KR102640106B1 - Syringe module for bio 3d printer - Google Patents

Abstract

The present invention relates to a syringe module for a bio 3D printer equipped with a syringe accommodating a bio material, comprising: a holder body having a seating groove on one side in contact with the outer peripheral surface of the syringe; a holder cover installed on the holder body in a direction opposite to the seating groove to be openable and closed; A temperature sensor that measures the temperature of the holder body; a heater installed on the other side of the holder body opposite the seating groove; It is installed on the side of the heater and includes a cooling block connected to a peltier and a cooling water pipe, or a cooling unit including a cooling block connected to a coolant pipe.

Description

Syringe module for bio 3D printer {SYRINGE MODULE FOR BIO 3D PRINTER}

The present invention relates to a syringe module for a bio 3D printer, and more specifically, a syringe module for receiving and discharging bio materials, and is used to print structures by the operation of the bio 3D printer. It's about the syringe module.

3D bioprinting, a field of application and development of 3D printing technology, is based on 3D printing technology and uses extracellular matrix (ECM) such as collagen or bio-ink (bio-ink) that mimics it. It is a technology that combines ink with cells and other biomaterials to create the desired shape. Currently, various methods of 3D bioprinting are being developed to suit the desired purpose and biological environment, and various bioinks are also being studied.

This 3D bioprinting constructs ECM or bio-ink into a desired shape and cultivates the cells required for the ECM or bio-ink to produce biological organs or tissues with realistic functions. One of the most important issues in 3D bioprinting is to store and use cells and biomaterials as stably as possible so that they can continue to function without dying.

However, biomaterials are very sensitive to various environmental conditions such as temperature and pressure, and unlike general 3D printer polymers, they do not have a specific shape, so it is difficult to manufacture them in the required form when using existing 3D bio printers. In addition, there is a problem that it causes great stress to cells, greatly reducing cell viability and stability.

Korean Patent Publication No. 10-2017-0001444 (published on January 4, 2017)

The purpose of the present invention is to provide a syringe for a bio 3D printer that accommodates a syringe for printing bio materials in a bio 3D printer.

Another object of the present invention is to provide a syringe module for a bio 3D printer that can adjust the temperature of the syringe according to the characteristics of the bio material contained in the syringe.

The present invention to solve the above problems provides a syringe module for a bio 3D printer equipped with a syringe that accommodates bio materials.

According to an embodiment of the present invention, the syringe module includes a holder body having a seating groove formed on one side that contacts the outer peripheral surface of the syringe; a holder cover installed on the holder body in a direction opposite to the seating groove to be openable and closed; A temperature sensor that measures the temperature of the holder body; a heater installed on the other side of the holder body opposite the seating groove; It is installed on the side of the heater and includes a cooling block connected to a peltier and a cooling water pipe, or a cooling unit including a cooling block connected to a coolant pipe.

According to an embodiment of the present invention, the holder cover is formed to accommodate the syringe by having a support portion in which the lower end of the syringe is inserted and supported, and is hingedly coupled to the holder body by a hinge axis to be openable and closed.

According to an embodiment of the present invention, the holder body includes a hollow fixing portion formed on an upper side of the heater and connected to a side surface of the body of the holder.

According to an embodiment of the present invention, the heater may be a film-type heater with a temperature sensor attached.

According to an embodiment of the present invention, a locking portion that fits into a locking hole formed in the syringe adapter is protrudingly formed on one side of the holder body, so that when the holder cover rotates around the hinge axis and is closed to the holder body, The locking portion is fitted into the locking hole of the adapter of the syringe stored in the holder cover.

According to an embodiment of the present invention, a circumferential groove is formed on one side of the holder body in a shape corresponding to the outer peripheral surface of the adapter upper part of the syringe adapter, and the locking portion is formed to protrude on the surface of the circumferential groove.

