KR880001635A - 5-Fluorouracil derivatives, preparation method and use thereof - Google Patents

5-Fluorouracil derivatives, preparation method and use thereof Download PDF

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Publication number
KR880001635A
KR880001635A KR870002961A KR870002961A KR880001635A KR 880001635 A KR880001635 A KR 880001635A KR 870002961 A KR870002961 A KR 870002961A KR 870002961 A KR870002961 A KR 870002961A KR 880001635 A KR880001635 A KR 880001635A
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South Korea
Prior art keywords
general formula
following general
compound represented
organic solvent
intermediate product
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KR870002961A
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Korean (ko)
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KR950009857B1 (en
Inventor
세쓰로 후지이
Original Assignee
오오쓰까 아끼히꼬
오오쓰까 세이야꾸 가부시끼 가이샤
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Priority claimed from JP61181027A external-priority patent/JPS63301880A/en
Priority claimed from JP62034161A external-priority patent/JPS63201127A/en
Application filed by 오오쓰까 아끼히꼬, 오오쓰까 세이야꾸 가부시끼 가이샤 filed Critical 오오쓰까 아끼히꼬
Publication of KR880001635A publication Critical patent/KR880001635A/en
Application granted granted Critical
Publication of KR950009857B1 publication Critical patent/KR950009857B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

내용 없음No content

Description

5-플루오로우라실 유도체, 그의 제조방법 및 용도5-Fluorouracil derivatives, preparation method and use thereof

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (1)

하기 일반식(I)로 나타내는 5-플루오로우라실 유도체의 제조방법으로서;As a manufacturing method of the 5-fluorouracil derivative represented by the following general formula (I); [상기 식중, Ra는 C1~C6알콕시메틸기이다].[Wherein R a is a C 1 to C 6 alkoxymethyl group]. (a) 하기 일반식(2)로 나타내는 화합물을, 산 스케빈저 존재하의 유기용매내에 하기 일반식(3)으로 나타내는 화합물과 반응시켜서 하기 일반식(4)로 나타내는 중간 생성물을 수득하여, 일반식(4)의 중간 생성물을 유기용매내에서 하기 일반식(5)로 나타내는 화합물과 반응시키거나;(a) The compound represented by the following general formula (2) is reacted with the compound represented by the following general formula (3) in an organic solvent in the presence of an acid scavenger to obtain an intermediate product represented by the following general formula (4). Reacting the intermediate product of formula (4) with a compound represented by the following formula (5) in an organic solvent; [상기 식들중, Ra는 상기에서 정의한 바와 동일하며, Rb는 수소원자 또는 트리(저급알킬)실릴기이고, X는 할로겐원자이다.] 또는[Wherein R a is the same as defined above, R b is a hydrogen atom or a tri (lower alkyl) silyl group, and X is a halogen atom. (b) 하기 일반식(6)으로 나타내는 화합물을, 산 스캐빈저 존재하의 유기용매내에서 하기 일반식(3)으로 나타내는 화합물과 반응시켜서 하기 일반식(7)로 나타내는 중간 생성물을 수득하여, 일반식(7)의 중간 생성물을 산 스캐빈저 존재하의 유기용매내에서 하기 일반식(2)로 나타내는 화합물과 반응시킴 ;(b) reacting the compound represented by the following general formula (6) with the compound represented by the following general formula (3) in an organic solvent in the presence of an acid scavenger to obtain an intermediate product represented by the following general formula (7), Reacting the intermediate product of general formula (7) with a compound represented by the following general formula (2) in an organic solvent in the presence of an acid scavenger; [상기 식들중, Ra및 X는 상기에서 정의한 바와 동일하다.]을 특징으로 하는 상기 일반식(I)의 5-플루오로우라실 유도체의 제조방법.[Wherein, R a and X are the same as defined above.] A process for producing the 5-fluorouracil derivative of the general formula (I). ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019870002961A 1986-07-25 1987-03-30 Process for preparing 5-fluorouracil derivatives KR950009857B1 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
JP176464/1986 1986-07-25
JP176464 1986-07-25
JP17646486 1986-07-25
JP181027/1986 1986-07-30
JP181027 1986-07-30
JP61181027A JPS63301880A (en) 1985-09-03 1986-07-30 5-fluorouracil derivative
JP34161 1987-02-17
JP34161/1987 1987-02-17
JP62034161A JPS63201127A (en) 1987-02-17 1987-02-17 Carcinostatic agent containing 5-fluorouracil derivative

Publications (2)

Publication Number Publication Date
KR880001635A true KR880001635A (en) 1988-04-25
KR950009857B1 KR950009857B1 (en) 1995-08-29

Family

ID=27288338

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1019870002961A KR950009857B1 (en) 1986-07-25 1987-03-30 Process for preparing 5-fluorouracil derivatives
KR1019870006895A KR950011394B1 (en) 1986-07-25 1987-07-01 5-fluorouracil depivatives

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1019870006895A KR950011394B1 (en) 1986-07-25 1987-07-01 5-fluorouracil depivatives

Country Status (10)

Country Link
KR (2) KR950009857B1 (en)
CH (1) CH671578A5 (en)
DE (1) DE3709699C2 (en)
DK (1) DK169520B1 (en)
ES (1) ES2004904A6 (en)
FR (1) FR2605006B1 (en)
GB (1) GB2192880B (en)
IT (1) IT1207785B (en)
NL (1) NL194043C (en)
SE (1) SE464303B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4864021A (en) * 1984-10-30 1989-09-05 Otsuka Pharmaceutical Co., Ltd. 5-fluorouracil derivatives
DE69003670T2 (en) 1989-01-05 1994-01-27 Otsuka Pharma Co Ltd NON-INJECTABLE CARCINOSTATIC AGENT FOR PREVENTING INFLAMMATION BY 5-FLUORURACIL AND METHOD FOR TREATING CANCER.
WO1992001453A1 (en) * 1990-07-19 1992-02-06 Otsuka Pharmaceutical Co., Ltd. Solid preparation
TWI481604B (en) 2009-10-27 2015-04-21 Delta Fly Pharma Inc Novel 5-fluorouracil derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0323441B1 (en) * 1984-10-30 1996-04-24 Otsuka Pharmaceutical Co., Ltd. 5-Fluorouracil derivatives
JPS61114739A (en) * 1984-11-08 1986-06-02 Mitsubishi Rayon Co Ltd Preparation of catalyst for preparing unsaturated carboxylic acid

Also Published As

Publication number Publication date
SE8701118L (en) 1988-01-26
GB2192880B (en) 1990-05-09
DK169520B1 (en) 1994-11-21
CH671578A5 (en) 1989-09-15
GB8706972D0 (en) 1987-04-29
SE8701118D0 (en) 1987-03-18
IT1207785B (en) 1989-06-01
IT8705150A0 (en) 1987-03-30
NL194043C (en) 2001-05-03
SE464303B (en) 1991-04-08
DE3709699C2 (en) 1996-09-05
FR2605006B1 (en) 1990-01-12
GB2192880A (en) 1988-01-27
DE3709699A1 (en) 1988-02-04
ES2004904A6 (en) 1989-02-16
KR880001630A (en) 1988-04-25
DK133387A (en) 1988-01-26
KR950009857B1 (en) 1995-08-29
NL194043B (en) 2001-01-02
KR950011394B1 (en) 1995-10-02
FR2605006A1 (en) 1988-04-15
NL8700742A (en) 1988-02-16
DK133387D0 (en) 1987-03-16

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