JPS63141918A - Aerosol composition for anti-pruritic use - Google Patents

Abstract

PURPOSE:To provide the titled composition composed of a stock liquid and a propellant each having specific component and composition, and having improved dispersibility of a water-soluble component and a water-insoluble component, quick-drying property and bubble-bursting sound, etc., by using ethanol and/or isopropyl alcohol. CONSTITUTION:100pts.wt. of an aqueous solution containing 3-60wt% ethanol and/or isopropyl alcohol is compounded with 0.01-10pts.wt. of a surfactant and/or 0.1-50pts.wt. of powder and 0.1-50pts.wt. of an active component of anti-pruritic to obtain a stock liquid. The titled composition is produced by compounding 2-30pts.wt. of the stock liquid with 70-98pts.wt. of a propellant composed mainly of dichlorotetrafluoroethane. The composition forms foam by spraying in the form of bubbles or mist and produces cracking sound by the bursting of the bubbles. The water-soluble component and the water-insoluble component can be uniformly dispersed in the above composition by the aid of the above alcohol. The composition produces large sound by the bursting of bubbles, has quick-drying property, is free from sticky feeling and dripping of liquid and gives refreshing feeling to the skin.

Description

[Detailed description of the invention] [Industrial application field] The present invention relates to an anti-itch aerosol composition.

[Conventional technology]

Traditionally, aerosol products include those that spray active ingredients in the form of a mist, such as hair spray, and those that spray the active ingredients in a foam, such as shaving cream. 32
As described in Publication No. 053, a composition for producing a pressurized foam that produces a crackling sound when the user rubs the foam sprayed from an aerosol product onto the skin layer with his/her hand has been developed. .

[Problem that the invention seeks to solve]

However, conventional compositions for producing pressurized foams, such as those described above, are made by mixing the water-insoluble oil components present in the cosmetically active ingredients with water to form an emulsion, and the emulsion is prepared over a long period of time. If the product is not used, the water and oil components will separate, requiring strong shaking or long-term shaking each time the product is used in order to evenly disperse the water and oil components, as well as requiring a large amount of water. When the sprayed foam is rubbed onto the skin by the user's hands, there is a problem in that it dries slowly on the skin.

Therefore, the present inventors conducted extensive research in order to solve the above problems, and found that ethanol and/or ethanol, which can easily and uniformly disperse oil-based active ingredients that are insoluble in water and have excellent quick-drying properties, It was discovered that the above problems could be solved by using isopropyl alcohol, and the present invention was completed.

[Means for solving problems]

The present invention uses 0.01-10 tfrffi parts of surfactant and/or 0.1-50 ffiffi parts of powder and 0.1-50 tfrffi parts of anti-itch active ingredient per 100 parts by weight of 3-60 wt% aqueous solution of ethanol and/or isopropyl alcohol. The present invention relates to an anti-itch aerosol composition comprising 2 to 30 parts by weight of a stock solution containing 70 to 98 parts by weight of a propellant containing dichlorotetrafluoroethane as a main component.

〔Example〕

The alcohol aqueous solution used in the present invention is ethanol and/or
Alternatively, it consists of a 3-60% (wt%) aqueous solution of isopropyl alcohol, preferably a 10-40% aqueous solution. Here, ethanol as used herein includes not only pure ethanol but also denatured ethanol.

Ethanol and isopropyl alcohol are soluble in water-soluble components and various water-insoluble organic compounds, so they are used as solubilizers or dispersants for both of these components, but ethanol and isopropyl alcohol have low boiling points. Because it evaporates easily, it is also used as an ingredient to dry quickly and provide a cooling sensation.Furthermore, ethanol and isopropyl alcohol have excellent foam-breaking properties, and are useful as ingredients that increase the foam-breaking level. be. If the concentration of the alcohol aqueous solution is less than 3%, it will be difficult for the water-insoluble oily active ingredient to disperse uniformly with the aqueous component, and drying will be slow; if it exceeds 60%, dichlorotetrafluoroethane (hereinafter referred to as (called Freon 114)
Since the compatibility with the propellant containing as the main component becomes too high, there will be less foaming and no crackling sound when sprayed, so it is preferable to use it within the range of 3 to 60%.

The surfactant used in the present invention is a component for uniformly dispersing the stock solution and the propellant, and includes, for example, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene alkylphenyl ether, polyoxyethylene alkyl ether, Examples include ethylene castor oil derivatives, but are not limited to these as long as they can be dispersed.

The surfactant is added in an amount of 0.01 to 10 parts, preferably 0.01 to 10 parts by weight, per 100 parts of a 3 to 80% aqueous solution of ethanol and/or isopropyl alcohol.
It is used by adding 1 to 5 parts. If the amount added is less than 0.01 part, strong shaking or long-term shaking is required to uniformly disperse the stock solution and propellant;
If the amount exceeds 0 parts, the stickiness of the surfactant itself will cause discomfort, which is not preferable.