According to an embodiment of the present invention, the cooling unit includes a plate-shaped peltier installed in contact with a side of the plate-shaped heater, and the cooling block installed in contact with the peltier and connected to a cooling water pipe, and the cooling block has an inlet port. It includes an internal flow path having an inlet and an outlet and is connected to a coolant supply unit through the inlet and outlet, wherein the coolant supply unit includes a coolant pump installed in the lower space of the printer chamber of the bio 3D printer connected to the inlet, and the outlet. It includes a connected radiator, a fan for dissipating heat from the radiator, and a coolant tank that accommodates water passing through the radiator and is connected to the coolant pump.

According to an embodiment of the present invention, it includes a control unit that controls the temperature of the syringe module, wherein the control unit has a reference temperature for the holder body as a set value, and the reference temperature and the holder in a state before mounting the syringe. By comparing the temperature of the body, it is selected whether to heat the holder body by operating the heater, and when the set temperature of the mounted syringe is input, the heater or the cooling unit is operated by comparing the reference temperature and the set temperature of the syringe. control.

According to an embodiment of the present invention, an NFC tag on which a set temperature suitable for the characteristics of the bio material is recorded is attached to the syringe mounted on the syringe module, and the control unit receives information read from the NFC tag by an NFC reader and Enter the set temperature.

According to the syringe module for a bio 3D printer according to the present invention, it is possible to simply and conveniently store a syringe for printing bio materials in a bio printer.

Additionally, according to the present invention, the temperature can be adjusted to suit the characteristics of the biomaterial contained within the syringe.

Additionally, according to the present invention, the fixing force of the syringe adapter that seals the syringe can be increased. This can prevent accidents such as separation of the syringe adapter due to a sudden increase in pressure inside the syringe.

Figure 1 is a perspective view from the front of the bio 3D printer according to the present invention.
Figure 2 is a perspective view of the bio 3D printer according to the present invention as seen from the rear.
Figure 3 is a diagram showing a syringe module for a bio 3D printer according to the present invention.
Figure 4 is a diagram showing the syringe module of Figure 3 in an open state.
Figure 5 is a cross-sectional view of the syringe module of Figure 3.
Figure 6 is a diagram showing an example of a temperature control unit of a syringe module for a bio 3D printer according to the present invention, where (a) is a parts diagram and (b) is a combination diagram.
Figure 7 is a diagram showing another example of a temperature control unit of a syringe module for a bio 3D printer according to the present invention, where (a) is a parts diagram and (b) is a combination diagram.
Figure 8 is a diagram showing the NFC tag and NFC reader attached to the syringe in the syringe module for a bio 3D printer according to the present invention.

Hereinafter, embodiments of the present invention will be described with reference to the attached drawings. The present invention may be implemented in many different forms and is therefore not limited to the embodiments described herein. In addition, the attached drawings are only for easy understanding of the embodiments disclosed in this specification, and the technical idea disclosed in this specification is not limited by the attached drawings, and all changes included in the spirit and technical scope of the present invention are not limited. It should be understood to include water, equivalents or substitutes. In order to clearly explain the present invention in the drawings, parts not related to the description are omitted, and the size, shape, and shape of each component shown in the drawings may be modified in various ways.

The suffixes “module” and “part” for components used in the following description are given or used interchangeably only for the ease of preparing the specification, and do not have distinct meanings or roles in themselves. Additionally, in describing the embodiments disclosed in this specification, if it is determined that detailed descriptions of related known technologies may obscure the gist of the embodiments disclosed in this specification, the detailed descriptions are omitted.

Throughout the specification, when a part is said to be connected (coupled, fixed) with another part, this means not only directly connected (coupled, fixed), but also indirectly connected (coupled) with another member in between. , fixed) is also included.

