JPS5740492A - Novel 2-phenylimidazo 2,1-b benzothiazole derivative - Google Patents

Novel 2-phenylimidazo 2,1-b benzothiazole derivative

Info

Publication number
JPS5740492A
JPS5740492A JP55115610A JP11561080A JPS5740492A JP S5740492 A JPS5740492 A JP S5740492A JP 55115610 A JP55115610 A JP 55115610A JP 11561080 A JP11561080 A JP 11561080A JP S5740492 A JPS5740492 A JP S5740492A
Authority
JP
Japan
Prior art keywords
formula
agent
halogen
nitroso
nitro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP55115610A
Other languages
Japanese (ja)
Other versions
JPH0138791B2 (en
Inventor
Kiyoshi Murase
Toshiyasu Mase
Kenichi Tomioka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamanouchi Pharmaceutical Co Ltd
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd
Priority to JP55115610A priority Critical patent/JPS5740492A/en
Publication of JPS5740492A publication Critical patent/JPS5740492A/en
Publication of JPH0138791B2 publication Critical patent/JPH0138791B2/ja
Granted legal-status Critical Current

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  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:The titled derivative of formula I (R<1>, R<2> and R<3> are H, halogen, OH, nitro, nitroso, carboxy, etc.; R<4>, R<5> and R<6> are H, halogen, OH, nitro, nitroso, thiocyanate, etc.; the dotted line represents the presence or absence of double bond) and a salt thereof. EXAMPLE:7-Hydroxy-2-(p-methoxyphenyl)imidazo[2,1-b]benzothiazole. USE:Useful as an immunological regulator, antiallergic agent, antiasthmatic agent, antirheumatic agent, anticancer agent, remedy for autoimmune diseases, and rejection inhibitor in organ transplantation or skin grafting. PROCESS:A compound of formula II [A is carbonyl or formula III (X is halogen)] is cyclized to give the compound of formula I. The reaction is carried out in a solvent, e.g. methanol, if necessary in the presence of a base.
JP55115610A 1980-08-22 1980-08-22 Novel 2-phenylimidazo 2,1-b benzothiazole derivative Granted JPS5740492A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP55115610A JPS5740492A (en) 1980-08-22 1980-08-22 Novel 2-phenylimidazo 2,1-b benzothiazole derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55115610A JPS5740492A (en) 1980-08-22 1980-08-22 Novel 2-phenylimidazo 2,1-b benzothiazole derivative

Publications (2)

Publication Number Publication Date
JPS5740492A true JPS5740492A (en) 1982-03-06
JPH0138791B2 JPH0138791B2 (en) 1989-08-16

Family

ID=14666900

Family Applications (1)

Application Number Title Priority Date Filing Date
JP55115610A Granted JPS5740492A (en) 1980-08-22 1980-08-22 Novel 2-phenylimidazo 2,1-b benzothiazole derivative

Country Status (1)

Country Link
JP (1) JPS5740492A (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6479162A (en) * 1987-06-17 1989-03-24 Eisai Co Ltd Benzothiazole derivative
US4968708A (en) * 1988-06-22 1990-11-06 Nikken Chemicals Co., Ltd. Imidazo[2,1-B]benzothiazole compounds and antiulcer compositions containing the same
EP0816366A1 (en) * 1995-03-13 1998-01-07 Nikken Chemicals Company, Limited Imidazothiazole compounds
WO1998006724A1 (en) * 1996-08-09 1998-02-19 Yamanouchi Pharmaceutical Co., Ltd. Metabotropic glutamate receptor agonists
US7820657B2 (en) 2006-03-17 2010-10-26 Ambit Biosciences Corporation Imidazolothiazole compounds for the treatment of disease
US8883783B2 (en) 2007-09-19 2014-11-11 Ambit Biosciences Corporation Solid forms comprising N-(5-tert-butyl-isoxazol-3-yl)-N′-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea, compositions thereof, and uses therewith

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6248672A (en) * 1985-06-18 1987-03-03 ビオガル　ジヨジセルジヤ−ル Thiazolinedicarboxylic acid derivative
JPS6320237A (en) * 1986-07-11 1988-01-27 Kubota Ltd Driving device for hydraulic pump of vehicle
JPS6320236A (en) * 1986-07-11 1988-01-27 Daihatsu Motor Co Ltd Control device for two/four wheel drive changeover mechanism

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6248672A (en) * 1985-06-18 1987-03-03 ビオガル　ジヨジセルジヤ−ル Thiazolinedicarboxylic acid derivative
JPS6320237A (en) * 1986-07-11 1988-01-27 Kubota Ltd Driving device for hydraulic pump of vehicle
JPS6320236A (en) * 1986-07-11 1988-01-27 Daihatsu Motor Co Ltd Control device for two/four wheel drive changeover mechanism

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6479162A (en) * 1987-06-17 1989-03-24 Eisai Co Ltd Benzothiazole derivative
US4968708A (en) * 1988-06-22 1990-11-06 Nikken Chemicals Co., Ltd. Imidazo[2,1-B]benzothiazole compounds and antiulcer compositions containing the same
EP0816366A1 (en) * 1995-03-13 1998-01-07 Nikken Chemicals Company, Limited Imidazothiazole compounds
EP0816366A4 (en) * 1995-03-13 1998-07-08 Nikken Chemicals Co Ltd Imidazothiazole compounds
US5919799A (en) * 1995-03-13 1999-07-06 Nikken Chemicals Co., Ltd. Imidazothiazole compound
WO1998006724A1 (en) * 1996-08-09 1998-02-19 Yamanouchi Pharmaceutical Co., Ltd. Metabotropic glutamate receptor agonists
US7820657B2 (en) 2006-03-17 2010-10-26 Ambit Biosciences Corporation Imidazolothiazole compounds for the treatment of disease
US8129374B2 (en) 2006-03-17 2012-03-06 Ambit Bioscience Corporation Method of using imidazolothiazole compounds for the treatment of disease
US8557810B2 (en) 2006-03-17 2013-10-15 Ambit Biosciences Corporation Imidazolothiazole compounds for the treatment of disease
US8921546B2 (en) 2006-03-17 2014-12-30 Ambit Biosciences Corporation Imidazolothiazole compounds for the treatment of disease
US8883783B2 (en) 2007-09-19 2014-11-11 Ambit Biosciences Corporation Solid forms comprising N-(5-tert-butyl-isoxazol-3-yl)-N′-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea, compositions thereof, and uses therewith
US9585892B2 (en) 2007-09-19 2017-03-07 Ambit Biosciences Solid forms comprising N-(5-tert-butyl-isoxazol-3-yl)-N′-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea, compositions thereof, and uses therewith

Also Published As

Publication number Publication date
JPH0138791B2 (en) 1989-08-16

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