LU91562B1 - Hydroquinone derivatives. - Google Patents

Hydroquinone derivatives.

Info

Publication number
LU91562B1
LU91562B1 LU91562A LU91562A LU91562B1 LU 91562 B1 LU91562 B1 LU 91562B1 LU 91562 A LU91562 A LU 91562A LU 91562 A LU91562 A LU 91562A LU 91562 B1 LU91562 B1 LU 91562B1
Authority
LU
Luxembourg
Prior art keywords
hydroquinone derivatives
hydroquinone
derivatives
Prior art date
Application number
LU91562A
Inventor
Djalil Coowar
Emmanuel Couche
Aurelie Dubois
Eric Koncina
Original Assignee
Axoglia Therapeutics S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Axoglia Therapeutics S A filed Critical Axoglia Therapeutics S A
Priority to LU91562A priority Critical patent/LU91562B1/en
Priority to PCT/EP2010/056023 priority patent/WO2010128038A1/en
Application granted granted Critical
Publication of LU91562B1 publication Critical patent/LU91562B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C251/48—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/02—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring monocyclic with no unsaturation outside the aromatic ring
    • C07C39/11—Alkylated hydroxy benzenes containing also acyclically bound hydroxy groups, e.g. saligenol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
LU91562A 2009-05-04 2009-05-04 Hydroquinone derivatives. LU91562B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
LU91562A LU91562B1 (en) 2009-05-04 2009-05-04 Hydroquinone derivatives.
PCT/EP2010/056023 WO2010128038A1 (en) 2009-05-04 2010-05-04 Hydroquinone derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LU91562A LU91562B1 (en) 2009-05-04 2009-05-04 Hydroquinone derivatives.

Publications (1)

Publication Number Publication Date
LU91562B1 true LU91562B1 (en) 2010-11-05

Family

ID=41162291

Family Applications (1)

Application Number Title Priority Date Filing Date
LU91562A LU91562B1 (en) 2009-05-04 2009-05-04 Hydroquinone derivatives.

Country Status (2)

Country Link
LU (1) LU91562B1 (en)
WO (1) WO2010128038A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2720693T3 (en) 2011-06-17 2017-06-12 Ludwig Aigner CHROMAN-LIKE CYCLIC PRENYLFLAVONOIDS FOR MEDICAL INTERVENTION IN NEUROLOGICAL DISEASES
EP3389646A1 (en) 2015-12-17 2018-10-24 BioElectron Technology Corporation Flouroalkyl, flouroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders
CN109336935A (en) * 2018-11-29 2019-02-15 雷逸鸥 The preparation method and its pharmaceutical usage of dihydroxy-benzoic acid ester glucoside

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6140236A (en) * 1984-08-02 1986-02-26 Yamanouchi Pharmaceut Co Ltd Hydroquinone derivative
WO2005030748A1 (en) * 2003-09-26 2005-04-07 Universite Louis Pasteur Tocopherol derivatives with a long hydroxylated chain, which can be used as neurotrophics
US20060193797A1 (en) * 2005-02-25 2006-08-31 Galileo Pharmaceuticals, Inc Chroman derivatives as lipoxygenase inhibitors
EP1854777A1 (en) * 2005-02-28 2007-11-14 Meiji Dairies Corporation Hydroquinone long-chain derivative and/or phenoxy long-chain derivative, and pharmaceutical preparation comprising the same
WO2009040423A1 (en) * 2007-09-26 2009-04-02 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of tocopherol derivatives as inhibitors of the notch signalling pathway

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6140236A (en) * 1984-08-02 1986-02-26 Yamanouchi Pharmaceut Co Ltd Hydroquinone derivative
WO2005030748A1 (en) * 2003-09-26 2005-04-07 Universite Louis Pasteur Tocopherol derivatives with a long hydroxylated chain, which can be used as neurotrophics
US20060193797A1 (en) * 2005-02-25 2006-08-31 Galileo Pharmaceuticals, Inc Chroman derivatives as lipoxygenase inhibitors
EP1854777A1 (en) * 2005-02-28 2007-11-14 Meiji Dairies Corporation Hydroquinone long-chain derivative and/or phenoxy long-chain derivative, and pharmaceutical preparation comprising the same
WO2009040423A1 (en) * 2007-09-26 2009-04-02 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of tocopherol derivatives as inhibitors of the notch signalling pathway

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
HANBALI M ET AL: "Quinol fatty alcohols as promoters of axonal growth", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 16, no. 10, 15 May 2006 (2006-05-15), pages 2637 - 2640, XP025106811, ISSN: 0960-894X, [retrieved on 20060515] *
JANERO D A ET AL: "Novel 6-hydroxychroman-2-carbonitrile inhibitors of membrane peroxidative injury", BIOCHEMICAL PHARMACOLOGY, vol. 40, no. 3, 1 August 1990 (1990-08-01), pages 551 - 558, XP025515600, ISSN: 0006-2952, [retrieved on 19900801] *
MULLER T ET AL: "Improved synthesis of tocopherol fatty alcohols and analogs: microglial activation modulators", TETRAHEDRON, vol. 62, no. 51, 18 December 2006 (2006-12-18), pages 12025 - 12040, XP025003017, ISSN: 0040-4020, [retrieved on 20061218] *
MULLER T ET AL: "Tocopherol long chain fatty alcohols decrease the production of TNF-alpha and NO radicals by activated microglial cells", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 14, no. 24, 20 December 2004 (2004-12-20), pages 6023 - 6026, XP004645147, ISSN: 0960-894X *

Also Published As

Publication number Publication date
WO2010128038A1 (en) 2010-11-11

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