The terms used herein are only used to describe specific embodiments and are not intended to limit the invention. Unless the context clearly indicates otherwise, a singular expression includes plural expressions, and components implemented separately may be implemented in a combined form unless there are special restrictions. In this specification, terms such as “comprise” or “have” are intended to indicate the presence of features, numbers, steps, operations, components, parts, or combinations thereof described in the specification, but are not intended to indicate the presence of one or more other features. It should be understood that this does not exclude in advance the possibility of the existence or addition of elements, numbers, steps, operations, components, parts, or combinations thereof.

Additionally, terms including ordinal numbers, such as first, second, etc., used in this specification may be used to describe various components, but the components should not be limited by the terms. The above terms are used only for the purpose of distinguishing one component from another. For example, a first component may be named a second component, and similarly, the second component may also be named a first component without departing from the scope of the present invention.

Figure 1 is a perspective view of the bio 3D printer according to the present invention viewed from the front, and Figure 2 is a perspective view of the bio 3D printer according to the present invention viewed from the rear.

The syringe module according to the present invention is configured to store a syringe containing biomaterials therein. The syringe module is used by being mounted on an output module that prints bio materials in a bio 3D printer. The bio 3D printer shown in FIGS. 1 and 2 is an implementation example of a bio 3D printer to which the syringe module according to the present invention can be applied.

Referring to Figure 1, the bio 3D printer according to the present invention includes a housing, and inside the housing is a printing chamber (1), an output plate (2), a first output module (3), and a second output module (4). may include.

The printing chamber 1 is formed by being surrounded by a bottom surface, an upper surface, and side walls so that the inside can be isolated from the outside.

The output plate 2 is movably disposed on the bottom of the printing chamber 1. A sample container is placed on the upper part of the output plate 2, and the material discharged from the output module is stacked on the sample container to form the required three-dimensional shape.

The bio 3D printer according to the present invention may be equipped with a plurality of output modules.

The first output module 3 may be provided to discharge solid biomaterials for forming structures such as scaffolds, pharmaceutical structures, and framework structures. For example, as the first output module (3), an extruder module that outputs filament, a hot melting module that is a melting high-pressure injection molding machine that puts a polymer material in the form of a drug or granule inside, melts it at high heat, and outputs it with pneumatic pressure, etc. can be used. You can.

The second output module (4) is disposed on one side of the first output module (3). The second output module 4 includes a syringe module. The second output module 4 may include a plurality of syringe modules. The syringes 6 mounted on the syringe module can each store different bio materials, and can selectively discharge the bio materials in a set order.

Referring to FIG. 2, the bio 3D printer may have a coolant supply unit and an air supply unit supplied to the syringe module.

The air supply unit includes an air compressor 8 installed in the space below the bottom of the printer chamber 1, an expansion tank 150, a water separator 120, and first to It may include a third air filter (131, 132, 133).

The coolant supply unit includes a coolant pump 7 installed with an air compressor 8 in the space below the bottom of the printer chamber 1, and a radiator 320 installed at the rear of the printer chamber 1 to dissipate heat from the coolant. ) and a fan 321.

The air supply unit and the cooling water supply unit, along with the cooling block of the syringe and temperature control unit, respectively, are described in more detail below.

The syringe module according to the present invention is not limited to the bio 3D printer shown as an example in the drawing and can be applied to various bio 3D printers that print bio materials. Additionally, a plurality of syringe modules according to the present invention may be mounted on one output module, as shown in the embodiments shown in FIGS. 1 and 2. However, it is not limited to this.

Figure 3 is a diagram showing a syringe module for a bio 3D printer according to the present invention. Figure 4 is a diagram showing the syringe module of Figure 3 in an open state. Figure 5 is a cross-sectional view of the syringe module of Figure 3.

Referring to FIGS. 3 to 5, the syringe module of the present invention is equipped with a syringe 6 that accommodates biomaterials.

The syringe module may include a holder body 10, a holder cover 20, and a temperature control unit. Depending on the embodiment, the temperature control unit includes a heater 40 and a cooling unit, and the cooling unit may include a peltier 70, a cooling block 30, or may be composed of a cooling block 30.

