MX2010004546A - Nuevos intermedios de pregabalina y procedimiento para prepararlos y para preparar pregabalina. - Google Patents

Nuevos intermedios de pregabalina y procedimiento para prepararlos y para preparar pregabalina.

Info

Publication number
MX2010004546A
MX2010004546A MX2010004546A MX2010004546A MX2010004546A MX 2010004546 A MX2010004546 A MX 2010004546A MX 2010004546 A MX2010004546 A MX 2010004546A MX 2010004546 A MX2010004546 A MX 2010004546A MX 2010004546 A MX2010004546 A MX 2010004546A
Authority
MX
Mexico
Prior art keywords
pregabalin
intermediates
preparing
novel
preparation
Prior art date
Application number
MX2010004546A
Other languages
English (en)
Inventor
Graziano Castaldi
Marcello Rasparini
Roberto Tufaro
Giovanni Marras
Giovanni Gionvenzana
Original Assignee
Chemo Iberica Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemo Iberica Sa filed Critical Chemo Iberica Sa
Publication of MX2010004546A publication Critical patent/MX2010004546A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C233/05—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C233/07—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención proporciona nuevos compuestos, que son especialmente útiles como intermedios para la preparación de Pregabalina. La invención también está relacionada con un proceso para preparar estos intermedios y Pregabalina.
MX2010004546A 2007-10-26 2008-10-23 Nuevos intermedios de pregabalina y procedimiento para prepararlos y para preparar pregabalina. MX2010004546A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07119355A EP2053040A1 (en) 2007-10-26 2007-10-26 Pregabalin intermediates and process for preparing them and Pregabalin
PCT/EP2008/064402 WO2009053446A2 (en) 2007-10-26 2008-10-23 Pregabalin intermediates and process for preparing them and pregabalin

Publications (1)

Publication Number Publication Date
MX2010004546A true MX2010004546A (es) 2010-05-05

Family

ID=39092555

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010004546A MX2010004546A (es) 2007-10-26 2008-10-23 Nuevos intermedios de pregabalina y procedimiento para prepararlos y para preparar pregabalina.

Country Status (3)

Country Link
EP (1) EP2053040A1 (es)
MX (1) MX2010004546A (es)
WO (1) WO2009053446A2 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009087674A2 (en) * 2007-12-18 2009-07-16 Watson Pharma Private Limited Improved process for the preparation of (s)-pregabalin
CN102459169B (zh) 2009-05-15 2014-12-31 莱德克斯制药有限公司 氧化还原药物衍生物
WO2011086565A1 (en) * 2010-01-15 2011-07-21 Lupin Limited Method for preparation of enantiomerically enriched and/or racemic gamma-amino acids
US8212072B2 (en) 2010-08-13 2012-07-03 Divi's Laboratories, Ltd. Process for the preparation of pregabalin
CN103159636B (zh) * 2013-04-05 2015-02-25 李兴惠 氨甲基己酸衍生物和用途
CN105085302B (zh) * 2015-09-14 2020-09-15 浙江华海药业股份有限公司 一种Pregabalin中间体母液及废水套用的方法
DK3371150T3 (en) * 2015-11-03 2021-11-15 UCB Biopharma SRL Fremgangsmåde til at fremstille brivaracetam
CN109046465B (zh) * 2018-07-25 2021-03-26 华东师范大学 一种介孔硅材料固载手性金催化剂的制备及应用
CN110903228A (zh) * 2019-11-07 2020-03-24 南通常佑药业科技有限公司 一种无溶剂法制备4-异丁基吡咯烷酮的制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA004934B1 (ru) * 2000-01-27 2004-10-28 Уорнер-Ламберт Компани Асимметрический синтез прегабалина

Also Published As

Publication number Publication date
EP2053040A1 (en) 2009-04-29
WO2009053446A2 (en) 2009-04-30
WO2009053446A3 (en) 2009-08-13

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