MA35455B1 - (wo2013045407) dérivés d'estra-1,3,5(10),16-tétraène-3-carboxamide, procédé pour leur fabrication, préparations pharmaceutiques contenant ces substances ainsi que leur utilisation dans la fabrication de médicaments - Google Patents

(wo2013045407) dérivés d'estra-1,3,5(10),16-tétraène-3-carboxamide, procédé pour leur fabrication, préparations pharmaceutiques contenant ces substances ainsi que leur utilisation dans la fabrication de médicaments

Info

Publication number
MA35455B1
MA35455B1 MA36857A MA36857A MA35455B1 MA 35455 B1 MA35455 B1 MA 35455B1 MA 36857 A MA36857 A MA 36857A MA 36857 A MA36857 A MA 36857A MA 35455 B1 MA35455 B1 MA 35455B1
Authority
MA
Morocco
Prior art keywords
manufacture
medicaments
estra
tetraene
carboxamide
Prior art date
Application number
MA36857A
Other languages
English (en)
Inventor
Ulrich Bothe
Naomi Barak
Matthias Busemann
Oliver Martin Fischer
Andrea Rotgeri
Isabella Gashaw
Ingo Hartung
Tobias Marquardt
Original Assignee
Bayer Ip Gmbh
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46963705&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA35455(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Ip Gmbh, Bayer Pharma AG filed Critical Bayer Ip Gmbh
Publication of MA35455B1 publication Critical patent/MA35455B1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J43/00Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/08Antiseborrheics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/10Anti-acne agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/14Drugs for dermatological disorders for baldness or alopecia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32Antioestrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne des inhibiteurs d'akr1c3 et le procédé pour leur fabrication, leur utilisation dans le traitement et/ou la prévention de maladies ainsi que leur utilisation dans la fabrication de médicaments pour le traitement et/ou la prévention de maladies, notamment de troubles hémorragiques et de l'endométriose.
MA36857A 2011-09-29 2014-03-27 (wo2013045407) dérivés d'estra-1,3,5(10),16-tétraène-3-carboxamide, procédé pour leur fabrication, préparations pharmaceutiques contenant ces substances ainsi que leur utilisation dans la fabrication de médicaments MA35455B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102011083725A DE102011083725A1 (de) 2011-09-29 2011-09-29 Estra-1,3,5(10),16-tetraen-3-carboxamid-Derivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate die diese enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln
PCT/EP2012/068803 WO2013045407A1 (fr) 2011-09-29 2012-09-24 Dérivés d'estra-1,3,5(10),16-tétraène-3-carboxamide, procédé pour leur fabrication, préparations pharmaceutiques contenant ces substances ainsi que leur utilisation dans la fabrication de médicaments

Publications (1)

Publication Number Publication Date
MA35455B1 true MA35455B1 (fr) 2014-09-01

Family

ID=46963705

Family Applications (1)

Application Number Title Priority Date Filing Date
MA36857A MA35455B1 (fr) 2011-09-29 2014-03-27 (wo2013045407) dérivés d'estra-1,3,5(10),16-tétraène-3-carboxamide, procédé pour leur fabrication, préparations pharmaceutiques contenant ces substances ainsi que leur utilisation dans la fabrication de médicaments

Country Status (42)

