JPS577465A - Preparation of indole derivative - Google Patents

Preparation of indole derivative

Info

Publication number
JPS577465A
JPS577465A JP7912880A JP7912880A JPS577465A JP S577465 A JPS577465 A JP S577465A JP 7912880 A JP7912880 A JP 7912880A JP 7912880 A JP7912880 A JP 7912880A JP S577465 A JPS577465 A JP S577465A
Authority
JP
Japan
Prior art keywords
formula
compound
alkyl
water
basic substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP7912880A
Other languages
Japanese (ja)
Inventor
Yoshinori Tsuda
Kiyonori Yokogoshi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PAAMAKEMU ASIA KK
Permachem Asia Ltd
Original Assignee
PAAMAKEMU ASIA KK
Permachem Asia Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PAAMAKEMU ASIA KK, Permachem Asia Ltd filed Critical PAAMAKEMU ASIA KK
Priority to JP7912880A priority Critical patent/JPS577465A/en
Publication of JPS577465A publication Critical patent/JPS577465A/en
Pending legal-status Critical Current

Links

Landscapes

  • Indole Compounds (AREA)

Abstract

PURPOSE: To obtain the titled compound useful for the remedy and prevention of arrhythmia and atrial fibrillation by a simple and economical means in high purity and yield, by reacting 4-hydroxyindole with an oxazolidine derivative in the presence of water and a basic substance.
CONSTITUTION: A compound of formula I (Y is H or equivalent amount of a metallic atom) is reacted with an oxazolidine derivative of formula I (R is alkyl; X is halogen, alkyl or arylsulfonyloxy) in the presence of water and a basic substance, e.g. potassium hydroxide, in a solvent, e.g. dimethylformamide, preferably at 50W 150°C, to give a compound of formula III. The compound of formula II is synthesized by alkylating the nitrogen atom at the 3-position of a 5-halogenomethyloxazolidin-2- one with an alkyl halide.
COPYRIGHT: (C)1982,JPO&Japio
JP7912880A 1980-06-13 1980-06-13 Preparation of indole derivative Pending JPS577465A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP7912880A JPS577465A (en) 1980-06-13 1980-06-13 Preparation of indole derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7912880A JPS577465A (en) 1980-06-13 1980-06-13 Preparation of indole derivative

Publications (1)

Publication Number Publication Date
JPS577465A true JPS577465A (en) 1982-01-14

Family

ID=13681298

Family Applications (1)

Application Number Title Priority Date Filing Date
JP7912880A Pending JPS577465A (en) 1980-06-13 1980-06-13 Preparation of indole derivative

Country Status (1)

Country Link
JP (1) JPS577465A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2366431A1 (en) * 2010-03-19 2011-09-21 Universitätsklinikum Hamburg-Eppendorf Myeloperoxidase as a target in atrial fibrillation

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53119824A (en) * 1977-03-24 1978-10-19 Sandoz Ag Improvement in organic compound
JPS5622765A (en) * 1979-08-02 1981-03-03 Fujimoto Seiyaku Kk Novel method of preparing pindolol
JPS5683471A (en) * 1979-12-10 1981-07-08 Fujimoto Seiyaku Kk Novel preparation of pindolol

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53119824A (en) * 1977-03-24 1978-10-19 Sandoz Ag Improvement in organic compound
JPS5622765A (en) * 1979-08-02 1981-03-03 Fujimoto Seiyaku Kk Novel method of preparing pindolol
JPS5683471A (en) * 1979-12-10 1981-07-08 Fujimoto Seiyaku Kk Novel preparation of pindolol

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2366431A1 (en) * 2010-03-19 2011-09-21 Universitätsklinikum Hamburg-Eppendorf Myeloperoxidase as a target in atrial fibrillation

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