The powder used in the present invention may be any powder that is difficult to dissolve in water, ethanol and/or isopropyl alcohol, and a propellant mainly composed of Freon 114, but in particular, talc, which has a shaping effect, It is preferable to use nylon or the like. The powder is prepared in a 3-60% aqueous solution of ethanol and/or isopropyl alcohol.
It is used by adding 0.1 to 50 parts, preferably 1 to 30 parts. If the amount added is less than 0.1 part, the effect of forming an emulsion by shaking the water component and oil component is small, and the resulting composition exceeding 50 parts may not be sprayed onto the skin, etc. After drying, the powder remains as a smear on the skin, which is undesirable.

For example, if an emulsion is prepared by shaking the water and oil components using talc in the range mentioned above,
It has the same effect as a surfactant or enhances the effect of a surfactant, and in some cases allows the emulsion to be mixed with simple shaking without the use of a surfactant.

The active ingredients used in the present invention for treating itch, heat rash, sores, eczema, diaper rash, sores, rashes, hives, etc. include, for example, methyl salicylate, g-menthol, diphenhydramine, dg
-camphor, benzyl alcohol, capsicum extract,
Peppermint oil, thymol, isothipendyl hydrochloride, β-glycyrrhetinic acid, dexamethacin, isopropylmethylphenol, dibucaine, hydrocortisone acetate, buiazulene, zinc oxide, ethyl aminobenzoate, phenol, boric acid, salicylamide, prednisolone, diphenhydramine hydrochloride, proton hydrochloride in, hydrochloric acid Ebiro force in,
Examples include dg-methylephedrine hydrochloride, zinc oxide starch, sulfadiazine, egg yolk oil, pyridoxine hydrochloride, allantoin, benzalkonium chloride, tocopherol acetate, etc. These anti-itch active ingredients may be used alone, or two or more of them may be used. may be used in combination.

The anti-itch active ingredient is used by adding 0.1 to 50 parts, preferably 1 to 30 parts, to 100 parts of ethanol and/or isopropyl alcohol 3 to 6096 aqueous solution. If the amount added is less than 0.1 part, it will not be effective for purposes of administration, and if it exceeds 50 parts, it will be difficult to disperse the active ingredient, which is not preferred.

As mentioned above, the stock solution used in the present invention can be changed by adding surfactants and active ingredients to the alcohol aqueous solution, but in addition to the above ingredients, depending on the application, for example,
Monohydric alcohols such as low propyl alcohol and n-butyl alcohol and their denatured alcohols; polyarsenic alcohols such as propylene glycol, ethylene glycol, diethylene glycol, triethylene glycol, and glycerin; ketones such as acetone, methyl ethyl ketone, and methyl isobutyl ketone; diethyl ether,
Ethers such as ethylene glycol monoethyl ether; esters such as isopropyl myristate, isopropyl palmitate, butyl myristate, and castor oil; liquid paraffin, kerosene, xylene, vegetable oil, etc. may also be added.

The anti-itch aerosol composition of the present invention can then be modified by preparing a stock solution and a propellant.

By the way, the crackling sound of bubbles ejected from an aerosol product is due to the rapid evaporation of the propellant trapped in the bubbles, causing the bubbles to burst. You can make even louder sounds.

In order for the injected foam to burst with a crackling sound, it is preferable that the boiling point of the propellant is within the range of -5℃ to 5℃. It is preferable that the main component is Freon 114, which is resistant to water, does not liberate hydrogen halide in the presence of water, and does not corrode metal containers for aerosols. Since the vapor pressure of Freon 114 alone is low, N? , dichlorodifluoromethane (hereinafter referred to as Freon 12), which is a nonflammable gas with a high vapor pressure, may be pressurized with CO2 or air. As a specific example, Freon 114 100-7
5 parts and vapor pressure at 20°C is 0.8-8.0k
Propellant consisting of 0 to 25 parts of liquefied petroleum gas, g/cd; Propellant consisting of 100 to 70 parts of Freon 114 and 0 to 30 parts of dimethyl ether; 100 to 100 parts of Freon 114
70# and a propellant consisting of 120 to 30 parts of Freon. Also, if compressed gas is used together, 35
A range of product pressures of up to 8 kg/c at °C can be used, but various other propellants can also be used.

The stock solution/propellant is used in a weight ratio of 2/98 to 30/70. If the mixing ratio is less than 2,798, there is a limit to the amount of active ingredients that can be added, and there is a problem with the dispersibility of the stock solution and propellant. Even if you do, the crackling sound will not be produced, which is not desirable.

Next, the present invention will be explained in more detail based on Examples, but the present invention is not limited to these Examples.

Example 1 9596 geraniol denatured ethanol 2.0 parts, pure water i
Parts t and a, 5 parts of PBC-440 as a surfactant, 0.5 parts of methyl salicylate as an anti-itch active ingredient,
0.5 parts of menthol, 0.2 parts of diphenhydramine, 0.5 parts of camphor, 0.5 parts of talc as an excipient, and 11484.0 parts of Freon as a propellant in an aluminum pressure-resistant container for aerosol (temperature Et: 300 m
An anti-itch aerosol composition (250r) was prepared by filling a container (250r) with an aerosol valve and a button.