Country Link
US (1) US9487554B2 (fr)
EP (1) EP2760878B1 (fr)
JP (1) JP5791810B2 (fr)
KR (1) KR20140069013A (fr)
CN (1) CN103827133B (fr)
AP (1) AP2014007598A0 (fr)
AR (1) AR088180A1 (fr)
AU (1) AU2012314627B2 (fr)
BR (1) BR112014007223A2 (fr)
CA (1) CA2850047C (fr)
CL (1) CL2014000775A1 (fr)
CO (1) CO6920294A2 (fr)
CR (1) CR20140144A (fr)
CU (1) CU20140037A7 (fr)
CY (1) CY1117123T1 (fr)
DE (1) DE102011083725A1 (fr)
DK (1) DK2760878T3 (fr)
DO (1) DOP2014000059A (fr)
EA (1) EA025518B9 (fr)
EC (1) ECSP14013275A (fr)
ES (1) ES2560257T3 (fr)
GT (1) GT201400059A (fr)
HK (1) HK1197414A1 (fr)
HR (1) HRP20160050T1 (fr)
HU (1) HUE026645T2 (fr)
IL (1) IL231755A (fr)
JO (1) JO3122B1 (fr)
MA (1) MA35455B1 (fr)
MX (1) MX2014003823A (fr)
MY (1) MY175804A (fr)
PE (1) PE20141554A1 (fr)
PL (1) PL2760878T3 (fr)
PT (1) PT2760878E (fr)
RS (1) RS54521B1 (fr)
SG (1) SG11201400144SA (fr)
SI (1) SI2760878T1 (fr)
TN (1) TN2014000131A1 (fr)
TW (1) TWI537284B (fr)
UA (1) UA107550C2 (fr)
UY (1) UY34356A (fr)
WO (1) WO2013045407A1 (fr)
ZA (1) ZA201401568B (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104428309B (zh) * 2012-07-10 2016-09-14 拜耳医药股份有限公司 3-取代的雌甾-1,3,5(10),16-四烯衍生物、其制备方法、包含其的药物制剂及其用于制备药物的用途
PE20151754A1 (es) 2013-02-21 2015-12-20 Bayer Pharma AG Estra-1,3,5(10),16-tetraeno-3-carboxamidas para la inhibicion de la 17b-hidroxiesteroide deshidrogenasa (akr1 c3)
WO2016037956A1 (fr) * 2014-09-11 2016-03-17 Bayer Pharma Aktiengesellschaft Inhibiteurs d'akr1c3 de type œstra-1,3,5(10),16-tétraène substitués par un 3-azote ou soufre
US10167293B2 (en) 2016-05-26 2019-01-01 Bayer Pharma Aktiengesellschaft [8-(phenylsulfonyl)-3,8-diazabicyclo[3.2.1]oct-3-yl](1H-1,2,3-triazol-4-yl)methanones
CZ307437B6 (cs) 2016-06-07 2018-08-22 Ăšstav organickĂ© chemie a biochemie AV ÄŚR, v.v.i. 15β-substituované deriváty estronu jako selektivní inhibitory 17β-hydroxysteoiddehydrogenáz
EP3269373A1 (fr) 2016-07-11 2018-01-17 Bayer Pharma Aktiengesellschaft Formes posologiques orales à faible dosage d'un inhibiteur de akr1c3 pour le traitement des maladies
CA3047191A1 (fr) 2016-12-19 2018-06-28 Bayer Pharma Aktiengesellschaft [4-(phenylsulfonyl)piperazin-1-yl](1h-1,2,3-triazol-4-yl)methanones
TW201825478A (zh) 2016-12-19 2018-07-16 德商拜耳製藥公司 [4-(苯基磺醯基)哌嗪-1--基](1h-1,2,3-三唑-4-基)甲酮
CA3047196A1 (fr) 2016-12-19 2018-06-28 Bayer Pharma Aktiengesellschaft [(phenylsulfonyl)octahydro-epiminoisoindol-yl](1h-1,2,3-triazol-5-yl)methanones
EP3421483A1 (fr) 2017-06-29 2019-01-02 Bayer Pharma Aktiengesellschaft Nouveaux dérivés 17-beta-hétéroaryle des stéroïdes comme inhibiteurs de akr1c3
CN108503695B (zh) * 2018-03-09 2021-06-08 南方医科大学南方医院 基于GnRH多肽衍生物的示踪剂及其制备方法和应用
CN110693892A (zh) * 2018-07-09 2020-01-17 深圳艾欣达伟医药科技有限公司 化合物用于制备预防、治疗或改善疼痛的药物的用途
CN113683648A (zh) * 2021-08-26 2021-11-23 上海皓鸿生物医药科技有限公司 一种2’-氟-2’-脱氧尿苷的合成方法及其中间体

