MA37963A1 - Protéines de fusion pour traiter un syndrome métabolique - Google Patents

Protéines de fusion pour traiter un syndrome métabolique

Info

Publication number
MA37963A1
MA37963A1 MA37963A MA37963A MA37963A1 MA 37963 A1 MA37963 A1 MA 37963A1 MA 37963 A MA37963 A MA 37963A MA 37963 A MA37963 A MA 37963A MA 37963 A1 MA37963 A1 MA 37963A1
Authority
MA
Morocco
Prior art keywords
treat
fusion proteins
metabolic syndrome
fusion protein
adiposity
Prior art date
Application number
MA37963A
Other languages
English (en)
Inventor
Oliver Boscheinen
Matthias Dreyer
Paul Habermann
Hans-Ludwig Schaefer
Mark Sommerfeld
Thomas Langer
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46888349&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA37963(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of MA37963A1 publication Critical patent/MA37963A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57563—Vasoactive intestinal peptide [VIP]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/90—Fusion polypeptide containing a motif for post-translational modification

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

L'invention concerne une protéine de fusion comprenant au moins un composé fgf-21 (facteur 21 de croissance fibroblastique) et au moins un agoniste de glp-1r (récepteur du peptide 1 de type glucagon), ainsi que des compositions pharmaceutiques, des utilisations médicales et des méthodes de traitement impliquant la protéine de fusion, en particulier dans le domaine du diabète, de la dyslipidémie, de l'obésité et/ou de l'adiposité.
MA37963A 2012-09-07 2013-09-04 Protéines de fusion pour traiter un syndrome métabolique MA37963A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12306072 2012-09-07
PCT/EP2013/068239 WO2014037373A1 (fr) 2012-09-07 2013-09-04 Protéines de fusion pour traiter un syndrome métabolique

Publications (1)

Publication Number Publication Date
MA37963A1 true MA37963A1 (fr) 2018-06-29

Family

ID=46888349

Family Applications (1)

Application Number Title Priority Date Filing Date
MA37963A MA37963A1 (fr) 2012-09-07 2013-09-04 Protéines de fusion pour traiter un syndrome métabolique

Country Status (25)

