JPS5798298A - Preparation of 17beta-ethinylsteroid - Google Patents

Preparation of 17beta-ethinylsteroid

Info

Publication number
JPS5798298A
JPS5798298A JP17406580A JP17406580A JPS5798298A JP S5798298 A JPS5798298 A JP S5798298A JP 17406580 A JP17406580 A JP 17406580A JP 17406580 A JP17406580 A JP 17406580A JP S5798298 A JPS5798298 A JP S5798298A
Authority
JP
Japan
Prior art keywords
salt
ethinyl
dien
ono
pref
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP17406580A
Other languages
Japanese (ja)
Other versions
JPS6352632B2 (en
Inventor
Kazumasa Nitta
Shinichiro Fujimori
Toshio Haruyama
Shinya Inoue
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Kasei Corp
Original Assignee
Mitsubishi Kasei Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Kasei Corp filed Critical Mitsubishi Kasei Corp
Priority to JP17406580A priority Critical patent/JPS5798298A/en
Priority to US06/325,026 priority patent/US4585591A/en
Priority to HU813691A priority patent/HU187382B/en
Priority to DE8181110321T priority patent/DE3169906D1/en
Priority to AT81110321T priority patent/ATE12648T1/en
Priority to DD23563581A priority patent/DD202438A5/en
Priority to EP81110321A priority patent/EP0053845B1/en
Publication of JPS5798298A publication Critical patent/JPS5798298A/en
Publication of JPS6352632B2 publication Critical patent/JPS6352632B2/ja
Granted legal-status Critical Current

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  • Catalysts (AREA)
  • Steroid Compounds (AREA)

Abstract

PURPOSE: To prepare the titled compound useful as an intermediate for hydrocortisone, prednisolone, etc., economically in an industrial scale, by hydrolyzing 17α-ethinylsteroids using a cuprous salt in place of conventional expensive silver nitrate as a catalyst.
CONSTITUTION: A steroid having the partial structure of formulaI[X is -ONO2, -ONO, or OSO2R (R is alkyl or aryl)]e.g. 17α-ethinyl-17β-nitroxyandrosta-1, 4-dien-3-one, is hydrolyzed with water in the presence of a coprous salt (e.g. cuprous chloride) pref. at 30W80°C to obtain the objective compound having the partial structure of formula II (e.g. 17β-ethinyl-17α-hydroxyanodrosta-1,4-dien- 3-one). The amount of the cuprous salt is pref, 0.05W0.4 mole per 1 mole of the steroid used as the raw material.
EFFECT: The use of highly toxic sodium cyanide is not necessary.
COPYRIGHT: (C)1982,JPO&Japio
JP17406580A 1980-12-10 1980-12-10 Preparation of 17beta-ethinylsteroid Granted JPS5798298A (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP17406580A JPS5798298A (en) 1980-12-10 1980-12-10 Preparation of 17beta-ethinylsteroid
US06/325,026 US4585591A (en) 1980-12-10 1981-11-25 17β-ethynylsteroids and process for preparing same
HU813691A HU187382B (en) 1980-12-10 1981-12-08 Process for producing 17-beta-ethnyl-steroides
DE8181110321T DE3169906D1 (en) 1980-12-10 1981-12-10 17-beta-ethynylsteroids and process for preparing same
AT81110321T ATE12648T1 (en) 1980-12-10 1981-12-10 17-BETA-AETHYNYL STEROIDS AND PROCESS FOR THEIR PREPARATION.
DD23563581A DD202438A5 (en) 1980-12-10 1981-12-10 PROCESS FOR THE PREPARATION OF 17 BETA AETHINYL STEROIDS
EP81110321A EP0053845B1 (en) 1980-12-10 1981-12-10 17-beta-ethynylsteroids and process for preparing same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP17406580A JPS5798298A (en) 1980-12-10 1980-12-10 Preparation of 17beta-ethinylsteroid

Publications (2)

Publication Number Publication Date
JPS5798298A true JPS5798298A (en) 1982-06-18
JPS6352632B2 JPS6352632B2 (en) 1988-10-19

Family

ID=15972005

Family Applications (1)

Application Number Title Priority Date Filing Date
JP17406580A Granted JPS5798298A (en) 1980-12-10 1980-12-10 Preparation of 17beta-ethinylsteroid

Country Status (1)

Country Link
JP (1) JPS5798298A (en)

Also Published As

Publication number Publication date
JPS6352632B2 (en) 1988-10-19

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