The holder body 10 and the holder cover 20 form a holder that stores and secures the syringe inside.

A seating groove 11 is formed to accommodate the syringe 6 in the holder body 10. The seating groove 11 may be formed on one side of the holder body 10 in a semicircular shape corresponding to the shape of the syringe 6. The seating groove 11 is in contact with the outer peripheral surface of the syringe. The holder body 10 may be made of a metal material, for example, an aluminum material with excellent thermal conductivity.

The holder cover 20 is installed to be openable and closed on the holder body 10 at a position opposite the seating groove 11. The holder cover 20 is hingedly coupled to the holder body 10 by a hinge shaft 21 provided on the lower side.

The holder cover 20 has a conical support portion 22 formed on the lower side into which the lower end of the syringe 6 is inserted and supported. A through hole through which the nozzle of the syringe 6 penetrates is formed at the lower end of the support portion 22. With the holder cover 20 open, the syringe 6 is stored in the holder cover 20 and rotates around the hinge axis 21 to close. The syringe (6) comes into contact with the seating groove (11). During the syringe installation process, interference with structures located above the syringe module can be prevented.

According to an embodiment of the present invention, the holder cover 20 may be made of a material different from that of the holder body 10, for example, a plastic material.

A temperature control unit including a heater 40 may be installed on the other side opposite to one side of the holder body 20. The temperature control unit is provided to control the temperature of the syringe mounted inside, or more specifically, the temperature of the biomaterial contained within the syringe.

The holder body 10 may be provided with a hollow fixing part 50 at the top connected to the other side of the holder body 10. The fixing part 50 may be used to fix the syringe module to a mounting part (eg, output module 4, see FIG. 1) of a bio 3D printer. Cooling water pipes and refrigerant pipes can pass through the hollow of the fixing part 50.

The fixing part 50 is made of the same material as the holder body 10 and is integrated with the holder body 10. Advantageously, it is molded in one piece. Since the fixing part 50 extends from the other side 12 of the holder body 10, the heat generated from the heater 40 is transmitted to the fixing part 50 along the other side 12 of the holder body 10. do. Due to the fixing part 50, the volume capable of receiving heat of the holder body 20 increases, thereby increasing the heat receiving capacity.

A locking portion 51 capable of fastening the syringe adapter 60 is formed at the top of the seating groove 11 on one side of the holder cover 20. The locking portion 51 will be described later.

The holder body 10 according to an embodiment of the present invention is provided with a temperature controller for controlling the temperature of the syringe.

The temperature control unit includes a heater 40 and a cooling unit.

The heater 40 is installed on the other side 12 of the holder body 10 opposite the seating groove 11. According to an embodiment of the present invention, the heater 40 may be a film-type heater. The heater 40 can heat the syringe 6 by applying heat to the seating groove 11 where the syringe 6 is accommodated. According to an embodiment of the present invention, the heater 40 heats the syringe by indirect heating. By heating the other side 12 opposite the seating groove 11 where the syringe 6 is in contact, the heat of the heater 40 is transmitted through the holder body 10 in a conductive manner.

In addition, since the heating heat of the heater 40 is transmitted not only to the side of the holder body 10 but also to the fixing part 50 connected to the side, the heat of the heater 40 can be stored in the holder body 10. This indirect heating method makes it possible to effectively heat the syringe even with a heater 40 with a small heater capacity, and can prevent damage to the biomaterial in the syringe due to local heating.

The heater 40 generates heat by receiving power from a separate power source, and a temperature sensor 41 is attached to sense the temperature. The temperature sensor 41 may be attached to the upper surface of the heater and placed in the inner space of the other side 12 of the holder body 10. Since the heater 40 can be formed as a film, the temperature of the heater 40 can be quickly and accurately measured just by attaching the temperature sensor 41 to the heater 40.

