кабусики Кайся Антигенсвязывающие молекулы, активность связывания антигена которых варьируется в зависимости от концентрации соединений, и библиотеки указанных молекул
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WO2021023609A1 (en) * 2019-08-02 2021-02-11 Glaxosmithkline Intellectual Property Development Limited Combination of a type i protein arginine methyltransferase (type i prmt) inhibitor and a methionine adenosyltransferase ii alpha (mat2a) inhibitor
WO2021158792A1 (en) * 2020-02-04 2021-08-12 Agios Pharmaceuticals, Inc. Methods of treating autoimmune or inflammatory diseases or disorders
CN113999232A (zh) * 2020-07-28 2022-02-01 南京正大天晴制药有限公司 Mat2a抑制剂
TW202227082A (zh) * 2020-08-12 2022-07-16 美商施維雅製藥有限公司 用於治療癌症之組合療法
AU2022287057A1 (en) 2021-06-02 2023-12-14 Ideaya Biosciences, Inc. Combination therapy comprising a mat2a inhibitor and a type ii prmt inhibitor
CN113476450B (zh) * 2021-08-10 2023-04-28 江南大学 Epz015666在制备用于防治血管内膜增生类疾病的药物中的应用
CN114028572B (zh) * 2021-11-30 2022-11-25 清华大学 Mat2a抑制剂用于治疗哮喘的新应用
TW202415370A (zh) 2022-10-13 2024-04-16 南韓商韓美藥品股份有限公司 新穎三環衍生物化合物以及其應用
CN115825214B (zh) * 2022-11-30 2024-07-30 厦门镜祥医药科技有限公司 一种基于MALDI-TOF-MS体外筛选hMAT2A蛋白抑制剂的方法及其应用

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Also Published As

Publication number Publication date
IL259773A (en) 2018-07-31
CN108601752A (zh) 2018-09-28
EP3383375A1 (en) 2018-10-10
WO2017096165A1 (en) 2017-06-08
US20180371551A1 (en) 2018-12-27
JP2021098736A (ja) 2021-07-01
EA201891304A1 (ru) 2019-01-31
SG11201804360XA (en) 2018-06-28
AU2016364855A1 (en) 2018-07-05
JP6877429B2 (ja) 2021-05-26
AU2016364855B2 (en) 2019-08-29
CA3006743A1 (en) 2017-06-08
JP2018537473A (ja) 2018-12-20
KR20180100125A (ko) 2018-09-07

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