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4632003A (en) 1985-07-15 1986-12-30 Kopp William L Musical instrument sound quality enhancement device
US5604213A (en) 1992-03-31 1997-02-18 British Technology Group Limited 17-substituted steroids useful in cancer treatment
AU668144B2 (en) * 1992-03-31 1996-04-26 Btg International Limited 17-substituted steroids useful in cancer treatment
RU2000125533A (ru) 1998-03-11 2002-10-20 Эндорешерш, Инк. (Ca) Ингибиторы 17-бета-гидроксистероиддегидрогеназ 5 и 3 типа и способы их применения
WO2005089256A2 (fr) * 2004-03-12 2005-09-29 Entremed, Inc. Agents anti-angiogeniques
JP5264760B2 (ja) * 2006-11-30 2013-08-14 アボット プロダクツ ゲゼルシャフト ミット ベシュレンクテル ハフツング 17β−HSDインヒビターとしての置換エストラトリエン誘導体
GB2470700B (en) 2008-03-25 2012-08-08 Univ Maryland C-17 heteroaryl steroidal CYP17 inhibitors
CN102686600A (zh) 2009-02-05 2012-09-19 托凯药业股份有限公司 甾体cyp17抑制剂/抗雄激素物质的新型药物前体
US8962602B2 (en) 2010-04-27 2015-02-24 Pharma Mar, S.A. Anticancer steroidal lactones unsaturated in position 7 (8)

Also Published As

Publication number Publication date
WO2013045407A1 (fr) 2013-04-04
EA025518B9 (ru) 2017-10-31
TW201317253A (zh) 2013-05-01
RS54521B1 (en) 2016-06-30
AU2012314627B2 (en) 2016-08-18
HRP20160050T1 (hr) 2016-02-12
UY34356A (es) 2013-04-30
CN103827133A (zh) 2014-05-28
KR20140069013A (ko) 2014-06-09
EP2760878A1 (fr) 2014-08-06
MY175804A (en) 2020-07-09
PL2760878T3 (pl) 2016-04-29
IL231755A (en) 2016-06-30
MX2014003823A (es) 2014-06-04
SI2760878T1 (sl) 2016-02-29
AU2012314627A1 (en) 2014-04-10
DK2760878T3 (en) 2016-01-25
HUE026645T2 (en) 2016-07-28
TN2014000131A1 (en) 2015-07-01
DOP2014000059A (es) 2014-06-15
JP5791810B2 (ja) 2015-10-07
CO6920294A2 (es) 2014-04-10
ZA201401568B (en) 2016-11-30
PE20141554A1 (es) 2014-10-24
ES2560257T3 (es) 2016-02-18
DE102011083725A1 (de) 2013-04-04
CL2014000775A1 (es) 2014-08-18
SG11201400144SA (en) 2014-05-29
TWI537284B (zh) 2016-06-11
PT2760878E (pt) 2016-02-26
NZ622081A (en) 2015-10-30
HK1197414A1 (zh) 2015-01-16
JP2014527994A (ja) 2014-10-23
US9487554B2 (en) 2016-11-08
JO3122B1 (ar) 2017-09-20
GT201400059A (es) 2015-02-17
CN103827133B (zh) 2015-11-25
EP2760878B1 (fr) 2015-10-28
EA201490653A1 (ru) 2014-09-30
UA107550C2 (uk) 2015-01-12
CA2850047A1 (fr) 2013-04-04
AP2014007598A0 (en) 2014-04-30
US20140249119A1 (en) 2014-09-04
CR20140144A (es) 2014-05-16
AR088180A1 (es) 2014-05-14
CA2850047C (fr) 2016-03-29
BR112014007223A2 (pt) 2017-04-04
CY1117123T1 (el) 2017-04-05
EA025518B1 (ru) 2016-12-30
CU20140037A7 (es) 2014-07-30
ECSP14013275A (es) 2014-04-30

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