A cooling unit is provided on one side of the heater 40, that is, in the direction opposite to the holder body 20. The cooling unit cools the syringe (6) by cooling the holder body (10).

According to an embodiment of the present invention, the cooling unit of the temperature control unit may be comprised of a first embodiment that uses circulation of coolant and a second embodiment that uses circulation of refrigerant.

Figure 6 is a diagram showing an example of a temperature control unit of a syringe module for a bio 3D printer according to the present invention, and shows an example in which the cooling unit according to the first embodiment is applied. In Figure 6, (a) is a parts diagram and (b) is a combination diagram.

Referring to FIG. 6, the cooling unit includes a cooling block 30 connected to a peltier 70 and a cooling water pipe.

The peltier 70 is disposed on a side of the heater 40 in contact with the heater 40. Peltier 70 is a known device that uses the phenomenon of joining two different types of metals and cooling the joint when an electric current passes through it.

Since the heater 40 and the peltier 70 are each formed in a plate shape, they can be placed in contact with each other.

According to an embodiment of the present invention, the Peltier 70 may include a first Peltier 71 and a second Peltier 72 that are double-overlapping and arranged adjacent to each other. It is primarily cooled through the first Peltier 71, and the heat cooled through the first Peltier 71 is secondarily cooled through the adjacent second Peltier 72, which is advantageous for rapid cooling.

A cooling block 30 is provided on the side of the Peltier 70. Accordingly, the heater 40 and the peltier 70 are sequentially arranged between the holder body 10 and the cooling block 30. Since the heater 40 and the peltier 70 are arranged adjacent to each other in a plate shape, heat generated from the heater 40 can be easily dissipated.

The cooling block 30 is disposed on the side of the Peltier 70 and in contact with the Peltier 70. The cooling block 30 has a flow path (not shown) inside, and in the first embodiment, coolant flows through the flow path. The flow path is connected to the outside through a connector (31). The connector 31 includes an inlet 311 and an outlet 312. Cooling water pipes are connected to the inlet 311 and outlet 312. A plurality of cooling fins may be formed in the cooling block 30. The cooling block 30 can perform primary cooling by flowing coolant inside through the connector 31, and can perform secondary cooling by dissipating heat into the printer chamber through a plurality of cooling fins.

With reference to FIGS. 2 and 6 , the cooling water circulation path connected to the cooling block 30 in the first embodiment of the cooling unit will be described.

According to an embodiment of the present invention, a coolant pump 7 is disposed in the lower space of the printer chamber 1 in the bio 3D printer housing. The coolant pump 7 may be arranged in a vibration reduction structure using a damper or the like. This prevents vibration generated by driving the coolant pump 7 from affecting the printing space within the printer chamber. The coolant pump 7 is connected to the inlet 311 of the cooling block 30 through a pipe. The coolant flows into the inlet 311 of the cooling block 30, performs a cooling function, and then is discharged through the outlet 312 and flows to the radiator 320.

For example, three fans 321 may be placed on the radiator 320 located at the rear of the bio 3D printer, and the heat of the coolant circulating in the radiator is discharged to the outside through the plurality of fans 321. can do. Coolant that has passed through the radiator 320 flows into the coolant tank 310 and then flows back into the water pump 7.

Referring to FIG. 7, a second embodiment using circulation of refrigerant in the cooling part of the syringe module according to the embodiment of the present invention will be described. Figure 7 is a diagram showing another example of the temperature control unit of the syringe module for a bio 3D printer according to the present invention, and shows an example in which the cooling unit according to the second embodiment is applied. Figure 7 (a) is a parts diagram and (b) is a combination diagram.

Referring to FIG. 7, in the cooling unit according to the second embodiment, the cooling block 30 is coupled to the side of the heater 40. And the refrigerant gas is connected to flow in the cooling block 30. Unlike the first embodiment, the second embodiment does not include a separate Peltier because sufficient cooling function can be achieved with only refrigerant gas.