Country Link
US (3) US20140073563A1 (fr)
EP (1) EP2892919A1 (fr)
JP (1) JP2015533483A (fr)
KR (1) KR20150043505A (fr)
CN (1) CN104736558A (fr)
AR (1) AR092456A1 (fr)
AU (1) AU2013311777B2 (fr)
BR (1) BR112015004734A2 (fr)
CA (1) CA2880929A1 (fr)
CL (1) CL2015000379A1 (fr)
CR (1) CR20150149A (fr)
DO (1) DOP2015000020A (fr)
EA (1) EA201590525A1 (fr)
GT (1) GT201500049A (fr)
HK (1) HK1207097A1 (fr)
IL (1) IL237032A0 (fr)
MA (1) MA37963A1 (fr)
MX (1) MX2015002985A (fr)
PE (1) PE20150648A1 (fr)
PH (1) PH12015500194A1 (fr)
SG (1) SG11201500682WA (fr)
TN (1) TN2015000053A1 (fr)
TW (1) TW201414750A (fr)
UY (1) UY35018A (fr)
WO (1) WO2014037373A1 (fr)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008121563A2 (fr) 2007-03-30 2008-10-09 Ambrx, Inc. Polypeptides fgf-21 modifiés, et leurs utilisations
ES2748038T3 (es) 2011-07-01 2020-03-12 Ngm Biopharmaceuticals Inc Composiciones, usos y métodos para el tratamiento de trastornos y enfermedades metabólicos
AU2013352363B2 (en) 2012-11-28 2018-04-12 Ngm Biopharmaceuticals, Inc. Compositions and methods for treatment of metabolic disorders and diseases
US9290557B2 (en) 2012-11-28 2016-03-22 Ngm Biopharmaceuticals, Inc. Compositions comprising variants and fusions of FGF19 polypeptides
US9273107B2 (en) 2012-12-27 2016-03-01 Ngm Biopharmaceuticals, Inc. Uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases
SG11201504815QA (en) 2012-12-27 2015-07-30 Ngm Biopharmaceuticals Inc Methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases
RU2707531C2 (ru) 2013-10-28 2019-11-27 ЭнДжиЭм БАЙОФАРМАСЬЮТИКАЛЗ, ИНК. Модели рака и соответствующие способы
MY191944A (en) 2014-01-24 2022-07-20 Ngm Biopharmaceuticals Inc Binding proteins and methods of use thereof
JP6712230B2 (ja) 2014-03-11 2020-06-17 ノバルティス アーゲー リポジストロフィーおよびインスリン産生の欠損またはインスリンシグナル伝達の欠損と関連する代謝性障害を処置する方法
US10398758B2 (en) 2014-05-28 2019-09-03 Ngm Biopharmaceuticals, Inc. Compositions comprising variants of FGF19 polypeptides and uses thereof for the treatment of hyperglycemic conditions
EP3155005A4 (fr) 2014-06-16 2018-07-11 NGM Biopharmaceuticals, Inc. Procédés et utilisations pour la modulation de l'homéostasie de l'acide biliaire et le traitement de troubles et maladies de l'acide biliaire
CN106687460B (zh) * 2014-07-29 2019-05-17 深圳君圣泰生物技术有限公司 小檗碱盐、熊去氧胆酸盐、相关复方及其制备方法和应用
RU2729161C2 (ru) 2014-10-23 2020-08-04 ЭнДжиЭм БАЙОФАРМАСЬЮТИКАЛЗ, ИНК. Фармацевтические композиции, содержащие варианты пептидов, и способы их применения
EP3412302B1 (fr) 2014-10-24 2021-05-12 Bristol-Myers Squibb Company Polypeptides fgf-21 modifiées et leurs utilisations
US10434144B2 (en) 2014-11-07 2019-10-08 Ngm Biopharmaceuticals, Inc. Methods for treatment of bile acid-related disorders and prediction of clinical sensitivity to treatment of bile acid-related disorders
CA2972128A1 (fr) * 2014-12-23 2016-06-30 Novo Nordisk A/S Derives de fgf21 et utilisations de ceux-ci
CN110204617B (zh) * 2014-12-31 2023-06-16 天境生物科技(上海)有限公司 含胰高血糖素样肽-1和免疫球蛋白杂合Fc的融合多肽及其用途
WO2017019957A2 (fr) 2015-07-29 2017-02-02 Ngm Biopharmaceuticals, Inc. Protéines de liaison et leurs procédés d'utilisation
US11458205B2 (en) 2015-08-04 2022-10-04 Duke University Genetically encoded intrinsically disordered stealth polymers for delivery and methods of using same
KR102670157B1 (ko) * 2015-10-28 2024-05-29 주식회사유한양행 이중 작용 단백질 및 이를 포함하는 약학적 조성물
CA3082794A1 (fr) 2015-11-09 2017-05-18 Ngm Biopharmaceuticals Inc. Methodes de traitement de troubles associes aux acides biliaires
US11752213B2 (en) 2015-12-21 2023-09-12 Duke University Surfaces having reduced non-specific binding and antigenicity
AU2017207862B2 (en) 2016-01-13 2020-12-17 Novo Nordisk A/S EGF(A) analogues with fatty acid substituents
AU2017258242B2 (en) * 2016-04-29 2024-04-04 Novozymes A/S Treatment of liver, biliary tract and pancreatic disorders
WO2017210476A1 (fr) 2016-06-01 2017-12-07 Duke University Biocapteurs ne s'encrassant pas
WO2018032638A1 (fr) 2016-08-19 2018-02-22 安源医药科技（上海）有限公司 Peptide de liaison pour la construction d'une protéine de fusion
CN107759694B (zh) 2016-08-19 2023-01-13 安源医药科技（上海）有限公司 双特异性抗体及其制备方法与用途
CN106279437B (zh) 2016-08-19 2017-10-31 安源医药科技（上海）有限公司 高糖基化人凝血因子viii融合蛋白及其制备方法与用途
US11370841B2 (en) 2016-08-26 2022-06-28 Ngm Biopharmaceuticals, Inc. Methods of treating fibroblast growth factor 19-mediated cancers and tumors
US11155584B2 (en) 2016-09-23 2021-10-26 Duke University Unstructured non-repetitive polypeptides having LCST behavior
