KR20190025307A - Oil in water type cosmetic composition containing stabilized high-content oil inner phase - Google Patents

Abstract

The present invention relates to a semi-transparent liquid-phase oil-in-water type cosmetic composition comprising glycerin, ceramide, and sodium surfactin, one of biological surfactants, as essential ingredients, and having a high-content oil inner phase stabilized by using a preparation method through high-pressure emulsification. The composition according to the present invention is very excellent in long-term stability and high-temperature stability of formulations, and can be expected to have a skin barrier improving effect, anti-inflammation, antibacterial effect, and/or skin moisturizing effect.

Description

[0001] The present invention relates to an oil-in-water type cosmetic composition containing a stabilized high-content oil inner phase,

The present invention relates to an underwater type cosmetic composition stabilizing a high amount of oil in a semi-transparent liquid formulation having flowability using a high pressure emulsion production method. More particularly, the present invention relates to a method of stabilizing a high amount of oil inner phase by using high pressure emulsion production method using sodium surfactin, ceramide, and glycerine together with biosurfactants, The present invention relates to a translucent aqueous liquid cosmetic composition.

In general, a nanoemulsion refers to a mini-emulsion that is a fine oil / water or water / oil dispersion stabilized by the interfacial membrane of a surfactant molecule with a droplet size range of 20 to 600 nm (Manjit Jaiswal et al., Nanoemulsion: an advanced mode of Drug Delivery System, 3 Biotech, April 2015, Volume 5, Issue 2, pp 123-127).

When the droplet size of the emulsion is reduced to nano units, the physical stability of the emulsion is greatly improved. In addition, a low-viscosity emulsion having high transparency can be prepared to make a cosmetic composition having various feelings. The cosmetic composition has a large surface area and a small particle size, so that the effective ingredient can be effectively delivered to the skin.

For producing the nano emulsion, the phase temperature emulsification method and the high pressure emulsification method have been used. However, the nano-emulsion prepared by the prior art usually contains about 5% of oil, and it is difficult to secure long-term stability and high-temperature stability when a high content of oil-in-phase is stabilized in a translucent emulsion. Also, since a large amount of surfactant is used together to stabilize the oil, it is not only sticky, frustrating, and unpleasant, but also has a problem causing skin irritation.

1. Korean Registered Patent No. 10-0452165 (issued on October 08, 2004) 2. Korean Patent No. 10-0236304 (issued on December 15, 1999) 3. Korean Patent No. 10-0181104 (issued on May 15, 1999)

 1. Manjit Jaiswal et al., Nanoemulsion: an advanced mode of drug delivery system, 3 Biotech, April 2015, Volume 5, Issue 2, pp 123-127

The present invention seeks to provide an underwater-type cosmetic composition having a high flowability and a low viscosity and, in particular, a high translucency liquid formulation and stabilizing a high oil level in the oil. At this time, the oil to be stabilized is a high amount of 10 to 40% by weight of oil contained in the internal phase of the oil, and even if stored at room temperature for 12 months or more, the formulation is not separated and secures long-term stability so as to maintain a translucent liquid phase.

Further, it has been found that a problem that a large amount of a surfactant is contained in order to stabilize a high oil content in the prior art by using a surfactant, a ceramide and a glycerin simultaneously to reduce the amount of a surfactant, that is, a sticky, It is intended to overcome the problems of giving bad feeling and causing skin irritation.

In order to solve the above problems, the present invention provides a semi-transparent liquid-type cosmetic composition for underwater in which a high content of oil phase is stabilized by a high pressure emulsion production method.

More particularly, the present invention relates to a method for producing a biosurfactant, which comprises the steps of preparing a biosurfactant containing sodium surfactin, ceramide, and glycerine as essential components, To provide an oil-in-water type cosmetic composition excellent in long-term stability.

According to the studies of the present inventors, it has been found that when a high pressure emulsion containing sodium surfactant, ceramide and glycerin is added, a nano emulsion having a uniform particle size of 200 nm or less can be formed while stabilizing a high content of oil phase, Of the present invention is possible.

In addition, while the nano-emulsion to which the conventional technique is applied is difficult to maintain long-term stability, the translucent liquid-type underwater-type cosmetic composition according to the present invention maintains stability when it is stored at room temperature for 1 year or more or at 45 ° C for 1 month or more Long-term stability and high-temperature stability.

The water-in-oil type cosmetic composition according to the present invention, which stabilizes a high-content oil inner phase, is excellent in long-term stability and high-temperature stability, and at the same time has a skin barrier improvement effect according to the content of ceramides, anti-inflammation, antimicrobial effect, And skin moisturizing effect depending on the content can be expected.