Referring to (b) of FIG. 7, the inlet 311 and outlet 330 of the cooling block 30 are connected to the cooler 330 through a refrigerant pipe (not shown). The cooler 330 may be placed outside the bio 3D printer. However, it is not limited to this. The cooling block 30 is connected to the cooler 330 and functions like an evaporator in the refrigerant cycle. Heat exchange is performed while the refrigerant flows in the cooling block 30, and the holder body 10 and the syringe 6 are cooled.

The second embodiment of the cooling unit of the present invention is advantageous when the biomaterial contained in the syringe requires cooling at a relatively very low temperature, that is, when it is difficult to lower the temperature to the required temperature by the flow of cooling water.

Referring again to FIGS. 3 to 5, the holder body 10 according to an embodiment of the present invention is provided with a locking portion 51 for fastening the syringe adapter 60 at the upper part of the seating groove 11.

A syringe adapter 60 is coupled to the top of the syringe 6. The syringe adapter 60 protects the biomaterial inside the syringe by isolating the inside and outside of the syringe. The syringe adapter 60 is connected to an air inlet pipe for supplying air into the syringe 6. The syringe adapter 60 can be fitted into the top opening of the syringe 6 in the form of a stopper.

In the syringe adapter 60, the adapter upper part 611 disposed outside the syringe 6 is formed in a cylindrical shape, and a locking hole 61 formed in the circumferential direction may be formed. The locking hole 61 corresponds to the locking portion 51 of the holder body 10. The locking portion 51 is formed as an arc-shaped protrusion.

A circumferential groove 511 of a shape corresponding to the outer peripheral surface of the adapter upper part 611 is formed on the upper side of the holder body 10, and a locking portion 51 is formed in the circumferential groove 511.

Since the holder cover 20 is hingedly coupled to the holder body 10, when the holder cover 20 is closed toward the holder body 10, the upper part of the adapter 611 is received in the circumferential groove 511, and the upper part of the adapter The locking portion 51 of the holder body 10 is fitted into the locking hole 61 of (611).

When discharging biomaterial from the syringe 6, pneumatic pressure is provided into the syringe through the air inlet pipe. Therefore, a pressure higher than the external pressure is formed inside the syringe. The pressure inside the syringe 6 may act toward the syringe adapter 60. Therefore, the syringe adapter 60 may explosively separate from the syringe 6, in which case damage to the device and output may occur. However, according to the present invention, when the holder cover 20 is closed, the locking portion 51 is coupled to the locking hole 61 of the syringe adapter 60 to fix the syringe adapter 60, so that the syringe adapter 60 It is possible to effectively prevent the syringe adapter 60 from being separated from the syringe 6 due to pressure applied in the longitudinal direction. In addition, since the locking hole 61 and the locking portion 51 are coupled by closing the holder cover 20, the syringe adapter 60 can be easily fixed.

According to the present invention, air is provided into the syringe 6 to discharge the biomaterial. Referring to FIG. 2, a configuration for supplying air to the syringe 6 will be described.

In a bio 3D printer, an air compressor 8 may be placed in the lower space of the printer chamber 1 (see FIG. 1). The air compressor 8 may be arranged in a vibration reduction structure using a damper, etc. together with the coolant pump 7.

The air compressed by the air compressor (8) is supplied to the expansion tank (150) located at the rear of the bio 3-filler printer. A water separator 120 is connected to the expansion tank 150 to remove moisture contained in the air. The air passing through the water separator 120 sequentially passes through first to third air filters 131, 132, and 133 configured to purify the air according to the size of dust. The first to third air filters 131, 132, and 133 may be formed of, for example, HEPA filters.

The purified air that has passed through the first to third air filters 131, 132, and 133 flows into the distributor 200. The air flowing into the distributor 200 is supplied to each syringe 6 at a preset flow rate by the control unit. A regulator and valve are installed in the distributor 200, and a pressure sensor is installed in the air supply pipe connected to the syringe.

