KR102199462B1 - Method and apparatus for measuring biometric information - Google Patents

Abstract

Disclosed is a method of measuring biometric information in a terminal. The terminal receives the image of the strip including the reagent pad from which the sample was collected, determines the color and brightness information of the test line of the reagent pad on the received image, and provides the determined brightness information of the test line. Disclosed is a method for measuring biometric information in which a quantitative value of a reagent reaction of the sample is derived by comparing with reference brightness information on a received image, and a result of the reagent reaction is determined based on the derived quantitative value.

Description

Method and apparatus for measuring biometric information TECHNICAL FIELD

The present invention relates to a method and an apparatus for measuring biometric information from a collected sample.

A method of measuring biometric information through a sample collected from a body continues to be developed. Urine or blood is generally used as a sample, and as measurement methods develop, a method of measuring biometric information such as diabetes using sweat or tears as a sample has been developed. In addition, a method of measuring biometric information by collecting samples from saliva and exhaled breath is under development.

As a general method of measuring biometric information using a sample, biometric information can be easily measured through a qualitative analysis that determines whether it is positive or negative by visually checking the reaction result of urine to a reagent on a urine diagnostic stick. .

In measuring biometric information, many reagent reactions to various diseases are required, and in addition, quantitative judgment is required to determine the level of status through measurement values as well as qualitative analysis of positive/negative reactions. .

Various information, such as diabetes level, acidity (pH), and protein level, can be obtained through reaction tests using blood as well as urine, but there is a problem that the measurement equipment must be separately provided depending on the type of information to be measured. . In addition, the measurement equipment is medium-sized and large-sized equipment, and the equipment cost is relatively high, and the specialized knowledge is required for the measurement method, so that only some experts such as doctors and clinical pathologists have limited access.

In order to solve this problem, the development of home and portable measuring equipment that can be easily used by the general public has become active, and recently, a method of measuring biometric information by inputting sample information into a portable terminal such as a smartphone has been studied.

A technology that analyzes a strip from which a sample is collected through an optical image sensor such as a camera included in a terminal has been recently developed with a lot of interest, and accurately analyzes the reaction between the reagent pad attached to the strip and the sample. For this purpose, a method of obtaining an accurate degree of discoloration by analyzing and correcting the degree of discoloration of a reagent pad is being actively researched.

However, in order to correct the degree of discoloration of the reagent pad, the color may be displayed differently depending on the lighting of the space in which the sample is measured, only by compensating the discoloration value with the standard color part, so there is a limitation in accurate correction. . For example, there may be a problem in that a camera sensor may incorrectly recognize a discoloration value because it is measured in a dark space or covered by a strip in a shadow of a terminal user.

In addition, when the temperature of the reagent is significantly different from the room temperature at which the measurement is performed, correction of the quantitative value of the quantitative reaction according to the temperature may be required. In addition, if the reagent itself is a temperature sensitive reagent, that is, if the degree of discoloration is large depending on the temperature, correction of the quantitative value according to the temperature is an essential step.

Accordingly, a correction method is required to reduce various errors that may occur in a measurement environment, and in the present invention, a method of deriving an accurate result by correcting a quantitative value using brightness in a reagent reaction will be described.

According to the described embodiment, a method and apparatus for measuring biometric information that can more easily and accurately derive biometric information from an image obtained by photographing a biosensor may be provided.

In the method of measuring biometric information according to an embodiment, in the method of measuring biometric information by a terminal, the terminal receiving an image of a biosensor including a reagent pad from which a sample was collected, the reagent pad on the received image Determining color and brightness information of the reaction unit of, comparing the determined brightness information of the reaction unit with reference brightness information on the received image, and deriving a quantitative value of the reagent reaction of the sample, and the derived quantification Based on the value, it may include determining the result of the reagent reaction.

In addition, it may further include identifying the biosensor by using the identification information displayed on the received image, and determining a result of the reagent reaction based on the identified biosensor information.

In addition, the identification information displayed on the received image may include at least one of a QR code, a bar code, an image, and a text.

In addition, it may further include determining the temperature of the sample based on temperature information indicated by a temperature measuring unit attached to the reagent pad on the received image.

In addition, the step of deriving the quantitative value of the reagent reaction of the sample may further include deriving a quantitative value of the reagent reaction based on the determined temperature information of the sample and the temperature information of the quantitative reaction of the sample. I can.

In addition, the temperature measurement unit attached to the reagent pad may include at least one of a temperature measurement unit attached to the sample input unit of the reagent pad and a temperature measurement unit attached to the reaction unit of the reagent pad.

In addition, the terminal may further include measuring room temperature by using a temperature sensor built into the terminal.

In addition, the terminal may further include determining a temperature indicated by a temperature sensor attached to the biosensor on the received image as room temperature.

In addition, the reference brightness information includes a plurality of brightness information discretely representing different brightnesses for the same color, and the step of deriving the quantitative value includes brightness information of the reaction unit among the plurality of brightness information It may include detecting first brightness information corresponding to, and deriving the quantitative value corresponding to the first brightness information.

In addition, the reference brightness information includes a plurality of brightness information continuously representing different brightnesses for the same color, and the plurality of brightness information is continuously arranged within the reference brightness information, and the quantitative value is The deriving may include detecting first brightness information corresponding to brightness information of the reaction unit from among the plurality of brightness information, detecting a position in which the first brightness information is arranged in the reference brightness information, and the It may include the step of deriving the quantitative value corresponding to the detected position.

In addition, the reference brightness information includes a plurality of brightness information discretely representing different brightnesses for the same color, and the step of deriving the quantitative value may include a portion corresponding to the reagent pad in the image. Detecting an area including pixels having the same brightness as the brightness of, recognizing the shape of the detected area, determining the actual brightness of the reagent pad based on the recognized shape, and the determination It may include the step of deriving the quantitative value corresponding to the brightness.

In addition, the quantitative value of the reagent reaction may be a value corresponding to the color and brightness of the sample determined in the database previously stored in the storage unit of the terminal.

In addition, the reagent pad may further include a control line whose color is changed according to the presence or absence of the reagent reaction.

In addition, based on the positions of the plurality of reagent pads on the received biosensor image, it may further include the step of identifying the biosensor.

In addition, when it is determined that the temperature of the sample is equal to or higher than a preset temperature, the terminal may further include displaying that measurement of the sample is impossible.

In addition, when it is determined that the temperature of the sample is less than or equal to a preset temperature, the terminal may further include displaying that measurement of the sample is impossible.

In addition, when the terminal determines that the expiration date of the biosensor included in the identification information of the biosensor has elapsed, displaying at least one or more of the biosensor not available or the reagent reaction is invalid. It may contain more.

In addition, the temperature measuring unit may be attached as at least one of a straight type, a radial type, and a circular shape.

In addition, the biosensor may be configured to analyze at least one of a user's urine, blood, sweat, tears, saliva, and exhalation.

A terminal for measuring biometric information according to an embodiment includes: an input unit for receiving an image of a biosensor including a reagent pad from which a sample is collected, a storage unit for storing the received image of the biosensor, and a control unit; Including, wherein the control unit determines the color and brightness information of the test line of the reagent pad on the received image, compares the determined brightness information of the test line with reference brightness information on the received image, the It may be set to derive a quantitative value of the reagent reaction of the sample, and to determine a reaction result of the sample based on the derived quantitative value.

The biosensor supporting measurement of biometric information according to the embodiment includes a reagent pad including a sample input unit from which a sample is collected and a reaction unit to which the sample is reacted, an identification information display unit that displays identification information of the strip, and the same A reference brightness display unit for displaying a plurality of different brightness information for color may be included, and the reaction unit may be set to change color according to a reaction result of the sample.

In addition, the sample input unit may include a temperature measuring unit that measures the temperature of the collected sample.

A method for measuring biometric information according to another embodiment includes: photographing an image of a biosensor including a reagent pad from which a sample is collected, transmitting the photographed image to a server, and the reagent pad on the image from the server. It may include receiving biometric information derived by comparing brightness information of the reaction unit with reference brightness information on the image, and displaying the received biometric information.

According to the described embodiment, biometric information can be more easily and accurately derived from an image obtained by photographing a biosensor.

1 illustrates a terminal and a biosensor according to an embodiment of the present invention.
2 shows a reagent pad to which a temperature measuring unit is attached according to an embodiment of the present invention.
3 illustrates various locations to which a temperature measuring unit is attached according to an embodiment of the present invention.
4 is a cross-sectional view of a sample input portion of a reagent pad according to an embodiment of the present invention.
5 is a diagram illustrating a temperature measuring unit attached to a reaction part of a reagent pad according to an embodiment of the present invention.
6 illustrates a biosensor with a temperature measuring unit attached to measure room temperature according to an embodiment of the present invention.
7 shows various forms of a temperature measuring unit according to an embodiment of the present invention.
8 shows a temperature measuring unit of a terminal according to an embodiment of the present invention.
9 illustrates various devices for measuring temperature and room temperature of a sample according to an embodiment of the present invention.
10 is a diagram illustrating a state in which a terminal photographs an image of a biosensor according to an embodiment of the present invention.
11 illustrates a biosensor on which reference brightness information is displayed according to an embodiment of the present invention.
12 illustrates reference brightness information for each color according to an embodiment of the present invention.
13 illustrates a process of measuring biometric information through a biosensor image in a terminal according to an embodiment of the present invention.
14 is a graph showing a brightness value according to a sample temperature according to an embodiment of the present invention.
15 illustrates an identification display unit indicating identification information of a biosensor according to an embodiment of the present invention.
16 illustrates a reaction with a sample in a reagent pad according to an embodiment of the present invention.
17 is a graph showing the degree to which a result of reaction of a reagent pad with a sample varies with temperature according to an embodiment of the present invention.
18 is a graph showing a temperature and a correction temperature of a sample determined according to an embodiment of the present invention.
19 and 20 are graphs showing that the degree of reaction varies according to temperature during reaction according to an embodiment, respectively.
21 and 22 are flowcharts illustrating a process of determining whether the temperature of a sample is within an appropriate temperature range according to an embodiment of the present invention.
23 illustrates a biosensor equipped with a plurality of reagent pads according to an embodiment of the present invention.
24 illustrates a biosensor equipped with a plurality of reagent pads according to an embodiment of the present invention.
25 illustrates a biosensor provided with a plurality of reagent pads including biosensor identification information according to an embodiment of the present invention.
26 illustrates a biosensor in which reference brightness information is displayed around a reagent pad according to an embodiment of the present invention.
27 is a reference diagram for explaining a method of detecting actual brightness of a reagent pad according to an embodiment of the present invention.
28 is a reference diagram for explaining a method of detecting actual brightness of a reagent pad according to an embodiment of the present invention.
29 is a reference diagram for explaining a method of detecting actual brightness of a reagent pad according to an embodiment of the present invention.
30 is a reference diagram for explaining a method of detecting actual brightness of a reagent pad according to an embodiment of the present invention.
31 is a reference diagram for explaining a method of detecting actual brightness of a reagent pad according to an embodiment of the present invention.
32 illustrates a biosensor with reference brightness information displayed around a reagent pad according to an embodiment of the present invention.
33 is a flowchart illustrating an entire process of executing a sample measurement program in a terminal according to an embodiment of the present invention.
34 illustrates a biosensor in which reference color information is displayed according to an embodiment of the present invention.
35 illustrates a method of analyzing biometric information using exhalation measurement according to an embodiment of the present invention.
36 illustrates an example of a biosensor measuring exhalation according to an embodiment of the present invention.
37 illustrates a medical system supporting a measurement service to a sample measurement terminal according to an embodiment of the present invention.
38 illustrates a screen in which a sample measurement program is executed in a terminal according to an embodiment of the present invention.
39 is a network configuration diagram illustrating a network environment in which a terminal operates according to an embodiment of the present invention.
40 is a flowchart illustrating a process of performing a method of displaying biometric information using an image of a biosensor according to an embodiment of the present invention.
41 is an analysis result screen displayed on a terminal according to an embodiment of the present invention.
42 is a block diagram showing the structure of a terminal according to an embodiment of the present invention.

Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings. In the drawings, the same reference numerals refer to the same components, and the size or thickness of each component may be exaggerated for clarity of description.

Hereinafter, a method of acquiring and processing biometric information from a biosensor in which a sample including biometric information is collected by a terminal according to an embodiment of the present invention will be described in detail with reference to FIGS. 1 to 42.

1 shows a terminal and a biosensor according to an embodiment of the present invention.

The terminal 100 of the present invention includes an input unit 110. The input unit 110 includes a button input unit in the case of the terminal 100 equipped with a button, and an optical input unit in the case of the terminal 100 equipped with an optical image sensor. It is preferable to understand it as an input unit in a broad sense including a module into which information such as voice or text is input. In FIG. 1, the terminal 100 may include a camera unit receiving an optical image at the rear side, and a non-contact temperature sensor 112 below the camera unit. Since the temperature sensor also serves to input external temperature to the terminal 100, it can be understood as the input unit 110 of the terminal 100.

The biosensor of the present invention is a device used for analysis by collecting a sample containing biometric information. Samples containing biometric information may include urine, blood, sweat, tears, saliva, and exhaled breath, and the reagent pad of the biosensor 200 and the sample react chemically or physically to the reagent pad. The color of the body is changed or specific information is displayed to determine the state of the body.

In recent years, technologies for measuring various biometric information through exhalation are being developed. Each person or animal has its own characteristics in the exhaled exhalation, so the exhalation can act like a kind of chemical breathprint. In the exhalation, not only carbon dioxide, but also volatile organic compounds such as acetone, toluene, nitrogen monoxide, and ammonia can be discharged together, so it is possible to diagnose diseases such as diabetes by measuring the emission of each substance in the exhalation. For example, in the case of a normal person without diabetes, 900 parts per billion (ppb) of acetone gas is released through exhalation, and in the case of diabetic patients, about 1800 ppb of acetone gas is released through exhalation. Diabetes can be diagnosed by measuring the amount of discharge.

A variety of diseases such as diabetes, asthma, lung cancer, kidney disease, and heart disease can be diagnosed through biosensors such as an exhalation sensor. syndrome). Or, when fat is burned, acetone is mixed with exhalation, so it can be determined whether a person running a treadmill is getting a sufficient diet effect.

Exhalation measurement is also carried out by measuring the discharge amount of substances contained in the exhalation, but the color of the substance in the exhalation changes through a chemical or physical reaction (dye reaction) with the test substance (e.g., color according to pH in the BTB solution). Change), it can also be measured based on color change information. Accordingly, a method of measuring biometric information by measuring a sample collected in exhalation with a biosensor can also be applied to the present invention.

The biosensor 200 of the present invention includes a sample input unit 210 for inputting a sample for reaction with a reagent pad, a control line 220 that is a reference for comparing and determining a reaction on a reagent pad, and a reagent of the reagent pad. Identification of the reference brightness information 240 and the biosensor 200 to be compared to determine the color and brightness level of the test line 230 and the test line 230 that can directly determine the response of the sample and the test line An identification information display unit 250 for displaying information may be included.

The reaction between the reagent pad and the sample in the present invention enables a qualitative analysis through the reaction result through the discoloration of the control line 220 and the test line 230, as shown in FIG. 1, and the degree of discoloration or brightness It also enables quantitative analysis through change. For example, in the case of a pregnancy test, the presence or absence of pregnancy can be measured according to the presence or absence of discoloration in the control line and the test line.

As shown in FIG. 1, the biosensor 200 of the present invention includes a sample input unit 210 into which a sample is injected for reaction between a reagent pad and a sample, and the sample input to the sample input unit 210 is immune. It may react with the control line 220 and the test line 230 of the reagent pad by using an immunochromatography method.

The immunochromatography method is a method that uses the reaction characteristics of an antibody and an antigen. An antibody is a type of protein that is made in our body and plays a role in removing invading pathogens, and substances such as pathogens to which these antibodies bind are used as antigens. It is referred to as this. One type of antibody is characterized by very specific binding to only a specific portion of a specific antigen. Taking the immunochromatographic method applied to the pregnancy test as an example, two types of antibodies that specifically bind to HCG are prepared using human chorionic gonadotropin (HCG), which is excreted in blood or urine after pregnancy as an antigen. . One type of antibody is attached to red-purple gold particles, and the other type of antibody is fixed in a straight line on a thin plate called a nitrocellulose membrane. Antibodies are invisible proteins, so no color appears on the test line immobilized on the nitcellulose membrane.

When urine containing HCG is dropped, the antibody immobilized on the gold particles binds to the HCG and moves the nitrocellulose membrane by capillary action. When the HCG-bound antibody passes the test line, the gold particles form a red-purple straight line as it binds to another antibody immobilized on the nitrocellulose membrane, and this discoloration can be visually judged to determine whether or not to be pregnant. If the urine does not contain HCG, since binding to the antibody cannot occur in the test line, no line will appear, and the user can determine that he is not pregnant.

On the other hand, in all cases of pregnancy or non-pregnancy, the test end line (which may be referred to as "control line" in the present invention) is a line designed to always appear regardless of the presence of HCG. The test end line is also a line using the antigen-antibody reaction and plays a role of displaying information that the strip function has functioned normally and that the result can be read when the test is completed to the biosensor user.

In the above, a pregnancy test using an immunochromatographic method has been described as an example, but it is a fact that those skilled in the art can know that it can be used for diagnosis of various diseases such as ovulation, hepatitis, and AIDS.

2 shows a reagent pad to which a temperature measuring unit is attached according to an embodiment of the present invention.

The biosensor 200 in the present invention may include a temperature measuring unit 215 in the sample input unit 210. Since the temperature of the sample can act as an important variable in measuring biometric information, accurate measurement is required. The part of the biosensor 200 that can accurately measure the temperature of the sample collected by being separated from the body is the sample input unit 210, which is an area where the sample is directly collected, which is the sample measured by the sample input unit 210 This is because there is a high possibility that the temperature of the body will not differ significantly from the temperature in the body.

In the present invention, the sample input unit 210 is a part of the reagent pad and when a sample is input to the sample input unit, the reaction unit in the sample input unit 210 (the reaction unit of the reagent pad includes a control line and a test line). Means), and the components of the sample are moved by immunochromatography. Therefore, it is preferable to maintain a distance between the sample input unit 210 and the reaction unit. If the distance between the sample input unit 210 and the reaction unit is considerably close and the sample is directly in contact with the reaction unit, the reagent reaction in the control line and the test line, which is the reaction unit, may not be performed properly.

The sample input unit 210 may receive (collect) samples in various ways. As shown in FIG. 2, there may be a method of dropping the sample into the sample input part of the biosensor by a dropper, etc., and the method of inserting the sample by directly immersing the biosensor in the liquid sample. There may be.

3 illustrates various locations to which a temperature measuring unit is attached according to an embodiment of the present invention.

As shown in FIG. 3, the temperature measuring unit 215 may be attached to the sample input unit in various forms. In the drawings, an example of attachment in the form of a temperature tape is shown, but it is noted that it is not only in the form of a temperature tape, but also can be attached in various forms capable of measuring temperature.

As shown in FIG. 3(a), the temperature measuring part 215 may be attached to the edge of the sample input part. The temperature measuring unit 215 may display a temperature in a predetermined range by using a scale or calibration for each step. The temperature measuring unit 215 may be set to change color at the measured temperature.

As a method of setting the color to change according to the temperature in the temperature measuring unit 215, Zion ink may be used. For example, you can print on the surface of a beer can with Zion ink to change the color at a certain temperature to inform the consumer of the right temperature. Zion ink refers to an ink made by mixing a thermochromic material that changes color at a specific temperature. In Zion ink, there are two-color reversible ink and irreversible ink that can be re-colored after discoloration due to a change in temperature. In the present invention, the temperature measurement unit may be suitable for determining the temperature of a sample by using a bicolor reversible ink. Such Zion ink can be produced by using a stilbene derivative, which is an organic compound, as a raw material.

In the present invention, the temperature measuring unit 215 prints using Zion ink corresponding to each display value in a measurable temperature range in the form of a date tape, so that when a sample is input, it is set to change color at a specific temperature so that the user can It can be provided so that the temperature of the sample can be judged with the naked eye.

As shown in Fig. 3(b), the temperature measurement unit may be designed to be located at the center of the sample input unit. If the temperature measurement part is located in the center of the sample input part, it can be in contact with the sample in a large area, and there is an advantage over the one located at the edge of the sample input part for visual confirmation. However, if the temperature measurement unit is located in the center, it may inhibit the movement of the sample by the immunochromatography method, so it is preferable to position it in consideration of a method that has minimal influence on the movement of the sample.

4 is a cross-sectional view of a sample input portion of a reagent pad according to an embodiment of the present invention.

4 is a diagram showing a cross section of the sample input unit 210 of the reagent pad of the present invention. Since the sample pad is connected to the sample input unit 210 and the sample reaction unit, a reagent reaction can be detected by immunochromatography. . A temperature measurement unit 215 capable of measuring the temperature of the sample 400 may be attached to an upper portion of the sample input unit 210 of the reagent pad to be designed to directly measure the temperature of the sample 400. In FIG. 4, it is shown that the sample 400 contacts the temperature measuring unit 215 and does not contact the sample input unit 210, which is a part of the reagent pad, but the reagent pad is used for the reagent reaction of the sample 400. It is obvious to those skilled in the art that it should be in direct contact with. Therefore, it is preferable to understand that the sample 400 is in direct contact with the sample input unit 210 of the reagent pad, and the temperature measuring unit 215 is attached to the upper end of a partial region of the reagent pad. As a method of measuring the temperature in the temperature measuring unit, a method using Zion ink or the like has been described above, and thus, refer to FIG. 3 for a detailed description.

5 is a diagram illustrating a state in which a temperature measuring part is attached to a reaction part of a reagent pad according to an embodiment of the present invention.

As shown in FIG. 5, the temperature measurement unit 525 may be designed to be located near the reaction units 220 and 230 of the reagent pad. This is to measure the temperature at which the reaction takes place in the test line 230 of the actual reaction units 220 and 230, and it is possible to increase the accuracy in deriving the quantitative value of the sample by acquiring the temperature information at which the reaction takes place.

The temperature of the sample in the reaction units 220 and 230 where the reaction is performed is a variable having an important meaning in correcting the quantitative value. Since the temperature in the reaction units 220 and 230, that is, the temperature in the control line 220 and the test line 230, is the temperature in a situation in which the test line is discolored due to the reaction between the actual reagent and the sample, the terminal theoretically This is because the theory of the reagent reaction can be applied to the measurement only when it is similar to the temperature of the obtained reagent reaction (the temperature in the quantitative reaction). The terminal may compare the measured temperature with the temperature in the quantitative reaction, and may reduce an error according to the measurement environment by comparing and determining the measured temperature with the quantitative value in the quantitative reaction.

The temperature measurement unit 525 located at the reaction units 220 and 230 of the reagent pad may be designed to be located farther than the control line based on the sample input unit. The reaction units 220 and 230 of the reagent pad mean a region of the control line 220 and the test line 230, and are more than the control line 220 so as not to act as a variable in the reaction of the reagent by the immunochromatographic method. It can be designed to be located far away. However, it is not necessarily limited to design to be located farther than the control line 220, and in the range that does not inhibit the reagent reaction between the sample and the test line 230 and the control line 220, the vicinity of the reaction units 220 and 230 It would be okay to attach to it.