AU2017382038A1 (en) * 2016-12-22 2019-08-08 Sanofi FGF21 compound / GLP-1R agonist combinations with optimized activity ratio
US11648200B2 (en) 2017-01-12 2023-05-16 Duke University Genetically encoded lipid-polypeptide hybrid biomaterials that exhibit temperature triggered hierarchical self-assembly
CN108440668A (zh) * 2017-02-16 2018-08-24 瑞阳(苏州)生物科技有限公司 Fgf21与igf-1的融合蛋白及其应用
EP3596130A4 (fr) * 2017-03-14 2020-12-30 Sunshine Lake Pharma Co., Ltd. Protéines de fusion à double cible comprenant la partie fc d'une immunoglobuline
WO2018194413A1 (fr) 2017-04-21 2018-10-25 Yuhan Corporation Procédé de production de protéines à double fonction et ses dérivés
US11554097B2 (en) 2017-05-15 2023-01-17 Duke University Recombinant production of hybrid lipid-biopolymer materials that self-assemble and encapsulate agents
WO2019006374A1 (fr) 2017-06-30 2019-01-03 Duke University Ordre et désordre en tant que principe de conception pour des réseaux de biopolymère sensibles à des stimuli
AR112760A1 (es) 2017-07-19 2019-12-11 Novo Nordisk As Compuestos bifuncionales que comprenden un análogo de glp-1 y un análogo de egf(a)
WO2019060653A1 (fr) 2017-09-22 2019-03-28 Regeneron Pharmaceuticals, Inc. Agonistes du récepteur glp-1 (glucagon-like peptide 1) et leurs utilisations
DK3707261T3 (da) * 2017-11-06 2022-07-11 Thena Biotech S R L Fusionsproteiner baseret på humant ferritin og protease-spaltbare peptider og deres anvendelse som kemoterapi-bærestoffer
CN109836504B (zh) * 2017-11-24 2022-08-02 浙江道尔生物科技有限公司 一种治疗代谢疾病的多结构域活性蛋白
CN109929806B (zh) 2017-12-19 2020-05-08 北京吉源生物科技有限公司 一种表达glp1和fgf21的干细胞及其用途
CN113603794B (zh) * 2018-01-11 2024-01-16 安源医药科技（上海）有限公司 用于调节血糖和脂质的增效型双功能蛋白
US11679143B2 (en) * 2018-02-08 2023-06-20 Sunshine Lake Pharma Co., Ltd. FGF21 variant, fusion protein and application thereof
EP3810183A1 (fr) * 2018-06-21 2021-04-28 Sanofi Combinaisons associant le composé fgf21 et un agoniste du glp-1r selon un rapport optimisant leur activité
WO2020028806A1 (fr) * 2018-08-02 2020-02-06 Duke University Protéines de fusion à double agoniste
CN109836486B (zh) * 2019-01-30 2020-09-08 北京双因生物科技有限公司 成纤维生长因子21变体、其融合蛋白及其用途
CN111944055B (zh) * 2019-05-16 2022-08-02 浙江道尔生物科技有限公司 一种治疗代谢疾病的融合蛋白
US11512314B2 (en) 2019-07-12 2022-11-29 Duke University Amphiphilic polynucleotides
WO2021136223A1 (fr) 2019-12-31 2021-07-08 Beijing Ql Biopharmaceutical Co., Ltd. Protéines de fusion de glp-1 et de gdf15 et leurs conjugués
WO2021139744A1 (fr) 2020-01-11 2021-07-15 Beijing Ql Biopharmaceutical Co., Ltd. Conjugués de protéines de fusion du glp-1 et du fgf21
US11981718B2 (en) 2020-05-27 2024-05-14 Ampsource Biopharma Shanghai Inc. Dual-function protein for lipid and blood glucose regulation
CN113735977A (zh) * 2020-05-28 2021-12-03 江苏康缘瑞翱生物医药科技有限公司 rhFGF21融合蛋白、编码其的多核苷酸、包含其组合物及其用途
US12054551B2 (en) 2020-07-02 2024-08-06 Sanofi FGFR1/KLB targeting agonistic antigen-binding proteins and conjugates thereof with GLP-1R agonistic peptides
TW202216747A (zh) * 2020-07-10 2022-05-01 南韓商Ｇｉ醫諾微新股份有限公司 包含類升糖素胜肽—１及介白素—１受體拮抗物的融合蛋白及其用途
WO2022117044A1 (fr) * 2020-12-03 2022-06-09 Sunshine Lake Pharma Co., Ltd. Polypeptide agoniste du récepteur double glp-1/gcg et sa protéine de fusion
TWI837615B (zh) * 2021-03-23 2024-04-01 美商美國禮來大藥廠 含腸促胰島素(incretin)類似物之組合物及其用途
CN113150172B (zh) * 2021-04-28 2023-09-22 中国药科大学 Glp-1r/gipr双靶点激动剂融合蛋白及其制备方法与应用
US20240245791A1 (en) * 2021-06-02 2024-07-25 Arizona Board Of Regents On Behalf Of The University Of Arizona Methods and compositions for localization of growth factors
CA3224743A1 (fr) * 2021-07-14 2023-01-19 Beijing Ql Biopharmaceutical Co., Ltd. Polypeptides de fusion pour troubles metaboliques
CN113583142A (zh) * 2021-08-20 2021-11-02 赣江中药创新中心 双靶点融合蛋白、编码基因、载体或宿主细胞及其应用与表达和纯化方法
WO2023049631A2 (fr) * 2021-09-09 2023-03-30 Northwestern University Procédés et compositions acellulaires comprenant des hormones thérapeutiques sans marqueur
WO2024064842A1 (fr) 2022-09-21 2024-03-28 Regeneron Pharmaceuticals, Inc. Méthodes de traitement de l'obésité, du diabète et de la dysfonction hépatique
WO2024097875A1 (fr) * 2022-11-02 2024-05-10 Shattuck Labs, Inc. Protéines de fusion pour le traitement de la stéatohépatite non alcoolique
CN115991793A (zh) * 2023-01-16 2023-04-21 上海民为生物技术有限公司 具有多重活性的融合蛋白及其应用
WO2024165571A2 (fr) 2023-02-06 2024-08-15 E-Therapeutics Plc Inhibiteurs d'expression et/ou de fonction
CN117801124A (zh) * 2024-02-29 2024-04-02 天津凯莱英生物科技有限公司 利西那肽前体的融合蛋白及其应用
CN117801125B (zh) * 2024-02-29 2024-05-24 天津凯莱英生物科技有限公司 艾塞那肽前体的融合蛋白及其应用

