MA20499A1 - Derives d'indole - Google Patents

Derives d'indole

Info

Publication number
MA20499A1
MA20499A1 MA20725A MA20725A MA20499A1 MA 20499 A1 MA20499 A1 MA 20499A1 MA 20725 A MA20725 A MA 20725A MA 20725 A MA20725 A MA 20725A MA 20499 A1 MA20499 A1 MA 20499A1
Authority
MA
Morocco
Prior art keywords
indole derivatives
indole
derivatives
Prior art date
Application number
MA20725A
Other languages
English (en)
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10564759&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA20499(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of MA20499A1 publication Critical patent/MA20499A1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D203/00Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/04Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D203/06Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D203/08Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom
    • C07D203/14Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom with carbocyclic rings directly attached to the ring nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/08Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12Radicals substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16Tryptamines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
MA20725A 1984-08-01 1985-08-01 Derives d'indole MA20499A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848419575A GB8419575D0 (en) 1984-08-01 1984-08-01 Chemical compounds

Publications (1)

Publication Number Publication Date
MA20499A1 true MA20499A1 (fr) 1986-04-01

Family

ID=10564759

Family Applications (1)

Application Number Title Priority Date Filing Date
MA20725A MA20499A1 (fr) 1984-08-01 1985-08-01 Derives d'indole

Country Status (42)