6 illustrates a biosensor with a temperature measuring unit attached to measure room temperature according to an embodiment of the present invention.

As shown in FIG. 6, the temperature measuring unit may exist at various locations of the biosensor 200. As previously described in FIGS. 2 to 4, the temperature of the sample can be measured by placing it in the sample input section 615, and as described in FIG. 5, the temperature of the reagent reaction state is measured by placing it around the reaction section of the reagent pad. You may.

In the present invention, a temperature measuring unit 635 separate from the reagent pad may be attached to the biosensor so that room temperature can be measured in the biosensor 200. The temperature measuring unit 635 attached to the biosensor 200 may be attached not for the purpose of measuring the temperature of the sample, but for the purpose of measuring the room temperature, that is, a space in which the sample reaction takes place. Therefore, if the room temperature can be measured in other ways (for example, if the terminal is equipped with a temperature sensor and the terminal can measure the room temperature), the temperature measuring unit 635 attached to the biosensor 200 exists. I can't.

In some cases, the temperature measurement unit 635 attached to the biosensor 200 may be used to measure the temperature of the reaction unit. If the temperature measurement unit 625 cannot be attached to the reaction unit of the reagent pad, the temperature measurement unit 635 is placed on the biosensor 200 around the reaction unit to measure the reaction temperature of the sample. Can be used as.

7 shows various forms of a temperature measuring unit according to an embodiment of the present invention.

The temperature measuring unit according to an embodiment of the present invention may be attached to the biosensor in various forms. The temperature measuring unit may be attached to the biosensor in the form of a tape like a temperature tape, or may be printed and produced from the biosensor process step. The temperature tape may be generated using the above-described Zion ink, and a temperature measuring unit having a bicolor reversibility that discolors above a set temperature and returns to its original color below a set temperature is preferable for measuring the temperature of a sample.

As shown in Fig. 7(a), the straight temperature measuring unit may be attached to the biosensor. In the case of the straight temperature measuring unit, as a form similar to a commonly used mercury thermometer, a biosensor user can provide an environment in which temperature can be intuitively measured. It can be displayed with a scale in the range of measurable temperatures, and a specific part of the temperature measuring unit corresponding to the measured temperature is discolored, and the measured temperature value can be displayed in numbers or colors. As shown in Fig. 7(a), when a scale of 2 degrees Celsius (2° C.) is displayed, if the measurement temperature is 22° C., 20° C. and 24° C. at the boundary of the measurement temperature can be distinguished from 22° C. Can be set to In addition, if the color changes over three scales from 20°C to 24°C on the temperature measuring unit, the temperature may be determined by the average value of the lowest temperature and the highest temperature of the color change. Alternatively, the temperature with the greatest degree of discoloration may be determined as the measured temperature value. For the discoloration of the temperature measuring unit, the user can make various settings to determine the measured temperature.

As shown in FIG. 7(b), a circular temperature measuring unit may be attached to the biosensor. The temperature tape of Fig. 7(a) is transformed into a circular shape, and its principle is the same as that of a straight line, so a detailed description will be omitted.

As shown in FIG. 7(c), a temperature measuring unit that changes color only at a specific temperature may be attached to the biosensor. This case can be useful under restrictive conditions in which the reaction between the reagent and the sample takes place at a specific temperature.

8 shows a temperature measuring unit of a terminal according to an embodiment of the present invention.

The terminal 100 may measure the room temperature of the space in which the measurement is performed using the temperature sensor 810 provided in the terminal 100. Recently, a temperature sensor and a humidity sensor are often embedded in a terminal 100 such as a smartphone or a tablet PC, and a temperature sensor inside or outside the terminal 100 can be measured through the temperature sensor.

As shown in Figs. 8(a) and 8(b), the temperature sensor 810 may be located at a certain position of the terminal 100, and the terminal 100 through the measured value input through the temperature sensor Room temperature can be determined. The temperature sensor 810 may exist in various forms in the terminal 100 and will be described in detail in FIG. 9 below.

9 illustrates various devices for measuring temperature and room temperature of a sample according to an embodiment of the present invention.

9(a) to 9(c), a temperature measuring unit is built into various types of terminals such as a smartphone, a tablet PC, and a wearable device to measure the temperature.

As shown in FIG. 9(d), it is possible to measure room temperature by providing an infrared (IR) thermometer in the terminal. In the case of an infrared temperature sensor, it measures infrared rays radiated from an object with heat. Since infrared radiation energy radiated from the surface of the object to be measured propagates through space, it measures temperature without contact This is possible. There are a monochromatic type that measures infrared radiation energy at a specific wavelength, and a ratio type temperature sensor that measures the radiation intensity ratio of two or more specific wavelengths, and a suitable type of temperature sensor is provided according to the measurement situation of the sample. You will have to use it. The terminal converts the intensity of radiation input to the infrared sensor as heat to increase the temperature of the heat sensor, converts the temperature change into an electronic signal, amplifies it, and displays the measured temperature information.

As shown in FIG. 9(e), the terminal may be equipped with a laser thermometer to measure the temperature. A laser is a form of light and can measure temperature using a photoconductive or photodiode semiconductor. Temperature can be measured based on the intensity of light radiated through a change in resistance corresponding to temperature or a change in current or voltage.

In addition, a thermal imaging camera may be embedded in the terminal, and temperature measurement may be performed using the function of the thermal imaging camera. Therefore, even if not shown in the drawing, when the terminal performs a function of measuring temperature, it can be applied to the temperature measurement in the present invention.

10 is a diagram illustrating a state in which a terminal photographs an image of a biosensor according to an embodiment of the present invention.

After the sample is collected from the sample input unit, the terminal may photograph the biosensor and receive the biosensor image. Information displayed on the biosensor is received by the terminal in the form of an image, and the terminal analyzes the received image to determine a reaction result of the sample.

1, the biosensor may display discoloration information, reference brightness information, identification information, etc. in the reaction part of the reagent pad, and the terminal uses a camera sensor to store information displayed on the biosensor. Can be obtained. For example, when a temperature measurement unit for measuring room temperature is attached to the biosensor, and the temperature measurement unit displays a specific temperature, the terminal can read the specific temperature displayed in the received image (optical character recognition (OCR)). have.

When the terminal receives the image of the biosensor, it may store metadata about the image together. When a biosensor image is captured using an optical image sensor (camera) in a terminal, information such as shooting time, location, temperature, humidity, air pressure, and lighting is measured simultaneously or sequentially and stored as metadata of the biosensor image. I can. The storage unit of the terminal may convert metadata information on the biosensor image into a database for each item, and each item may be adopted as a variable during image analysis.

In addition, since the identification information included in the biosensor image may include various information as well as identification information of the biosensor itself, the terminal may analyze the identification information to obtain measurement-related information. Identification information will be described in detail in FIG. 14 to be described later.

11 illustrates a biosensor on which reference brightness information is displayed according to an embodiment of the present invention.

As shown in FIG. 11, the biosensor may display reference brightness information 1140. The reference brightness information 1140 means information in which brightness for a specific color is arranged according to the degree. It is preferable to set the specific color to be the same or similar to the discolored color in the case of discoloration due to reaction in the reaction part test line of the reagent pad. This is to perform correction by comparing the reference brightness information 1140 with the brightness of the discolored color of the test line when the reaction is made.

The terminal may compare the brightness information of the color change of the test line and the reference brightness information 1140 displayed on the biosensor in the received image and determine a brightness level of the most similar degree. The quantitative value in the quantitative reaction can be derived through the grade of the reference brightness.

The reference brightness information 1140 displayed on the biosensor is information that arranges the brightness (brightness) value for one color according to the degree.In the art field, the darkest color is 0 and the brightest color is 10, and it is divided into 11 steps. The brightness is also distinguished. However, it is not necessarily limited to the division into 11 stages, and since the more detailed division, the more accurate brightness comparison is possible, so it is preferable to divide the stage into many stages.

In addition, since brightness is related to reflectance, the actual color brightness is important, but the lighting environment of the environment in which the brightness is measured is also important. Accordingly, the measurement of the brightness of the color in the test line of the biosensor may be corrected by comparing it with the reference brightness information 1140.

The reference brightness information 1140 is also information displayed on the biosensor and may change according to the lighting of the environment to be measured. Accordingly, the terminal may compare the brightness of the color in the test line and the brightness of the reference brightness information to correct the measured environment so as not to affect the lighting.

12 illustrates reference brightness information for each color according to an embodiment of the present invention.

12(a) to 12(c), various types of reference brightness information may be displayed on the biosensor. 12(a) to 12(c) are described on the premise that there is only a difference in brightness for a specific color, and the color has a brighter value from 5 to 1, respectively.

As shown in FIG. 12(a), various brightness levels for the first color may be divided and displayed. In the drawing, the brightness is divided into five grades into grades 1 to 5, and the brightest grade is indicated as grade 1. However, by dividing into grades of 2 or more, the brightness most similar to the brightness of the discolored color can be determined in the test line. In order to determine the brightness similar to the brightness of the discolored color as much as possible, the brightness level can be classified in maximum detail and set to accurately compare the brightness in the terminal.

The biosensor producer may set the biosensor to display reference brightness information for two or more colors. If there are two or more types of reagent-reacting sample pads, it is required to display reference brightness information for two or more colors, but in order to detect one reagent reaction, reference brightness information for two or more colors may be displayed. This is to derive a quantitative value through accurate brightness comparison. For example, if the color of discoloration after reaction in the reagent pad is green, reference brightness information for green is displayed on the biosensor, and reference brightness information for yellow or blue, which has a high color similarity to green, is displayed. , It is possible to increase the accuracy by providing various criteria for the case of comparing brightness in the terminal.

13 illustrates a process of measuring body information through a biosensor image in a terminal according to an embodiment of the present invention.

In step S1310, the terminal may receive an image of a biosensor (eg, a urine diagnostic strip) including a reagent pad in which the collected sample is absorbed. For example, a biosensor image may be obtained through an optical image sensor (camera) of the terminal. The biosensor image may display color change information, reference brightness information, or identification information in the reaction part of the reagent pad. 14(a) to 14(c), the identification information may be displayed as a QR code, a barcode, or text. Therefore, the terminal can acquire various information on the reagent reaction only by analyzing the received image.

In step S1320, the terminal may detect color and brightness information of the test line of the reagent pad on the received image.

The terminal may determine whether the test line of the reaction unit displayed on the received biosensor image is discolored. For example, after a sample reaction occurs, the test line may change color from white to red (red), and the terminal may determine whether the color is changed using an RGB value or a CMYK value corresponding to the color of the test line.

The terminal may also detect the brightness (brightness) of the color. The detected brightness can be set in a range from the darkest level (black) to the brightest level (white). The storage unit of the terminal may store information corresponding to each brightness for each color in advance. Alternatively, the storage unit of the terminal may receive and store information corresponding to each brightness for each color in advance from the server.

In step S1330, the terminal may derive a quantitative value corresponding to the reagent reaction of the sample by comparing the detected brightness information of the test line with the reference brightness information on the received image.

The terminal may detect the color and brightness of the test line in step S1320. The terminal may pre-store the brightness that the test line can have in a fixed quantity reaction. The terminal may derive a quantitative value corresponding to the reagent reaction by comparing the brightness in the quantitative reaction and the brightness of the measured test line. The terminal may store information about the brightness in the quantitative reaction in advance in the storage unit of the terminal. In addition, the terminal may request the information from the external device and then receive the information from the external device.

Whether the quantitative value increases or decreases as the brightness of the test line increases may be determined according to the type of sample. The terminal may detect the same brightness as or most similar to the measured brightness of the test line by using reference brightness information of the same color as the detected test line color.

