KR102004826B1 - A compositon for maintaining tooth-whitening effect - Google Patents

Abstract

An aspect of the present invention relates to a binder comprising a water-soluble polymer and a water-insoluble polymer; Vitamins or derivatives thereof; phosphate; And a solvent.

Description

A COMPOSITE FOR MAINTAINING TOOTH-WHITENING EFFECT

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a tooth whitening oil retainer composition, and more particularly, to a tooth whitening oil retainer composition which is capable of effectively restoring a denatured tooth surface while preventing a tooth surface structure vulnerable to re- ≪ / RTI >

As the society develops and the level of living becomes higher, the trend of dental treatment is changing from the center of treatment to the center of esthetics. Especially, the interest in the whitening treatment which restores the color of discolored teeth to the original color is increasing.

The influence of the tooth's aesthetics is on the arrangement, size, color, texture and light transmittance of the teeth, among which the color of the tooth is the most sensitive and important factor, It can also cause psychological problems such as inducing passive interpersonal relationships or lacking self-confidence.

The cause of tooth discoloration is classified into internal human factors and external human factors. The internal human factors are the deposition of a substance having a double bond chromophore contained in food in the enamel layer outside the tooth, It means that the precipitate adheres to the surface of teeth and causes discoloration of teeth.

The most common treatment for tooth discoloration is a whitening treatment using peroxide. The free radicals generated from the peroxide move through enamel and dentin of teeth to oxidize the pigment existing in the teeth .

The higher the amount of peroxide used as the main component of tooth whitening, the faster and higher whitening effect can be expected. However, excessive peroxide is known to change the microstructure of the surface of enamel, and in particular, There is a problem that the enamel surface is excessively roughened by acid corrosion.

The change in the surface of the enamel immediately after the whitening procedure changed to a structure that is vulnerable to recoloring, causing it to recover to the color before whitening in a relatively short time after whitening. The rapid recolonization after the whitening treatment not only inhibits the patient's aesthetic satisfaction with the procedure but also increases the complaints about the whitening procedure.

Accordingly, there is a need for a tooth whitening preservative composition capable of effectively restoring the modified tooth surface while preventing the tooth surface structure vulnerable to recoloring after tooth whitening treatment from absorbing the recoloring material.

SUMMARY OF THE INVENTION The present invention has been made to solve the problems of the prior art described above, and it is an object of the present invention to provide a tooth surface treatment method and a tooth surface treatment method capable of effectively restoring a denatured tooth surface while preventing a tooth surface structure susceptible to re- And a tooth whitening preservative composition.

An aspect of the present invention relates to a binder comprising a water-soluble polymer and a water-insoluble polymer; Vitamins or derivatives thereof; phosphate; And a solvent.

In one embodiment, the water soluble polymer is selected from the group consisting of polyvinylpyrrolidone, polyvinyl alcohol, hydroxymethylcellulose, hydroxypropylcellulose, hydroxyethylcellulose, methylcellulose, poloxamer, and mixtures of two or more thereof May be selected from the group consisting of

In one embodiment, the content of the water-soluble polymer may be 5 to 30% by weight based on the total weight of the tooth whitening preservative composition.

In one embodiment, the water-insoluble polymer may be selected from the group consisting of shellac, rosin, zein, Eudragit, ethylcellulose, and mixtures of two or more thereof .

In one embodiment, the content of the water-insoluble polymer may be 1 to 30% by weight based on the total weight of the tooth whitening preservative composition.

In one embodiment, the vitamin may be vitamin C.

In one embodiment, the content of vitamin may be 1 to 10% by weight based on the total weight of the tooth whitening preservative composition.

In one embodiment, the phosphate may comprise sodium phosphate.

In one embodiment, the content of sodium phosphate may be 1-10% by weight based on the total weight of the tooth whitening oil composition.

In one embodiment, the phosphate may further comprise an amorphous calcium phosphate.

In one embodiment, the content of the amorphous calcium phosphate may be 1 to 10% by weight based on the total weight of the tooth whitening preservative composition.

In one embodiment, the solvent may be selected from the group consisting of water, ethanol, glycerol, and mixtures of two or more thereof.

In one embodiment, the solvent may comprise water, ethanol and glycerol in a weight ratio of 1: 1 to 2: 1.5 to 5, respectively.

The tooth whitening preservative composition according to one aspect of the present invention can effectively prevent the penetration of the coloring material of the external environment into the tooth surface by coating the surface of the whitened teeth for a long time by including the two kinds of polymeric binders.

