JPS5738777A - 2-sufanilamidopyrathyn derivative - Google Patents

2-sufanilamidopyrathyn derivative

Info

Publication number
JPS5738777A
JPS5738777A JP11297280A JP11297280A JPS5738777A JP S5738777 A JPS5738777 A JP S5738777A JP 11297280 A JP11297280 A JP 11297280A JP 11297280 A JP11297280 A JP 11297280A JP S5738777 A JPS5738777 A JP S5738777A
Authority
JP
Japan
Prior art keywords
formula
dialkylpyrathyn
give
sulfanilamido
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP11297280A
Other languages
Japanese (ja)
Other versions
JPH0142947B2 (en
Inventor
Akihiro Oota
Norihiro Watanabe
Sadamitsu Kono
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sogo Pharmaceutical Co Ltd
Original Assignee
Sogo Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sogo Pharmaceutical Co Ltd filed Critical Sogo Pharmaceutical Co Ltd
Priority to JP11297280A priority Critical patent/JPS5738777A/en
Publication of JPS5738777A publication Critical patent/JPS5738777A/en
Publication of JPH0142947B2 publication Critical patent/JPH0142947B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A 2-sulfanilamidopyrathyn derivative shown by the formula I (R is branched or straight-chain lower alkyl).
EXAMPLE: 2-Sulfanilamido-3,6-dinormal-propylpyrathyn.
USE: An antibacterial agent. Exhibiting extremely improved antibacterial activities especially against Gram-negative bacilli.
PROCESS: A 2-amino-3,6-dialkylpyrathyn shown by the formula II is condensed with p-acetylaminosulfonyl chloride in pyridine, to give a 2-acetylsulfanylamido-3,6-dialkylpyrathyn shown by the formula III, which is hydrolyzed with NaOH, to give sodium salt of a 2-sulfanilamido-3,6-dialkylpyrathyn shown by the formula IV. This compound is further neutralized with H2SO4, to give a compound shown by the formula I.
COPYRIGHT: (C)1982,JPO&Japio
JP11297280A 1980-08-19 1980-08-19 2-sufanilamidopyrathyn derivative Granted JPS5738777A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP11297280A JPS5738777A (en) 1980-08-19 1980-08-19 2-sufanilamidopyrathyn derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11297280A JPS5738777A (en) 1980-08-19 1980-08-19 2-sufanilamidopyrathyn derivative

Publications (2)

Publication Number Publication Date
JPS5738777A true JPS5738777A (en) 1982-03-03
JPH0142947B2 JPH0142947B2 (en) 1989-09-18

Family

ID=14600162

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11297280A Granted JPS5738777A (en) 1980-08-19 1980-08-19 2-sufanilamidopyrathyn derivative

Country Status (1)

Country Link
JP (1) JPS5738777A (en)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59203816A (en) * 1983-05-04 1984-11-19 Nissan Motor Co Ltd Direct injection type diesel engine
JPS6170695A (en) * 1984-09-14 1986-04-11 ニツタン株式会社 Repeater for alarm
US7625922B2 (en) 2004-10-22 2009-12-01 Cancer Research Technology Limited Imidazo[4,5-b]pyridin-2-one and oxazolo[4,5-b]pyridin-2-one compounds and analogs thereof as therapeutic compounds
US7951819B2 (en) 2006-04-26 2011-05-31 Cancer Research Technology Limited Imidazo[4, 5-B]pyridin-2-one and oxazolo[4, 5-B] pyridin-2-one compounds and analogs thereof as cancer therapeutic compounds
US8198279B2 (en) 2007-12-19 2012-06-12 Institute Of Cancer Research: Royal Cancer Hospital (The) Pyrido[2,3-b]pyrazin-8-substituted compounds and their use
US8383816B2 (en) 2008-04-25 2013-02-26 Cancer Research Technology Limited Aryl-quinolyl compounds and their use
US8815896B2 (en) 2010-02-01 2014-08-26 The Institute Of Cancer Research: Royal Cancer Hospital 1-(5-tert-butyl-2-phenyl-2H-pyrazol-3-yl)-3-[2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-B]pyridin-7-yloxy)-phenyl]-urea and related compounds and their use in therapy
US9505115B2 (en) 2011-02-18 2016-11-29 Max Co., Ltd. Driving tool with reaction absorbing mechanism
US9708317B2 (en) 2013-11-25 2017-07-18 Cancer Research Technology Limited Process for the preparation of 8-(4-aminophenoxy)-4H-pyrido[2,3-B]pyrazin-3-one derivatives
US9725447B2 (en) 2013-11-25 2017-08-08 Cancer Research Technology Limited 1-(5-tert-butyl-2-aryl-pyrazol-3-yl)-3-[2-fluoro-4-[(3-oxo-4H-pyrido[2,3-b]pyrazin-8-yl)oxy]phenyl]urea derivatives as RAF inhibitors for the treatment of cancer