By using the reference brightness information displayed around the reaction part on the biosensor, measurement errors due to lighting can be minimized. Even if the lighting is changed, since both the brightness of the test line and the reference brightness information are changed at the same time, there is an effect that measurement errors caused by the external environment can be reduced. In the conventional color correction method, since variables such as external lighting are not considered in the process of comparing the color of the reference color and the test line, there is a problem in that the terminal may erroneously detect the color after discoloration due to an actual reagent reaction. However, when the color and brightness of the test line are simultaneously compared and detected as in the above embodiment, a measurement error due to external lighting or the like may be reduced.

The terminal may derive a relative difference of the measured brightness based on the brightness in the quantitative reaction as a quantitative value by comparing the measured brightness with reference brightness information. For example, the terminal may detect red as the color of the test line. In addition, the terminal may detect the second level (meaning that it is the second brightest) among all 5 levels of brightness as the red brightness. In the database stored in the terminal, the brightness in the quantitative reaction may be a third grade (meaning that it is the third brightest) among all five levels of brightness. Since there is a difference of one level between the measured brightness of the test line (2nd grade) and the brightness in the quantitative reaction (3rd grade), the terminal The relative difference in brightness (second grade) of the test line can be derived as a quantitative value called "one level".

In step S1340, the terminal may derive a reaction result of the sample based on the derived quantitative value. For example, the value corresponding to sample A may be lower as the brightness measured after the reaction is brighter. When the brightness of the measured test line is brighter than that in the quantitative reaction, the terminal may determine that the value corresponding to sample A is lower than the reference value. In addition, the terminal may derive a value corresponding to sample A as a result of the reaction of sample A. The difference between the derived value and the reference value may correspond to a difference between the measured brightness of the test line and the brightness in the quantitative response.

Information on brightness and reference values in the quantitative reaction for each sample may be previously stored in the terminal. In addition, the terminal may request the information from the external device and then receive the information from the external device.

The terminal may detect a color changed due to a reaction between the reagent pad and the sample on the received image. The detected color may be stored in a format such as red, green, blue (RGB) value or cyan, magenta, yellow, black (CMYK) value. In addition, brightness of the detected color may also be detected and stored.

The color and brightness displayed in the received image may be different from the color and brightness in the actual reagent pad. Accordingly, for more accurate measurement, the terminal may detect the brightness of the test line by comparing the reference brightness information on the received image with the brightness of the test line on the received image. In addition, by using the information on the brightness in the quantitative reaction, a relative difference in brightness of the test line based on the brightness in the quantitative reaction may be derived as a quantitative value.

The terminal may analyze the reaction result of the collected sample based on the color of the reaction part of the reagent pad and the derived temperature information. Since the control line and the test line are present in the reaction unit, it is possible to determine whether the corresponding biosensor is in a normal state according to whether the control line is discolored due to a reagent-sample reaction. Since the control line is premised that the color changes when the sample is input, if the control line does not change color even when the sample is input, the corresponding biosensor may be determined as an invalid biosensor that cannot determine a normal reaction. In this case, the terminal may receive an image of the biosensor in which the control line is not discolored, and may indicate to the user that the biosensor is invalid.

When the color changes due to a reagent-sample reaction in the test line, that is, when a positive reaction occurs, the terminal may receive an image of the biosensor in which the color is changed. Accordingly, the terminal can perform qualitative detection according to the presence or absence of discoloration, and quantitative detection according to the degree of discoloration.

The terminal may perform quantitative analysis according to the degree of discoloration of the reagent pad of the received image. Quantitative analysis can be performed by comparing the discolored color and brightness of the test line on the received image with reference brightness information. The storage unit of the terminal may store a database of temperature, color, and brightness values in the quantitative reaction, and the terminal compares the temperature, color, and brightness values in the database to detect a corresponding value for the reagent-sample reaction. I can. Since a calibration curve or line value according to each temperature is embedded in the storage unit of the terminal, the cloud, or the server, the value can be corrected based on the detected temperature.

For more accurate measurement in steps S1330 to S1340, the temperature measured by the temperature measuring unit of the biosensor or the terminal may be referred to. As previously described with reference to FIGS. 6 and 8 to 9, reference temperature information indicating room temperature may be obtained by the temperature measuring unit 635 attached to the biosensor, or the temperature sensor of the terminal may be used. Thus, reference temperature information can be obtained.

As another method of obtaining reference temperature information from the terminal, the reference temperature information may be obtained by accessing a network. The terminal may be connected to another terminal or a network device such as a server through a communication unit. The terminal may receive and obtain temperature information measured by another terminal located on the measurement space connected to the network. The location of the terminal can be measured through a location sensor such as GPS built into the terminal, or the location of the terminal can be measured by a Wi-Fi access point (AP) installed indoors. The terminal may receive room temperature information according to a location through a server such as the Meteorological Agency based on such location information, and may apply this information as reference temperature information.

The terminal may not only store color change information in the quantitative reaction in the storage unit, but also store appropriate temperature information in the quantitative reaction in the storage unit. Since the color change according to the temperature may be different for each reagent reaction, the room temperature in the space where the reagent reaction takes place and the temperature of the sample in the reaction part can also be important variables. For example, if a sample reacts to a test line marked in white before the reagent reaction, it may turn red at room temperature 25℃, which is an appropriate temperature for quantitative reaction, and light red at a lower temperature of 15℃, and a higher temperature. At 35 ℃ phosphorus, it may discolor to dark red. As another example, when the temperature of the sample is 25° C., the reagent reaction turns blue, but at a higher temperature of 35° C., the sample itself may undergo a reaction different from the quantitative reaction through a chemical reaction, and thus a different color may be changed.

Accordingly, the terminal may compare the color change information, brightness, and temperature of the reagent reaction on the received image with the color change color and temperature in the quantitative reaction to detect the color change as a quantitative value. The terminal may detect a quantitative value by matching the results of each reagent reaction in a database classified according to reference brightness information and temperature information of a color change.

14 is a graph showing a brightness value according to a sample temperature according to an embodiment of the present invention.

Each sample may have a different degree of discoloration depending on the temperature. Color and brightness information according to temperature may be stored in a terminal or a cloud (server) as described above, or may be received from another terminal. The terminal may derive a quantitative value corresponding to the reagent reaction by comparing color change information and brightness according to temperature.

For example, as shown in FIG. 14, the brightness according to the concentration at 22° C. and the brightness according to the concentration at 37° C. may vary at different ratios. In this case, when analyzing only the color change information and brightness information in the received image, the brightness when the sample temperature is 22°C and the density is 4 and the brightness when the sample temperature is 37°C and the density is 1, the brightness is the same. Therefore, there is a possibility that an incorrect quantitative value will be derived. However, when the terminal stores the brightness values according to the concentration at 22℃ and 37℃ in a database, the brightness when the sample temperature is 22℃ and the concentration is 4 and the sample temperature is 37℃ and the concentration is 4 Since the difference in brightness in the case of 1 can be known, a more accurate quantitative value can be derived.

15 illustrates an identification display unit indicating identification information of a biosensor according to an embodiment of the present invention.

The identification information displayed on the biosensor may include various types of information. As shown in FIG. 15(a), it may be displayed in the form of a QR code, and as shown in FIG. 15(b), it may be displayed in the form of a barcode. Alternatively, it may be displayed in the form of text consisting of numbers and/or letters as shown in FIG. 15(c). Although not shown, it can also be displayed in the form of an image such as a specific symbol. Note that it is sufficient if the biosensor is displayed in a form that can be identified, and is not necessarily limited to the form described above.

The identification information displayed on the biosensor may include not only identification information on the biosensor itself, but also information on qualitative/quantitative reactions in the corresponding biosensor. It may include information that the test line turns red as a result of the reagent-sample reaction, information that the reagent is for analysis of diabetes, protein, and the like.

Accordingly, the terminal analyzes the identification information included in the received biosensor image, and the purpose of the biosensor is for what purpose, the manufacturer of the biosensor is, when is the manufacturing date of the biosensor, and Information such as how long the expiration date is available can be identified.

Such information can be analyzed only by displaying the identification information, or can be analyzed by a database (DB) stored in the storage unit of the terminal analyzing the identification information image. In other words, the identification information itself can be displayed as identification information by encoding the above purpose, manufacturer, and expiration date information itself, and through the identification information, the terminal can search in a pre-stored database (DB) to analyze the information.

Additionally, the terminal may transmit identification information related information to a server or the like to obtain information indicated by the identification information from the server. Additional information on the identification information received by the terminal may be requested to a server, such as a server related to a corresponding biosensor manufacturer, and additional information on the identification information may be provided to the terminal from the server receiving the request message.

In more detail, the identification information displayed on the biosensor may include unique information about a user. The user may mean a person who provided a sample, that is, a person to be measured. When the user periodically measures body information or when it is necessary to measure body information for the purpose of diagnosing a specific disease, the user's previous measurement information may be included.

For example, when a user attempts to measure a diabetes level through a sample collected by a biosensor, the terminal may analyze the received biosensor image to obtain identification information, and transmit the identification information to a hospital server. Diabetes level information measured by the user in the past may be provided to the terminal from a hospital server that has received information on identification information from the terminal. Accordingly, the terminal may determine a change in the user's diabetes level based on information received from the server. A method of obtaining various information using a server or the like will be described later.

16 illustrates a reaction with a sample in a reagent pad according to an embodiment of the present invention.

As shown in FIG. 16, an antigen-antibody reaction may occur in the reaction part of the sample pad. Control lines and test lines including antigens or antibodies may be printed on the reaction section. In the control line and the test line, a reaction of a sample introduced into the reaction unit may occur. There may be a light source in the space where this reaction takes place. For example, if the reaction occurs indoors, there may be artificial lighting such as a fluorescent lamp. Since the terminal acquires the image of the biosensor in which the reaction occurs, the color or brightness displayed in the acquired image may be different from the actual color or brightness according to the light source.

Since the terminal detects the biometric information based on the discolored color of the control line and the test line in the obtained biosensor image, the detected biometric information may vary according to the color and brightness of the control line and the test line. In particular, as illustrated in FIG. 15, when several reagent reactions are performed through one sample, the color and brightness of the color change may be displayed differently according to each reagent reaction, and thus the detected quantitative value may need to be corrected.

Hereinafter, a method of correcting the quantitative value according to temperature as one method of correcting the quantitative value will be described.

17 is a graph showing the degree to which a result of reaction of a reagent pad with a sample varies with temperature according to an embodiment of the present invention.

In a reagent reaction, the reaction temperature can also be a variable that has an important influence on the reaction result. 16 is a graph showing the change in quantitative value according to the reaction temperature of the stress hormone cortisol. It is a graph measuring the quantitative value according to the reaction temperature of the stress hormone cortisol for a total of 6 patients, and it indicates that the amount of cortisol measured increases as the reaction temperature increases.

This indicates a phenomenon in which the quantitative value varies according to the reaction rate of the antigen and the antibody according to the reaction temperature in the quantitative reaction. In general, the quantitative measurement equipment maintains a constant temperature to prevent the phenomenon that the quantitative value varies. However, since the terminal in the present invention is a small terminal that is easy to carry and it is difficult to incorporate equipment for maintaining a constant temperature, it may be difficult to prevent a phenomenon in which the quantitative value varies depending on the temperature.

Hereinafter, a method of correcting a quantitative value will be described while explaining that the temperature of the sample and the temperature in the quantitative reaction can be important variables in the reagent reaction.

18 is a graph showing the temperature and correction temperature of a sample. 18 is a graph showing the results of BNP analysis (B-type natriuretic peptide Assay) of a specific sample as an example of the present disclosure. Referring to FIG. 18, fluorescence units corresponding to a sample capture zone and fluorescence units corresponding to a calibration capture zone may be different from each other. In other words, there may be a difference between the quantitative value corresponding to the sample capture area related to the actual reaction in the test line and the quantitative value corresponding to the calibration capture area related to the quantitative reaction.