In addition, the tooth whitening oil retainer composition can further improve the color of the teeth in the state where the composition is applied to the whitened teeth by coating the teeth with a vitamin or a derivative thereof, and the tooth whitening oil composition can contain one or more kinds of phosphates (phosphate) The tooth remineralization can be promoted.

It should be understood that the effects of the present invention are not limited to the effects described above, but include all effects that can be deduced from the description of the invention or the composition of the invention set forth in the claims.

FIG. 1 and FIG. 2 show the results of the evaluation of the whitening maintenance function using a colorimetric spectrophotometer (CM-3500D) of the tooth whitening preservative composition according to Examples and Comparative Examples of the present invention.
FIG. 3 is a visual observation of the whitening-maintaining function of the tooth whitening preservative compositions according to the examples and comparative examples of the present invention.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, the present invention will be described with reference to the accompanying drawings. The present invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. In order to clearly illustrate the present invention, parts not related to the description are omitted, and similar parts are denoted by like reference characters throughout the specification.

Throughout the specification, when a part is referred to as being "connected" to another part, it includes not only "directly connected" but also "indirectly connected" . Also, when an element is referred to as "comprising ", it means that it can include other elements, not excluding other elements unless specifically stated otherwise.

An aspect of the present invention relates to a binder comprising a water-soluble polymer and a water-insoluble polymer; Vitamins or derivatives thereof; phosphate; And a solvent.

The water-soluble polymer may be one selected from the group consisting of polyvinylpyrrolidone, polyvinyl alcohol, hydroxymethylcellulose, hydroxypropylcellulose, hydroxyethylcellulose, methylcellulose, poloxamer, and mixtures of two or more thereof. And may preferably be polyvinylpyrrolidone, polyvinyl alcohol or hydroxymethylcellulose, and more preferably polyvinylpyrrolidone, but is not limited thereto.

The water-insoluble polymer may be selected from the group consisting of shellac, rosin, zein, Eudragit, ethyl cellulose, and mixtures of two or more thereof, Or ethylcellulose, and more preferably rosin, but is not limited thereto.

The water-soluble and water-insoluble polymer is a component acting as a binder in the tooth whitening preservative composition, and the tooth whitening retention composition is coated on the teeth surface by a combination of the above components, It is possible to effectively suppress the penetration of the coloring material of the external environment into the tooth surface.

The content of the water-soluble polymer may be 5 to 30% by weight, preferably 15 to 25% by weight, more preferably 18 to 22% by weight, based on the total weight of the tooth whitening preservative composition, It is not.

The content of the water-insoluble polymer may be 1 to 30% by weight, preferably 1 to 15% by weight, more preferably 2 to 8% by weight, based on the total weight of the tooth whitening preservative composition, But is not limited thereto.

In addition, the content of the water-soluble polymer in the tooth whitening preservative composition may be larger than that of the water-insoluble polymer. That is, considering that the water-soluble and water-insoluble polymer is provided in a state dissolved in a solvent to be described later, the water-soluble polymer may be provided in a concentrated state as compared with the water-insoluble polymer, The adhesive force and the holding force can be maximized.

The vitamin or a derivative thereof is a component having a tooth whitening function and can effectively remove the coloring material penetrating the tooth surface in a state where the tooth whitening preservative composition is coated on the tooth surface.

The vitamin may be vitamin C, and the derivative of vitamin C may be ascorbic acid 2-glucoside (AA-2G), magnesium ascorbyl phosphate, sodium ascorbyl phosphate, ascorbyl glucoside, aminopropyl ascorbyl phosphate And a mixture of two or more thereof, but is not limited thereto.

The content of the vitamin may be 1 to 10% by weight based on the total weight of the tooth whitening preservative composition. If the content of the vitamin is less than 1% by weight, the effect of removing the coloring material may be insufficient. If the content of the vitamin is less than 10% by weight, the content of other ingredients in the tooth whitening preservative composition is relatively decreased, Retention, and remelting functions may be degraded.

The phosphate can induce and / or induce remineralization of the teeth or adjust the pH of the tooth whitening preservative composition to a range where the functions of other ingredients can be smoothly implemented.

The phosphate may be selected from the group consisting of amorphous calcium phosphate, sodium phosphate, potassium phosphate, calcium pyrophosphate, sodium metaphosphate, disodium orthophosphate ), Trimagnesium phosphate, monomagnesium phosphate, sodium glycerophosphate, sodium trimetaphosphate, organic phosphates, and mixtures of two or more thereof. , And may include sodium phosphate and / or amorphous calcium phosphate, and more preferably sodium phosphate and amorphous calcium phosphate, but is not limited thereto .