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59203816A (en) * 1983-05-04 1984-11-19 Nissan Motor Co Ltd Direct injection type diesel engine
JPS6170695A (en) * 1984-09-14 1986-04-11 ニツタン株式会社 Repeater for alarm
US7625922B2 (en) 2004-10-22 2009-12-01 Cancer Research Technology Limited Imidazo[4,5-b]pyridin-2-one and oxazolo[4,5-b]pyridin-2-one compounds and analogs thereof as therapeutic compounds
US7951819B2 (en) 2006-04-26 2011-05-31 Cancer Research Technology Limited Imidazo[4, 5-B]pyridin-2-one and oxazolo[4, 5-B] pyridin-2-one compounds and analogs thereof as cancer therapeutic compounds
US8198279B2 (en) 2007-12-19 2012-06-12 Institute Of Cancer Research: Royal Cancer Hospital (The) Pyrido[2,3-b]pyrazin-8-substituted compounds and their use
US8546387B2 (en) 2007-12-19 2013-10-01 Cancer Research Technology Limited Pyrido[2,3-b]pyrazin-8-substituted compounds and their use
US9540372B2 (en) 2007-12-19 2017-01-10 Institute Of Cancer Research: Royal Cancer Hospital (The) Pyrido[2,3-b]pyrazin-8-substituted compounds and their use
US8912191B2 (en) 2007-12-19 2014-12-16 Cancer Research Technology Limited Pyrido[2,3-B]pyrazin-8-substituted compounds and their use
US9155737B2 (en) 2007-12-19 2015-10-13 Institute Of Cancer Research: Royal Cancer Hospital (The) Pyrido[2,3-B]pyrazin-8-substituted compounds and their use
US8383816B2 (en) 2008-04-25 2013-02-26 Cancer Research Technology Limited Aryl-quinolyl compounds and their use
US9439893B2 (en) 2010-02-01 2016-09-13 Cancer Research Technology Limited 1-(5-tert-butyl-2-phenyl-2H-pyrazol-3-yl)-3-[2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-B]pyridin-7-yloxy)-phenyl]-urea and related compounds and their use in therapy
US8815896B2 (en) 2010-02-01 2014-08-26 The Institute Of Cancer Research: Royal Cancer Hospital 1-(5-tert-butyl-2-phenyl-2H-pyrazol-3-yl)-3-[2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-B]pyridin-7-yloxy)-phenyl]-urea and related compounds and their use in therapy
US9820976B2 (en) 2010-02-01 2017-11-21 Cancer Research Technology Limited 1-(5-tert-butyl-2-phenyl-2H-pyrazol-3-yl)-3-[2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yloxy)-phenyl]-urea and related compounds and their use in therapy
US9505115B2 (en) 2011-02-18 2016-11-29 Max Co., Ltd. Driving tool with reaction absorbing mechanism
US10377026B2 (en) 2011-02-18 2019-08-13 Max Co., Ltd. Driving tool with reaction absorbing mechanism
US11396094B2 (en) 2011-02-18 2022-07-26 Max Co., Ltd. Driving tool with reaction absorbing mechanism
US9708317B2 (en) 2013-11-25 2017-07-18 Cancer Research Technology Limited Process for the preparation of 8-(4-aminophenoxy)-4H-pyrido[2,3-B]pyrazin-3-one derivatives
US9725447B2 (en) 2013-11-25 2017-08-08 Cancer Research Technology Limited 1-(5-tert-butyl-2-aryl-pyrazol-3-yl)-3-[2-fluoro-4-[(3-oxo-4H-pyrido[2,3-b]pyrazin-8-yl)oxy]phenyl]urea derivatives as RAF inhibitors for the treatment of cancer
US10100053B2 (en) 2013-11-25 2018-10-16 Cancer Research Technology Limited Process for the preparation of 8-(4-aminophenoxy)-4H-pyrido[2,3-b]pyrazin-3-one derivatives
US10167282B2 (en) 2013-11-25 2019-01-01 Cancer Research Technology Limited 1-(5-tert-butyl-2-aryl-pyrazol-3-yl)-3-[2-fluoro-4-[(3-oxo-4H-pyrido [2, 3-B]pyrazin- 8-yl)oxy]phenyl]urea derivatives as RAF inhibitors for the treatment of cancer

Also Published As

Publication number Publication date
JPH0142947B2 (en) 1989-09-18

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