19 and 20 are graphs showing values before and after correcting the temperature of a sample according to an example of the present invention, respectively.

The vertical axis of Fig. 19(a) is the value of R10, and the value of R10 is a value representing a specific ratio of the test line (Test Line; TL; sample capture zone) and the test line (Internal Standard Line; ISL; calibration capture zone) in the quantitative reaction. And it can be calculated as Equation 1 below.

The vertical bar graph located on the left side of the x-axis of FIG. 19(a) represents the R10 value of the reagent when the sample is 0, and the vertical bar graph located on the right represents the R10 value of the reagent when the sample is 10 ng/ml. . The left side of each vertical bar graph represents the R10 value of the reagent at 22°C, and the right side of each vertical bar graph represents the R10 value of the reagent at 37°C. It can be seen that the R10 value increases as the amount of the sample increases, and the R10 value decreases as the temperature increases. That is, it is a graph showing that the result value of the reagent reaction may vary depending on the temperature.

19(b) is a graph showing the reagent value of the test line TL, and FIG. 19(c) is a graph showing the reagent value (ISL) in the quantitative reaction. 19(b) shows that the larger the sample amount, the larger the reagent TL value. When the sample is 0, there is no significant difference in the TL value according to the temperature, but when the sample is 10 ng/ml, the TL value according to the temperature. You can see the difference increases. Similarly, in Fig. 19(c), it can be seen that when the sample is 10 ng/ml, the difference in the ISL value according to the temperature increases.

FIG. 20(a) shows the R10 value after temperature correction corresponding to the R10 value of FIG. 18(a). After temperature correction, the R10 value at 22℃ and at 37℃ is higher than when the sample is 0 at 22℃ and at 37℃, but is equal to each other at 5ng/ml. It can be seen that the value at 37°C becomes larger as the sample increases. Through this graph, it can be seen that accurate measurement of the sample is possible by correcting the quantitative value. 20(b) and 20(c) are TL values and ISL values, respectively, which support accurate measurement of a sample by correction.

21 and 22 are flowcharts illustrating a process of determining whether the temperature of a sample is within an appropriate temperature range according to an embodiment of the present invention.

The reagent reaction is an antigen-antibody reaction, and it has been described above that the reaction temperature is important. Accordingly, a reaction at a temperature within a certain range may be data for accurate measurement of a quantitative value, and a normal reaction may not occur due to modification of an antigen or an antibody at a temperature above a predetermined temperature or below a predetermined temperature.

The terminal may determine the temperature of the sample, the reaction temperature, etc. by analyzing the image of the received biosensor, and may also obtain the temperature in the quantitative reaction through various paths.

Accordingly, the terminal may determine whether or not the reagent reaction is effective by comparing the determined temperature of the sample to the temperature within an appropriate range preset in the terminal. In step S2110, the terminal may determine the temperature of the sample by analyzing the temperature indicated by the temperature measuring unit on the received biosensor image. For example, if the temperature indicated by the temperature measuring unit is 22°C, the terminal may determine the temperature of the sample as 22°C.

In step S2120, the terminal may determine whether the determined temperature of the sample is equal to or higher than a preset temperature. If the sample is a sample that undergoes a normal reagent reaction at 20°C or higher, it is difficult to expect a normal reagent reaction at 0°C or 5°C. Accordingly, it is possible to determine whether the reagent reaction can be performed in a normal environment by determining the temperature of the sample. If the terminal determines that a normal reagent reaction cannot be expected, the terminal may notify the user by indicating that the measurement is in a situation where measurement is impossible.

In step S2130, if a normal reagent reaction is possible, a quantitative value may be obtained through temperature correction, and accurate measurement may be performed through the color and brightness of the test line at this time.

In FIG. 22, similarly to FIG. 21, the terminal may be set to perform temperature correction only when the temperature is below a certain temperature. In the case of an antigen-antibody, there is a high possibility that the tissues of the body and its components are similar, and therefore, when the temperature exceeds a certain temperature, the antigen and the antibody are modified and the result of a normal reagent reaction cannot be expected. Accordingly, when the terminal determines that the temperature of the sample is less than or equal to a preset predetermined temperature, it may be configured to perform temperature correction and quantitative reaction measurement.

In step S2210, the terminal may measure the temperature of the sample in the temperature measuring unit on the biosensor image. Since the method of measuring the temperature of the sample has been described in detail above, it will be omitted.

In step S2220, the terminal may determine whether the determined temperature of the sample is less than or equal to a preset temperature. Since information on the sample may already be stored in the storage unit, a range of an appropriate reaction temperature of the sample may be determined. The terminal may determine whether the temperature of the sample exceeds the upper limit threshold of the range of the appropriate reaction temperature.

In step S2230, when it is determined that the temperature of the sample does not exceed the upper limit threshold value of the appropriate reaction temperature range, that is, when it is determined that the temperature of the sample is less than the upper limit threshold value, the terminal refers to the brightness of the test line described above. Compared with, the quantitative value can be corrected. If the determined temperature of the sample is out of the upper limit threshold of the appropriate reaction temperature range, the terminal may not perform a subsequent measurement process and may display information indicating that the temperature is out of the appropriate temperature range.

23 illustrates a biosensor equipped with a plurality of reagent pads according to an embodiment of the present invention.

In the above, the process of reacting a reagent to one sample has been described as an example. However, it is possible to obtain various measurement values by simultaneously measuring the reaction of a plurality of reagents through one sample.

Conventional urine diagnostic strips can measure reactions of a plurality of reagents, and are used to measure various diseases in a short form. By attaching a reagent pad for measuring reactions of various reagents on the urine diagnostic strip, it is possible to informally determine whether various diseases have occurred with a single injection of a urine sample.

Table 1 below is a table showing an example of a list of diseases that can be expected as a reagent reaction to a sample.

Select item Benign findings Test part Screening Kidney urinary tract disease Urinary tract infection Hepatobiliary disease diabetes Suspected disease Additional inspection Occult blood ◎ ◎ ◎ ○ ○ Renal urinary tract disease (excluding nephrotic syndrome), Hb urine, Mb urine, menstrual blood contamination Urine sediment, urine specific gravity, BUN, CBC, Creatinine, renal function test Bilirubin ◎ ◎ Hepatocellular disorder, biliary tract obstruction Liver function test Urobilinogen ◎ ◎ Hepatocellular disorder, hemolytic anemia Liver function test, CBC Ketone body ◎ ◎ Diabetic Ketosis, starvation, vomiting,
Glycogen storage disease, self-poisoning Blood sugar, urine sugar, serum, lipid, blood gas protein ◎ ◎ ◎ ○ ◎ Kidney disease, kidney failure, overwork, urinary tract infection, physiological proteinuria Urine sedimentation, urine specific gravity, BUN, creatine, renal function test nitrite ◎ ○ ◎ ○ Cystitis, pyelonephritis Urine sedimentation, urine bacteria test glucose ◎ ◎ ○ ○ ◎ Diabetes mellitus, renal diabetes mellitus, gastroenteritis, pregnancy intracerebral haemorrhage, hyperactivity of the brain Blood sugar, glucose load test pH ◎ ◎ ◎ ○ ○ Acidic: severe diabetes, gout, hunger,
Nephritis, dehydration, stones Urine sedimentation, clinical chemistry test, blood gas Alkaline: urinary tract infection, stone disease,
Hyperventilation, vomiting importance ◎ ◎ ◎ ◎ ◎ Low specific gravity: excessive water intake,
Kidney failure, diuresis,
Diabetes insipidus, pyelonephritis Urine sedimentation, kidney function test, urine bacteria test, Hormone measurement High specific gravity: Restriction of water intake,
Dehydration, diabetes Blood sugar, plasma osmotic pressure leukocyte ◎ ○ ◎ ○ Cystitis, pyelonephritis, aseptic pyuria Urine sedimentation, urine bacteria test, CBC

Since different reagents are used for each of the diseases in Table 1 above, the reagent reaction may also change color to different colors. Even if the color changes to the same color, the brightness values may be different. Accordingly, the terminal must store information about the color and brightness in the storage unit, and can perform a quantitative reaction by analyzing the received image and comparing it with the color change and brightness in a normal positive reaction.

Hereinafter, an example of diagnosing a disease using information on a color change for each reagent reaction in a urine diagnostic strip and optionally its brightness will be described.

In the reaction of the occult blood (hematuria) reagent, it may turn green when hematuria is present. Red blood cells in the urine sample may indicate kidney disease or bleeding in the urinary tract.

In the reaction of the biliruben reagent, it is possible to check whether liver and kidney abnormalities and bile are excreted. If it turns red, it means that bilirubin came from the urine sample, suggesting that hepatocytes may have been damaged or that the secretion of bile bile may be blocked.

In the reaction with the urobilagen reagent, when urobilinogen is detected in a urine sample due to liver and kidney abnormalities, it turns red.

In the ketone reagent reaction, if there is a lot of foam in the urine sample, it may mean that there are many protein components. When you are tired or starved, ketonic acid is formed in the body, which lowers the pH and increases the amount of gas that dissolves in the urine, creating bubbles, and discolors dark purple.

In the protein reaction, if the color changes to dark green, it can be seen that the kidney is abnormal and the protein excretion increases. It is normal for less than 150mg of protein to be excreted in the urine per day, and when it is excreted more than that, it is called'positive urine protein'. If there is an abnormality in the kidney, the protein may increase, and in the case of chronic nephritis, nephrotic syndrome, or diabetic nephropathy, the amount of protein in the urine increases as the condition worsens, so the color becomes dark green.

In the reaction of the nitrite (urinary tract infection) reagent, it is examined whether nitrite is released, and the bacteria in the urine play a role in converting nitrate into nitrite. When nitrite is detected, the color of the test line is discolored, and when nitrite is detected, it means that the urinary tract is infected with bacteria.

In the glucose reagent reaction, the more dark brown it is, the higher the possibility of diabetes.

In a pH (hydrogen ion concentration) reagent reaction, the pH of urine usually has an acidity between 4.6 and 8, and the higher the pH (the higher the pH value is), the more green it is.

In the specific gravity reagent reaction, the value of 1.016 to 1.022 is a normal range as measuring a substance dissolved in urine.

In the leukocyte reagent reaction, if there is a problem with the leukocyte count, the color changes to purple.

The color change information and brightness information may be previously stored in the terminal, or may be included in identification information on the strip. If the terminal or the strip cannot obtain the information, it is also possible to obtain the information by accessing a server storing the information.

Accordingly, the terminal may receive a strip image that reacts with several reagents at the same time as a single sample collection to make complex judgments on various diseases.

24 illustrates a biosensor equipped with a plurality of reagent pads according to an embodiment of the present invention.

As described above with reference to FIG. 23, through a biosensor that reacts with multiple reagents through a single sample input, the terminal can measure various biometric information. As shown in FIG. 24, a plurality of reagent pads may be attached to the biosensor, and samples may be respectively added to each reagent pad, and a unified sample input unit exists, so that a plurality of reagent pads may be added with a single sample input. The reaction may proceed in the reagent pad. Although not shown in the drawing, as described above, the temperature measurement unit may be attached to a reagent pad or biosensor to measure the temperature and/or room temperature of the sample.

25 illustrates a biosensor provided with a plurality of reagent pads including biosensor identification information according to an embodiment of the present invention.

As shown in FIG. 25, identification information including biosensor-related information may be displayed on the biosensor. As in "12345-6789 Hong Gil-dong", the biosensor can be identified as identification information in text format, and the biosensor can also be identified through a QR code or barcode.

Additionally, the arrangement position information of a plurality of reagent pads positioned on the biosensor may be determined as biosensor identification information. As shown in FIG. 24, when eight reagent pads are located on one biosensor, each reagent pad may have a different color, and since these colors are arranged according to the position, the terminal is prepared with pre-stored reagent pad arrangement information. It can be used as identification information of the biosensor by matching with.