The physical properties of the resulting aerosol composition, such as dispersibility, foam adhesion, foam bursting sound, and drying properties, were investigated using the following methods. The results are shown in Table 1.

(Dispersibility) The dispersibility of the aerosol composition was examined when the aerosol composition was shaken 20 times with a width of about 500111, and evaluated according to the following criteria.

(Judgment criteria) O: Emulsion formed and uniformly dispersed; The aerosol composition was sprayed, the presence or absence of dripping was observed, and the adhesion of the foam of the aerosol composition was examined, and evaluation was made according to the following criteria.

(Judgment criteria) 0: No dripping Δ: Slight dripping The presence or absence of foam breaking sound was investigated using the following method, and evaluation was made according to the following criteria.

(Judgment criteria) ○: There is a bubble breaking sound Δ: There is a slight bubble breaking sound After leaving it for another minute, the dryness on the surface of the arm was observed and evaluated according to the following criteria.

(Judgment criteria) ○: Feels smooth to the touch Δ: Feels slightly damp to the touch X: Feels slimy to the touch Example 2 2.5 parts of isopropyl alcohol, 9.9 parts of pure water, surfactant As an agent lIC0-80 (manufactured by Nikko Chemicals) 0
．． 4 parts, 0 methyl salicylate as an anti-itch active ingredient
．． 7 parts, menthol 0.3 parts, camphor 0.3 parts, glycol salicylate 0.3 parts and tocopherol acetate 0
．． 2 parts of 11,485.0 parts of fluorocarbons were added to a pressure-resistant container made of polyethylene terephthalate for aerosol (temperature El:
95ml) and attach the aerosol valve and button to the anti-itch aerosol composition (80g).
was created.

The physical properties of the obtained aerosol composition, such as dispersibility, foam adhesion, foam breaking sound, and drying properties, were measured in the same manner as in Example 1. The results are shown in Table 1.

Example 3 95% brucine denatured ethanol 2.0 parts, pure water 14.2 parts
Part, PBC-44 (Nikko Chemicals ■) as a surfactant
Co., Ltd.), 1.0 part of methyl salicylate as an anti-itch active ingredient, 0.3 part of talc as an excipient, and 11,482.0 parts of Freon as a propellant in an aluminum pressure-resistant container for aerosol (dropping amount: 300ml). ), and an aerosol valve and button were attached to prepare an anti-itch aerosol composition (250 g).

The physical properties of the resulting aerosol composition, such as dispersibility, foam adhesion, foam breakage, and drying properties, were measured in the same manner as in Example 1. The results are shown in Table 1.

Comparative Example 1 95% geraniol-denatured ethanol 2 used in Example 1
．． Example 1 except that 2.0 parts of pure water was used instead of 0 parts.
An anti-itch aerosol composition was obtained in exactly the same manner as above.

The physical properties of the resulting aerosol composition, such as dispersibility, foam adhesion, foam breakage, and drying properties, were measured in the same manner as in Example 1. The results are shown in Table 1.

Comparative Example 2 An anti-itch aerosol composition was obtained in exactly the same manner as in Example 1, except that 2.5 parts of pure water was used instead of 2.5 parts of isopropyl alcohol used in Example 2.

The physical properties of the resulting aerosol composition, such as dispersibility, foam adhesion, foam breakage, and drying properties, were measured in the same manner as in Example 1. The results are shown in Table 1.

Comparative Example 3 95% brucine denatured ethanol 2.0 used in Example 3
An anti-itch aerosol composition was obtained in exactly the same manner as in Example 1 except that 2.0 parts of pure water was used instead of 2.0 parts of pure water.

The physical properties of the resulting aerosol composition, such as dispersibility, foam adhesion, foam breakage, and drying properties, were measured in the same manner as in Example 1. The results are shown in Table 1.

[Margins below] [Effects of the Invention] In the anti-itch aerosol composition of the present invention, ethanol and/or isopropyl alcohol is used as a solubilizer or dispersant in a uniformly dispersed manner,
Since it is soluble in water-soluble ingredients and water-insoluble a-compounds, various active ingredients can be uniformly dispersed and used, thus widening the formulation range, and ethanol and/or isopropyl Since alcohol has a defoaming effect, it produces a loud sound when the bubbles break.

In addition, ethanol and isopropyl alcohol have low boiling points and are easily vaporized, so they dry quickly, do not have a sticky feeling, and do not drip, so they can be used on vertical surfaces of the human body, and they also provide a cooling sensation when used. It also has an effect.

Claims (1)

[Scope of Claims] 1. 0.01 to 10 parts by weight of surfactant and/or 0.1 to 50 parts by weight of powder per 100 parts by weight of 3 to 60% by weight aqueous solution of ethanol and/or isopropyl alcohol.
An anti-itch aerosol composition comprising 2-30 parts by weight of a stock solution prepared by adding 0.1-50 parts by weight of an anti-itch active ingredient and 70-98 parts by weight of a propellant whose main component is dichlorotetrafluoroethane. thing. 2. The anti-itch aerosol composition according to claim 1, which forms a foam that makes a crackling sound by bursting when sprayed in the form of a foam or mist.