Country Link
US (1) US5037845A (fr)
JP (1) JPH0623197B2 (fr)
KR (1) KR930003759B1 (fr)
AT (1) AT386196B (fr)
AU (1) AU573878B2 (fr)
BE (1) BE903006A (fr)
CA (1) CA1241004A (fr)
CH (1) CH666026A5 (fr)
CZ (1) CZ280530B6 (fr)
DE (1) DE3527648A1 (fr)
DK (1) DK158942C (fr)
DO (1) DOP1989004759A (fr)
EC (1) ECSP941096A (fr)
EG (1) EG17283A (fr)
ES (6) ES8700234A1 (fr)
FI (1) FI78466C (fr)
FR (1) FR2568571B1 (fr)
GB (1) GB8419575D0 (fr)
GR (1) GR851850B (fr)
HK (1) HK33289A (fr)
HU (1) HU201738B (fr)
IE (1) IE58122B1 (fr)
IL (1) IL75986A (fr)
IS (1) IS1430B6 (fr)
IT (1) IT1207325B (fr)
JO (1) JO1379B1 (fr)
KE (1) KE3858A (fr)
LU (2) LU86032A1 (fr)
MA (1) MA20499A1 (fr)
MX (2) MX159672A (fr)
NL (2) NL188642C (fr)
NO (2) NO164653C (fr)
NZ (1) NZ212948A (fr)
PH (2) PH22850A (fr)
PL (1) PL146005B1 (fr)
PT (1) PT80900B (fr)
SE (1) SE452460B (fr)
SK (1) SK277952B6 (fr)
SU (1) SU1498386A3 (fr)
UA (1) UA6329A1 (fr)
ZA (1) ZA855818B (fr)
ZW (1) ZW12485A1 (fr)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
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US5270333A (en) * 1986-01-28 1993-12-14 Glaxo Group Limited Indole derivatives
US5155218A (en) 1990-05-08 1992-10-13 Neurogenetic Corporation Dna encoding human 5-ht1d receptors
US5935925A (en) * 1990-05-08 1999-08-10 Synaptic Pharmaceutical Corporation Methods of treating migraine and compounds useful for such methods
GB9013845D0 (en) * 1990-06-21 1990-08-15 Glaxo Group Ltd Process
GB9022250D0 (en) * 1990-10-12 1990-11-28 Glaxo Group Ltd Medicaments
GB9101592D0 (en) * 1991-01-24 1991-03-06 Glaxo Group Ltd Compositions
GB9102579D0 (en) * 1991-01-24 1991-03-27 Glaxo Group Ltd Compositions
SK278998B6 (sk) * 1991-02-01 1998-05-06 Merck Sharp & Dohme Limited Deriváty imidazolu, triazolu a tetrazolu, spôsob i
GB9104890D0 (en) 1991-03-08 1991-04-24 Glaxo Group Ltd Compositions
AT399870B (de) * 1991-06-06 1995-08-25 Vita Invest Sa Verfahren zur herstellung von 3-(2-(dimethylamino)ethyl)-n-methyl-1h-indol-5- ethansulfonamid
GB9209882D0 (en) * 1992-05-07 1992-06-24 Glaxo Lab Sa Compositions
ES2059236B1 (es) * 1992-06-18 1995-06-16 Imidex S A Procedimiento para la sintesis de la 3-(2-dimetilamino) etil)-n-metil-1h-indol-5-metanosulfonamida.
ES2055651B1 (es) * 1992-07-20 1995-03-01 Vita Invest Sa Procedimiento para la obtencion de nuevas amidinas derivadas de 3-aminoetilindoles.
IL106445A (en) * 1992-07-30 1998-01-04 Merck Sharp & Dohme History of 1,2,4-Trans-Triazole 4-Transform, Preparation and Pharmaceutical Preparations Containing Them
AT399871B (de) * 1993-02-15 1995-08-25 Vita Invest Sa Verfahren zur herstellung von 2-carboxy-3-(2- (dimethylamino)ethyl)-n-methyl-1h-indol-5- methansulfonamid und dessen niederalkylestern
US5807571A (en) * 1993-05-06 1998-09-15 Lts Lohmann Therapie-Systeme Gmbh Transdermal therapeutic systems for administering indole serotonin agonists
GB9401436D0 (en) * 1994-01-26 1994-03-23 Wellcome Found Therapeutic heterocyclic compounds
ES2084560B1 (es) * 1994-03-09 1997-01-16 Almirall Lab Procedimiento de preparacion de derivados el indol.
ES2079323B1 (es) * 1994-06-21 1996-10-16 Vita Invest Sa Derivados de indol utiles para el tratamiento de la migraña, composicion y uso correspondientes.
EP0804434A1 (fr) * 1994-08-02 1997-11-05 MERCK SHARP & DOHME LTD. Derives de l'azetidine, de la pyrrolidine et de la piperidine
US5521197A (en) 1994-12-01 1996-05-28 Eli Lilly And Company 3-<1-alkylenearyl>-4-<1,2,3,6-tetrahydropyridinyl>-and 3-<1-alkylenearyl>-4-piperidinyl-1h-indoles: new 5-HT1F agonists
US8022095B2 (en) 1996-08-16 2011-09-20 Pozen, Inc. Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
AU4074897A (en) * 1996-09-18 1998-04-14 Eli Lilly And Company A method for the prevention of migraine
WO1998015545A1 (fr) * 1996-10-08 1998-04-16 Eli Lilly And Company Nouveaux agonistes de la serotonine 5-ht¿1f?
GB9714383D0 (en) * 1997-07-08 1997-09-10 Pfizer Ltd Improved process
US6066092A (en) * 1997-11-06 2000-05-23 Cady; Roger K. Preemptive prophylaxis of migraine device and method
US6416472B1 (en) 1997-11-06 2002-07-09 Edus Inc. Method and device for measuring cognitive efficiency
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
AT500063A1 (de) * 1999-11-23 2005-10-15 Sandoz Ag Beschichtete tablettenkerne
NZ528377A (en) * 2001-03-27 2005-05-27 Galen Chemicals Ltd Intravaginal drug delivery devices for the administration of an antimicrobial agent
