ME02352B - PROTUTIJELA PROTIV N3pGiu-AMILOlDNOG BETA PEPTlDA l NJIHOVA UPOTREBA - Google Patents

PROTUTIJELA PROTIV N3pGiu-AMILOlDNOG BETA PEPTlDA l NJIHOVA UPOTREBA

Info

Publication number
ME02352B
ME02352B MEP-2016-28A MEP2816A ME02352B ME 02352 B ME02352 B ME 02352B ME P2816 A MEP2816 A ME P2816A ME 02352 B ME02352 B ME 02352B
Authority
ME
Montenegro
Prior art keywords
amyloid beta
beta peptide
peptide antibodies
n3pglu amyloid
n3pglu
Prior art date
Application number
MEP-2016-28A
Other languages
German (de)
English (en)
French (fr)
Inventor
Jirong Lu
Ying Tang
Ronald Bradley Demattos
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of ME02352B publication Critical patent/ME02352B/me

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567Framework region [FR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/28Neurological disorders
    • G01N2800/2814Dementia; Cognitive disorders
    • G01N2800/2821Alzheimer

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
MEP-2016-28A 2010-08-12 2011-08-09 PROTUTIJELA PROTIV N3pGiu-AMILOlDNOG BETA PEPTlDA l NJIHOVA UPOTREBA ME02352B (me)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37302610P 2010-08-12 2010-08-12
PCT/US2011/046994 WO2012021469A1 (en) 2010-08-12 2011-08-09 ANTI-N3pGlu AMYLOID BETA PEPTIDE ANTIBODIES AND USES THEREOF
EP11745672.3A EP2603523B1 (en) 2010-08-12 2011-08-09 ANTI-N3pGlu AMYLOID BETA PEPTIDE ANTIBODIES AND USES THEREOF

Publications (1)

Publication Number Publication Date
ME02352B true ME02352B (me) 2016-06-20

Family

ID=44543826

Family Applications (3)

Application Number Title Priority Date Filing Date
MEP-2019-356A ME03661B (me) 2010-08-12 2011-08-09 Protutijela protiv amiloidnog beta peptida n3pglu i njihova upotreba
MEP-2016-28A ME02352B (me) 2010-08-12 2011-08-09 PROTUTIJELA PROTIV N3pGiu-AMILOlDNOG BETA PEPTlDA l NJIHOVA UPOTREBA
MEP-2018-79A ME03032B (me) 2010-08-12 2011-08-09 Protutijela protiv amiloidnog beta peptida n3pglu i njihova upotreba

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MEP-2019-356A ME03661B (me) 2010-08-12 2011-08-09 Protutijela protiv amiloidnog beta peptida n3pglu i njihova upotreba

Family Applications After (1)

Application Number Title Priority Date Filing Date
MEP-2018-79A ME03032B (me) 2010-08-12 2011-08-09 Protutijela protiv amiloidnog beta peptida n3pglu i njihova upotreba

Country Status (38)

Country Link
US (2) US8679498B2 (me)
EP (3) EP2603523B1 (me)
JP (2) JP5980207B2 (me)
KR (1) KR101498833B1 (me)
CN (2) CN105111308B (me)
AU (1) AU2011289629B2 (me)
BR (1) BR112013004056B8 (me)
CA (1) CA2805114C (me)
CL (1) CL2013000390A1 (me)
CO (1) CO6670526A2 (me)
CR (1) CR20130016A (me)
CY (2) CY1120144T1 (me)
DK (3) DK2603523T3 (me)
DO (1) DOP2013000029A (me)
EA (1) EA023021B1 (me)
EC (1) ECSP13012436A (me)
ES (3) ES2564252T3 (me)
GT (1) GT201300036A (me)
HK (1) HK1180703A1 (me)
HR (3) HRP20160151T1 (me)
HU (2) HUE028678T2 (me)
IL (2) IL224030B (me)
LT (2) LT3042917T (me)
MA (1) MA34461B1 (me)
ME (3) ME03661B (me)
MX (2) MX342782B (me)
MY (2) MY181969A (me)
NO (1) NO3042917T3 (me)
NZ (2) NZ626665A (me)
PE (1) PE20130817A1 (me)
PL (3) PL3042917T3 (me)
PT (2) PT3042917T (me)
RS (3) RS59652B1 (me)
SG (2) SG187586A1 (me)
SI (3) SI3339323T1 (me)
UA (1) UA107600C2 (me)
WO (1) WO2012021469A1 (me)
ZA (1) ZA201300437B (me)

