JPS6127906A - Sintered article having antimicrobial action - Google Patents

Abstract

PURPOSE:A sintered article containing heavy metal elements mentioned below, having an antimicrobial action with an improved stability of antibacterial action against heat, light, etc., obtained by sintering heavy metal elements having antibacterial action selected from silver, copper and zinc. CONSTITUTION:A sintered article obtained by sintering (a) about 5-80wt%, preferably about 10-40wt%, fine powder of a compound containing a heavy metal element selected from silver, copper and zinc using both (b) about 20- 95wt%, preferably about 50-90wt%, fine powder of inorganic substances usable as the sintered article and (c) about 0-20wt%, preferably about 0-10wt%, fine powder of inorganic glasses or alkali metal compounds used to make the sintering easy, to obtain the sintered article having the antimicrobial action containing the above-mentioned heavy metal components. Said sintered article has superior heat resistance and light resistance, is durable in strength and exhibits a long-period stable antimicrobial action.

Description

[Detailed description of the invention] [Technical field of invention] The present invention relates to a sintered body that has antibacterial properties.

[Conventional technology W- and its problems]

Conventionally, there have been attempts to exert antibacterial effects using heavy metals.

For example, as disclosed in U.S. Pat. Is there a storage device for hydrogel bodies that is characterized by immersion? Part C disclosed in Publication No. 96608 is a contact lens storage device in which heavy metals (silver, antimony) having an antibacterial effect are brought into contact with a contact lens storage solution, and the contact lenses stored therein are brought into contact with a contact lens storage solution. There are devices that provide antibacterial effects to lenses.

The former uses metallic silver, which is a heavy metal, contained inside a cation-exchange coating in the form of porous peas or membrane sheets, and the latter stores the heavy metal in a part of the device. A space is set up and heavy metals are placed there, or the surface of the contact lens storage area inside the device is coated with heavy metals.

In these conventional techniques, it is possible for heavy metal ions to exert antibacterial effects, but as will be explained later, for example, silver compounds are unstable to heat, light, etc.
When such antibacterial systems are used, problems remain in maintaining stable antibacterial effects.

Therefore, the present inventor continued intensive research in order to utilize the antibacterial effect of heavy metal compound ions disclosed in the prior art and to develop a system that can sustain the effect more stably, and as a result, the present invention was developed. completed.

[Eighth Advantages of the Invention] That is, the present invention relates to a sintered body having an antibacterial effect and containing a heavy metal element selected from the group consisting of silver, silver, and zinc.

The sintered body of the present invention is suitable for sintering, especially for
2. It is stable against heat, light, etc., and can provide continuous FL bacterial action.

Next, a method for manufacturing the sintered body of the present invention will be explained.

The raw materials for producing the sintered body of the present invention are as follows:
Consists of groups.

Group 1: 58iI fine powder Xm that can be used as a sintered body
: Fine powder of a compound containing a heavy metal element selected from silver, sawdust and zinc.Group 2.Fine powder of an inorganic glass or alkali metal compound for facilitating sintering.For example, kaolin. Various oxides such as silica, alumina, and zirconia are used.

Examples of compounds belonging to the first group include oxides, chlorides, carbonates, nitrates, and sulfates of various heavy metals.

Compounds belonging to this group include water-soluble compounds such as silicates, carbonates, chlorides, nitrates, sulfates, and hydroxides of alkali metals such as sodium and potassium; Examples of compounds include inorganic glasses such as Pyrex glass.

The amount of each raw material used to manufacture the sintered body of the invention is:
Group 1 is about 20-95% (wt%, the same applies hereinafter), Group 1 is about 5-80%, Group 1 is about 0-20%, preferably Group 1 is about 50-905X, Group 11 is about 10 -40%, and group ■ about 0-10%. Group 1 is an essential raw material for making a sintered body, and if it is not used at least 20%, it will be difficult to form a sintered body. Group 1 is a raw material that is the source of the antibacterial action of the present invention, and contains at least 596 If the above amount is not used, sufficient antibacterial effect will not be exhibited, preferably about 10%
That's all. Group 1 is used auxiliary to facilitate sintering, and its usage limit is about 20%.
If it is used more than this, the porosity of the sintered body of the present invention will be impaired.
A sufficient antibacterial effect cannot be expected.

When a water-soluble compound is used as Group (1) among the raw materials for production, first, the compound of Group 1 and the compound of Group 1 are mixed with an appropriate amount of water to form a paste, and then concentrated to dryness. The mixture was thoroughly kneaded with the first group of compounds using an appropriate amount of alcoholic solvent, and the mixture was press-fitted into a desired mold and molded at several hundred to several hundred degrees centigrade. The sintered body may be obtained by baking it for several to several tens of hours.