In addition to the color arrangement of the reagent pads, various combinations of identification information can be obtained by changing the position of the reagent pad in the biosensor, and when the terminal receives and reads the image of the corresponding biosensor, the position of the reagent pad is identified as biosensor identification information. Can be used as.

The terminal may use the form of the biosensor itself as identification information of the corresponding biosensor. For example, the biosensor can be used as identification information of the biosensor according to the aspect ratio of the biosensor, and can be used as identification information of the biosensor through whether the biosensor is in a rectangular shape or an oval shape. Alternatively, the color of the biosensor itself can be used as one piece of identification information.

The identification information displayed on the biosensor including the plurality of reagent pads may include information on reagent reactions of each of the plurality of reagent pads. It may include information that the reagent pad is discolored into a specific color as a result of the reagent reaction, information that the reagent reaction is for analysis of diabetes or protein, and the like.

A terminal receiving an image of a biosensor including a plurality of reagent pads may obtain information on each reagent reaction, and may determine a result of the reagent reaction as measured color and brightness information. If the color is simply discolored as a positive reaction, a qualitative judgment can be made as to the presence or absence of a disease, and a quantitative judgment can be made to determine the value based on the brightness (darkness) of the color after the discoloration.

26 illustrates a biosensor in which reference brightness information is displayed around a reagent pad according to an embodiment of the present invention.

Reference brightness information for each of the plurality of reagent pads may be displayed on the biosensor. Depending on the reagent reaction to be measured, each reagent pad can predict different discoloration results, and the terminal receives the brightness information for each discoloration color as an image, and corrects the quantitative value based on this to perform accurate measurement. have.

As illustrated in FIG. 26, reference brightness information including various brightness information about a color change in the reagent pad may be displayed for one reagent pad 2600. For example, if the reagent pad 2600 discolors to the first grade (the grade corresponding to the brightest brightness) among all five levels of brightness of blue and blue as a result of the reagent reaction, the biosensor is placed around the reagent pad. Reference brightness information 2601 to 2605 having brightness information of the first to fifth grades of blue may be displayed.

The terminal may receive all of the color, brightness, and reference brightness information 2601 to 2605 for the reagent pad 2600. The terminal may derive a relative difference in brightness of the reagent pad 2600 based on the brightness in the quantitative reaction as a quantitative value. The terminal may correct the measured brightness of the reagent pad 2600 using the received reference brightness information. In the case where the lighting of the space where the measurement was performed in the previous example is quite bright, the brightness of the reagent pad color and the reference brightness information are affected by the same illumination, and thus, the measurement can be made brighter than when a darker illumination is used.

Since the terminal already stores brightness information of the reagent reaction in the quantitative reaction, correction may be performed using information on the brightness in the quantitative reaction. For example, it is assumed that the brightness of the part corresponding to the quantitative response among the already stored reference brightness information is 2, and the brightness of the same part of the reference brightness information in the image acquired by the terminal is 1. In addition, it is assumed that brightness 1 is brighter than brightness 2. In addition, it is assumed that the brightness of the reagent pad in the received image is 1. The terminal may lower the brightness of a portion corresponding to the quantitative reaction among the reference brightness information on the received image from 1 to 2, and the brightness of the reagent pad may also decrease from 1 to 2. As described above, the terminal may correct the measured brightness of the reagent pad by using the brightness in the previously stored quantitative reaction.

Since the brightness of the corrected reagent pad is 2 (even if the brightness in the acquired image is 1), the terminal can determine that the quantitative value corresponding to the reagent reaction and the quantitative value corresponding to the quantitative reaction are the same. Therefore, the terminal can determine as a positive reaction as a result of the reaction. In addition, the terminal may specify the presence or absence of a disease corresponding to a positive reaction and a related value.

The above-described example may be described on a different premise. Although not shown in the drawing, it is assumed that the terminal has already stored information indicating that the brightness in the quantitative reaction is the middle 3rd grade among all 5 brightness levels and the brightness of the 3rd grade is 3.

In addition, it is assumed that the color of the reagent pad is changed to red on the biosensor image acquired by the terminal, the brightness of the reagent pad is 2, and the brightness of the part corresponding to the quantitative reaction in the reference brightness information is 4.

The terminal may determine that a positive reaction has progressed since the color of the reagent pad has changed to red in the acquired biosensor image. In addition, since the brightness in the quantitative response is 3 in the stored information, and the brightness of the portion corresponding to the quantitative response in the reference brightness information in the acquired image is 4, the terminal may determine that the measurement is performed in a darker environment. Accordingly, the terminal can correct the acquired image to become brighter. By such correction, the brightness of the portion corresponding to the quantitative reaction among the reference brightness information in the image may be corrected from 4 to 3, and the brightness of the reagent pad may be corrected from 2 to 1.

The terminal may quantitatively measure biometric information using the corrected brightness of the reagent pad. It is assumed that the brighter the brightness of the reagent pad, the lower the corresponding value, and the darker the brightness, the higher the corresponding value. Since the brightness of the reagent pad is 1, which is brighter than 3, which is the brightness in the quantitative reaction, the terminal can determine that the value corresponding to the reagent reaction is lower than the value corresponding to the quantitative reaction. The terminal may display the detected value as biometric information.

According to another embodiment, the terminal may calculate quantitative biometric information using the acquired image without correcting the acquired image. For example, as shown in FIG. 26, the biosensor may include a reagent pad 2600 and reference brightness information 2601 to 2605 displayed around the reagent pad 2600. The terminal may calculate quantitative biometric information by using an image obtained by photographing the reagent pad 2600 and reference brightness information 2601 to 2605.

At least two reference brightness information 2601 to 2605 may be displayed around the reagent pad 2600. For example, as shown in FIG. 26, five pieces of reference brightness information 2601 to 2605 may be displayed. Each displayed reference brightness information 2601 to 2605 may have different brightness. Referring to FIG. 26, five pieces of reference brightness information 2601 to 2605 may each have a brightness corresponding to one of five brightness levels. The first reference brightness information 2601 may have brightness corresponding to the first grade. The second reference brightness information 2602 may have brightness corresponding to the second grade. The third reference brightness information 2603 may have brightness corresponding to a third grade. The fourth reference brightness information 2604 may have brightness corresponding to a fourth grade. The fifth reference brightness information 2605 may have brightness corresponding to a fifth grade.

The reagent pad 2600 may be discolored as a result of a reagent reaction. For example, the reagent pad 2600 may be colored blue. The reagent pad 2600 may be colored blue with various brightnesses according to a reagent reaction. As illustrated in FIG. 26, the reagent pad 2600 may be colored blue with a brightness corresponding to the first grade among the five levels of brightness of blue. The brightness of the reagent pad 2600 may be the same as the brightness of the first reference brightness information 2601.

The terminal may acquire an image by photographing the reagent pad 2600 and reference brightness information 2601 to 2605. The brightness of the image may vary depending on the surrounding environment when the image is captured. For example, when an image is photographed in an environment in which sufficient lighting is provided, the brightness of the image may be higher than that of an image photographed in an environment in which lighting is insufficient. Accordingly, even if the reagent pad 2600 is actually discolored to the brightness corresponding to the first grade, the brightness of the reagent pad 2600 displayed on the acquired image may be different.

The effect of illumination received by the reagent pad 2600 may equally affect the reference brightness information 2601 to 2605. The effect of illumination received by the first reference brightness information 2601 having the same brightness as the brightness of the reagent pad 2600 may be the same as the effect of illumination received by the reagent pad 2600. Accordingly, the brightness of the reagent pad 2600 and the brightness of the first reference brightness information 2601 shown on the obtained image may be the same. In other words, when reference brightness information 2601 to 2605 having the same brightness as the brightness of the reagent pad 2600 exists, the brightness of the reagent pad 2600 shown on the acquired image and the brightness of the reagent pad 2600 shown on the acquired image. The brightness of the reference brightness information 2601 to 2605 may also be the same. In addition, when reference brightness information 2601 to 2605 having a brightness different from that of the reagent pad 2600 is present, the brightness of the reagent pad 2600 shown on the acquired image and the brightness of the reagent pad 2600 shown on the acquired image. The brightness of the reference brightness information 2601 to 2605 may also be different.

Accordingly, the terminal may compare the brightness of the reagent pad 2600 shown on the acquired image and the brightness of the reference brightness information 2601 to 2605 shown on the acquired image without correcting the acquired image. As a result of the comparison, the terminal may detect reference brightness information 2601 to 2605 having the same brightness as that of the reagent pad 2600 from among the five reference brightness information 2601 to 2605. Referring to FIG. 26, the detected reference brightness information 2601 to 2605 may be first reference brightness information 2601.

The terminal may acquire the actual brightness of the reagent pad 2600 by using the detection result. Referring to FIG. 26, the terminal may obtain information that the actual brightness of the reagent pad 2600 is the brightness corresponding to the first grade. In conclusion, regardless of the surrounding environment when the image was captured, the terminal may acquire the actual brightness of the reagent pad 2600 by using the information included in the image.

The terminal may calculate quantitative biometric information corresponding to the reagent reaction by using the actual brightness of the obtained reagent pad 2600. For example, it is assumed that the brighter the brightness of the reagent pad 2600, the lower the corresponding value, and the darker the brightness, the higher the corresponding value. In addition, it is assumed that the brightness in the quantitative reaction corresponds to the third grade. Referring to FIG. 26, since the actual brightness of the reagent pad 2600 corresponds to the first grade, the terminal may determine that the value corresponding to the reagent reaction is lower than the value corresponding to the quantitative reaction. The terminal may display the detected value as biometric information.

27 to 31 are reference diagrams for explaining a method of detecting the actual brightness of the reagent pad 2600 according to another embodiment of the present invention. Referring to FIG. 31, the biosensor may include a reagent pad 2600 and five reference brightness information 2601 to 2605 displayed around the reagent pad 2600. The terminal may acquire an image by photographing the biosensor.

The terminal may process the acquired image. The terminal may process the image using brightness information of pixels included in the image. The terminal may detect a region including pixels having the same brightness as that of a portion corresponding to the reagent pad 2600 in the image.

The terminal can recognize the shape of the detected area. The brightness of the reagent pad 2600 may vary depending on the reagent reaction, while the brightness of the reference brightness information 2601 to 2605 may be constant regardless of the reagent reaction. Accordingly, the shape of the detected region may vary depending on the reagent reaction.

For example, it is assumed that the actual brightness of the reagent pad 2600 according to the reagent reaction is the first grade. In this case, the terminal may acquire the image shown on the left of FIG. 27 by photographing the biosensor. The terminal may detect the shape shown on the right side of FIG. 27 by processing the acquired image.

As another example, it is assumed that the actual brightness of the reagent pad 2600 according to the reagent reaction is the second grade. In this case, the terminal may acquire the image shown on the left of FIG. 28 by photographing the biosensor. The terminal may detect the shape shown on the right side of FIG. 28 by processing the acquired image.

As another example, it is assumed that the actual brightness of the reagent pad 2600 according to the reagent reaction is the third grade. In this case, the terminal may acquire the image shown on the left of FIG. 29 by photographing the biosensor. The terminal may detect the shape shown on the right of FIG. 29 by processing the acquired image.

As another example, it is assumed that the actual brightness of the reagent pad 2600 according to the reagent reaction is the fourth grade. In this case, the terminal may acquire the image shown on the left of FIG. 30 by photographing the biosensor. The terminal may detect the shape shown on the right side of FIG. 30 by processing the acquired image.

As another example, it is assumed that the actual brightness of the reagent pad 2600 according to the reagent reaction is the fifth grade. In this case, the terminal may acquire the image shown on the left of FIG. 31 by photographing the biosensor. The terminal may detect the shape shown on the right side of FIG. 31 by processing the acquired image.