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PL3042917T3 (pl) * 2010-08-12 2018-07-31 Eli Lilly And Company Przeciwciała przeciwko peptydowi beta amyloidu N3pGlu i ich zastosowanie
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CN106699888B (zh) * 2015-07-28 2020-11-06 上海昀怡健康科技发展有限公司 一种pd-1抗体及其制备方法和应用
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JOP20170004B1 (ar) * 2016-01-15 2022-09-15 Lilly Co Eli الأجسام المضادة لببتيد بيتا النشوي مضاد N3pGlu واستخداماته
TW201740944A (zh) 2016-03-15 2017-12-01 美國禮來大藥廠 組合療法
TW201740954A (zh) * 2016-03-16 2017-12-01 美國禮來大藥廠 組合療法
TWI798751B (zh) * 2016-07-01 2023-04-11 美商美國禮來大藥廠 抗-N3pGlu類澱粉β肽抗體及其用途
US10034861B2 (en) 2016-07-04 2018-07-31 H. Lundbeck A/S 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
CA3032692A1 (en) * 2016-08-09 2018-02-15 Eli Lilly And Company Combination antibody therapy for the treatment of neurodegenerative diseases
WO2018034977A1 (en) 2016-08-18 2018-02-22 Eli Lilly And Company Combination therapy of bace-1 inhibitor and anti-n3pglu abeta antibody
TWI669119B (zh) * 2016-10-21 2019-08-21 美國禮來大藥廠 組合療法
BR112018013247A2 (pt) 2016-10-28 2018-12-04 H Lundbeck As tratamentos de combinação compreendendo imidazopirazinonas para o tratamento de distúrbios psiquiátricos e/ou cognitivos
EP3532053A1 (en) 2016-10-28 2019-09-04 H. Lundbeck A/S Combination treatments comprising administration of imidazopyrazinones
TW201827467A (zh) 2016-11-03 2018-08-01 比利時商健生藥品公司 焦穀胺酸類澱粉蛋白-β之抗體及其用途
JOP20190247A1 (ar) * 2017-04-20 2019-10-20 Lilly Co Eli أجسام بيتا ببتيد النشوانية المضادة لـ N3pGlu واستخداماتها
CN111201037B (zh) 2017-08-22 2024-04-02 比奥根Ma公司 含有抗β淀粉样蛋白抗体的药物组合物
CA3085201A1 (en) 2017-12-14 2019-06-20 H. Lundbeck A/S Combination treatments comprising administration of 1h-pyrazolo[4,3-b]pyridines
AR113926A1 (es) 2017-12-14 2020-07-01 H Lundbeck As Derivados de 1h-pirazolo[4,3-b]piridinas
WO2019121840A1 (en) 2017-12-20 2019-06-27 H. Lundbeck A/S Pyrazolo[3,4-b]pyridines and imidazo[1,5-b]pyridazines as pde1 inhibitors
US20220177560A1 (en) * 2019-03-26 2022-06-09 Janssen Pharmaceutica Nv Antibodies to Pyroglutamate Amyloid-B and Uses Thereof
JP7551744B2 (ja) 2019-10-15 2024-09-17 イーライ リリー アンド カンパニー 組換え操作された、リパーゼ/エステラーゼ欠損哺乳動物細胞株
US20230250193A1 (en) * 2020-06-17 2023-08-10 Proviva Therapeutics (Hong Kong) Limited Antibodies to fibroblast activation protein and b7h3
JP2023535024A (ja) 2020-07-23 2023-08-15 オター プロシーナ リミテッド 抗aベータ抗体
AU2021355521A1 (en) 2020-10-02 2023-05-11 Eli Lilly And Company Methods for reducing host cell protein content in antibody purification processes and antibody compositions having reduced host cell protein content
TWI843040B (zh) 2021-01-11 2024-05-21 美商美國禮來大藥廠 抗N3pGlu類澱粉β抗體及其用途
TW202300518A (zh) 2021-03-12 2023-01-01 美商美國禮來大藥廠 抗N3pGlu類澱粉β抗體及其用途
TW202300517A (zh) 2021-03-12 2023-01-01 美商美國禮來大藥廠 抗類澱粉β抗體及其用途
KR20240099297A (ko) 2021-10-22 2024-06-28 일라이 릴리 앤드 캄파니 O-GlcNAcase (OGA) 억제제 조합 요법
MX2024005145A (es) 2021-10-29 2024-05-13 Lilly Co Eli Compuestos y metodos dirigidos a la interleucina-34.
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KR20240099347A (ko) 2021-10-29 2024-06-28 일라이 릴리 앤드 캄파니 인터류킨-34를 표적화하는 화합물 및 방법
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Also Published As