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03219892A (ja) * 1990-01-24 1991-09-27 Kyowa Hakko Kogyo Co Ltd タンパク質の製造法
GB9725556D0 (en) * 1997-12-03 1998-02-04 Ciba Geigy Ag Organic compounds
EP1141013A2 (fr) * 1999-01-07 2001-10-10 Lexigen Pharmaceuticals Corp. EXPRESSION ET EXPORTATION DE PROTEINES ANTI-OBESITE SOUS FORME DE PROTEINES HYBRIDE Fc
US7754208B2 (en) * 2001-01-17 2010-07-13 Trubion Pharmaceuticals, Inc. Binding domain-immunoglobulin fusion proteins
US7138370B2 (en) * 2001-10-11 2006-11-21 Amgen Inc. Specific binding agents of human angiopoietin-2
CN1480466A (zh) * 2002-09-03 2004-03-10 �й������ž�����ҽѧ��ѧԺ����ҽ 一类溶栓抗凝双功能融合蛋白及应用
CN1993378A (zh) * 2004-08-03 2007-07-04 转化技术制药公司 Rage融合蛋白及使用方法
SG176459A1 (en) * 2005-07-05 2011-12-29 Univ California Polynucleotides encoding isoprenoid modifying enzymes and methods of use thereof
US7625564B2 (en) * 2006-01-27 2009-12-01 Novagen Holding Corporation Recombinant human EPO-Fc fusion proteins with prolonged half-life and enhanced erythropoietic activity in vivo
US7825093B2 (en) * 2006-10-25 2010-11-02 Amgen Inc. Methods of using OSK1 peptide analogs
JP2010535781A (ja) * 2007-08-03 2010-11-25 イーライ リリー アンド カンパニー 肥満に対する処置
AU2008287340A1 (en) * 2007-08-15 2009-02-19 Amunix, Inc. Compositions and methods for modifying properties of biologically active polypeptides
NZ593833A (en) * 2009-02-03 2013-10-25 Amunix Operating Inc Extended recombinant polypeptides and compositions comprising same
CN101993485B (zh) * 2009-08-20 2013-04-17 重庆富进生物医药有限公司 促胰岛素分泌肽类似物同源二聚体及其用途
JP2013507926A (ja) * 2009-10-14 2013-03-07 メリマック ファーマシューティカルズ インコーポレーティッド ＩＧＦ−１Ｒ及びＥｒｂＢ３シグナル伝達を標的とする二重特異的結合剤及びその使用
WO2011084808A2 (fr) * 2009-12-21 2011-07-14 Amunix Operating Inc. Compositions de polypeptides bifonctionnels et procédés pour le traitement de maladies métaboliques et cardiovasculaires
EP2460527A1 (fr) * 2010-01-21 2012-06-06 Sanofi Composition pharmaceutique pour le traitement d'un syndrome métabolique
AU2011350066A1 (en) * 2010-12-27 2013-07-11 Alexion Pharma International Sarl Compositions comprising natriuretic peptides and methods of use thereof
UY34347A (es) * 2011-09-26 2013-04-30 Novartis Ag Proteínas de función dual para tratar trastornos metabólicos
US9676857B2 (en) * 2012-03-16 2017-06-13 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Soluble engineered monomeric Fc