US20030013753A1 (en) * 2001-06-05 2003-01-16 Ronald Aung-Din Transdermal migraine therapy
US8329734B2 (en) 2009-07-27 2012-12-11 Afgin Pharma Llc Topical therapy for migraine
FR2827287B1 (fr) * 2001-07-13 2003-10-31 Servier Lab Nouveaux derives de benzene sulfonamide, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CA2477088A1 (fr) 2002-02-22 2003-10-02 New River Pharmaceuticals Inc. Systemes de distribution d'agents actifs et methodes de protection et d'administration d'agents actifs
US20060106227A1 (en) * 2002-06-13 2006-05-18 Dr Reddy's Laboratories Limited 3-'2-(Dimethylamino) ethyl!-n-methyl-1h-indole-5-methanesulfonamide and the succinate thereof
US20040068000A1 (en) * 2002-10-02 2004-04-08 Mintong Guo Compression coated tablets
CN1176649C (zh) * 2002-10-16 2004-11-24 上海医药工业研究院 舒马普坦干粉吸入剂及其制备方法
EP1572647B1 (fr) 2002-12-20 2016-09-21 Basf Se Préparation d´amines et de leurs intermédiaires
US20080213363A1 (en) * 2003-01-23 2008-09-04 Singh Nikhilesh N Methods and compositions for delivering 5-HT3 antagonists across the oral mucosa
WO2004076403A1 (fr) * 2003-02-24 2004-09-10 Transform Pharmaceuticals, Inc. Formes cristallines du sumatriptan, compositions pharmaceutiques et procedes
WO2004099141A1 (fr) * 2003-05-12 2004-11-18 Ramesh Babu Potluri Nouveau procede pour la preparation de derives d'indole
BRPI0410807A (pt) * 2003-06-06 2006-06-27 Glaxo Group Ltd composição farmacêutica, e, método pata tratar um mamìfero sofrendo de ou susceptìvel a condições associadas com dor cefálica
EP1644004A4 (fr) * 2003-06-20 2010-10-06 Ronald Aung-Din Therapie locale pour le traitement des migraines, des claquages musculaires, des spasmes musculaires, de la spasticite et d'etats apparentes
GB2407498B (en) * 2003-10-30 2008-06-11 Cipla Ltd Oral formulations for 5-HT receptor agonists with reduced degradation of active ingredient
US20060002989A1 (en) * 2004-06-10 2006-01-05 Ahmed Salah U Formulations of sumatriptan for absorption across biological membranes, and methods of making and using the same
DK1883451T3 (da) 2005-04-13 2011-03-14 Neuraxon Inc Substituerede indolforbindelser med NOS-hæmmende virkning
WO2007070504A2 (fr) * 2005-12-13 2007-06-21 Morton Grove Pharmaceuticals, Inc. Compositions orales liquides de sumatriptan stables et de gout agreable
US7989447B2 (en) * 2006-04-13 2011-08-02 Neuraxon, Inc. 1,5 and 3,6-substituted indole compounds having NOS inhibitory activity
CN101687788A (zh) 2006-10-19 2010-03-31 奥斯拜客斯制药有限公司 取代的吲哚
US20090076121A1 (en) * 2007-09-14 2009-03-19 Protia, Llc Deuterium-enriched sumatriptan
KR20100103799A (ko) * 2007-11-16 2010-09-28 네우렉슨 인코포레이티드 내장통을 치료하기 위한 인돌 화합물 및 방법
EP2220074A4 (fr) * 2007-11-16 2012-01-04 Neuraxon Inc Composés d'indole 3,5-substitués ayant une activité d'inhibition de la réabsorption de la nos et de la noradrénaline
WO2009064505A1 (fr) * 2007-11-16 2009-05-22 The Arizona Board Of Regents On Behalf Of The University Of Arizona Procédés de traitement de la douleur viscérale
WO2009128089A2 (fr) * 2008-02-11 2009-10-22 Matrix Laboratories Limited Nouvelle forme de solvate de succinate de sumatriptan et procédé de préparation d'un sel de sumatriptan l'utilisant
US20090252791A1 (en) * 2008-04-02 2009-10-08 Venkata Nookaraju Sreedharala Pharmaceutical compositions comprising a triptan and a nonsteroidal anti-inflammatory drug
KR101517415B1 (ko) * 2008-05-14 2015-05-07 에스케이바이오팜 주식회사 난용성 항경련제를 함유하는 경비 항경련성 약학 조성물
EP2296652B1 (fr) * 2008-06-30 2017-11-08 Afgin Pharma, Llc Traitement neuro-affectif régional topique
EP2337566A1 (fr) * 2008-10-22 2011-06-29 Novartis AG Combinaisons pour le traitement de la migraine
EP2480197B1 (fr) 2009-09-25 2015-11-11 Dr. Reddy's Laboratories Ltd. Formulations comprenant des composés triptan
US11337962B2 (en) 2009-09-25 2022-05-24 Upsher-Smith Laboratories, Llc Formulations comprising triptan compounds
JP5660817B2 (ja) * 2010-07-21 2015-01-28 高田製薬株式会社 スマトリプタンコハク酸塩を含有する内用液剤
CN102432520B (zh) * 2011-11-21 2013-10-09 山东新华制药股份有限公司 3-[2-(二甲氨基)乙基]-n-甲基吲哚-5-甲烷磺酰胺琥珀酸盐的制备方法
US10716766B2 (en) 2015-03-02 2020-07-21 Afgin Pharma, Llc Topical regional neuro-affective therapy with cannabinoids
US10383816B2 (en) 2015-03-02 2019-08-20 Afgin Pharma, Llc Topical regional neuro-affective therapy with cannabinoid combination products
US20180049994A1 (en) 2016-08-16 2018-02-22 Afgin Pharma, Llc Topical regional neuro-affective therapy with caryophyllene