FIG. 1 is a photograph showing the size and distribution of nanoemulsion particles of Examples 1, 2, and Comparative Example 3 immediately after the first emulsification by an optical microscope.
FIG. 2 is a photograph showing the size and distribution of the nanoemulsion particles of Comparative Example 3 immediately after high-pressure emulsification with an optical microscope.
3 is a photograph of the appearance of the composition immediately after the first emulsification (left) of Example 1, immediately after the first pass of the high-pressure emulsifier (middle) and immediately after the third pass of the high-pressure emulsifier (right).
Fig. 4 is a photograph of the appearance of the composition immediately after the first emulsification of Comparative Example 1. Fig.
5 is a graph comparing the particle size values of the nanoemulsion immediately after the preparation of Example 1 (above) and after 12 months of storage at room temperature (below).

The present invention relates to a semi-transparent liquid-type underwater-type cosmetic composition which stabilizes a high content of oil-in-phase by a high-pressure emulsification process and is highly stable over time. More particularly, the present invention relates to a semi-transparent aqueous liquid cosmetic composition containing sodium surfactin, ceramide, and glycerine as essential ingredients and stabilizing a high amount of oil in-vivo using a high pressure emulsification preparation method .

The sodium surfactant contained as an essential ingredient in the present invention is a sodium salt form of surfactin, which is a lipopeptide surfactant.

Surfactin is a biosurfactant obtained by fermentation of Bacillus subtilis . Antiphlogistic, anticancer, cholesterol lowering, phosphodiesterase inhibiting and antifungal action are known.

In the present invention, sodium surfactant is used as a surfactant for stabilizing a semi-transparent liquid formulation by controlling the particle size of the nano emulsion, and commercially available products can be used.

The ceramide contained as an essential ingredient in the present invention may be a natural ceramide, a pseudoceramide, a ceramide derivative, or a mixture thereof.

Ceramides are important materials that make up the stratum corneum of human skin, including sphingosine and phytosphingosine. When the ceramide content in the stratum corneum is decreased due to aging, or when the stratum corneum is damaged due to external stimuli, the ceramide can be supplemented in the form of cosmetics or external preparation for external skin to restore the skin lamella structure to restore the skin to a normal state, It is known to play a role in improving skin barrier.

In the present invention, ceramide is used not only as a skin barrier improving agent but also in stabilizing an emulsion containing a high-content oil phase.

When the natural ceramide is used in the present invention, it is extracted from plants, animals, microorganisms and the like, and its origin is not limited to a great extent. It may be directly extracted and used, and commercially available products may be used.

When the ceramide derivative is used in the present invention, the kind of the ceramide derivative is not limited to a kind that can be applied to the skin. Preferably, the ceramide derivative is selected from the group consisting of P- 104, P-102 described in Korean Patent No. 10-0181104 (published on May 15, 1999), and mixtures thereof.

The glycerin contained as an essential ingredient in the present invention is an essential ingredient for preparing a semi-transparent liquid type cosmetic composition for aquatic life with long-term stability.

In the present invention, glycerin is not limited to be formulated in an underwater type cosmetic composition and plays a role of exhibiting a moisturizing effect. When glycerin is blended with other essential ingredients of the present invention in a specific amount, it serves to stabilize the emulsion.

In the present invention, a high-pressure emulsion production method is used to stabilize a high amount of oil in-phase in a semi-transparent liquid formulation. The method for producing a high-pressure emulsion according to the present invention specifically includes the following steps.

i) mixing an aqueous phase containing sodium surfactant and glycerin and an oily phase containing ceramide, heating and dissolving the mixture to 70 DEG C, and emulsifying the homomixer at 3000 rpm for 5 minutes to obtain an opaque, liquid primary emulsion;

ii) homogenizing the primary emulsion obtained in step i) in a high-pressure emulsifier under a pressure of 1000 to 1500 bar for 2 to 3 times to obtain a final translucent nanoemulsion;

The particle size of the nanoemulsion obtained through the high-pressure emulsion production method of the present invention is 200 nm or less, preferably 180 nm or less.

These nanoparticles are uniformly dispersed throughout the composition to form a semitransparent liquid formulation, and the nanoparticle size remains constant even after storage at room temperature for 12 months without separation of the formulations. In addition, even at a high temperature of 45 캜 and a low temperature of -4 캜, the formulation is not separated for more than one month, and the nanoparticle size is kept constant.