The terminal may detect the actual brightness of the reagent pad 2600 based on the shape of the detected region. For example, when the shape shown on the right of FIG. 27 is detected, the terminal may determine that the actual brightness of the reagent pad 2600 is the first grade. In addition, when the shape shown on the right of FIG. 28 is detected, the terminal may determine that the actual brightness of the reagent pad 2600 is the second grade. In addition, when the shape shown on the right side of FIG. 29 is detected, the terminal may determine that the actual brightness of the reagent pad 2600 is the third grade. In addition, when the shape shown on the right of FIG. 30 is detected, the terminal may determine that the actual brightness of the reagent pad 2600 is the fourth grade. In addition, when the shape shown on the right of FIG. 31 is detected, the terminal may determine that the actual brightness of the reagent pad 2600 is the fifth grade.

32 illustrates a biosensor in which reference brightness information 2606 is displayed around a reagent pad 2600 according to another embodiment of the present invention. Referring to FIG. 32, unlike the reference brightness information 2601 to 2605 of FIG. 26 displayed as discrete, reference brightness information 2606 may be continuously displayed. For example, as shown in FIG. 32, from the brightness corresponding to the first grade to the brightness corresponding to the fifth grade, it may be continuously displayed from the bottom to the top. Also, the reference brightness information 2606 may be continuously displayed from the bottom to the top, from the brightness corresponding to the case where the reagent reaction occurs at the maximum to the brightness corresponding to the case where the reagent reaction does not occur at all. For example, if no reagent reaction occurs at all is defined as a reagent reaction rate of 0%, and the case in which the reagent reaction occurs at the maximum is defined as a reagent reaction rate of 100%, the brightness corresponding to the reagent reaction rate of 0% is changed to 100% of the reagent reaction rate. Reference brightness information 2606 may be continuously displayed up to the corresponding brightness.

The terminal may acquire an image by photographing the reagent pad 2600 and reference brightness information 2606. The terminal may compare the brightness of the portion corresponding to the reagent pad 2600 in the acquired image and the brightness of the portion corresponding to the reference brightness information 2606 in the acquired image. The terminal may detect a position of a portion having the same brightness as the brightness of the reagent pad 2600 in the reference brightness information 2606. For example, it is assumed that the actual brightness of the reagent pad 2600 corresponds to the third grade. The terminal may determine that a portion of the reference brightness information 2606 having the same brightness as the brightness of the reagent pad 2600 is located in the middle of the reference brightness information 2606.

As another example, when no reagent reaction occurs at all is defined as a reagent reaction rate of 0%, and when the maximum reaction rate is defined as a reagent reaction rate of 100%, the reagent reaction rate of the actual reagent reaction occurring in the reagent pad 2600 It is assumed that this is 56%. The terminal may detect that the position of the portion having the same brightness as the brightness of the reagent pad 2600 in the reference brightness information 2606 corresponds to 56% of the total length of the reference brightness information 2606. The terminal may detect that the reagent reaction rate of the actual reagent reaction is 56% based on the detected position.

The terminal may detect the actual brightness of the reagent pad 2600 based on the detected position. For example, when it is determined that a portion having the same brightness as the brightness of the reagent pad 2600 is located in the middle of the reference brightness information 2606, the terminal corresponds to the third grade of the actual brightness of the reagent pad 2600. It can be determined that it is. As another example, when it is determined that the position of the portion having the same brightness as the brightness of the reagent pad 2600 is a point corresponding to 56% of the total length of the reference brightness information 2606, the terminal It can be determined that the brightness corresponds to the reagent reaction rate of 56%.

33 is a flowchart illustrating an entire process of executing a sample measurement program in a terminal according to an embodiment of the present invention.

In step (a), the terminal user can insert his or her sample into the biosensor.

In step (b), the terminal user may acquire a biosensor image using the input unit (camera unit) of the terminal.

In step (c), the terminal analyzes the acquired image, and based on whether or not discoloration has occurred in the reagent pad, the brightness of the reagent pad of the discoloration color, and reference brightness information, the reagent based on the brightness in the quantitative reaction. The relative difference in the brightness of the pad can be derived as a quantitative value.

In step (d), the terminal may provide the detected and measured biometric information to the terminal user by displaying the detected and determined biometric information.

34 illustrates a biosensor in which reference color information is displayed according to an embodiment of the present invention.

When a plurality of reagent pads are present in the biosensor, the color change color may be different for each reagent pad, and it may be difficult to distinguish each color. Therefore, it is possible to obtain accurate color change information by displaying the reference color information A to F on the biosensor.

If a positive reaction to the reagent reaction is shown, the discolored color may be displayed on the biosensor as a reference color. For example, if a positive reaction occurs in a ketone reagent reaction, it may turn dark purple. By displaying dark purple on the biosensor as reference color information, it is possible to support accurate measurement of body information.

35 illustrates a method of analyzing biometric information using exhalation measurement according to an embodiment of the present invention.

As described above, as a sample including biometric information, urine, sweat, tears, saliva, blood, and the like may correspond, and a form of gas such as exhaled breath may correspond to one form of the sample.

As shown in FIG. 35, the user can exhale against a biosensor capable of measuring exhalation. In this case, the biosensor may be in the form of an electronic device as in the conventional alcohol measurement, or may be in the form of a gas tube containing a specific dye.

The biosensor contains a dye, and a method of measuring biometric information can be used through a method in which the dye changes color by reacting with exhalation. This bio-sensing technology is called colorimetric sensor array technology, and a pattern of color change can be read by arranging a plurality of dyes that change color on a two-dimensional plane.

36 illustrates an example of a biosensor measuring exhalation according to an embodiment of the present invention.

As shown in FIG. 36, a tube capable of containing a certain amount of gas may be used as a device for measuring exhalation. In such a tube, a plurality of dyes are arranged on a two-dimensional plane, and biometric information may be measured using the result of discoloration of the plurality of dyes according to a reaction with exhalation.

Each of the dyes can be used to diagnose different diseases. For example, the dye in the reagent pad (a) is used to diagnose asthma, the dye in the reagent pad (b) is used for bad breath, and the dye in the reagent pad (c) is used to diagnose chronic obstructive pulmonary disease. Can be used for Each of the plurality of reagent pads may be dyes for diagnosing unique diseases, or a combination of reagent pads including dyes may diagnose a disease.

For example, it is possible to determine whether cancer has occurred through exhalation, and metabolites of cancer cells may be dissolved in the blood, and these substances may be included in the exhalation and discharged to the outside. By reacting the discharged substances with a plurality of dyes arranged in the tube, metabolites of cancer cells may be detected by whether or not the colors of the dyes change.

As shown in FIG. 36, various dyes (a to h) are two-dimensionally arranged in a tube as a biosensor, and each dye has its own color. When a substance in the exhalation reacts to the arranged dyes and discolors, the user can take a picture of the tube using the optical image sensor (camera) of the terminal.

Reagent pads including dyes may be distinguished and displayed to have various colors and brightnesses. For example, the reagent pad (b) may be displayed by being divided into red, yellow, and blue colors, and three groups having different brightness for each color.

The terminal may acquire an image of the tube, and acquire color change information, reference brightness information, identification information, etc. of a reagent pad stained with a dye within the obtained image. The reference brightness information may be displayed together around the dye, or may be displayed at a location separate from the reagent pad with the dye. A detailed description of the reference brightness information has been described above with reference to FIGS. 10 to 13, so refer to this.

The terminal may determine the brightness of the reagent pad stained with the dye, and may previously store brightness information in a quantitative reaction between the dye and the substance contained in the exhalation in the storage unit. Accordingly, the terminal may derive a quantitative value corresponding to the reagent reaction by referring to a reagent pad having a high similarity to the color and brightness that is discolored as a result of the reagent reaction in the received image. The terminal may derive a quantitative value corresponding to a reagent reaction by searching inside or outside the terminal for information on reference brightness information that is the same/similar to the brightness information of the dye.

The biosensor for exhalation may be configured to arrange a plurality of dye-soaked reagent pads on two dimensions, and the two-dimensional arrangement information may be used as identification information of the biosensor. Each dye has its own color, and it is converted into a database for each pattern in which various colors are arranged, and can be used as identification information of a user or a biosensor. For example, if 8 reagent pads for each dye reaction are included in the biosensor, the positions of the 8 reagent pads can be combined to be displayed in one pattern, and the terminal can be displayed on the acquired biosensor image. Based on the pattern information of, information on a patient using a biosensor or information specific to a biosensor may be obtained.

37 illustrates a medical system supporting a measurement service to a sample measurement terminal according to an embodiment of the present invention.

Correction of quantitative values and measurement of body information through reagent reactions described in FIGS. 1 to 34 may be formed as a single medical service system between a terminal manufacturer, a service provider providing medical services, and a terminal user substantially using the service. .

A manufacturer of a terminal may produce a terminal capable of measuring body information from a biosensor through an optical image sensor. In addition, terminal manufacturers can also produce biosensors capable of point-of-care diagnostics (POCT).

The service provider may be a medical institution such as a hospital or pharmacy, or an institution that requires physical information such as an insurance company. A network system such as a server capable of communicating with a terminal must be established, and various information such as reagent reaction results can be stored and stored in a database. Service providers can also produce biosensors capable of field inspection (POCT).

A terminal user, as a subject receiving medical services, may collect samples of his/her urine, blood, etc. and measure them as an application (eg, S-health) of the terminal. The terminal user can establish a contract relationship (subscription) with the service provider offline/online. For example, a terminal user may be a patient and a service provider may be a hospital in which the terminal user was hospitalized. When a terminal user has difficulty in outpatient treatment at a hospital or requires only a very simple measurement, the measurement can be performed through the terminal, so the hospital, which is a service provider, can send a POCT biosensor to the terminal user. For another example, a terminal user may be a subject who wants to subscribe to insurance, and a service provider may be an insurance company. Since the terminal user needs to measure and transmit his/her body information for the purpose of insurance subscription, the insurance company can send the POCT biosensor to the terminal user.

The terminal user can measure his/her body information using the application of the terminal and transmit it to the service provider, and the service provider can store the measurement information of the terminal user. There is an effect of sharing information on treatment of various diseases by storing the body information of the terminal user by the service provider and the terminal user.

The service provider may provide the measurement service to the terminal user periodically or aperiodically to manage the health status of the terminal user. A service for managing a user's health status in real time together with body information measured by a wearable device such as a smart watch or smart glasses may be provided to a terminal user.

38 illustrates a screen in which a sample measurement program is executed in a terminal according to an embodiment of the present invention.

The terminal user can inject his/her urine sample into the sample input unit of the biosensor, and obtain the result of the reagent reaction as an image using the terminal.

The terminal may analyze the obtained image and perform quantitative measurement and qualitative measurement based on the discoloration result of the reagent reaction, color and brightness, and reference brightness information.

The display unit of the terminal may display the measured body information on the display areas 142 and 144 of the terminal. It can be displayed as text such as "The user's urine is being analyzed", and it is also possible to display it as information such as an image.

The terminal's manipulation area 144 may receive an input from a terminal user. For example, the terminal may display the normal range of protein values and the measured values as a result of the sample measurement, and the terminal user may operate to display brief information on protein diagnosis by pressing a protein button. Alternatively, when the protein button is pressed, other measured information can be displayed.

The terminal may indicate whether to transmit the measured information to an external device, and if there is an abnormality in the measurement information, it may display a remeasurement guide. If an abnormality occurs in the measurement information, the temperature of the sample is out of the appropriate temperature range, the expiration date of the biosensor has elapsed, or the measured value is significantly different from the normal range, etc. .

In connection with the medical service system described above with reference to FIG. 37, a screen capable of remote image communication with a doctor as a service provider may be provided. When information on the measured values in the terminal is stored, the stored information of the terminal itself may be provided to the user. For example, if the terminal stores information on recommended food and prohibited food for diabetic symptoms, the terminal may display the recommended food information and prohibited food information when it is determined that the measurement information is diabetes.