On the other hand, when a water-insoluble compound is used as Group ①, the compounds of Group 1, Group 1 and Group ① are mixed into a 1- base using an appropriate amount of water, and the mixture is press-fitted into the desired mold and molded. The process is the same as in the case of using the water-soluble compound 'fm' except that.

The alcohols used as the solvent include, for example, methanol, ethanol, propatool, isopropateol,
Common alcohols such as butanol are used. The mold to be used may be of any shape such as SS, plate, cylinder, block, or spherical. For example, if the sintered body of the present invention is to be used as it is as a bottom lid of a bottle or container, The sintered body of the present invention may be manufactured using a shape and size (mm) suitable for such uses, and the sintered body of the present invention may be used in containers for storing medical devices such as contact lenses and catheters that are stored in solutions. When applied, it may be made using a mold that can form part or all of it.

[Effects of the Invention] The sintered body having antibacterial properties of the present invention is not simply a mixture of a heavy metal compound and an inorganic compound. It has excellent durability and light resistance, and is also durable in terms of strength, thus making it possible to provide stable antibacterial action over a long period of time. Furthermore, the sintered body of the present invention can be made into any shape and size by freely selecting the mold used for molding, and therefore has high industrial applicability.

[Industrial applicability of the invention]

Due to its effectiveness, the sintered body of the present invention having sintered properties can be used in the field and applications of heels. For example, since it is possible to prevent microbial contamination, it can also be used to prevent microbial contamination of hometown water, goldfish bee water, flower vase water, etc. In addition, from the viewpoint of the safety of the aqueous solution in which the sintered body of the present invention is immersed, among the articles that must be kept in an aqueous solution, it is particularly important to maintain sterile conditions, such as medical devices such as contact lenses and catheters. It can be preferably applied to the prevention of contamination of types.

〔Example〕

Example 1 After mixing 100 g of finely powdered kaolin and sodium carbonate 3Ii using an appropriate amount of water to form a paste,
The mixture was concentrated to dryness in an evaporator at 45° C. under a reduced pressure of 20 to 3011 JIHg, and then pulverized using a glass mortar.

Next, the kaolin-lium carbonate mixed fine powder 101i and 2 g of silver oxide were thoroughly kneaded using an appropriate amount of isopropyl alcohol.
7 x 17 x 3 m), dried, and the molded product taken out was kneaded at i 100 ''C for 6 hours to obtain a sintered body.

Example 2 The kaolin-sodium carbonate-silver oxide mixture obtained in Example 1 was press-fitted into a mold suitable for forming the housing part of a soft contact lens case, and after drying, it was taken out and heated to 1100°C. At 10 o'clock, I got the storage part for the soft contact lens case.

Examples 3 to 4 Example 3 was made in the same manner as in Example 1, except that the silver oxide 21 used in Example 1 was changed to oxide@2g, and Example 1 was used, except that zinc oxide was changed to 2g. As Example 4, cast ffi (17X17X3M
) was used to obtain a sintered body in the same manner as in Example 1.

Examples 5 to 7 Selectively finely powdered kaolin 1001i, finely powdered Pyhex glass 0.311, and 2g of finely powdered metal oxide shown in Table 1 were mixed with an appropriate amount of water to make a paste. After kneading them, they were press-fitted into cylindrical molds (diameter 10, thickness 5 in order) and dried at 1100℃.
A cylindrical sintered body was obtained by kneading for 6 hours.

Table 1 Example 8 After being toclaved and sterilized, E. coli suspension (10@/fig) was added in 100 μl portions using an Eppendorf micropipettor to give a concentration of 10·/1.

After that, Sample 1 Kasumi! The number of viable bacteria after one day (24 hours) was determined using the membrane filter method (Note 1), and the results were as shown in Table 2.

Table 2 (Note 1) Membrane filter method Collect 1 nt of sample solution with a tuberculin syringe (Terumo syringe 1 frLl), filter it with a membrane filter (13 heads in diameter) with a pore size o of 45 μm, and then remove 1 nt of sterile peptone water. The above filter was washed and measured.

Examples 9 to 16 Sintered body powder 102K with sintered body composition as shown in Table 3
Put F into a test tube (φ = 25 order), autoquark o, snt
After 1 hour and 6 hours of contact, while shaking at 20℃,
The number of viable bacteria after 24 hours was measured by the agar plate pouring method (Note 2). The results are shown in Table 3.

(Note 2) Agar plate pouring method sample solution 1rrL7! Collected in a petri dish, preheated and dissolved, poured 30M of 5CDLP agar medium kept at 45 to 50°C aseptically, and gently rotated or cultured for a day.
The number of colonies that appeared was measured.

Claims (1)

[Claims] A sintered body having an antibacterial effect and containing a heavy metal element selected from the group consisting of silver, copper and zinc.