JPS5735576A - 4,1-benzoxazepin-3-acetic derivative and its production - Google Patents
4,1-benzoxazepin-3-acetic derivative and its productionInfo
- Publication number
- JPS5735576A JPS5735576A JP9900380A JP9900380A JPS5735576A JP S5735576 A JPS5735576 A JP S5735576A JP 9900380 A JP9900380 A JP 9900380A JP 9900380 A JP9900380 A JP 9900380A JP S5735576 A JPS5735576 A JP S5735576A
- Authority
- JP
- Japan
- Prior art keywords
- lower alkyl
- formula
- benzoxazepin
- compound
- acetic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:4,1-Benzoxazepin-3-acetic derivatives of formula I [R, R1 are H, lower alkyl, phenyl; R2 is H, halogen, lower alkyl which may be substituted with nitro or hydroxyl groups, aralkyl, formula II (n is 1W3; R5, R6 are lower alkyl, heteroring forming along with adjacent nitrogen atom); ring A may be substituted with halogen, nitro, lower alkyl or lower alkoxy] or their salts or esters.
EXAMPLE: 1-Benzyl-7-chloro-3,5-didhydro-5-β-phenyl-4,1-benzoxazepin-2(1H)- one-3- acetic ethyl ester.
USE: They are used as a tranquilizer or synthetic intermediate of medicines.
PREPARATION: A compound of formula III (R3 is H, lower alkyl; R4 is H, lower acyl) is subjected to ring-closing reaction and, when necessary, the product is hydrolyzed to give the compound of formula IV among compound of formula I.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9900380A JPS5735576A (en) | 1980-07-18 | 1980-07-18 | 4,1-benzoxazepin-3-acetic derivative and its production |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9900380A JPS5735576A (en) | 1980-07-18 | 1980-07-18 | 4,1-benzoxazepin-3-acetic derivative and its production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5735576A true JPS5735576A (en) | 1982-02-26 |
Family
ID=14234821
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP9900380A Pending JPS5735576A (en) | 1980-07-18 | 1980-07-18 | 4,1-benzoxazepin-3-acetic derivative and its production |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5735576A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58119645A (en) * | 1982-01-07 | 1983-07-16 | Mitsubishi Electric Corp | Resin sealing device |
| EP0645377A1 (en) * | 1993-09-24 | 1995-03-29 | Takeda Chemical Industries, Ltd. | Benzoxazepine derivatives useful as squalene synthetase inhibitors |
| CN1044237C (en) * | 1992-04-20 | 1999-07-21 | 武田药品工业株式会社 | 4,1-benzoxazep in derivatives and their use |
| US6352982B1 (en) | 1997-04-21 | 2002-03-05 | Takeda Chemical Industries, Ltd. | 4,1-benzoxazepines, their analogues, and their use as somatostatin agonists |
| EP1407782A1 (en) * | 2001-06-28 | 2004-04-14 | Takeda Chemical Industries, Ltd. | Preventives/remedies for organ functional disorders and organ dysfunction |
-
1980
- 1980-07-18 JP JP9900380A patent/JPS5735576A/en active Pending
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58119645A (en) * | 1982-01-07 | 1983-07-16 | Mitsubishi Electric Corp | Resin sealing device |
| CN1044237C (en) * | 1992-04-20 | 1999-07-21 | 武田药品工业株式会社 | 4,1-benzoxazep in derivatives and their use |
| SG82630A1 (en) * | 1992-04-20 | 2001-08-21 | Takeda Chemical Industries Ltd | 4,1-benzoxazepin derivatives and their use |
| KR100293338B1 (en) * | 1992-04-20 | 2001-11-22 | 다케다 야쿠힌 고교 가부시키가이샤 | 4,1-benzoxazepine derivative and use thereof |
| EP0645377A1 (en) * | 1993-09-24 | 1995-03-29 | Takeda Chemical Industries, Ltd. | Benzoxazepine derivatives useful as squalene synthetase inhibitors |
| EP0645378A1 (en) * | 1993-09-24 | 1995-03-29 | Takeda Chemical Industries, Ltd. | Condensed seven- or eight-membered heterocyclic compounds useful as squalene synthetase inhibitors |
| US5677298A (en) * | 1993-09-24 | 1997-10-14 | Takeda Chemical Industries | Benzoxazepine-2-one compounds and their use |
| US5698691A (en) * | 1993-09-24 | 1997-12-16 | Takeda Chemical Industries, Ltd. | Condensed cyclic compounds and their use |
| US6352982B1 (en) | 1997-04-21 | 2002-03-05 | Takeda Chemical Industries, Ltd. | 4,1-benzoxazepines, their analogues, and their use as somatostatin agonists |
| EP1407782A1 (en) * | 2001-06-28 | 2004-04-14 | Takeda Chemical Industries, Ltd. | Preventives/remedies for organ functional disorders and organ dysfunction |
| EP1407782A4 (en) * | 2001-06-28 | 2004-10-20 | Takeda Chemical Industries Ltd | Preventives/remedies for organ functional disorders and organ dysfunction |
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