The bio 3D printer according to an embodiment of the present invention has the advantage of being able to operate the bio 3D printer without being connected to an external air supply system due to the above-described configuration.

According to an embodiment of the present invention, each syringe includes an NFC tag 80, and a bio 3D printer to which the syringe module is applied may be provided with an NFC reader 81. The NFC reader 81 is connected to the control unit of the bio 3D printer.

As shown in FIG. 8, an NFC tag 80 that describes the temperature conditions and discharge pressure of the biomaterial contained in the syringe 6 may be attached to each syringe 6.

An NFC reader 81 that reads information written on the NFC tag 80 may be installed inside the printer chamber.

The control unit can control the temperature of the syringe from information recorded on the NFC tag 80 read by the NFC reader 81. However, the control unit is not limited to the information recorded in the NFC tag 80 and may appropriately control the temperature of the syringe according to the usage environment regardless of the NFC tag 80.

The control unit may include a processor, and the processor may include a microprocessor, an application-specific integrated circuit (ASIC), other chipsets, logic circuits, registers, and communication modems known in the art to perform calculations and various control logic. , data processing devices, etc. Additionally, when the above-described control logic is implemented as software, the processor may be implemented as a set of program modules. At this time, the program module may be stored in the memory device and executed by the processor.

The program includes C/C++, C#, JAVA, Python, It may include code encoded in a computer language such as machine language. These codes may include functional codes related to functions that define the necessary functions for executing the methods, and include control codes related to execution procedures necessary for the computer's processor to execute the functions according to predetermined procedures. can do. In addition, these codes may further include memory reference-related codes that indicate at which location (address address) in the computer's internal or external memory additional information or media required for the computer's processor to execute the above functions should be referenced. there is. In addition, if the computer's processor needs to communicate with any other remote computer or server to execute the above functions, the code uses the computer's communication module to determine how to communicate with any other remote computer or server. It may further include communication-related codes regarding whether communication should be performed and what information or media should be transmitted and received during communication.

According to an embodiment of the present invention, the control unit sets a reference temperature in advance for each syringe module and controls the temperature of the syringe 6 by comparing the reference temperature with the set temperature condition of each syringe read from the NFC tag 80. You can.

At this time, the control unit may control the heater 40 to preheat the holder body 10 to the reference temperature before the syringe is mounted on the syringe module. The temperature sensor is provided in the heater 40 and is placed in contact with the holder body 10 to measure the temperature of the holder body 10.

When power is applied and the control unit determines that the current temperature of the holder body 10 is below the reference temperature before the syringe is mounted on the syringe module, it drives the heater 40 to preheat the holder body 10. The heat applied by the heater 40 heats the holder body 10 and the holder body 10 reaches the reference temperature. Afterwards, when the syringe is mounted and the temperature condition recorded on the NFC tag 80 of the syringe is read by the NFC reader 81, the control unit compares the temperature of the holder body 10 with the information recorded on the NFC tag 80 and The temperature controller is controlled by the syringe set temperature written on the tag 80. When the set temperature value and PID value of the syringe are determined by the NFC tag 80, the control unit compares the reference temperature and the set temperature value and performs cooling on the peltier 70 or heating by the heater 40. At this time, temperature control is performed by PID control.

In controlling the temperature of the syringe, the cooling unit performs cooling using coolant or refrigerant gas introduced from the outside. Therefore, the impact of cooling performance on the design of the syringe module is relatively small. However, in the case of temperature increase, since it is achieved only with the heater 40 attached to the syringe module, the size of the heater 40 has a relatively large influence on the syringe module. However, according to the present invention, since the temperature is increased by using the holder body 10 as a heat storage unit, a heater with a relatively small heat capacity, such as a film heater, can be used.