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DE311728C (fr) *
US3322787A (en) * 1964-09-25 1967-05-30 Merck & Co Inc Alpha-hydrazino-beta-(3-indolyl) alkanoic acid derivatives
IT1036004B (it) * 1968-05-21 1979-10-30 Abc Ist Biolog Chem Spa Acidt 3 indolil adetoidrossamici
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ZA795239B (en) * 1978-10-12 1980-11-26 Glaxo Group Ltd Heterocyclic compounds
FR2488606A1 (fr) * 1980-08-12 1982-02-19 Glaxo Group Ltd Derives indoliques, leur preparation et leurs applications en tant que medicaments
CH651551A5 (fr) * 1980-08-12 1985-09-30 Glaxo Group Ltd Derives de l'indole, leur preparation et compositions pharmaceutiques les contenant.
ZW19381A1 (en) * 1980-08-12 1983-03-09 Glaxo Group Ltd Heterocyclic compounds
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GB8332434D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Production of chemical compounds

Also Published As

Publication number Publication date
KR860001788A (ko) 1986-03-22
CZ280530B6 (cs) 1996-02-14
ES557480A0 (es) 1988-02-16
NL8502171A (nl) 1986-03-03
NZ212948A (en) 1989-05-29
CH666026A5 (fr) 1988-06-30
NL188642C (nl) 1992-08-17
MX159672A (es) 1989-08-02
DE3527648C2 (fr) 1993-08-26
IT8548435A0 (it) 1985-08-01
IS1430B6 (is) 1990-07-16
DK158942B (da) 1990-08-06
FI852969L (fi) 1986-02-02
HU201738B (en) 1990-12-28
PH24117A (en) 1990-03-05
ES552047A0 (es) 1987-12-16
FI78466B (fi) 1989-04-28
DK351185D0 (da) 1985-08-01
MX14221A (es) 1993-10-01
ECSP941096A (es) 1995-01-16
ES8801204A1 (es) 1987-12-16
EG17283A (en) 1992-06-30
US5037845A (en) 1991-08-06
DK351185A (da) 1986-02-02
IE851918L (en) 1986-02-01
HK33289A (en) 1989-04-28
ES8700234A1 (es) 1986-10-16
PL254800A1 (en) 1986-10-21
ES8801900A1 (es) 1988-03-01
IL75986A0 (en) 1985-12-31
BE903006A (fr) 1986-02-03
ES557482A0 (es) 1988-03-01
NL930065I1 (nl) 1993-09-01
PH22850A (en) 1989-01-19
AT386196B (de) 1988-07-11
PT80900A (en) 1985-09-01
SK404191A3 (en) 1995-09-13
SE452460B (sv) 1987-11-30
NO164653C (no) 1990-11-07
DE3527648A1 (de) 1986-02-13
PT80900B (pt) 1987-12-30
FR2568571A1 (fr) 1986-02-07
AU4568985A (en) 1986-02-06
NL930065I2 (nl) 1993-10-01
HUT40077A (en) 1986-11-28
JO1379B1 (en) 1986-11-30
KR930003759B1 (ko) 1993-05-10
ES545810A0 (es) 1986-10-16
FI852969A0 (fi) 1985-08-01
SK277952B6 (en) 1995-09-13
ATA226685A (de) 1987-12-15
CA1241004A (fr) 1988-08-23
ZW12485A1 (en) 1986-02-26
KE3858A (en) 1989-06-02
GR851850B (fr) 1985-11-26
LU88266I2 (fr) 1994-02-03
ES557483A0 (es) 1988-02-16
ES8801789A1 (es) 1988-02-16
SU1498386A3 (ru) 1989-07-30
DOP1989004759A (es) 1999-02-06
NO164653B (no) 1990-07-23
CZ404191A3 (en) 1993-04-14
SE8503680D0 (sv) 1985-08-01
ES8801790A1 (es) 1988-02-16
IL75986A (en) 1989-02-28
FR2568571B1 (fr) 1988-09-23
IT1207325B (it) 1989-05-17
SE8503680L (sv) 1986-02-02
ES557481A0 (es) 1988-02-16
IE58122B1 (en) 1993-07-14
LU86032A1 (fr) 1986-02-18
NO853046L (no) 1986-02-03
JPS6147464A (ja) 1986-03-07
NO1994023I1 (no) 1994-11-09
AU573878B2 (en) 1988-06-23
FI78466C (fi) 1989-08-10
JPH0623197B2 (ja) 1994-03-30
IS3034A7 (is) 1986-02-02
DK158942C (da) 1991-01-21
UA6329A1 (uk) 1994-12-29
ZA855818B (en) 1986-04-30
GB8419575D0 (en) 1984-09-05
PL146005B1 (en) 1988-12-31
ES8801788A1 (es) 1988-02-16

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