MX2014013758A - Derivados de tiazolcarboxamida para usarse como inhibidores de nampt. - Google Patents

Derivados de tiazolcarboxamida para usarse como inhibidores de nampt.

Info

Publication number
MX2014013758A
MX2014013758A MX2014013758A MX2014013758A MX2014013758A MX 2014013758 A MX2014013758 A MX 2014013758A MX 2014013758 A MX2014013758 A MX 2014013758A MX 2014013758 A MX2014013758 A MX 2014013758A MX 2014013758 A MX2014013758 A MX 2014013758A
Authority
MX
Mexico
Prior art keywords
nampt inhibitors
nampt
thiazolecarboxamide
derivatives
thiazolecarboxamide derivatives
Prior art date
Application number
MX2014013758A
Other languages
English (en)
Inventor
Marina A Pliushchev
Todd M Hansen
Michael L Curtin
Kenton Longenecker
Ramzi F Sweis
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of MX2014013758A publication Critical patent/MX2014013758A/es

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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Abstract

Se describen compuestos, los cuales inhiben la actividad de NAMPT, composiciones que contienen los compuestos y métodos para tratar enfermedades durante las cuales NAMPT es expresado.
MX2014013758A 2012-05-11 2013-05-10 Derivados de tiazolcarboxamida para usarse como inhibidores de nampt. MX2014013758A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CNPCT/CN2012/075327 2012-05-11
PCT/US2013/040485 WO2013170118A1 (en) 2012-05-11 2013-05-10 Thiazolecarboxamide derivatives for use as nampt inhibitors

Publications (1)

Publication Number Publication Date
MX2014013758A true MX2014013758A (es) 2015-02-05

Family

ID=48483233

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014013758A MX2014013758A (es) 2012-05-11 2013-05-10 Derivados de tiazolcarboxamida para usarse como inhibidores de nampt.

Country Status (7)

Country Link
US (2) US9334264B2 (es)
EP (1) EP2850081A1 (es)
JP (1) JP2015516437A (es)
CN (1) CN104271572A (es)
CA (1) CA2870566A1 (es)
MX (1) MX2014013758A (es)
WO (1) WO2013170118A1 (es)

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JP6510556B2 (ja) 2014-04-18 2019-05-08 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． キノキサリン化合物及びその使用
CN107438598A (zh) 2015-01-20 2017-12-05 米伦纽姆医药公司 喹唑啉和喹啉化合物及其用途
WO2017099237A1 (ja) 2015-12-11 2017-06-15 帝人ファーマ株式会社 アミノアゾール誘導体
US11638762B2 (en) 2016-10-18 2023-05-02 Seagen Inc. Targeted delivery of nicotinamide adenine dinucleotide salvage pathway inhibitors
JP7425606B2 (ja) 2017-04-27 2024-01-31 シージェン インコーポレイテッド 四級化ニコチンアミドアデニンジヌクレオチドサルベージ経路阻害剤コンジュゲート
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Also Published As

Publication number Publication date
US20140336167A1 (en) 2014-11-13
US20160193209A1 (en) 2016-07-07
EP2850081A1 (en) 2015-03-25
US9334264B2 (en) 2016-05-10
CN104271572A (zh) 2015-01-07
JP2015516437A (ja) 2015-06-11
WO2013170118A1 (en) 2013-11-14
CA2870566A1 (en) 2013-11-14

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