Publication number Publication date
AU2011289629B2 (en) 2014-07-03
HK1180703A1 (zh) 2013-10-25
AU2011289629A1 (en) 2013-02-14
RS54685B1 (en) 2016-08-31
IL224030B (en) 2022-04-01
IL285226B (en) 2022-10-01
SG10201509330XA (en) 2015-12-30
CN105111308A (zh) 2015-12-02
MA34461B1 (fr) 2013-08-01
US8679498B2 (en) 2014-03-25
SI3339323T1 (sl) 2019-12-31
EP2603523B1 (en) 2016-01-27
PL3339323T3 (pl) 2020-05-18
DK3339323T3 (da) 2020-01-20
EA023021B1 (ru) 2016-04-29
MY181969A (en) 2021-01-15
ES2564252T3 (es) 2016-03-21
EP3339323A1 (en) 2018-06-27
MY163521A (en) 2017-09-15
EA201270813A1 (ru) 2013-05-30
PE20130817A1 (es) 2013-07-18
PL2603523T3 (pl) 2016-07-29
HRP20180616T1 (hr) 2018-07-13
SI3042917T1 (en) 2018-04-30
UA107600C2 (uk) 2015-01-26
RS59652B1 (sr) 2020-01-31
KR20130051989A (ko) 2013-05-21
CN103068848A (zh) 2013-04-24
PL3042917T3 (pl) 2018-07-31
NZ626665A (en) 2016-04-29
DK2603523T3 (en) 2016-03-21
CN105111308B (zh) 2019-03-12
KR101498833B1 (ko) 2015-03-04
SG187586A1 (en) 2013-03-28
CR20130016A (es) 2013-03-21
GT201300036A (es) 2014-07-16
JP2013536191A (ja) 2013-09-19
CY1120144T1 (el) 2018-12-12
HRP20192233T1 (hr) 2020-03-06
WO2012021469A1 (en) 2012-02-16
NO3042917T3 (me) 2018-07-21
LT3339323T (lt) 2020-02-10
CA2805114C (en) 2017-12-05
CN103068848B (zh) 2015-11-25
ME03032B (me) 2018-10-20
JP5980207B2 (ja) 2016-08-31
US20130142806A1 (en) 2013-06-06
CA2805114A1 (en) 2012-02-16
CY1122458T1 (el) 2021-01-27
SI2603523T1 (sl) 2016-04-29
EP3042917B1 (en) 2018-02-21
ME03661B (me) 2020-07-20
ZA201300437B (en) 2014-06-25
EP3042917A1 (en) 2016-07-13
BR112013004056A2 (pt) 2020-08-04
HUE028678T2 (en) 2016-12-28
JP2016179985A (ja) 2016-10-13
US20140065138A1 (en) 2014-03-06
PT3339323T (pt) 2020-01-14
LT3042917T (lt) 2018-05-10
NZ606095A (en) 2014-11-28
RS57026B1 (sr) 2018-05-31
DK3042917T3 (en) 2018-04-23
IL285226A (en) 2021-09-30
MX355268B (es) 2018-04-11
BR112013004056B8 (pt) 2022-10-18
BR112013004056B1 (pt) 2022-05-17
EP3339323B1 (en) 2019-11-13
DOP2013000029A (es) 2013-03-15
HRP20160151T1 (hr) 2016-03-11
MX2013001716A (es) 2013-10-28
HUE037524T2 (hu) 2018-09-28
MX342782B (es) 2016-10-12
JP6395755B2 (ja) 2018-09-26
PT3042917T (pt) 2018-05-02
CO6670526A2 (es) 2013-05-15
US8961972B2 (en) 2015-02-24
IL285226B2 (en) 2023-02-01
ES2664128T3 (es) 2018-04-18
CL2013000390A1 (es) 2014-03-21
EP2603523A1 (en) 2013-06-19
ECSP13012436A (es) 2013-03-28
ES2764728T3 (es) 2020-06-04

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