In the present invention, the sodium surfactant is used in an amount of 0.1 to 5% by weight, more preferably 0.1 to 2% by weight, based on the total weight of the composition. If the blending amount of sodium surfactant is more than 5% by weight, skin irritation may be caused, which is not suitable as a cosmetic. If it is less than 0.1% by weight, the effect is too small to form emulsion particles.

In the present invention, ceramide is used in an amount of 0.1 to 10% by weight, more preferably 0.5 to 5% by weight, based on the total weight of the composition. When the amount of the ceramide is more than 10% by weight, the ceramide precipitates and the emulsion is not properly formed. If the amount of the ceramide is less than 0.1% by weight, the content is too small to give sufficient effect to the skin.

In the present invention, glycerin is used in an amount of 5 to 30% by weight, more preferably 10 to 20% by weight, based on the total weight of the composition.

If the blending amount of glycerin is more than 30% by weight, it may be too sticky and frustrating, and may not be suitable as a cosmetic. If it is less than 5% by weight, the emulsion is not properly formed.

In the present invention, the high-oil inner phase stabilized through the high-pressure emulsification manufacturing process contains 10 to 40% by weight of the oil based on the total weight of the composition.

The term " oil content " means the total amount of oily phase components not containing the emulsion stabilizer. In the present invention, oils usable in the above content range include dimethicone, cyclomethicone, phenyl trimethicone, Silicone oils including trisiloxane / dimethicone and the like; Ester-based oils including cetyl ethylhexanoate, isopropyl palmitate, isopropyl myristate, alkyl benzoate, diethoxy ethyl succinate and pentyl erythritetetraisostearate; Hydrocarbon oils such as mineral oil, isohexadecane, isodecane, undecane, squalane, hydrogenated polydecene, alpha olefin oligomer, and hydrogenated polyisobutene; Triglyceride oil including castor oil, castor oil, mefoform seed oil, caprylic / capric triglyceride, coconut oil and safflower seed oil, and mixtures thereof. But is not limited thereto.

The semi-transparent liquid type cosmetic composition for underwater type according to the present invention maintains the formulation stability at room temperature for 12 months or more and has long-term stability and high-temperature stability.

The semi-transparent liquid type submerged-type cosmetic composition according to the present invention contains anti-inflammatory and antimicrobial effects by containing sodium surfactant as an essential ingredient, and has an effect of improving skin barrier by containing ceramide as an essential ingredient. It has excellent moisturizing effect.

The cosmetic composition containing the translucent liquid type submerged-type cosmetic composition according to the present invention is not particularly limited, but can be used for skin, mucous membrane, scalp or hair, for example, softening longevity, nutrition lotion, cream, pack, And hair cosmetics such as lipsticks, makeup bases and foundation, shampoos, rinses, body cleansers, toothpastes, cleaning agents such as mouthwashes, hair tonics, gels, .

Hereinafter, the present invention will be described in more detail by way of examples. However, the embodiments according to the present invention can be modified into various other forms, and the scope of the present invention is not limited to the following embodiments.

[ Manufacturing example : Underwater type Cosmetics  Preparation of the composition]

An underwater type cosmetic composition of Examples 1 to 3 and Comparative Examples 1 to 3 was prepared by the following production method according to each ingredient and content shown in Table 1 below.

KANEKA surfactin of sodium surfactant, HYDROXYPROPYL BISPALMITAMIDE MEA of MacroCare, and GLYCERINE of LG Household & Health Care were used as a raw material of essential ingredient of the present invention.

Manufacturing method

The raw materials were weighed according to the following Table 1, and the water-based part and the oil-based part were each mixed with a disper, mixed and heated to 70 ° C and dissolved. Next, the water-based and oil-based parts were mixed and emulsified at 3000 rpm for 5 minutes using a homomixer to obtain an opaque liquid primary emulsion.

Then, the primary emulsion was passed through a high-pressure emulsifier (PANDA PLUS 2000 from GEA Niro Soavi) two to three times under a pressure of 1000 to 1500 bar and cooled to 30 DEG C to obtain a final translucent nanoemulsion.

ingredient Example 1 Example 2 Example 3 Comparative Example 1 Comparative Example 2 Comparative Example 3 Award Part water to 100 to 100 to 100 to 100 to 100 to 100 Glyceryl caprylate 0.1 0.1 0.1 0.1 0.1 0.1 Butylene glycol 8 8 8 8 8 8 glycerin 20 20 10 0 20 20 Sodium Surfactin One One One One One 0 Sodium stearoyl glutamate 0 0 0 0 0 One Paid part Ceramide 2 2 2 2 0 2 Glyceryl stearate 0.5 0.5 0.5 0.5 0.5 0.5 PEG-100 stearate 0.5 0.5 0.5 0.5 0.5 0.5 Cetearyl alcohol 0.5 0.5 0.5 0.5 0.5 0.5 Cetyl 2-ethylhexanoate 2 10 10 10 10 10 Caprylic / capric triglyceride 3 10 10 10 10 10 Squalane 5 10 10 10 10 10 Dimethicone 2 2 2 2 2 2

The compositions of Examples 1 to 3 and Comparative Examples 1 to 3 were prepared according to the above production method.