39 is a network configuration diagram illustrating a network environment in which the terminal 100 operates according to an embodiment of the present invention. Referring to FIG. 39, the terminal 100 may be connected to the server 300 through a communication network. The terminal 100 may acquire an image by photographing the biosensor 200. The terminal 100 may transmit the obtained image to the server 300. The terminal 100 may receive an analysis result of the image from the server 300. The terminal 100 may display the received analysis result. A more detailed description of the operations of the terminal 100 and the server 300 will be described with reference to FIG. 40.

40 is a flowchart illustrating a process of performing a method of displaying biometric information using an image of the biosensor 200 according to an embodiment of the present invention. Referring to FIG. 40, first, a step S100 of photographing an image of a biosensor 200 including a reagent pad 2600 from which a sample has been collected may be performed. The terminal 100 may take an image of the biosensor 200 through a camera of the terminal 100 or the like. The terminal 100 may acquire an image by photographing the reagent pad 2600 and reference brightness information 2601 to 2605 included in the biosensor 200.

Next, the step (S110) of transmitting the captured image to the server 300 may be performed. The terminal 100 may transmit the image obtained by photographing the biosensor 200 to the server 300. The server 300 may receive the image. The server 300 may process and analyze the image. The server 300 may detect information on the color and brightness of a portion corresponding to the reagent pad 2600 in the image. In addition, the server 300 may detect information on the color and brightness of a portion corresponding to the reference brightness information 2601 to 2605 in the image. The server 300 may compare information on a portion corresponding to the reagent pad 2600 and information on a portion corresponding to the reference brightness information 2601 to 2605 with each other. The server 300 may calculate quantitative biometric information corresponding to a reagent reaction using the comparison result.

Next, the step S120 of receiving biometric information corresponding to the image from the server 300 may be performed. The terminal 100 may receive an analysis result of the image from the server 300. The terminal 100 may receive quantitative biometric information corresponding to a reagent reaction as a result of the analysis from the server 300.

Next, displaying the received biometric information (S130) may be performed. The terminal 100 may display the analysis result received from the server 300. The terminal 100 may display quantitative biometric information included in the analysis result through the display of the terminal 100. 41 is an analysis result screen displayed on the terminal 100 according to an embodiment of the present invention.

42 is a block diagram showing the structure of a terminal according to an embodiment of the present invention.

In the present invention, the terminal 100 includes an input unit 110 that receives data from the outside, a control unit 120 that processes input data, a storage unit 130 that stores input or processed data, and displays on the screen of the terminal. It may include a display unit 140 for displaying data and a communication unit 150 for communicating with other devices. The terminal in the present invention may be a smart phone capable of running an Internet connection or various execution programs by embedding an operating system. Smartphones are equipped with operating systems and communication functions in digital portable devices to enable various contents to be used in a convenient user environment (UI/UX). Also, devices such as a multimedia player and a personal computer may correspond to the terminal of the present invention.

The input unit 110 is an interface for receiving data such as content displayed on the display unit, and is a universal serial bus (USB), a parallel Advanced Technology Attachment (PATA), or a SATA (Serial Advanced Technology Attachment, SATA), flash Media (Flash Media), Ethernet (Ethernet), Wi-Fi (Wi-Fi), may include at least one of Bluetooth (Bluetooth). In some cases, the terminal 100 may be provided with an information storage device (not shown) such as an optical disk drive, a hard disk, or the like, and receive data through it.

In addition, the terminal 100 in the present invention may include a camera unit including an optical image sensor as the input unit 110. An image received through the camera module may be processed as one piece of data.

The input unit 110 may further include a sensor unit such as temperature and humidity in addition to the camera unit. In addition to a temperature sensor unit that measures the temperature inside the terminal, a temperature sensor unit that measures the temperature outside the terminal may also be included, and a humidity measurement unit that measures humidity may also correspond to the input unit 110 in the present invention. .

In addition, the input unit 110 may be a touch screen in which a touch panel unit and an image panel unit have a layered structure. The touch panel unit may be, for example, a capacitive touch panel, a resistive touch panel, an infrared touch panel, or the like. The image panel unit may be, for example, a liquid crystal panel or an organic light emitting panel. Since such a touch screen panel is well known, a detailed description of the panel structure will be omitted. The image panel unit may display a graphic of a user interface.

The control unit 120 encodes or decodes data input through the input unit 110.

The control unit 120 provides a user interface based on an operating system (OS) of the terminal 100. This user interface may reflect the user's usage.

The storage unit 130 may store input data and data processed by the terminal. In the present invention, since it is necessary to analyze the biosensor image to determine body information about it, various information related to body information measurement, such as reaction information for various reagent reactions, identification information of the biosensor, and reference brightness information of the reagent pad, is stored in a database (DB). Can be saved as.

The display unit 140 may display data processed by the terminal in a user interface environment. In the present invention, since the biosensor image is acquired and analyzed, the biosensor image acquired by the camera unit can be displayed on the screen, and the reagent reaction analysis result according to the reagent reaction analysis process can be displayed as shown in FIG. . In addition, when an operation command from a terminal user is required, information guiding input of various manipulation commands may be displayed on the screen.

The communication unit 150 transmits and receives data and control commands from other devices. As the communication unit 150, a known communication module such as an infrared communication module, a radio communication module, and an optical communication module may be used. For example, an infrared communication module that satisfies the infrared communication standard IrDA (Infrared Data Association) protocol may be used as the communication unit 150. As another example, a communication module using a 2.4 GHz frequency or a communication module using Bluetooth may be used as the communication unit 140.

In the present invention, the communication unit 150 may request information on a server of a service provider such as hospitals, pharmacies, and insurance companies, and may receive data transmitted from the server.

Meanwhile, the above-described embodiments of the present invention can be written as a program that can be executed in a computer, and can be implemented in a general-purpose digital computer that operates the program using a computer-readable recording medium. The computer-readable recording media include storage media such as magnetic storage media (eg, ROM, floppy disk, hard disk, etc.) and optical reading media (eg, CD-ROM, DVD, etc.).

So far, the present invention has been looked at around its preferred embodiments. Those of ordinary skill in the art to which the present invention pertains will be able to understand that the present invention can be implemented in a modified form without departing from the essential characteristics of the present invention. Therefore, the disclosed embodiments should be considered from an illustrative point of view rather than a limiting point of view. The scope of the present invention is shown in the claims rather than the foregoing description, and all differences within the scope equivalent thereto should be construed as being included in the present invention.

Claims (24)

In the method of measuring biometric information of a terminal,
Receiving an image of a biosensor including a reaction unit including a reagent that reacts with the sample and reference brightness information configured to display different brightnesses for the same color; And
Comprising the step of comparing the brightness of the reaction unit on the received image and the reference brightness information on the received image to determine a reaction degree,
Comparing the brightness of the reaction unit on the received image and the reference brightness information on the received image to determine a reaction degree,
Detecting a region including pixels having the same brightness as the brightness of a portion corresponding to the reaction unit in the image;
Recognizing the shape of the detected area;
Determining the actual brightness of the reaction unit based on the recognized shape; And
Including the step of determining the response degree corresponding to the determined brightness,
How to measure biometric information. The method of claim 1,
Further comprising the step of obtaining identification information of the biosensor from the received image,
Comparing the brightness of the reaction unit on the received image and the reference brightness information on the received image to determine a reaction degree,
And determining the degree of reaction based on the obtained identification information of the biosensor. The method of claim 2,
The identification information of the biosensor,
A method for measuring biometric information comprising at least one of a QR code, a bar code, an image, and a text. The method of claim 1,
Obtaining temperature information indicated by a temperature measuring unit of the biosensor from the received image; And
Based on the obtained temperature information, further comprising the step of determining the temperature of the sample, biometric information measuring method. The method of claim 4,
Comparing the brightness of the reaction unit on the received image and the reference brightness information on the received image to determine a reaction degree,
And determining the reaction degree based on the determined temperature of the sample and temperature information according to the reaction of the sample. The method of claim 4,
The temperature measuring unit,
A method for measuring biometric information comprising at least one of a temperature measurement unit attached to a sample input unit of the biosensor and a temperature measurement unit attached to a reaction unit of the biosensor. The method of claim 1,
The method of measuring biometric information further comprising the step of measuring room temperature using a temperature sensor built into the terminal. The method of claim 1,
Further comprising determining a temperature indicated by a temperature sensor attached to the biosensor on the received image as room temperature. The method of claim 1,
The reference brightness information includes a plurality of brightness information discretely representing different brightnesses for the same color,
Comparing the brightness of the reaction unit on the received image and the reference brightness information on the received image to determine a reaction degree,
Detecting first brightness information corresponding to brightness information of the reaction unit from among the plurality of brightness information; And
And determining the reaction degree corresponding to the first brightness information. The method of claim 1,
The reference brightness information includes a plurality of brightness information continuously representing different brightnesses for the same color,
The plurality of brightness information is continuously arranged within the reference brightness information,
Comparing the brightness of the reaction unit on the received image and the reference brightness information on the received image to determine a reaction degree,
Detecting first brightness information corresponding to brightness information of the reaction unit from among the plurality of brightness information;
Detecting a position in which the first brightness information is disposed within the reference brightness information; And
And determining the degree of reaction corresponding to the detected position. The method of claim 1,
The reference brightness information includes a plurality of brightness information discretely representing different brightnesses for the same color. The method of claim 1,
The degree of reaction is,
Biometric information measurement method that is determined based on a database on the degree of reaction previously stored in the storage unit. The method of claim 1,
The reaction part,
A method of measuring biometric information, including a control line whose color changes according to the presence or absence of a reaction. The method of claim 1,
The method further comprising obtaining identification information of the biosensor based on positions of the plurality of reagent pads on the received biosensor image. The method of claim 4,
When it is determined that the temperature of the sample is higher than or equal to a preset temperature,
The method further comprising the step of indicating that the measurement of the sample is impossible. The method of claim 4,
When it is determined that the temperature of the sample is below a preset temperature, displaying that measurement of the sample is impossible. The method of claim 2,
When it is determined that the expiration date of the biosensor included in the identification information of the biosensor has elapsed, displaying at least one or more of the biosensor not available or the reaction is invalid, biometric information measuring method . The method of claim 4,
The temperature measuring unit is attached in the form of at least one of straight, radial and circular, biometric information measuring method. The method of claim 1,
The biosensor is configured to analyze at least one or more of a user's urine, blood, sweat, tears, saliva, and exhalation. In a terminal measuring biometric information,
An input interface for receiving an image of a biosensor including reference brightness information configured to display different brightness for the same color and a reaction unit including a reagent that reacts with the sample; And
By comparing the brightness of the reaction unit on the received image and the reference brightness information, determining a reaction degree, and determining the reaction degree,
In the image, an area including pixels having the same brightness as the brightness of a portion corresponding to the reaction unit is detected, the shape of the detected area is recognized, and the actual brightness of the reaction unit is based on the recognized shape. And a control unit configured to determine and determine the reaction degree corresponding to the determined brightness. The method of claim 20,
Biometric information measurement terminal further comprising a storage unit for storing the received image of the biosensor. delete delete Capturing an image of a biosensor including a reaction unit including a reagent that reacts with the sample;
Transmitting the captured image to a server;
Compare brightness information of the reaction unit on the image from the server to reference brightness information on the image,
In the image, a region including pixels having the same brightness as the brightness of a portion corresponding to the reaction unit is detected, the shape of the detected region is recognized, and the actual brightness of the reaction unit is determined based on the recognized shape. Determining and receiving biometric information derived by determining a response degree corresponding to the determined brightness; And
And displaying the received biometric information.

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