Also Published As

Publication number Publication date
US20160194371A1 (en) 2016-07-07
MX2015002985A (es) 2015-06-22
EA201590525A1 (ru) 2015-07-30
TW201414750A (zh) 2014-04-16
JP2015533483A (ja) 2015-11-26
AU2013311777B2 (en) 2018-02-01
GT201500049A (es) 2016-02-15
EP2892919A1 (fr) 2015-07-15
US20140073563A1 (en) 2014-03-13
CR20150149A (es) 2015-05-29
PH12015500194A1 (en) 2015-04-20
US20190085043A1 (en) 2019-03-21
DOP2015000020A (es) 2015-04-15
AR092456A1 (es) 2015-04-22
CA2880929A1 (fr) 2014-03-13
KR20150043505A (ko) 2015-04-22
TN2015000053A1 (en) 2016-06-29
CN104736558A (zh) 2015-06-24
IL237032A0 (en) 2015-03-31
PE20150648A1 (es) 2015-05-25
AU2013311777A1 (en) 2015-03-19
WO2014037373A1 (fr) 2014-03-13
BR112015004734A2 (pt) 2017-11-21
SG11201500682WA (en) 2015-02-27
CL2015000379A1 (es) 2015-06-05
UY35018A (es) 2014-03-31
HK1207097A1 (en) 2016-01-22

Similar Documents

Publication Publication Date Title
MA37963A1 (fr) Protéines de fusion pour traiter un syndrome métabolique
EA201290964A1 (ru) Пептидные конъюгаты агонистов рецептора glp-1 и их применение
EA201492053A1 (ru) Белки фактора роста фибробластов 21
MA35458B1 (fr) Variants du facteur de croissance des fibroblastes 21
EA201491644A1 (ru) Фармацевтические композиции
MA46219B1 (fr) Composés de co-agonistes du glucagon et du glp-1
EA201270815A1 (ru) Модуляторы рецепторов эстрогена и их применение
EA201792047A1 (ru) Новые соединения
EA201201047A1 (ru) Способы и композиции, в которых применяют слитые полипептиды fgf 23
EA201492064A1 (ru) Варианты фактора роста фибробластов 21
EA201101524A1 (ru) Способ и композиция для лечения состояния, связанного с хемосенсорным рецептором
MA38406A1 (fr) Virus de la maladie de newcastle et leurs utilisations
EA201100062A1 (ru) Соединения и способы модулирования рецепторов, связанных с белком g
EA201591176A1 (ru) Композиции и способы с использованием пептидной метки, связывающейся с гиалуронаном
EA201491530A1 (ru) Модуляторы рецепторов эстрогенов и их применение
EA033373B1 (ru) Композиции на водной основе, предварительно наполненный шприц, их применения и способ доставки гипофукозилированного или нефукозилированного антитела против baffr млекопитающему
EP2560660A4 (fr) Thérapies à base de ligands de récepteurs chimiosensibles
EA201370081A1 (ru) Антитела к cd48 и их применение
EA201270720A1 (ru) Модуляторы рецептора андрогенов и их применение
MX2014003579A (es) Peptidos de la superfamilia de glucagon que presentan actividad del receptor de glucocorticoide.
PE20161032A1 (es) Anticuerpos anti-tau(ps422) humanizados y metodos de utilizacion
EA201690064A1 (ru) Антитела к лектин-подобному рецептору 1 окисленных ldl и способы применения
EA201291167A1 (ru) Замещенные гетероциклилбензилпиразолы и их применение
EA201490790A1 (ru) Пептидные конъюгаты агониста рецептора гастрина и глюкагон подобного пептида 1
EA201190209A1 (ru) Соединения для лечения метаболических расстройств