The sodium phosphate can adjust and buffer the pH of the tooth whitening preservative composition to the extent that the functions of other ingredients can be smoothly realized.

The sodium phosphate content may be from 1 to 10% by weight based on the total weight of the tooth whitening preservative composition. If the sodium phosphate content is less than 1% by weight, the pH control and buffering effect may be weak. If the sodium phosphate content is more than 10% by weight, the content of the other components may be relatively decreased, and the adhesive strength, retention, whitening, Can be lowered.

The amorphous calcium phosphate is a component having remineralization function, and it is possible to prevent dental caries of the tooth surface in a state where the tooth whitening preservative composition is coated on the tooth surface.

The amount of the amorphous calcium phosphate may be 1 to 10% by weight based on the total weight of the tooth whitening preservative composition. If the content of the amorphous calcium phosphate is less than 1% by weight, the remineralizing effect of the teeth may be weak. If the amount of the amorphous calcium phosphate is more than 10% by weight, the content of the other components may be relatively decreased to deteriorate the adhesive force, .

The solvent has a role of a medium in which the respective components constituting the tooth whitening preservative composition are mixed and dispersed. The solvent may be selected from the group consisting of water, ethanol, glycerol and a mixture of two or more thereof, preferably water, ethanol and glycerol, more preferably water, ethanol and glycerol Can be contained in a weight ratio of 1: 1 to 2: 1.5 to 5, respectively.

When the solvent includes water as an aqueous solvent and ethanol and glycerol as a solvent, the water-soluble and water-insoluble polymer may be dissolved or dispersed in an aqueous or oil-based solvent, respectively.

Since the content of the water-soluble polymer in the tooth whitening preservative composition is larger than the content of the water-insoluble polymer and the content of the water-based solvent in which the water-soluble polymer is dissolved is smaller than the content of the oil-based solvent, The water-soluble polymer may be provided in a relatively concentrated state as compared with the water-insoluble polymer. Therefore, the adhesive force and the holding force that can be realized by the water-soluble polymer can be maximized.

The solvent may contain water, ethanol and glycerol in a weight ratio of 1: 1 to 2: 1.5 to 5, respectively. If the content of the ethanol and / or glycerol in the composition of the solvent is less than the content of water, the water-soluble polymer can not be concentrated to a required level, and the content of ethanol and glycerol relative to 1 part by weight of the water When the amount of the water-insoluble polymer is more than 2 parts by weight and more than 5 parts by weight, the water-insoluble polymer is excessively diluted and it is difficult to realize the adhesive force and the holding power by the water-insoluble polymer.

As described above, the tooth whitening preventive composition contains two kinds of polymeric binders, so that it is possible to effectively inhibit penetration of the coloring substance of the external environment into the surface of the teeth by coating the surface of the whitened teeth for a long time.

In addition, the tooth whitening oil retainer composition can further improve the color of the teeth in the state where the composition is applied to the whitened teeth by coating the teeth with a vitamin or a derivative thereof, and the tooth whitening oil composition can contain one or more kinds of phosphates (phosphate) The tooth remineralization can be promoted.

Hereinafter, embodiments of the present invention will be described in detail.

Examples and Comparative Examples

After dissolving vitamin C, sodium phosphate (SP) and amorphous calcium phosphate (ACP) in a mixed solvent of purified water, ethanol and glycerol in a container, polyvinylpyrrolidone (PVP) was added and mixed for at least 1 hour. Ethanol was further added and mixed for 1 hour or more. The contents of the components used in Examples and Comparative Examples are shown in Table 1 below.

division Example 1 Example 2 Example 3 Comparative Example 1 Comparative Example 2 PVP 20 20 20 20 0 rosin 3 3 3 0 3 Vitamin C 5 0 5 5 5 SP 3 3 3 3 3 ACP 3.5 3.5 0 3.5 3.5 Purified water 10.5 13.5 30.5 15.5 14 Glycerol 20 20 20 20 20 ethanol 35 35 35 35 35

(Unit: wt%)

Experimental Example

FIG. 1 and FIG. 2 show the results of the evaluation of the whitening maintenance function using a colorimetric spectrophotometer (CM-3500D) of the tooth whitening preservative composition according to Examples and Comparative Examples of the present invention.