In Examples 1, 2 and 3, it was possible to proceed from the first emulsification to the high-pressure emulsification, and a final translucent nano-emulsion type water-in-water cosmetic composition was prepared.

However, Comparative Examples 1 and 2 were not immediately able to proceed to high-pressure emulsification immediately after the first emulsification. In Comparative Example 3, high pressure emulsification proceeded immediately after the first emulsification, but the particles of the prepared composition were uneven and immediately separated on the next day.

[ Test Example  1: Observation of formulation stability during manufacture]

Immediately after the first emulsification, Emulsion  Transparency and particle size

The transparency and particle size of the emulsion were observed immediately after the first emulsification of Examples 1, 2 and 3 and Comparative Examples 1, 2 and 3 in the above Production Examples.

In Example 1, immediately after the first emulsification, an opaque emulsion was formed as shown in FIG. 3 (left). As shown in FIG. 1 (enlarged scale: length of the scale bar - 5 μm), the particle size of the emulsion was small Respectively.

Immediately after the first emulsification, opaque milky lotions were formed in Example 2 and Example 3, and emulsion particle sizes were all small and uniform.

However, in Comparative Example 1 in which glycerin was not contained, as shown in Fig. 1 (enlarged scale: length of the scale bar - 5 mu m) immediately after the first emulsification, the particles were relatively large and uneven. Further, as shown in Fig. 4, immediately after the first emulsification, separation could not proceed and high-pressure emulsification could not proceed.

In Comparative Example 2 in which ceramide was not contained, the particles were relatively large and non-uniform immediately after the first emulsification, and immediately after the first emulsification, separation could not proceed to the high-pressure emulsification.

Comparative Example 3 containing sodium stearoylglutamate, which is an anionic surfactant instead of sodium surfactant, was prepared in the same manner as in Comparative Example 3 except that the emulsion particle size was uniform after the first emulsification and as shown in Fig. 1 (enlarged scale bar length - It was on the one hand, but it was too large and unstable.

Therefore, in order to obtain a composition having a small particle size and uniform distribution of the emulsion including a high amount of oil phase in the preparation of the composition for underwater type cosmetic composition according to the present invention immediately after the first emulsification, , Ceramide, and glycerin.

High pressure oil painting  after Emulsion  Transparency and particle size

In the above preparation example, the emulsion was subjected to high-pressure emulsification in Examples 1, 2 and 3 and Comparative Example 3 in which separation did not occur after the primary emulsification, and the transparency and particle size of the emulsion were observed.

In Example 1, the opaque emulsion immediately after the first emulsification became a translucent nanoemulsion as shown in FIG. 3 (right) after the high-pressure emulsification. In addition, the particle size of the nanoemulsion was generally 200 nm or less.

Also in Example 2 and Example 3, after high-pressure emulsification, a translucent nanoemulsion was obtained, and the particle size was generally 200 nm or less.

However, even though high-pressure emulsification was carried out in Comparative Example 3, the particle size varied from several hundred nm to several 占 퐉 as shown in Fig. 2 (enlarged scale: scale bar length - 5 占 퐉) .

Therefore, in the preparation of an underwater-type cosmetic composition according to the present invention, it is possible to obtain a cosmetic composition which has a high emulsion particle size of 200 nm or less, a translucent appearance, It was confirmed that sodium surfactant, ceramide, and glycerin, which are essential components of the present invention, should be contained.

[ Test Example  2: Observation of stability over time after production]

According to the above preparation example, the compositions of Examples 1, 2 and 3, in which the primary emulsification only proceeded, and the compositions of Examples 1, 2 and 3, which were completed to high pressure emulsification, were prepared.

The prepared compositions were each kept at room temperature for at least 12 months, at a high temperature of 45 ° C for at least one month, at a low temperature of -4 ° C for at least one month, and the long term stability was observed.

As a result of observation of long-term stability, all of the compositions of Examples 1, 2 and 3, in which only the primary emulsification was carried out, were unclear in appearance and the particle size became larger within several months at room temperature and the formulations were separated.