Additionally, since the holder body 10 is first heated up, the heat of the holder body 10 is then transferred to the mounted syringe, so the syringe can be heated up more quickly. Through this, even if the syringe module according to the present invention is equipped with a low capacity heater, sufficient heating performance can be achieved.

When multiple syringe modules are used in the output module, a reference temperature may be set for each syringe module.

The scope of protection in this field is not limited to the description and expression of the embodiments explicitly described above. In addition, the scope of protection of the present invention may not be limited due to changes or substitutions that are obvious in the technical field to which the present invention pertains.

10: Holder body 11: Seating groove
20: Holder cover 21: Hinge axis
30: cooling block
311: Inlet of through hole 312: Outlet of through hole
40: Heater 50: Fixing part
51: Locking part
60: Syringe adapter 61: Locking hole
70: Peltier 80: NFC tag

Claims (9)

In the syringe module for a bio 3D printer equipped with a syringe that accommodates bio materials,
A holder body formed on one side with a seating groove that contacts the outer peripheral surface of the syringe;
a holder cover installed on the holder body in a direction opposite to the seating groove to be openable and closed;
A temperature sensor that measures the temperature of the holder body;
a heater installed on the other side of the holder body opposite the seating groove;
A cooling unit installed on a side of the heater and having a cooling block connected to a peltier and a coolant pipe or a cooling block connected to a coolant pipe; and
It includes a control unit that controls the temperature of the syringe module,
The control unit has a reference temperature for the holder body as a set value, compares the reference temperature with the temperature of the holder body in a state before mounting the syringe, and selects whether to heat the holder body by operating the heater. ,
A syringe module for a bio 3D printer, characterized in that when the set temperature of the mounted syringe is input, the operation of the heater or the cooling unit is controlled by comparing the reference temperature with the set temperature of the syringe.
According to paragraph 1,
The holder cover is formed to accommodate the syringe by having a support portion in which the lower end of the syringe is inserted and supported from the upper part of the holder cover, and is hinged and open/closeable coupled to the holder body by a hinge axis. , Syringe module for bio 3D printer.
According to paragraph 1,
The holder body is a syringe module for a bio 3D printer, characterized in that it includes a hollow fixing part formed on an upper part of the heater and connected to a side of the holder body.
According to paragraph 1,
A syringe module for a bio 3D printer, wherein the heater is a film-type heater with a temperature sensor attached.
According to paragraph 2,
On one side of the holder body, a locking portion that fits into the locking hole of the syringe adapter mounted on the syringe is formed to protrude, so that when the holder cover is rotated around the hinge axis and closed to the holder body, the holder cover is stored in the holder cover. A syringe module for a bio 3D printer, characterized in that the locking part is fitted into the locking hole of the syringe adapter.
According to clause 5,
A syringe module for a bio 3D printer, wherein a circumferential groove is formed on one side of the holder body and has a shape corresponding to the outer circumferential surface of the adapter upper part of the syringe adapter, and the locking portion protrudes from the circumferential groove.
According to paragraph 1,
The cooling unit,
It includes a plate-shaped peltier installed in contact with a side of the plate-shaped heater, and the cooling block connected to a cooling water pipe installed in contact with the peltier,
The cooling block includes an internal flow path having an inlet and an outlet and is connected to a coolant supply unit,
The coolant supply unit includes a coolant pump installed in the lower space of the printer chamber of the bio 3D printer connected to the inlet, a radiator connected to the outlet, a fan for heat dissipation of the radiator, and water passing through the radiator, and the coolant A syringe module for a bio 3D printer, comprising a coolant tank connected to a pump.
delete According to paragraph 1,
The syringe mounted on the syringe module is attached with an NFC tag recording a set temperature appropriate for the characteristics of the biomaterial.
The syringe module for a bio 3D printer, wherein the control unit receives information read by an NFC reader from the NFC tag and inputs the set temperature of the syringe.