The tooth extracted from a human was selected and treated three times for 20 minutes each time with a tooth whitening agent containing 15% by weight of hydrogen peroxide, and then the tooth whitening preservative composition according to the examples and the comparative examples was applied. The teeth to which the tooth whitening preservative composition was applied were immersed in a coloring agent (tea tea bag 1 ea / water 250 ml) at 37 ° C for 4 weeks, and the color change before and after immersion was evaluated using a colorimetric spectrophotometer (CM-3500D) . In addition, the tooth whitening preservative compositions were not applied and those immersed in the coloring agent under the same conditions were classified as a control group.

1 and 2, dE (ΔE) values of the dentifrice compositions of Examples 1 to 3 were 5.0 or more after 4 weeks, dE , Whitening retention was calculated to be 65% or more. On the other hand, the teeth to which the tooth whitening preservative compositions of Comparative Examples 1 and 2 were applied had a dE (ΔE) value of less than 5.0 after 4 weeks, And 64% or less.

Thus, the tooth whitening oil compositions of Examples 1 to 3, in which the water-soluble polymer, polyvinylpyrrolidone and the water-insoluble polymer, rosin were applied together as a binder, were coated on the surface of the whitened teeth for a long time, It is possible to effectively inhibit penetration of the tooth surface. In addition, it can be seen that vitamin C contained in the tooth whitening composition coating improves the color of teeth and that ACP promotes remineralization of teeth.

Particularly, in the case of the tooth whitening preservative compositions of Examples 1 and 2, in which ACP and SP were applied together, the whitening maintenance function was most excellent as SP maintained a pH suitable for realizing the remineralization function of ACP.

FIG. 3 is a visual observation of the whitening-maintaining function of the tooth whitening preservative compositions according to the examples and comparative examples of the present invention.

3, in the control group to which no composition was applied, the surface of the tooth was severely stained after 4 weeks of re-coloring, whereas when the tooth whitening preservative composition of Example 1 was applied, The tooth whitening preservative composition of Example 1 can effectively coat and protect the surface of teeth vulnerable to coloration immediately after bleaching.

It will be understood by those skilled in the art that the foregoing description of the present invention is for illustrative purposes only and that those of ordinary skill in the art can readily understand that various changes and modifications may be made without departing from the spirit or essential characteristics of the present invention. will be. It is therefore to be understood that the above-described embodiments are illustrative in all aspects and not restrictive. For example, each component described as a single entity may be distributed and implemented, and components described as being distributed may also be implemented in a combined form.

The scope of the present invention is defined by the appended claims, and all changes or modifications derived from the meaning and scope of the claims and their equivalents should be construed as being included within the scope of the present invention.

Claims (13)

A binder comprising a water-soluble polymer and a water-insoluble polymer;
Vitamins or derivatives thereof;
Sodium phosphate and amorphous calcium phosphate; And
A tooth whitening preservative composition comprising: a solvent; The method according to claim 1,
The water-soluble polymer is one selected from the group consisting of polyvinylpyrrolidone, polyvinyl alcohol, hydroxymethylcellulose, hydroxypropylcellulose, hydroxyethylcellulose, methylcellulose, poloxamer, and a mixture of two or more thereof , A tooth whitening preservative composition. The method according to claim 1,
Wherein the content of the water-soluble polymer is 5 to 30% by weight based on the total weight of the tooth whitening preservative composition. The method according to claim 1,
Wherein the water-insoluble polymer is one selected from the group consisting of shellac, rosin, zein, Eudragit, ethylcellulose, and mixtures of two or more thereof. The method according to claim 1,
Wherein the content of the water-insoluble polymer is 1 to 30% by weight based on the total weight of the tooth whitening preservative composition. The method according to claim 1,
Wherein said vitamin is vitamin C. The method according to claim 1,
Wherein the content of the vitamin is 1 to 10% by weight based on the total weight of the tooth whitening preservative composition. delete The method according to claim 1,
Wherein the sodium phosphate content is 1 to 10% by weight based on the total weight of the tooth whitening preservative composition. delete The method according to claim 1,
Wherein the content of the amorphous calcium phosphate is 1 to 10% by weight based on the total weight of the tooth whitening preservative composition. The method according to claim 1,
Wherein the solvent is one selected from the group consisting of water, ethanol, glycerol, and mixtures of two or more thereof. 13. The method of claim 12,
Wherein the solvent comprises water, ethanol and glycerol in a weight ratio of 1: 1 to 2: 1.5 to 5, respectively.

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