In contrast, the compositions of Examples 1, 2, and 3, which had been subjected to the above-described high-pressure emulsification, were translucent in appearance, and the formulations were not separated while maintaining transparency at room temperature for 12 months or more when observed with naked eyes. At 45 < 0 > C and -4 < 0 > C, the formulations were not separated while maintaining transparency for more than one month.

5, the particle size of the nanoemulsion was almost similar to that immediately after the high-pressure emulsification even after storage at room temperature for 12 months or more, and the stability of the composition of the nanoemulsion was less than 200 nm Respectively. The compositions of Examples 2 and 3, which had been subjected to the above-described high-pressure emulsification, were also stably maintained at a particle size of 200 nm or less after storage at room temperature for 12 months or longer.

Thus, through the above observations, it can be seen that Example 1 contains 12% by weight or more of oil, and Example 2 and Example 3 contain a high amount of 32% by weight or more of oil, And the stability of the formulation can be maintained for a long time. In addition, when the size of the emulsion particle was reduced to 200 nm or less through the high pressure emulsification process, it was confirmed that it was the most stable over time. That is, it has been found that the water-in-oil type cosmetic composition according to the present invention must undergo a high-pressure emulsification process during manufacture, and the semi-transparent liquid formulation and fine particle size are stably maintained even after the preparation.

The results of this study suggest that the combination of the three essential components of sodium surfactant, ceramide and glycerin together with a high content of oil droplets, and the subsequent production of a nanoemulsion through high pressure emulsion preparation, It was confirmed that an aqueous liquid formulation can be prepared.

It has been known that sodium surfactant, which is a kind of biological surfactant, has various skin effects such as antibacterial, anti-inflammation and antioxidant. It is well known that ceramide has an effect of improving skin barrier. Therefore, Of the oil in the inner skin contains the effect of increasing the skin moisturizing effect can be expected in addition to various skin benefits. In addition, it is possible to realize a feeling of good feeling that is not weightless and refreshing and refreshing with a refreshing water type formulation.

Thus, specific details of the present invention have been described in detail. It will be apparent to those skilled in the art that the specific technology of the present invention is merely a preferred embodiment, and the scope of the present invention is not limited thereby.

Claims (13)

A liquid semi-transparent underwater type cosmetic composition prepared by stabilizing a high-content oil inner phase by a method of manufacturing a high pressure emulsion comprising sodium surfactin, ceramide and glycerine as essential ingredients. The semi-transparent liquid type underwater type cosmetic composition according to claim 1, wherein the content of the sodium surfactant is 0.1 to 5% by weight based on the total weight of the composition. The semi-transparent liquid type underwater type cosmetic composition according to claim 1, wherein the content of the ceramide is 0.1 to 10% by weight based on the total weight of the composition. The cosmetic composition according to claim 1, wherein the content of glycerin is 5 to 30% by weight based on the total weight of the composition. 5. The cosmetic composition according to claim 4, wherein the glycerin content is 10 to 20% by weight based on the total weight of the composition. The method according to claim 1, wherein the high-
i) mixing an aqueous phase containing sodium surfactant and glycerin and an oily phase containing ceramide, heating and dissolving the mixture to 70 DEG C, and emulsifying the homomixer at 3000 rpm for 5 minutes to obtain an opaque, liquid primary emulsion;
ii) homogenizing the primary emulsion obtained in step i) in a high-pressure emulsifier under a pressure of 1000 to 1500 bar for 2 to 3 times to obtain a final translucent nanoemulsion;
Lt; RTI ID = 0.0 > cosmetic < / RTI > composition. 7. The cosmetic composition according to claim 6, wherein the nanoemulsion has a particle size of 200 nm or less. The semi-transparent liquid type underwater type cosmetic composition according to claim 1, wherein the oil content is 10 to 40% by weight based on the total weight of the composition. 9. Composition according to any one of claims 1 to 8, characterized in that the composition maintains a long-term stability of at least 12 months at room temperature. 9. The semi-transparent liquid type underwater type cosmetic composition according to any one of claims 1 to 8, wherein the composition has a skin barrier improving effect. 9. The semi-transparent liquid type underwater type cosmetic composition according to any one of claims 1 to 8, wherein the composition has anti-inflammatory and antibacterial effects. 9. The cosmetic composition according to any one of claims 1 to 8, wherein the composition has skin moisturizing effect. 9. The cosmetic composition according to any one of claims 1 to 8, wherein the cosmetic composition contains the semi-transparent liquid type underwater type cosmetic composition.

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